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	mso-ansi-language:RU;
	mso-fareast-language:EN-US;}
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	mso-margin-top-alt:auto;
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	mso-pagination:widow-orphan;
	font-size:12.0pt;
	font-family:"Times New Roman","serif";
	mso-fareast-font-family:"Times New Roman";
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.MsoChpDefault
	{mso-style-type:export-only;
	mso-default-props:yes;
	mso-ascii-font-family:Arial;
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@page WordSection1
	{size:595.3pt 841.9pt;
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	mso-header-margin:35.4pt;
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	mso-paper-source:0;}
div.WordSection1
	{page:WordSection1;}
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</style>
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<style>
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	{mso-style-name:"Обычная таблица";
	mso-tstyle-rowband-size:0;
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	mso-style-priority:99;
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	mso-pagination:widow-orphan;
	font-size:10.0pt;
	font-family:"Arial","sans-serif";
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<![endif]--><!--[if gte mso 9]><xml>
 <o:shapedefaults v:ext=3D"edit" spidmax=3D"1026"/>
</xml><![endif]--><!--[if gte mso 9]><xml>
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 </o:shapelayout></xml><![endif]-->
</head>

<body lang=3DRU style=3D'tab-interval:35.4pt'>

<div class=3DWordSection1>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:0cm;margin-bottom=
:0cm;
margin-left:178.9pt;margin-bottom:.0001pt;text-indent:1.1pt;line-height:nor=
mal'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>І Н С Т Р У К Ц І Я<o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:0cm;margin-bottom=
:0cm;
margin-left:72.0pt;margin-bottom:.0001pt;text-indent:36.0pt;line-height:nor=
mal'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>для медичного застосування лікарського засобу</span><=
/b><b
style=3D'mso-bidi-font-weight:normal'><span style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man"'><o:p></o:p></span></b></p>

<p class=3DMsoNormal align=3Dcenter style=3D'margin-bottom:0cm;margin-botto=
m:.0001pt;
text-align:center;line-height:normal;page-break-after:avoid;mso-outline-lev=
el:
1'><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal align=3Dcenter style=3D'margin-bottom:0cm;margin-botto=
m:.0001pt;
text-align:center;line-height:normal;page-break-after:avoid;mso-outline-lev=
el:
1'><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>СОЛІФУР®<o:p></o:p></span></b></p>

<p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:14=
.1pt;
margin-bottom:0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:center;
line-height:normal'><b><i style=3D'mso-bidi-font-style:normal'><span lang=
=3DUK
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'><o:p>&nbsp;=
</o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;line-=
height:
normal'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-=
style:
normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Tim=
es New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Склад:<o:p>=
</o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:14.1pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK;mso-bidi-font-weight:bold'>діюча речовина:</span></i><=
span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-bidi-fon=
t-style:
italic'> </span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;font-=
family:
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman";mso-ans=
i-language:
EN-US'>solifenacin</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'> </span><span lang=3DEN-US style=3D'mso-bidi-font-siz=
e:12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:EN-US'>succinate</span><span lang=3DUK style=3D'mso-bidi-=
font-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK;mso-bidi-font-style:italic'>;</span><b><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'><o:p></o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:14.1pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-bidi-fon=
t-style:
italic'>1 таблетка містить соліфенацину сукцинат</span><span style=3D'mso-b=
idi-font-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-bidi-font-style:italic'>у</span><span lang=3DUK style=3D'mso-bidi-font-=
size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK;mso-bidi-font-style:italic'> 5</span><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> мг або 10 =
мг;<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:14.1pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>допоміжні речовини:</span></i><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> лактоза, <=
span
style=3D'mso-spacerun:yes'> </span>гіпромелоза (6 мПас), магнію стеарат, кр=
охмаль
кукурудзяний прежелатинізований, магнію стеарат;<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;line-=
height:
normal'><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'ms=
o-bidi-font-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>склад оболонки:</span></i><span lang=3DUK style=3D'ms=
o-bidi-font-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'> опадрай пінк 03F14895 (гіпромелоза(6 мПас), тальк, т=
итану
діоксид <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;line-=
height:
normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Tim=
es New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>(Е 171), ма=
крогол
8000, заліза (ІІІ) оксид червоний (Е 172)).<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:14.1pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'><o:p>&nbsp;=
</o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:14.1pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'><span
style=3D'mso-spacerun:yes'> </span><b style=3D'mso-bidi-font-weight:normal'=
>Лікарська
форма.</b> Таблетки, вкриті </span><span style=3D'mso-bidi-font-size:12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man"'>плівковою
</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Time=
s New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>оболонкою. =
<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:14.1pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>Основні фізико-хімічні властивості: </span></i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>круглі
таблетки, вкриті плівковою оболонкою, від світло-рожевого до рожевого кольо=
ру. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'><o:p>&nbsp;</o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Фармакотера=
певтична
група. </span></b><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-f=
amily:
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman";mso-ans=
i-language:
UK;mso-bidi-font-weight:bold'>Засоби, що застосовуються в урології.</span><=
span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> Засоби для
лікування частого сечовипускання та нетримання сечі. Код АТХ </span><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>G</span>=
<span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>04</span><s=
pan
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US'>B</span>=
<span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> </span><sp=
an
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US'>D</span>=
<span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>08.<o:p></o=
:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'><o:p>&nbsp;=
</o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;line-=
height:
normal'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-=
style:
normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Tim=
es New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Фармакологі=
чні
властивості. <o:p></o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i><span lang=3DUK style=3D'mso-bidi-font-size:=
12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK;mso-bidi-font-weight:bold'>Фармакодинаміка. <o:p></o:p=
></span></i></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Соліфенацин є конкурентним, специфічним антагоністом
холінергічних рецепторів.<span style=3D'mso-spacerun:yes'>  </span>Сечовий =
міхур
іннервується парасимпатичними холінергічними нервами.<span
style=3D'mso-spacerun:yes'>  </span>Ацетилхолін скорочує гладкі м’язи детру=
зора,
впливаючи на мускаринові рецептори, що переважно представлені М3 підтипом. =
<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>У дослідженнях </span><i style=3D'mso-bidi-font-style=
:normal'><span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US'>in</span=
></i><i
style=3D'mso-bidi-font-style:normal'><span lang=3DEN-US style=3D'mso-bidi-f=
ont-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'> </span></i><i style=3D'mso-bidi-font-style:normal'><=
span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US'>vitro</s=
pan></i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> та </span>=
<i
style=3D'mso-bidi-font-style:normal'><span lang=3DEN-US style=3D'mso-bidi-f=
ont-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:EN-US'>in</span></i><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> </span></i=
><i
style=3D'mso-bidi-font-style:normal'><span lang=3DEN-US style=3D'mso-bidi-f=
ont-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:EN-US'>vivo</span></i><span lang=3DUK style=3D'mso-bidi-f=
ont-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'> було встановлено, що соліфенацин є конкурентним
специфічним антагоністом холінергічних рецепторів переважно М3<sub> </sub>п=
ідтипу.
Також було встановлено, що соліфенацин має слабку спорідненість або відсутн=
ість
спорідненості з іншими рецепторами і тестованими іонними каналами. <o:p></o=
:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Ефективність препарату, яку вивчали у кількох подвійн=
их
сліпих рандомізованих контрольованих клінічних дослідженнях у чоловіків та
жінок із синдромом гіперактивного сечового міхура, спостерігалася вже на пе=
ршому
тижні лікування та стабілізувалася протягом наступних 12 тижнів<span
style=3D'mso-spacerun:yes'>  </span>лікування. У відкритих дослідженнях при
тривалому застосуванні показано, що ефективність підтримується протягом
щонайменше 12 місяців. </span><span style=3D'mso-bidi-font-size:12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man"'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i><span style=3D'mso-bidi-font-size:12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man"'>Фармакокінетика.
<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'>Абсорбція. </span></i><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'>Після прийому таблеток максималь=
на
концентрація соліфенацину у плазмі крові (</span><span lang=3DEN-GB
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>C<sub>m<=
/sub></span><sub><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'>а</span></sub><sub><span lang=3D=
EN-GB
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>x</span>=
</sub><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'>) досягається через 3</span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>–</span><sp=
an
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'>8 годин. Значення часу досягнення
максимальної концентрації (</span><span lang=3DEN-GB style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:EN-GB'>t<sub>max</sub></span><span style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman"'>)<sub>
</sub>не залежить від дози препарату. Значення </span><span lang=3DEN-GB
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>C<sub>m<=
/sub></span><sub><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'>а</span></sub><sub><span lang=3D=
EN-GB
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>x</span>=
</sub><sub><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman"'> </span></sub><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'>і площі під кривою (</span><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>AUC</spa=
n><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'>) збільшуються пропорційно до до=
зи у
проміжку від 5 мг до 40 мг. Абсолютна біодоступність становить приблизно 90=
 %.
Прийом їжі на значення </span><span lang=3DEN-GB style=3D'mso-bidi-font-siz=
e:12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:EN-GB'>C<sub>m</sub></span><sub><span style=3D'mso-bidi-f=
ont-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman"'>а</span></sub><sub><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>x</span>=
</sub><sub><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman"'> </span></sub><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'>та </span><span lang=3DEN-GB
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>AUC</spa=
n><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'> соліфенацину не впливає. <o:p><=
/o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Розподіл. <=
/span></i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Соліфенацин
значною мірою (майже 98 %) зв'язується з білками плазми крові, головним чин=
ом з
</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:Symbo=
l;
mso-ascii-font-family:"Times New Roman";mso-fareast-font-family:"Times New =
Roman";
mso-hansi-font-family:"Times New Roman";mso-ansi-language:UK;mso-char-type:
symbol;mso-symbol-font-family:Symbol'><span style=3D'mso-char-type:symbol;
mso-symbol-font-family:Symbol'>a</span></span><sub><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>1</span></s=
ub><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>-кислим
глікопротеїном. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal;mso-pagination:widow-orphan lines-together;
page-break-after:avoid;mso-outline-level:2'><i style=3D'mso-bidi-font-style=
:normal'><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>Метабо=
лізм.
</span></i><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New =
Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>Соліфе=
нацин
значною мірою метаболізується у печінці, головним чином цитохромом Р450 3А4=
 (</span><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-bidi-=
font-weight:
bold'>CYP</span><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times=
 New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>3</spa=
n><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-bidi-=
font-weight:
bold'>A</span><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times N=
ew Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>4).
Системний кліренс соліфенацину становить приблизно<span
style=3D'mso-spacerun:yes'>    </span>9,5 л/години, і термінальний період й=
ого
напіввиведення становить 45</span><b><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Calibri Light","sans-serif";mso-fareast-font-family:"Ti=
mes New Roman";
mso-ansi-language:UK'>–</span></b><span style=3D'mso-bidi-font-size:12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-bidi-font-weight:bold'>68 годин. Після перорально</span><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-bidi-fon=
t-weight:
bold'>го</span><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times =
New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'> прийо=
му
препарату у плазмі крові, крім соліфенацину, був ідентифікований<span
style=3D'mso-spacerun:yes'>         </span>1 фармакологічно активний (4</sp=
an><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-bidi-=
font-weight:
bold'>R</span><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times N=
ew Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>-гідро=
ксисоліфенацин)
і 3 неактивні метаболіти <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal;mso-pagination:widow-orphan lines-together;
page-break-after:avoid;mso-outline-level:2'><span style=3D'mso-bidi-font-si=
ze:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-bidi-font-weight:bold'>(</span><span lang=3DEN-GB style=3D'mso-bidi-fon=
t-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:EN-GB;mso-bidi-font-weight:bold'>N</span><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>-глюку=
ронід,
</span><span lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"T=
imes New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-bidi-=
font-weight:
bold'>N</span><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times N=
ew Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>-оксид=
 і 4</span><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-bidi-=
font-weight:
bold'>R</span><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times N=
ew Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>-гідро=
кси-</span><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-bidi-=
font-weight:
bold'>N</span><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times N=
ew Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>-оксид
соліфенацину). <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal;mso-pagination:widow-orphan lines-together;
page-break-after:avoid;mso-outline-level:2'><i style=3D'mso-bidi-font-style=
:normal'><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>Екскре=
ція.
</span></i><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New =
Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>Після
одноразового застосування 10 мг [<sup>14</sup></span><span lang=3DEN-GB
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-bidi-=
font-weight:
bold'>C</span><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times N=
ew Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>-мічен=
ого]-соліфенацину
приблизно<span style=3D'mso-spacerun:yes'>   </span>70 % радіоактивної мітки
проявляється у сечі і 23 % у фекаліях. У сечі приблизно 11 % радіоактивної
мітки виводиться у вигляді незміненої активної субстанції; приблизно 18 % –=
 у
вигляді метаболіту </span><span lang=3DEN-GB style=3D'mso-bidi-font-size:12=
.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:EN-GB;mso-bidi-font-weight:bold'>N</span><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>-оксид=
у, 9
% – у вигляді метаболіту 4</span><span lang=3DEN-GB style=3D'mso-bidi-font-=
size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:EN-GB;mso-bidi-font-weight:bold'>R</span><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>-гідро=
кси-</span><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-bidi-=
font-weight:
bold'>N</span><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times N=
ew Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>-оксид=
 і 8
% – у вигляді 4</span><span lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:EN-GB;mso-bidi-font-weight:bold'>R</span><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-bidi-font-weight:bold'>-гідро=
ксиметаболіту
(активний метаболіт). <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Дозова
залежність</span></i><i style=3D'mso-bidi-font-style:normal'><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'>. </span></i><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>У проміжку
терапевтичних доз фармакокінетика препарату є лінійною. <o:p></o:p></span><=
/p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Особливості=
 фармакокінетики
в окремих категорій пацієнтів.<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Вік.</span>=
</i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> Немає
необхідності коригувати дозу залежно від віку хворих. Дослідження показали,=
 що
експозиція соліфенацину (5 і 10 мг), виражена у вигляді AUC, була подібною у
здорових добровольців літнього віку (від 65 до 80 років) і у здорових
добровольців молодого та зрілого віку (&lt; 55 років). Середня швидкість
абсорбції, виражена у вигляді t<sub>max</sub>,<sub> </sub>була дещо нижчою,=
 а
кінцевий період напіввиведення – приблизно на 20 % триваліший у пацієнтів
літнього віку. Ці незначні відмінності не є клінічно значущими.<o:p></o:p><=
/span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Фармакокінетику соліфенацину не вивчали у дітей та
підлітків.<sub><span style=3D'mso-spacerun:yes'>   </span></sub><o:p></o:p>=
</span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Стать. </sp=
an></i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Фармакокіне=
тика
соліфенацину не залежить від статі пацієнта.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Раса.</span=
></i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> Расова
приналежність не впливає на фармакокінетику соліфенацину. <o:p></o:p></span=
></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Ниркова
недостатність.</span></i><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'> AUC та C<sub>mаx </sub>соліфенацину у пацієнтів із
легкою та помірною нирковою недостатністю незначно відрізняються від
відповідних показників у здорових добровольців. У пацієнтів із тяжкою нирко=
вою
недостатністю (кліренс креатиніну <u>&lt;</u> 30 мл за хвилину) експозиція
соліфенацину значно вища – збільшення C<sub>mаx<span style=3D'mso-spacerun:=
yes'> 
</span></sub>становить приблизно<span style=3D'mso-spacerun:yes'>       </s=
pan>30
%, AUC – понад 100 % та період напіввиведення – понад 60 %. Відзначений
статистично значущий взаємозв`язок між кліренсом креатиніну і кліренсом
соліфенацину. Фармакокінетику у пацієнтів, які проходили гемодіаліз, не
вивчали. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Печінкова
недостатність.</span></i><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'> У пацієнтів із помірною печінковою недостатністю
(показник Чайлда–П`ю від 7 до 9) значення C<sub>mаx</sub> не змінюється, AUC
зростає на 60 % та період напіввиведення<sub><span style=3D'mso-spacerun:ye=
s'> 
</span></sub>збільшується вдвічі. Фармакокінетику у пацієнтів із тяжкою
нирковою недостатністю не вивчали. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span style=3D'mso-bidi-font-size:12.0pt;font-f=
amily:
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman"'><o:p>&=
nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Клінічні
характеристики.</span></b><span lang=3DUK style=3D'mso-bidi-font-size:12.0p=
t;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><i
style=3D'mso-bidi-font-style:normal'><span style=3D'mso-bidi-font-size:12.0=
pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"MS ??"'>Пока=
зання.</span></i></b><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"MS ??"'> <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span style=3D'mso-bidi-font-size:12.0pt;font-f=
amily:
"Times New Roman","serif";mso-fareast-font-family:"MS ??"'>Симптоматичне
лікування ургентного (імперативного) нетримання сечі та/або</span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"MS ??";mso-ansi-language:UK;mso-bidi-font-weight:b=
old'>
частого сечовипускання, а також ургентних (імперативних) позивів до сечовип=
ускання,
характерних для пацієнтів із синдромом гіперактивного сечового міхура. <o:p=
></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;line-=
height:
normal'><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Rom=
an","serif";
mso-fareast-font-family:"Times New Roman"'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-.05pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Протипоказа=
ння.</span></i></b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> </span><sp=
an
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span style=3D'mso-bidi-font-size:12.0pt;font-f=
amily:
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman"'>Препар=
ат
протипоказаний пацієнтам із підвищеною чутливістю до активної субстанції аб=
о до
</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Time=
s New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>будь-якої</=
span><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'> з допоміжних речовин; </span><s=
pan
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>пацієнтам <=
/span><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'>із затримкою сечовипускання</spa=
n><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>,</span><sp=
an
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman"'> </span><span style=3D'mso-bidi-=
font-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman"'>з
тяжкими шлунково-кишковими захворюваннями (включаючи токсичний мегаколон)</=
span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>,</span><sp=
an
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'> із міастенією </span><span lang=
=3DUK
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>гравіс або =
із
закритокутовою глаукомою та пацієнтам із ризиком розвитку цих станів; при
проведенні гемодіалізу (див. розділ «Фармакокінетика»); із тяжкою печінково=
ю недостатністю
(див. розділ «Фармакокінетика»); пацієнтам із тяжкою нирковою недостатністю=
 або
печінковою недостатністю середнього ступеня тяжкості, які перебувають на
лікуванні сильними інгібіторами цитохрому </span><span lang=3DEN-GB
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>CYP</spa=
n><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>3</span><sp=
an
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>A</span>=
<span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>4, наприклад
кетоконазолом (див. розділ «Взаємодія з іншими лікарськими засобами та інші
види взаємодій»).<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>Взаємодія з іншими лікарськими засобами та інші види
взаємодій. <o:p></o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Фармакологі=
чні
взаємодії</span></i><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font=
-family:
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman";mso-ans=
i-language:
UK'>. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Одночасний прийом інших лікарських препаратів з
антихолінергічними властивостями може дати виразніші терапевтичні, а також
небажані ефекти. Після припинення застосування соліфенацину до прийому
наступних лікарських засобів антихолінергічної терапії необхідно витримати
приблизно однотижневий інтервал. Терапевтичний ефект соліфенацину може
зменшитися при супутньому застосуванні агоністів холінергічних рецепторів.
Соліфенацин може знижувати ефект лікарських препаратів, які стимулюють
перистальтику шлунково-кишкового тракту, таких як метоклопрамід і цизаприд.=
 <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Фармакокіне=
тичні
взаємодії.<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Дослідження=
 </span></i><i
style=3D'mso-bidi-font-style:normal'><span lang=3DEN-US style=3D'mso-bidi-f=
ont-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:EN-US'>i</span></i><i style=3D'mso-bidi-font-style:normal=
'><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>n</span>=
</i><i
style=3D'mso-bidi-font-style:normal'><span lang=3DEN-GB style=3D'mso-bidi-f=
ont-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'> </span></i><i style=3D'mso-bidi-font-style:normal'><=
span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>vitro</s=
pan></i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> показало, =
що
соліфенацин у терапевтичних концентраціях не пригнічує мікросоми печінки </=
span><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>CYP</spa=
n><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>1</span><sp=
an
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>A</span>=
<span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>1/2, 2</spa=
n><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>C</span>=
<span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>9, 2</span>=
<span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>C</span>=
<span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>19, 2</span=
><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>D</span>=
<span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>6, чи 3</sp=
an><span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>A</span>=
<span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>4. Таким чи=
ном,
малоймовірно, що соліфенацин впливає на кліренс лікарських засобів, що
метаболізуються ферментами </span><span lang=3DEN-GB style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:EN-GB'>CYP</span><span lang=3DUK style=3D'mso-bidi-font-s=
ize:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Вплив інших
лікарських засобів на фармакокінетику соліфенацину.<o:p></o:p></span></i></=
p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Соліфенацин метаболізується ферментом CYP3A4. Одночас=
не
застосування кетоконазолу (200 мг/добу), сильного інгібітора CYP3A4, призво=
дило
до двократного підвищення AUC соліфенацину, тоді як прийом кетоконазолу<span
style=3D'mso-spacerun:yes'>  </span>в дозі 400 мг/добу спричиняє підвищення=
 AUC
соліфенацину в 3 рази. Таким чином, максимальну дозу соліфенацину необхідно
обмежити до 5 мг при одночасному застосуванні з кетоконазолом чи з
терапевтичними дозами інших активних інгібіторів ферменту CYP3A4 (наприклад
ритонавіру, нелінавіру, ітраконазолу) (див. розділ «Спосіб застосування та
дози»). <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Одночасне застосування соліфенацину та сильного
інгібітора ферменту CYP3A4 протипоказане пацієнтам із тяжкою нирковою або
помірно вираженою печінковою недостатністю.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Не досліджували вплив ферментів індукції на
фармакокінетику соліфенацину і його метаболітів, а також дію субстратів </s=
pan><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"MS Mincho";mso-ansi-language:UK;mso-fareast-langua=
ge:
JA'>CYP3A4 </span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-f=
amily:
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman";mso-ans=
i-language:
UK'>з підвищеною спорідненістю<span style=3D'mso-spacerun:yes'>  </span>та =
його
метаболітів на експозицію соліфенацину. Оскільки соліфенацин метаболізується
ферментом CYP3A4, фармакокінетичні взаємодії можливі з іншими субстратами ц=
ього
ферменту, що<span style=3D'mso-spacerun:yes'>  </span>мають підвищену
спорідненість (наприклад з верапамілом, дилтіаземом), та індукторами фермен=
ту
CYP3A4 (наприклад з рифампіцином, фенітоїном, карбамазепіном). <o:p></o:p><=
/span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Вплив
соліфенацину на фармакокінетику лікарських засобів.<o:p></o:p></span></i></=
p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;line-=
height:
normal;tab-stops:169.3pt'><i style=3D'mso-bidi-font-style:normal'><span lan=
g=3DUK
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Пероральні
контрацептиви.<span style=3D'mso-tab-count:1'>        </span><o:p></o:p></s=
pan></i></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Прийом препарату не впливає на фармакокінетичну взаєм=
одію
соліфенацину з комбінованими пероральними контрацептивами
(етинілестрадіол/левоноргестрел). <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Варфарин.<o=
:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Прийом препарату не впливає на фармакокінетичну взаєм=
одію
<i>R</i>-варфарину чи <i>S&#8209;</i>варфарину або його вплив на протромбін=
овий
час.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Дигоксин.<o=
:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Прийом препарату не впливає на фармакокінетику дигокс=
ину.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>Особливості застосування.<o:p></o:p></span></i></b></=
p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Перед початком лікування препаратом необхідно встанов=
ити
імовірність інших причин частого сечовипускання (серцева недостатність або
захворювання нирок). Якщо виявлена інфекція сечовивідних шляхів, слід розпо=
чати
відповідну антибактеріальну терапію.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Препарат необхідно приймати з обережністю пацієнтам: =
<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:0cm;margin-bottom=
:0cm;
margin-left:27.0pt;margin-bottom:.0001pt;text-align:justify;line-height:nor=
mal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>– із клініч=
но
значущою обструкцією вихідного отвору сечового міхура, що призводить до<span
style=3D'mso-spacerun:yes'>  </span>ризику затримки сечовипускання;<span
style=3D'mso-spacerun:yes'>  </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'><span style=3D'mso-spacerun:yes'>         </span>– зі
шлунково-кишковими обструктивними захворюваннями;<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:0cm;margin-bottom=
:0cm;
margin-left:27.0pt;margin-bottom:.0001pt;text-align:justify;line-height:nor=
mal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>– із ризиком
зниження моторики шлунково-кишкового тракту;<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:0cm;margin-bottom=
:0cm;
margin-left:27.0pt;margin-bottom:.0001pt;text-align:justify;line-height:nor=
mal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>– із тяжкою=
 нирковою
(кліренс креатиніну <u>&lt;</u> 30 мл за хвилину) та помірною печінковою
(показник за Чайлдом–П`ю від 7 до 9) недостатністю (див. розділи «Спосіб
застосування та дози» і «Фармакокінетика»); дози для цих пацієнтів не мають
перевищувати 5 мг;<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:0cm;margin-bottom=
:0cm;
margin-left:27.0pt;margin-bottom:.0001pt;text-align:justify;line-height:nor=
mal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>– при<span
style=3D'mso-spacerun:yes'>  </span>одночасному прийомі<span
style=3D'mso-spacerun:yes'>  </span>сильних інгібіторів </span><span lang=
=3DEN-US
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US'>CYP</spa=
n><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>3</span><sp=
an
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US'>A</span>=
<span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>4, наприклад
кетоконазолу (див. розділи «Спосіб застосування та дози» і «Взаємодія з інш=
ими
лікарськими засобами та інші види взаємодій»);<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:0cm;margin-bottom=
:0cm;
margin-left:27.0pt;margin-bottom:.0001pt;text-align:justify;line-height:nor=
mal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>– із грижею
стравохідного отвору діафрагми та/або шлунково-стравохідним рефлюксом та/або
тим, хто одночасно приймає лікарські препарати (такі як бісфосфонати), які
можуть<span style=3D'mso-spacerun:yes'>  </span>спричинити або посилити езо=
фагіт;<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:0cm;margin-bottom=
:0cm;
margin-left:27.0pt;margin-bottom:.0001pt;text-align:justify;line-height:nor=
mal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>– вегетатив=
ною
нейропатією.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK;mso-fareast-language:UK'>У пацієнтів із факторами ризи=
ку,
такими як раніше зареєстрований синдром подовження інтервалу QT, та гіпокал=
іємією
спостерігалося подовження інтервалу QT і тріпотіння шлуночків <i
style=3D'mso-bidi-font-style:normal'>(</i></span><i style=3D'mso-bidi-font-=
style:
normal'><span lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"=
Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>torsade<=
/span></i><i
style=3D'mso-bidi-font-style:normal'><span lang=3DEN-GB style=3D'mso-bidi-f=
ont-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'> </span></i><i style=3D'mso-bidi-font-style:normal'><=
span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>de</span=
></i><i
style=3D'mso-bidi-font-style:normal'><span lang=3DEN-GB style=3D'mso-bidi-f=
ont-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'> </span></i><i style=3D'mso-bidi-font-style:normal'><=
span
lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB'>pointes<=
/span></i><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>).</span></i><span lang=3DUK style=3D'mso-bidi-font-s=
ize:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK;mso-fareast-language:UK'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Безпека та ефективність застосування препарату не
досліджена для хворих із підвищеною активністю сфінктера нейрогенного
походження.<span style=3D'mso-spacerun:yes'>  </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Пацієнтам із рідкісними спадковими формами
непереносимості галактози, </span><span lang=3DEN-US style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:EN-US'>Lapp</span><span lang=3DUK style=3D'mso-bidi-font-=
size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>-дефіцитом лактази або з порушенням глюкозо-галактозн=
ої
мальабсорбції не слід приймати препарат.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK;mso-fareast-language:UK'>У деяких пацієнтів, які
застосовували соліфенацину сукцинат, повідомляли про ангіоневротичний набря=
к з
обструкцією дихальних шляхів. При виникненні набряку Квінке лікування
соліфенацину сукцинатом слід припинити та вжити відповідних заходів або
призначити належне лікування.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK;mso-fareast-language:UK'><span
style=3D'mso-spacerun:yes'> </span>У деяких пацієнтів, які застосовували
соліфенацину сукцинат, спостерігалися анафілактичні реакції. При виникненні
анафілактичних реакцій лікування соліфенацином сукцинатом слід припинити та
вжити відповідних заходів або призначити належне лікування.<o:p></o:p></spa=
n></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span style=3D'mso-bidi-font-size:12.0pt;font-f=
amily:
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman"'>Максим=
альний
ефект препарату досягається не раніше ніж через 4 тижні.</span><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> </span><sp=
an
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span style=3D'mso-bidi-font-size:12.0pt;font-f=
amily:
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman"'><o:p>&=
nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Застосуванн=
я у
період вагітності або годування груддю.<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;line-=
height:
normal'><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'ms=
o-bidi-font-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>Вагітність.<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Немає клінічних даних про жінок, які завагітніли під =
час
застосування соліфенацину. Досліди на тваринах не виявили прямої несприятли=
вої
дії на фертильність, розвиток ембріона/плода або пологи. Потенційний ризик =
невідомий.<span
style=3D'mso-spacerun:yes'>  </span>Слід дотримуватися обережності при
застосуванні даного препарату<span style=3D'mso-spacerun:yes'>  </span>вагі=
тним
жінкам. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Годування
груддю.<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Немає даних щодо екскреції соліфенацину у грудне моло=
ко.
У мишей соліфенацин та/або його метаболіти проникають у молоко і спричиняють
дозозалежну недостатність росту у новонароджених мишей.<span
style=3D'mso-spacerun:yes'>  </span>Застосування соліфенацину не рекомендує=
ться у
період годування груддю. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;line-=
height:
normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Tim=
es New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'><o:p>&nbsp;=
</o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Здатність
впливати на швидкість реакції при керуванні автотранспортом або іншими
механізмами. <o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>У зв'язку з тим, що соліфенацин, як і інші
антихолінергічні препарати, може спричинити нечіткість зору і нечасто
сонливість та підвищену втомлюваність (див. розділ «Побічні ефекти»), прийом
препарату може негативно впливати на здатність керувати автомобілем та інши=
ми
механізмами.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-.05pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'><o:p>&nbsp;=
</o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-.05pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Спосіб
застосування та дози.</span></i></b><b style=3D'mso-bidi-font-weight:normal=
'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> <o:p></o:p=
></span></b></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-.05pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>Дорослі, включаючи пацієнтів літнього віку: </span></=
i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>рекомендова=
на
доза </span><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New=
 Roman","serif";
mso-fareast-font-family:"Times New Roman"'>–</span><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> 5 мг препа=
рату
1 раз на добу. Якщо необхідно, дозу можна підвищити до 10 мг 1 раз на добу.=
<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Пацієнти з
нирковою недостатністю: </span></i><span lang=3DUK style=3D'mso-bidi-font-s=
ize:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>не потрібна корекція дози для пацієнтів із помірною та
середнього ступеня тяжкості нирковою недостатністю (кліренс креатиніну &gt;=
 30
мл/хв). Пацієнтам з тяжким ступенем ниркової недостатності (кліренс креатин=
іну
&#8804; 30 мл/хв) слід з обережністю застосовувати препарат у дозі не більше
ніж 5 мг 1 раз на добу (див. розділ «Фармакокінетика»). <o:p></o:p></span><=
/p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Пацієнти з
печінковою недостатністю: </span></i><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>не потрібна корекція дози для пацієнтів з помірною
печінковою недостатністю. Пацієнтам з помірною печінковою недостатністю
(показник за Чайлд</span><span style=3D'mso-bidi-font-size:12.0pt;font-fami=
ly:
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman"'>ом</sp=
an><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>–П`ю</span>=
<span
lang=3DUK style=3D'font-size:10.0pt;mso-bidi-font-size:12.0pt;font-family:"=
Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> </span><sp=
an
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>7–9) слід
приймати препарат з обережністю і не перевищувати дозування 5 мг 1 раз на д=
обу
(див. розділ «Фармакокінетика»).<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>При
застосуванні потужних інгібіторів цитохрому P450 3A4: </span></i><span lang=
=3DUK
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>максимальна
доза препарату має бути обмежена до 5 мг при одночасному прийомі з
кетоконазолом або терапевтичними дозами інших сильних інгібіторів ізоформи
цитохрому CYP3A4, наприклад ритонавіру, нелфінавіру, ітраконазолу (див. роз=
діл
«Взаємодія з іншими лікарськими засобами та інші види взаємодій»).<o:p></o:=
p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Препарат<sup><span style=3D'mso-spacerun:yes'>  </spa=
n></sup>приймати
перорально, ковтати таблетки цілими, запиваючи рідиною, незалежно від прийо=
му
їжі. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-.05pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'><o:p>&nbsp;=
</o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-.05pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>Діти.<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Не досліджували безпеку та ефективність застосування
препарату дітям, тому соліфенацин не слід призначати цій категорії пацієнті=
в.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><i
style=3D'mso-bidi-font-style:normal'><span style=3D'mso-bidi-font-size:12.0=
pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man"'><o:p>&nbsp;</o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>Передозування. <o:p></o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Симптоми. <=
o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Передозування соліфенацину сукцинату може призвести до
тяжких антихолінергічних ефектів. Найвища доза соліфенацину сукцинату, прий=
нята
випадково одним пацієнтом, становила 280 мг протягом 5 годин</span><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'>,</span><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'><span
style=3D'mso-spacerun:yes'>  </span>спостерігалися зміни психічного стану, =
що не
потребували госпіталізації.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><i style=3D'mso-bidi-font-style:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Лікування.<=
/span></i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> <o:p></o:p=
></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>У разі передозування соліфенацину сукцинату пацієнтові
необхідно прийняти активоване вугілля. Може бути корисним промивання шлунка,
якщо воно зроблене протягом 1 години після прийому препарату, але не слід
викликати блювання.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Щодо інших антихолінергічних ефектів, то симптоми слід
лікувати таким чином:<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>– тяжкі антихолінергічні ефекти з боку центральної
нервової системи, такі як галюцинації або підвищена збудливість: лікування
фізостигміном або карбахолом;<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>– судоми або підвищену збудливість: лікування
бензодіазепінами;<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span style=3D'mso-bidi-font-size:12.0pt;font-f=
amily:
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman"'>–</spa=
n><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> недостатні=
сть
з боку органів дихання: лікування </span><span style=3D'mso-bidi-font-size:=
12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man"'>–</span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> штучна
вентиляція легенів;<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span style=3D'mso-bidi-font-size:12.0pt;font-f=
amily:
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman"'>–</spa=
n><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> тахікардія:
лікування бета-блокаторами;<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>– затримка сечовипускання: лікування – катетеризація;=
<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>– мідріаз: лікування очними краплями, наприклад
пілокарпіном, та/або розміщення пацієнта у темній кімнаті.<o:p></o:p></span=
></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Як і у разі передозування іншими антихолінергічними
засобами, особливу увагу слід приділяти пацієнтам зі встановленим ризиком
подовження інтервалу </span><span lang=3DEN-US style=3D'mso-bidi-font-size:=
12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:EN-US'>QT</span><span lang=3DUK style=3D'mso-bidi-font-si=
ze:12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'> (при гіпокаліємії, брадикардії, при одночасному
застосуванні препаратів, що спричиняють подовження інтервалу </span><span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roma=
n","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US'>QT</span=
><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>) і пацієнт=
ам
із захворюваннями серця (ішемія міокарда, аритмії, застійна серцева
недостатність).<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'><o:p>&nbsp;</o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-.05pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Побічні
реакції.</span></i></b><b style=3D'mso-bidi-font-weight:normal'><span lang=
=3DUK
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'> <o:p></o:p=
></span></b></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-.05pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Лікарський
засіб може спричинити побічні ефекти, пов’язані з антихолінергічною дією
соліфенацину,<span style=3D'mso-spacerun:yes'>  </span>які,<span
style=3D'mso-spacerun:yes'>  </span>як правило, слабкі або помірні. Їхня<sp=
an
style=3D'mso-spacerun:yes'>  </span>частота залежить від дози препарату. <o=
:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-.05pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Найчастіше
побічне явище – сухість у роті, що спостерігалася у 11 % пацієнтів, які
отримували дозу 5 мг на добу, у 22 % пацієнтів, які отримували 10 мг на доб=
у, у
4 %, які отримували плацебо. Вираженість сухості у роті, як правило, була
слабкою, і тільки у поодиноких випадках призводила до припинення лікування.
Загалом лікарський препарат досить добре переносився (близько 99 %), і
приблизно 90 % пацієнтів приймали препарат протягом повного періоду дослідж=
ення,
який тривав 12 тижнів.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-.05pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>У таблиці н=
ижче
наведено інші побічні ефекти, зареєстровані при проведенні клінічних дослід=
жень
та у післяреєстраційний період.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-.05pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'><o:p>&nbsp;=
</o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D690
 style=3D'width:517.45pt;margin-left:-15.9pt;border-collapse:collapse;borde=
r:
 none;mso-border-alt:solid windowtext .5pt;mso-yfti-tbllook:1184;mso-paddin=
g-alt:
 0cm 5.4pt 0cm 5.4pt;mso-border-insideh:.5pt solid windowtext;mso-border-in=
sidev:
 .5pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"T=
imes New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>Класифікація MedDRA</span><span lang=3DEN-GB style=3D'mso-bidi-font-s=
ize:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p></o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border:solid windowtext=
 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
  solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:2.0pt;margin-right:0cm;margin-bo=
ttom:
  2.0pt;margin-left:0cm;line-height:normal;tab-stops:52.2pt'><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>Дуже часто &gt;1/10</span><span lang=3DEN-GB style=3D'mso-bidi-font-s=
ize:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p></o:p></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border:solid windowtext=
 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
  solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-bottom:0cm;margin-bot=
tom:.0001pt;
  text-align:center;line-height:normal'><span lang=3DUK style=3D'mso-bidi-f=
ont-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>Часто<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:2.0pt;margin-righ=
t:0cm;
  margin-bottom:2.0pt;margin-left:0cm;text-align:center;line-height:normal'=
><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>&gt; 1/100,<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:2.0pt;margin-righ=
t:0cm;
  margin-bottom:2.0pt;margin-left:0cm;text-align:center;line-height:normal'=
><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'><span style=3D'mso-spacerun:yes'> </span>&lt;1/10</span><span lang=3D=
EN-GB
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
  solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-bottom:0cm;margin-bot=
tom:.0001pt;
  text-align:center;line-height:normal'><span lang=3DUK style=3D'mso-bidi-f=
ont-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>Нечасто<o:p></o:p></span></=
p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:2.0pt;margin-righ=
t:0cm;
  margin-bottom:2.0pt;margin-left:0cm;text-align:center;line-height:normal'=
><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>&gt; 1/1000, &lt;1/100</span><span lang=3DEN-GB style=3D'mso-bidi-fon=
t-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p></o:p></span></p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border:solid windowtext=
 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
  solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-bottom:0cm;margin-bot=
tom:.0001pt;
  text-align:center;line-height:normal'><span lang=3DUK style=3D'mso-bidi-f=
ont-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>Рідкісні<o:p></o:p></span><=
/p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:2.0pt;margin-righ=
t:0cm;
  margin-bottom:2.0pt;margin-left:0cm;text-align:center;line-height:normal'=
><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>&gt; 1/10000, &lt;1/1000<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:2.0pt;margin-righ=
t:0cm;
  margin-bottom:2.0pt;margin-left:0cm;text-align:center;line-height:normal'=
><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border:solid windowtext=
 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
  solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-bottom:0cm;margin-bot=
tom:.0001pt;
  text-align:center;line-height:normal'><span lang=3DUK style=3D'mso-bidi-f=
ont-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>Дуже рідкісні<o:p></o:p></s=
pan></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-bottom:0cm;margin-bot=
tom:.0001pt;
  text-align:center;line-height:normal'><span lang=3DUK style=3D'mso-bidi-f=
ont-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>&lt;1/10000<o:p></o:p></spa=
n></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:2.0pt;margin-righ=
t:0cm;
  margin-bottom:2.0pt;margin-left:0cm;text-align:center;line-height:normal'=
><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border:solid windowtext=
 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
  solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:2.0pt;margin-righ=
t:0cm;
  margin-bottom:2.0pt;margin-left:0cm;text-align:center;line-height:normal'=
><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  UK'>Невідомо (частоту не можна оцінити на основі наявних даних)</span><sp=
an
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:JA'><o:p><=
/o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:0cm;margin-bott=
om:0cm;
  margin-left:1.05pt;margin-bottom:.0001pt;line-height:normal'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>Інфекції та інвазії<o:p></o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:1.05pt;margin-bottom:.0001pt;text-align:cen=
ter;
  line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;
  font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New =
Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-bottom:0cm;margin-bot=
tom:.0001pt;
  text-align:center;line-height:normal'><span lang=3DUK style=3D'mso-bidi-f=
ont-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"T=
imes New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>Інфекції сечовивідних шляхів, цистит<o:p></o:p></span></p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family=
:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family=
:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family=
:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'><span lang=3DEN-GB style=3D'font-size:12.0pt;
  font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New =
Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA;mso-bidi-language:AR-SA'>=
<br
  clear=3Dall style=3D'page-break-before:always'>
  </span>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>З боку імунної системи</spa=
n><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>Анафілактич-на реакція*</sp=
an><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>З боку метаболізму та травл=
ення</span><span
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK'><o:p><=
/o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>Зниження апетиту*,
  гіперкаліємія*</span><span lang=3DEN-GB style=3D'mso-bidi-font-size:12.0p=
t;
  font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New =
Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>Психічні розлади</span><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>Галюцина-ції*,</span><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>сплута-ність свідомості*</s=
pan><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>Марення*</span><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>З боку нервової системи</sp=
an><span
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:JA'><o:p><=
/o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"T=
imes New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>Сонливість,<o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>порушення смаку</span><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-5.7pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;line-height:normal'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>Запаморо-чення*, головний біль*<o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>З боку органів зору</span><=
span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-US style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-US;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>Нечіткість зору</span><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>Сухість очей</span><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>Глаукома*</span><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>З боку серця</span><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-US style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-US;mso-fareast-language:UK'>Torsades de pointes*</sp=
an><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  UK'>,<o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>подовження інтервалу QT на
  електрокар-діограмі*,</span><span lang=3DEN-GB style=3D'mso-bidi-font-siz=
e:12.0pt;
  font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New =
Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:UK'><o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>фібриляція передсердь*,<o:p=
></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>відчуття серцебиття*, <o:p>=
</o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>тахікардія*</span><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:8'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>З боку органів дихання, гру=
дної
  клітки та середостіння</span><span style=3D'mso-bidi-font-size:12.0pt;
  font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New =
Roman";
  mso-fareast-language:JA'><o:p></o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>Сухість слизової оболонки
  носової порожнини</span><span style=3D'mso-bidi-font-size:12.0pt;font-fam=
ily:
  "Times New Roman","serif";mso-fareast-font-family:"Times New Roman";
  mso-fareast-language:JA'><o:p></o:p></span></p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>Дисфонія</span><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'>*<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:9'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>З боку шлунково-кишкового
  тракту</span><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times =
New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:JA'><o:p><=
/o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>Сухість у роті</span><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"T=
imes New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>Запор,<o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"T=
imes New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>нудота,<o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"T=
imes New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>диспепсія,<o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"T=
imes New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>біль у животі<o:p></o:p></span></p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"T=
imes New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>Гастро-езофагеаль-ний рефлюкс,<o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>сухість у глотці</span><span
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:JA'><o:p><=
/o:p></span></p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-5.4pt;margin-b=
ottom:
  0cm;margin-left:.2pt;margin-bottom:.0001pt;text-align:justify;line-height:
  normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"T=
imes New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>Непрохід-ність товстого кишечни-ку, копро-стаз</span><span
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:JA'>, </sp=
an><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  UK'>блюван-ня*</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;
  font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New =
Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'><o:p></o:p></span></p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>Кишкова непрохід-ність*,
  абдоміналь-ний дискомфорт*</span><span style=3D'mso-bidi-font-size:12.0pt;
  font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New =
Roman";
  mso-fareast-language:JA'><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:10'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>Гепатобілі-арні розлади</sp=
an><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DEN-GB style=3D'mso=
-bidi-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p>&nbsp;</o:p></span>=
</p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>Порушення функцій печінки*,
  порушення<span style=3D'mso-spacerun:yes'>  </span>даних лабораторних
  досліджень печінкових проб*</span><span style=3D'mso-bidi-font-size:12.0p=
t;
  font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New =
Roman";
  mso-fareast-language:JA'><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:11'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>З боку шкіри і підшкірних
  тканин</span><span style=3D'mso-bidi-font-size:12.0pt;font-family:"Times =
New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:JA'><o:p><=
/o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>Сухість шкіри</span><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:-5.7pt;margin=
-bottom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:JA'>Свербіж*, висипан-ня*</span=
><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"T=
imes New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  UK'>Мульти-формна еритема*, <o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>кропив'ян-ка*, <o:p></o:p><=
/span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>набряк Квінке*</span><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>Ексфоліатив-ний дерматит*</=
span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:12'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"T=
imes New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  UK'>З боку опорно-рухового апарату <o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>та сполучної тканини</span>=
<span
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:JA'><o:p><=
/o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span style=3D'mso-bidi-font-si=
ze:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal'><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:UK;mso-fareast-language:UK'>М'язова слабкість *</span><=
span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-far=
east-language:
  JA'><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:13'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>З боку нирок та сечовивідної системи</span><span style=3D'mso-bidi-fo=
nt-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-fareast-language:JA'><o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:JA'><o:p>&=
nbsp;</o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:JA'><o:p>&=
nbsp;</o:p></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:JA'><o:p>&=
nbsp;</o:p></span></p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:-9.75pt;margi=
n-bottom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>Утруднене сечовипускан-ня</span><span lang=3DEN-GB style=3D'mso-bidi-=
font-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p></o:p></span></p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:-5.7pt;margin=
-bottom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>Затримка сечовипу-скання<o:p></o:p></span></p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  UK'>Ниркова недостат-ність*</span><span lang=3DEN-GB style=3D'mso-bidi-fo=
nt-size:
  12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Tim=
es New Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:14;mso-yfti-lastrow:yes'>
  <td width=3D113 valign=3Dtop style=3D'width:85.1pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>Загальні розлади </span><span lang=3DEN-GB style=3D'mso-bidi-font-siz=
e:12.0pt;
  font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New =
Roman";
  mso-ansi-language:EN-GB;mso-fareast-language:JA'><o:p></o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.4pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  lang=3DEN-GB style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Ro=
man","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-far=
east-language:
  JA'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D108 valign=3Dtop style=3D'width:81.0pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;lin=
e-height:
  normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"T=
imes New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>Підвищена втомлюва-ність, <o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
","serif";
  mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareas=
t-language:
  JA'>периферич-ний набряк</span><span style=3D'mso-bidi-font-size:12.0pt;
  font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New =
Roman";
  mso-fareast-language:JA'><o:p></o:p></span></p>
  </td>
  <td width=3D82 valign=3Dtop style=3D'width:61.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:JA'><o:p>&=
nbsp;</o:p></span></p>
  </td>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:JA'><o:p>&=
nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt'>
  <p class=3DMsoNormal style=3D'margin-top:1.0pt;margin-right:0cm;margin-bo=
ttom:
  1.0pt;margin-left:0cm;line-height:normal;page-break-after:avoid'><span
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
  mso-fareast-font-family:"Times New Roman";mso-fareast-language:JA'><o:p>&=
nbsp;</o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-.05pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>*післяреєст=
раційний
період.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:-.05pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><b
style=3D'mso-bidi-font-weight:normal'><span style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man"'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>Термін придатності. </span></i></b><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'>3 роки.<b style=3D'mso-bidi-font=
-weight:
normal'><i style=3D'mso-bidi-font-style:normal'><o:p></o:p></i></b></span><=
/p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span style=3D'mso-bidi-font-size:12.0pt;font-f=
amily:
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman"'><o:p>&=
nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Умови
зберігання. <o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Зберігати у недоступному для дітей місці. <o:p></o:p>=
</span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'>Не потребує особливих умов зберігання. <o:p></o:p></s=
pan></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:14.1pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'>Упаковка. <o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:14.1pt;margin-bot=
tom:
0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:no=
rmal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-bidi-fon=
t-weight:
bold'>По 10 таблеток у блістері, по 1 або по 3 блістери в картонній коробці=
.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><span
style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman"'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Категорія
відпуску. </span></b><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;fon=
t-family:
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman";mso-ans=
i-language:
UK;mso-bidi-font-weight:bold'>За</span><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK'> рецептом.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-=
language:
RU'>Виробник.</span></b><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK;mso-fareast-language:RU'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;line-=
height:
normal'><span lang=3DUK style=3D'mso-bidi-font-size:14.0pt;font-family:"Tim=
es New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-=
language:
RU'>Лабораторіос Медікаментос Інтернасьоналес, С. А.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;line-=
height:
normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Tim=
es New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-=
language:
RU'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-=
language:
RU'>Місцезнаходження виробника та адреса місця провадження його діяльності.=
</span></b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-=
language:
RU'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK;mso-fareast-language:RU'>вул. Солана, 26,<span
style=3D'mso-spacerun:yes'>  </span>Торрехон де Ардос, 28850, Мадрид, Іспан=
ія.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-=
language:
RU'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><b style=3D'mso-bidi-font-weight:normal'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",=
"serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-=
language:
RU'>Заявник. </span></b><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK;mso-fareast-language:RU'><o:p></o:p></span></p>

<p style=3D'margin:0cm;margin-bottom:.0001pt'><span lang=3DUK style=3D'mso-=
bidi-font-size:
14.0pt'>Еспарма ГмбХ.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Ro=
man";
mso-ansi-language:UK;mso-fareast-language:RU'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal;mso-pagination:none'><b style=3D'mso-bidi-font-w=
eight:
normal'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Tim=
es New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-=
language:
RU'>Місцезнаходження заявника.<o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal;mso-pagination:none'><span lang=3DUK style=3D'ms=
o-bidi-font-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK;mso-fareast-language:RU'>Білефельдер штрассе 1, 39171
Зюльцеталь, Німеччина.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;text-=
align:
justify;line-height:normal;mso-pagination:none'><span lang=3DUK style=3D'ms=
o-bidi-font-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times=
 New Roman";
mso-ansi-language:UK;mso-fareast-language:RU'><o:p>&nbsp;</o:p></span></p>

</div>

</body>

</html>

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