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=CF=EE=EA=E0=E7=E0=ED=ED=FF.

=CF=EE=EA=E0=E7=E0=ED=ED=FF =EF=F0=E8 =F2=F0=E0=ED=F1=EF=EB=E0=ED=F2=E0=F6=B3=FF=F5

=D2=F0=E0=ED=F1=EF=EB=E0=ED=F2=E0= =F6=B3=FF =F1=EE=EB=B3=E4=ED=E8=F5 =EE=F0=E3=E0=ED=B3=E2:=

- =E7=E0=EF=EE=E1=B3=E3=E0=ED=ED=FF =E2=B3=E4=F2=EE=F0=E3=ED=E5=ED=ED=FE =F2= =F0=E0=ED=F1=EF=EB=E0=ED=F2=E0=F2=B3=E2 =F1=EE=EB=B3=E4=ED=E8=F5 =EE=F0=E3=E0=ED=B3=E2;

- =EB=B3=EA=F3=E2=E0=ED=ED=FF =E2=B3=E4=F2=EE=F0=E3=ED=E5=ED=ED=FF =F2=F0=E0= =ED=F1=EF=EB=E0=ED=F2=E0=F2=E0 =F3 =EF=E0=F6=B3=BA=ED=F2=B3=E2, =FF=EA=B3 = =F0=E0=ED=B3=F8=E5 =EE=F2=F0=E8=EC=F3=E2=E0=EB=E8 =EB=B3=EA=F3=E2=E0=ED=ED=FF =B3=ED=F8=E8=EC=E8 =B3=EC=F3=ED=EE=F1=F3=EF=F0= =E5=F1=E8=E2=ED=E8=EC=E8 =EF=F0=E5=EF=E0=F0=E0=F2=E0=EC=E8.

=D2=F0=E0=ED=F1=EF=EB=E0=ED=F2=E0= =F6=B3=FF =EA=B3=F1=F2=EA=EE=E2=EE=E3=EE =EC=EE=E7=EA=F3:=

- =E7=E0=EF=EE=E1=B3=E3=E0=ED=ED=FF =E2=B3=E4=F2=EE=F0=E3=ED=E5=ED=ED= =FE =E0=EB=EE=E3=E5=ED=ED=EE=E3=EE =F2=F0=E0=ED=F1=EF=EB= =E0=ED=F2=E0=F2=E0 =EA=B3=F1=F2=EA=EE=E2=EE=E3=EE =EC=EE=E7=EA=F3 =F2=E0 =F2=F0=E0=ED=F1=EF=EB=E0=ED=F2=E0=F2=E0 =F1=F2=EE=E2=E1=F3=F0=EE=E2=E8=F5 = =EA=EB=B3=F2=E8=ED;

- =E7=E0=EF=EE=E1=B3=E3=E0=ED=ED=FF =F2=E0 =EB=B3=EA=F3=E2=E0=ED=ED=FF =F0=E5= =E0=EA=F6=B3=BF =AB=F2=F0=E0=ED=F1=EF=EB=E0=ED=F2=E0=F2 =EF=F0=EE=F2=E8 =F5= =E0=E7=FF=BF=ED=E0=BB.

=CF=EE=EA=E0=E7=E0=ED=ED=FF, =ED=E5 =EF=EE=E2=92=FF=E7=E0=ED=B3 =E7 =F2=F0=E0=ED=F1=EF=EB=E0=ED=F2=E0=F6= =B3=BA=FE

=C5=ED=E4=EE=E3=E5=ED=ED=E8=E9 = =F3=E2=E5=BF=F2:

- =E0=EA=F2=E8=E2=ED=E8=E9 =F1=E5=F0=E5=E4=ED=B3=E9 =E0=E1=EE =E7=E0=E4= =ED=B3=E9 =F3=E2=E5=BF=F2, =F9=EE =E7=E0=E3=F0=EE=E6=F3=BA =E2=F2=F0=E0=F2= =EE=FE =E7=EE=F0=F3, =ED=E5=B3=ED=F4=E5=EA=F6=B3=E9=ED=EE=BF =E5=F2=B3=EE=EB=EE=E3=B3=BF =F3 =E2= =E8=EF=E0=E4=EA=E0=F5, =EA=EE=EB=E8 =E0=EB=FC=F2=E5=F0=ED=E0=F2=E8=E2=ED=E5= =EB=B3=EA=F3=E2=E0=ED=ED=FF =E2=E8=FF=E2=E8=EB=EE=F1=FC =ED=E5=E5=F4=E5=EA=F2=E8=E2=ED=E8=EC =E0=E1=EE =ED=E5=EF=F0=E8=E9=ED=FF=F2= =ED=E8=EC =F7=E5=F0=E5=E7 =EF=EE=E1=B3=F7=ED=B3 =F0=E5=E0=EA=F6= =B3=BF;

- =F3=E2=E5=BF=F2 =EF=F0=E8 =E7=E0=F5=E2=EE=F0=FE=E2=E0=ED=ED=B3 =C1=E5= =F5=F7=E5=F2=E0 =E7 =EF=EE=E2=F2=EE=F0=ED=E8=EC=E8 =E7=E0=E3=EE=F1=F2=F0=E5= =ED=ED=FF=EC=E8 =E7=E0=EF=E0=EB=E5=ED=ED=FF =B3=E7 =E7=E0=EB=F3=F7=E5=ED=ED=FF=EC =F1=B3=F2=EA=B3=E2=EA=E8 =EE=EA=E0 =E1=E5=E7= =ED=E5=E2=F0=EE=EB=EE=E3=B3=F7=ED=EE=BF =F1=E8=EC=EF=F2=EE=EC=E0=F2=E8=EA= =E8.=

=CD=E5=F4=F0=EE=F2=E8=F7=ED=E8=E9= =F1=E8=ED=E4=F0=EE=EC:

- =F1=F2=E5=F0=EE=BF=E4=EE=E7=E0=EB=E5=E6=ED=E8=E9 =E0=E1=EE =F1=F2=E5=F0=EE= =BF=E4=EE=F0=E5=E7=E8=F1=F2=E5=ED=F2=ED=E8=E9 =ED=E5=F4=F0=EE=F2=E8=F7=ED= =E8=E9 =F1=E8=ED=E4=F0=EE=EC =E2=ED=E0=F1=EB=B3=E4=EE=EA =EC=B3=ED=B3=EC=E0=EB=FC=ED=E8=F5 =E7=EC=B3=ED =EF=F0=E8 =EF=E5=F0=E2=E8=ED= =ED=EE=EC=F3 =E3=EB=EE=EC=E5=F0=F3=EB=EE=ED=E5=F4=F0=E8=F2=B3, =F4=EE=EA=E0= =EB=FC=ED=E8=E9 =F1=E5=E3=EC=E5=ED=F2=E0=F0=ED=E8=E9 =E3=EB=EE=EC=E5=F0=F3=EB=EE=F1=EA=EB=E5=F0=EE=E7 =E0=E1=EE =EC=E5=EC=E1=F0= =E0=ED=EE=E7=ED=E8=E9 =E3=EB=EE=EC=E5=F0=F3=EB=EE=ED=E5=F4=F0=E8=F2;

- =B3=ED=E4=F3=EA=F6=B3=FF =E0=E1=EE =EF=B3=E4=F2=F0=E8=EC=E0=ED=ED=FF =F0=E5= =EC=B3=F1=B3=BF;

- =EF=B3=E4=F2=F0=E8=EC=E0=ED=ED=FF =F0=E5=EC=B3=F1=B3=BF, =F1=EF=F0=E8=F7=E8= =ED=E5=ED=EE=BF =EA=EE=F0=F2=E8=EA=EE=F1=F2=E5=F0=EE=BF=E4=E0=EC=E8, =F9=EE= =F3=EC=EE=E6=EB=E8=E2=EB=FE=BA =BF=F5 =E2=B3=E4=EC=B3=ED=F3.

=D0=E5=E2=EC=E0=F2=EE=BF=E4=ED=E8= =E9 =E0=F0=F2=F0=E8=F2:

- =EB=B3=EA=F3=E2=E0=ED=ED=FF =F2=FF=E6=EA=E8=F5 =F4=EE=F0=EC =E0=EA=F2=E8=E2= =ED=EE=E3=EE =F0=E5=E2=EC=E0=F2=EE=BF=E4=ED=EE=E3=EE =E0=F0=F2=F0=E8=F2=F3.=

=CF=F1=EE=F0=B3=E0=E7:=

- =F2=FF=E6=EA=B3 =F4=EE=F0=EC=E8 =EF=F1=EE=F0=B3=E0=E7=F3, =EA=EE=EB=E8 =F1= =F2=E0=ED=E4=E0=F0=F2=ED=E5 =EB=B3=EA=F3=E2=E0=ED=ED=FF =E2=E8=FF=E2=E8=EB= =EE=F1=FF =ED=E5=E5=F4=E5=EA=F2=E8=E2=ED=E8=EC =E0=E1=EE =ED=E5=EF=F0=E8=E9=ED=FF=F2=ED=E8=EC.

=C0=F2=EE=EF=B3=F7=ED=E8=E9 =E4= =E5=F0=EC=E0=F2=E8=F2:

- =EB=B3=EA=F3=E2=E0=ED=ED=FF =F2=FF=E6=EA=E8=F5 =F4=EE= =F0=EC =E0=F2=EE=EF=B3=F7=ED=EE=E3=EE =E4=E5=F0=EC=E0=F2=E8=F2=F3 =EF=F0=E8= =ED=E5=EE=E1=F5=B3=E4=ED=EE=F1=F2=B3 =F1=E8=F1=F2=E5=EC=ED=EE=BF =F2=E5=F0=E0=EF=B3=BF.

 

=CF=F0=EE=F2=E8=EF=EE=EA=E0=E7=E0=ED=ED=FF.<= /p>

= =CF=B3=E4=E2=E8=F9=E5=ED=E0 =F7=F3=F2=EB=E8=E2=B3=F1=F2=FC =E4=EE = =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3 =E0=E1=EE =E4=EE =B3=ED=F8=E8=F5 =EA= =EE=EC=EF=EE=ED=E5=ED=F2=B3=E2 =EF=F0=E5=EF=E0=F0=E0=F2=F3.

=CE=E4=ED=EE=F7=E0=F1=ED=E5 =E7=E0=F1=F2=EE= =F1=F3=E2=E0=ED=ED=FF =E7 =EB=B3=EA=E0=F0=F1=FC=EA=E8=EC=E8 =E7=E0=F1=EE=E1= =E0=EC=E8, =F9=EE =EC=B3=F1=F2=FF=F2=FC =E7=E2=B3=F0=EE=E1=B3=E9 =E7=E2=E8=F7=E0=E9=ED= =E8=E9 (Hypericum perforatum).

=CE=E4=ED=EE=F7=E0=F1=ED=E5 =E7=E0=F1=F2=EE= =F1=F3=E2=E0=ED=ED=FF =E7 =EB=B3=EA=E0=F0=F1=FC=EA=E8=EC=E8 =E7=E0=F1=EE=E1= =E0=EC=E8, =F9=EE =BA =F1=F3=E1=F1=F2=F0=E0=F2=E0=EC=E8 =EC=F3=EB=FC=F2=E8=EB=B3=EA=E0=F0=F1= =FC=EA=EE=E3=EE =E5=F4=EB=FE=EA=F1=ED=EE=E3=EE =EF=E5=F0=E5=ED=EE=F1=ED=E8= =EA=E0 =D0-=E3=EB=B3=EA=EE=EF=F0=EE=F2=E5=BF=ED=F3 (Pgp) =E0=E1=EE =EE=F0=E3=E0=ED=B3=F7=ED=E8=F5 =E0=ED=B3=EE=ED=B3=E2 =F2=F0=E0=ED= =F1=EF=EE=F0=F2=ED=E8=F5 =E1=B3=EB=EA=B3=E2 (=CE=C0=D2=C1), =E4=EB=FF =FF= =EA=E8=F5 =EF=B3=E4=E2=E8=F9=E5=ED=ED=FF =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=BF =F3 =EF=EB=E0=E7=EC=B3 =EA=F0=EE=E2=B3= =EF=EE=E2=92=FF=E7=E0=ED=E5 =E7 =F0=EE=E7=E2=E8=F2=EA=EE=EC =F1=E5=F0=E9= =EE=E7=ED=E8=F5 =EF=EE=E1=B3=F7=ED=E8=F5 =F0=E5=E0=EA=F6=B3=E9 =F2=E0/=E0=E1=EE =EF=EE=E1=B3=F7=ED=E8=F5 =F0=E5=E0=EA=F6=B3=E9, =F9=EE =E7= =E0=E3=F0=EE=E6=F3=FE=F2=FC =E6=E8=F2=F2=FE, =ED=E0=EF=F0=E8=EA=EB=E0=E4, = =E1=EE=E7=E5=ED=F2=E0=ED=EE=EC, =E4=E0=E1=B3=E3=E0=F2=F0=E0=ED=F3 =E5=F2=E5=EA=F1=E8=EB=E0=F2=EE=EC =F2=E0 = =E0=EB=B3=F1=EA=B3=F0=E5=ED=EE=EC.

=CD=E8=F0=EA=EE=E2=E0 =ED=E5=E4=EE=F1=F2=E0= =F2=ED=B3=F1=F2=FC, =E7=E0 =E2=E8=ED=FF=F2=EA=EE=EC =F5=E2=EE=F0=E8=F5 =E7 =ED=E5=F4=F0=EE=F2=E8=F7=ED=E8=EC =F1=E8=ED=E4=F0=EE=EC=EE=EC =F2=E0 =EF=EE= =EC=B3=F0=ED=EE =EF=B3=E4=E2=E8=F9=E5=ED=E8=EC=E8 =E2=E8=F5=B3=E4=ED=E8=EC= =E8 =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FF=EC=E8 =EA=F0=E5=E0=F2=E8=ED=B3=ED=F3 =EC=E0=EA=F1=E8=EC=F3=EC =E4=EE 200 =EC=EA= =EC=EE=EB=FC/=EB =F3 =E4=EE=F0=EE=F1=EB=E8=F5 =F2=E0 140 =EC=EA=EC=EE=EB=FC= /=EB =96 =F3 =E4=B3=F2=E5=E9. =CF=F0=E8 =ED=E5=F4=F0=EE=F2=E8=F7=ED=EE=EC=F3 =F1=E8=ED=E4=F0=EE=EC=B3 =E4=EE=E7=E2= =EE=EB=FF=BA=F2=FC=F1=FF =EE=E1=E5=F0=E5=E6=ED=E5 =E7=E0=F1=F2=EE=F1=F3=E2= =E0=ED=ED=FF =F3 =E4=EE=E7=E0=F5 =ED=E5 =E2=E8=F9=E5 2,5 =EC=E3/=EA=E3= /=E4=EE=E1=F3, =EB=E8=F8=E5 =E2 =F2=EE=EC=F3 =E2=E8=EF=E0=E4=EA=F3, =EA=EE=EB=E8 =E7=E0=F1= =F2=EE=F1=F3=E2=E0=ED=ED=FF =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3 =F1=EF=F0= =E8=FF=BA =ED=EE=F0=EC=E0=EB=B3=E7=E0=F6=B3=BF =EF=EE=EA=E0=E7=ED=E8=EA=B3=E2 =EA=F0=E5=E0=F2=E8=ED=B3=ED=F3, =EF=B3=E4=E2= =E8=F9=E5=ED=E8=F5 =E2=ED=E0=F1=EB=B3=E4=EE=EA =E7=E0=F5=E2=EE=F0=FE=E2=E0= =ED=ED=FF.

 

=C2=E7=E0=BA=EC=EE=E4=B3=FF = =E7 =B3=ED=F8=E8=EC=E8 =EB=B3=EA=E0=F0=F1=FC=EA=E8=EC=E8 =E7=E0=F1=EE=E1=E0=EC=E8 =F2=E0 =B3=ED=F8=B3 =E2=E8=E4=E8 =E2=E7=E0=BA=EC= =EE=E4=B3=E9.

=D5=E0=F0=F7=EE=E2= =B3 =E2=E7=E0=BA=EC=EE=E4=B3=BF

=CF=F0=E8 =F1=F3= =EF=F3=F2=ED=FC=EE=EC=F3 =E2=E6=E8=E2=E0=ED=ED=B3 =E3=F0=E5=E9=EF=F4=F0=F3= =F2=B3=E2 =E0=E1=EE =E3=F0=E5=E9=EF=F4=F0=F3=F2=EE=E2=EE=E3=EE =F1=EE=EA=F3 =E1=F3=EB= =EE =E2=E8=FF=E2=EB=E5=ED=EE =E7=F0=EE=F1=F2=E0=ED=ED=FF =E1=B3=EE=E4=EE=F1= =F2=F3=EF=ED=EE=F1=F2=B3 =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3.

=CB=B3=EA=E0=F0=F1= =FC=EA=B3 =E2=E7=E0=BA=EC=EE=E4=B3=BF

=CD=E8=E6=F7=E5 = =E7=E0=E7=ED=E0=F7=E5=ED=B3 =F2=B3 =EF=F0=E5=EF=E0=F0=E0=F2=E8, =E4=EB=FF =FF=EA=E8=F5 =E2=E7=E0=BA=EC=EE=E4= =B3=BF =E4=EE=E1=F0=E5 =E7=E0=E4=EE=EA=F3=EC=E5=ED=F2=EE=E2=E0=ED=B3 =B3 = =E2=E2=E0=E6=E0=FE=F2=FC=F1=FF =EA=EB=B3=ED=B3=F7=ED=EE =E7=ED=E0=F7=F3=F9=E8=EC=E8.

=DF=EA =E2=B3=E4= =EE=EC=EE, =F0=FF=E4 =EF=F0=E5=EF=E0=F0=E0=F2=B3=E2 =E7=E1=B3=EB=FC=F8=F3=BA =E0=E1=EE =E7=EC=E5= =ED=F8=F3=BA =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FE =F6=E8=EA=EB=EE=F1=EF=EE= =F0=E8=ED=F3 =F3 =EF=EB=E0=E7=EC=B3 =EA=F0=EE=E2=B3 =E0=E1=EE =F6=B3=EB=FC=ED=B3=E9 =EA=F0=EE=E2=B3 =F8=EB=FF=F5=EE=EC =B3=ED=E3=B3=E1=F3= =E2=E0=ED=ED=FF =E0=E1=EE =B3=ED=E4=F3=EA=F6=B3=BF =E4=B3=BF =F4=E5=F0=EC= =E5=ED=F2=B3=E2, =EE=F1=EE=E1=EB=E8=E2=EE CYP3A4, =F9=EE =E1=E5=F0=F3=F2=FC =F3=F7=E0=F1=F2=FC =F3 =EC=E5=F2=E0=E1=EE=EB=B3= =E7=EC=B3 =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3. =D2=E0=EA=EE=E6 =F6=E8=EA= =EB=EE=F1=EF=EE=F0=E8=ED =BA =B3=ED=E3=B3=E1=B3=F2=EE=F0=EE=EC CYP3A4, =EC=F3=EB=FC=F2=E8=EB= =B3=EA=E0=F0=F1=FC=EA=EE=E3=EE =E5=F4=EB=FE=EA=F1=ED=EE=E3=EE =EF=E5=F0=E5=ED=EE=F1=ED=E8=EA=E0 =D0-=E3=EB=B3=EA=EE=EF=F0=EE=F2=E5=BF=ED= =F3 =E0=E1=EE =EE=F0=E3=E0=ED=B3=F7=ED=E8=F5 =E0=ED=B3=EE=ED=B3=E2 =F2=F0= =E0=ED=F1=EF=EE=F0=F2=ED=E8=F5 =E1=B3=EB=EA=B3=E2. =D6=E5 =EC=EE=E6= =E5 =EF=B3=E4=E2=E8=F9=F3=E2=E0=F2=E8 =EF=EB=E0=E7=EC=EE=E2=B3 =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=BF =EE=E4=ED=EE= =F7=E0=F1=ED=EE =E7=E0=F1=F2=EE=F1=EE=E2=F3=E2=E0=ED=E8=F5 =EC=E5=E4=E8=F7= =ED=E8=F5 =EF=F0=E5=EF=E0=F0=E0=F2=B3=E2, =F9=EE =BA =F1=F3=E1=F1=F2=F0=E0=F2=E0=EC=E8 CYP3A4 =F2=E0/=E0=E1=EE =F6=E8=F5 =EF=E5= =F0=E5=ED=EE=F1=ED=E8=EA=B3=E2.

=CB=B3=EA=E0=F0=F1=FC=EA=B3= =E7=E0=F1=EE=E1=E8, =F9=EE =E7=ED=E8=E6=F3=FE=F2=FC =E0=E1=EE =EF=B3=E4=E2=E8=F9=F3=FE=F2=FC =E1=B3=EE=E4=EE=F1=F2=F3=EF=ED=B3=F1=F2=FC = =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3

=D3 =EF=E0=F6=B3=BA=ED=F2=B3=E2 =EF=B3=F1=EB=FF =F2=F0=E0=ED=F1=EF=EB= =E0=ED=F2=E0=F6=B3=BF =ED=E5=EE=E1=F5=B3=E4=ED=EE =F7=E0=F1=F2=EE =E2=E8=EC= =B3=F0=FE=E2=E0=F2=E8 =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FE =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3 =F2=E0 =EF=F0=E8 =ED=E5=EE=E1=F5=B3=E4= =ED=EE=F1=F2=B3 =EA=EE=F0=E5=E3=F3=E2=E0=F2=E8 =E9=EE=E3=EE =E4=EE=E7=F3, = =EE=F1=EE=E1=EB=E8=E2=EE =EF=F0=E8 =EF=F0=E8=E7=ED=E0=F7=E5=ED=ED=B3 =F7=E8 =E2=B3=E4=EC=B3=ED=B3 =F1=F3=EC=B3=F1=ED=E8=F5 =EB=B3=EA=E0=F0=F1=FC= =EA=E8=F5 =E7=E0=F1=EE=E1=B3=E2. =D3 =EF=E0=F6=B3=BA=ED=F2=B3=E2, =FF=EA=B3= =EF=F0=EE=F5=EE=E4=FF=F2=FC =EB=B3=EA=F3=E2=E0=ED=ED=FF =E7=E0 =EF=EE=EA=E0=E7=E0=ED=ED=FF=EC=E8, =ED=E5 =EF=EE=E2=92=FF=E7=E0=ED=E8=EC=E8= =E7 =F2=F0=E0=ED=F1=EF=EB=E0=ED=F2=E0=F6=B3=BA=FE, =E2=E7=E0=BA=EC=EE=E7= =E2=92=FF=E7=EE=EA =EC=B3=E6 =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=BA=FE =F3 =EA=F0=EE=E2=B3 =F2=E0 =EA=EB=B3=ED=B3=F7=ED=E8=EC=E8 =E5=F4=E5=EA=F2= =E0=EC=E8 =EC=E5=ED=F8 =E2=E8=E2=F7=E5=ED=E8=E9. =CF=F0=E8 =EE=E4=ED=EE=F7= =E0=F1=ED=EE=EC=F3 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=B3 =EB=B3=EA=E0=F0=F1=FC=EA=E8=F5 =E7=E0=F1=EE=E1=B3=E2, =F9=EE =EF=B3=E4=E2= =E8=F9=F3=FE=F2=FC =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FE =F6=E8=EA=EB=EE=F1= =EF=EE=F0=E8=ED=F3, =E1=B3=EB=FC=F8 =E4=EE=F6=B3=EB=FC=ED=E8=EC, =ED=B3=E6 =E2=E8=EC=B3=F0=FE=E2=E0=ED=ED=FF =F0=B3=E2=ED=FF =F3 =EA=F0=EE= =E2=B3, =EC=EE=E6=E5 =E1=F3=F2=E8 =F7=E0=F1=F2=E5 =EF=F0=EE=E2=E5=E4=E5=ED= =ED=FF =EE=F6=B3=ED=EA=E8 =F4=F3=ED=EA=F6=B3=BF =ED=E8=F0=EE=EA =F2=E0 =F0=E5=F2=E5=EB=FC=ED=E8=E9 =EC=EE=ED=B3=F2=EE=F0=E8=ED=E3 =EF=EE=E2= =92=FF=E7=E0=ED=E8=F5 =B3=E7 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF=EC =F6=E8= =EA=EB=EE=F1=EF=EE=F0=E8=ED=F3 =EF=EE=E1=B3=F7=ED=E8=F5 =E5=F4=E5=EA=F2=B3=E2.

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=CE=F7=B3=EA=F3=BA=F2=FC=F1=FF, =F9=EE =E2=F1=B3 =B3=ED=E4=F3=EA=F2=EE= =F0=E8 CYP3A4 =F2=E0/=E0=E1=EE =D0-=E3=EB=B3=EA=EE=EF=F0=EE=F2=E5=BF=ED=F3 = =E1=F3=E4=F3=F2=FC =E7=ED=E8=E6=F3=E2=E0=F2=E8 =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FE =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3.<= o:p>

=CF=F0=E8=EA=EB=E0=E4=E8 =EB=B3=EA=E0=F0=F1=FC=EA=E8=F5 =E7=E0=F1=EE=E1= =B3=E2, =F9=EE =E7=ED=E8=E6=F3=FE=F2=FC =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3= =FE =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3: =E1=E0=F0=E1=B3=F2=F3= =F0=E0=F2=E8, =EA=E0=F0=E1=E0=EC=E0=E7=E5=EF=B3=ED, =EE=EA=F1=EA=E0=F0=E1=E0=E7=E5=EF=B3=ED, =F4=E5=ED=B3=F2=EE=BF=ED, =ED=E0= =F4=F6=E8=EB=B3=ED, =F1=F3=EB=FC=F4=E0=E4=E8=EC=B3=E4=E8=ED (=E2=ED=F3=F2= =F0=B3=F8=ED=FC=EE=E2=E5=ED=ED=EE), =EE=F0=EB=B3=F1=F2=E0=F2, =EF=F0=EE=E1=F3=EA=EE=EB, =EF=F0=E5=EF=E0=F0=E0=F2=E8, =F9=EE =EC=B3=F1=F2= =FF=F2=FC =E7=E2=B3=F0=EE=E1=B3=E9 =E7=E2=E8=F7=E0=E9=ED=E8=E9, =F2=E8=EA= =EB=EE=EF=B3=E4=E8=ED, =F1=F3=EB=FC=F4=B3=ED=EF=B3=F0=E0=E7=EE=ED, =F2=E5=F0=E1=B3=ED=E0=F4=B3=ED, =E1=EE=E7=E5=ED=F2=E0=ED, =F0=E8=F4=E0=EC=EF=B3=F6=E8=ED, =EE=EA=F2=F0=E5=EE=F2=E8=E4, =F2=F0=E8=EC=E5=F2=EE=EF=F0=E8=EC (=E2=ED=F3= =F2=F0=B3=F8=ED=FC=EE=E2=E5=ED=ED=EE).

=CD=E5 =F1=EB=B3=E4 =EE=E4=ED=EE=F7=E0=F1=ED=EE =E7=E0=F1=F2=EE=F1=EE= =E2=F3=E2=E0=F2=E8 =EB=B3=EA=E0=F0=F1=FC=EA=B3 =E7=E0=F1=EE=E1=E8, =F9=EE = =EC=B3=F1=F2=FF=F2=FC Hypericum perforatum (=E7=E2=B3=F0=EE=E1=B3=E9 =E7=E2=E8=F7=E0=E9=ED=E8=E9), =E7 = =EF=F0=E5=EF=E0=F0=E0=F2=EE=EC =C5=EA=E2=EE=F0=E0=EB=AE =F7=E5=F0=E5=E7 =F0=E8=E7=E8=EA =E7=ED=E8=E6=E5=ED=ED=FF =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3= =BF =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3 =F3 =EA=F0=EE=E2=B3 =B3 =F2=E0=EA= =E8=EC =F7=E8=ED=EE=EC =96 =E7=ED=E8=E6=E5=ED=ED=FF =F2=E5=F0=E0=EF=E5=E2=F2=E8=F7=ED=EE=E3=EE =E5=F4=E5=EA=F2=F3.

=D0=E8=F4=E0=EC=EF=B3=F6=E8=ED= =BA =B3=ED=E4=F3=EA=F2=EE=F0=EE=EC =EC=E5= =F2=E0=E1=EE=EB=B3=E7=EC=F3 =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3 =E2 =EA=E8= =F8=E5=F7=ED=E8=EA=F3 =F2=E0 =EF=E5=F7=B3=ED=F6=B3. =D2=EE=EC=F3 =EF=F0=E8 =F1=F3=EC=B3=F1=ED=EE= =EC=F3 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=B3 =EC=EE=E6=E5 =E2=E8=ED=E8=EA=ED= =F3=F2=E8 =ED=E5=EE=E1=F5=B3=E4=ED=B3=F1=F2=FC =F3 =E7=E1=B3=EB=FC=F8=E5=ED= =ED=B3 =E4=EE=E7=E8 =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3 =F3
3=965 =F0=E0=E7=B3=E2.

=CE=EA=F2=F0=E5=EE=F2=E8=E4 =E7=ED=E8=E6=F3=BA =EF=E5=F0=EE=F0=E0=EB=FC= =ED=E5 =E2=F1=EC=EE=EA=F2=F3=E2=E0=ED=ED=FF =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8= =ED=F3, =E2=ED=E0=F1=EB=B3=E4=EE=EA =F7=EE=E3=EE =EC=EE=E6=E5 =E7=ED=E0=E4=EE=E1=E8= =F2=E8=F1=FF =E7=E1=B3=EB=FC=F8=E5=ED=ED=FF =E4=EE=E7=E8 =F6=E8=EA=EB=EE=F1= =EF=EE=F0=E8=ED=F3 =ED=E0 50 % =E0=E1=EE =EF=E5=F0=E5=F5=B3=E4 =ED=E0 =EB=B3=EA=E0=F0=F1=FC=EA=F3 =F4=EE=F0=EC=F3 = =E4=EB=FF =E2=ED=F3=F2=F0=B3=F8=ED=FC=EE=E2=E5=ED=ED=EE=E3=EE =E2=E2=E5=E4= =E5=ED=ED=FF.

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=D3=F1=B3 =B3=ED=E3=B3=E1=B3=F2=EE=F0=E8 CYP3A4 =F2=E0/=E0=E1=EE =D0-= =E3=EB=B3=EA=EE=EF=F0=EE=F2=E5=BF=ED=F3 =EC=EE=E6=F3=F2=FC =EF=B3=E4=E2=E8= =F9=F3=E2=E0=F2=E8 =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FE =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3. = =CF=F0=E8=EA=EB=E0=E4=E8 =F2=E0=EA=E8=F5 =EB=B3=EA=E0=F0=F1=FC=EA=E8=F5 =E7= =E0=F1=EE=E1=B3=E2: =F5=EB=EE=F0=EE=F5=B3=ED, =ED=B3=EA=E0=F0=E4=E8=EF=B3= =ED, =EC=E5=F2=EE=EA=EB=EE=EF=F0=E0=EC=B3=E4, =EF=E5=F0=EE=F0=E0=EB=FC=ED=B3 =EA= =EE=ED=F2=F0=E0=F6=E5=EF=F2=E8=E2=E8, =EC=E5=F2=E8=EB=EF=F0=E5=E4=ED=B3=E7= =EE=EB=EE=ED (=E2=E8=F1=EE=EA=B3 =E4=EE=E7=E8), =E0=EB=EE=EF=F3=F0=E8=ED=EE=EB, =F5=EE=EB=B3=BA=E2=E0 =EA=E8=F1=EB=EE=F2=E0= =F2=E0 =BF=BF =EF=EE=F5=B3=E4=ED=B3, =B3=ED=E3=B3=E1=B3=F2=EE=F0=E8 =EF=F0= =EE=F2=E5=E0=E7=E8, =B3=EC=E0=F2=E8=ED=B3=E1, =EA=EE=EB=F5=B3=F6=E8=ED, =ED=E5=F4=E0=E7=EE=E4=EE=ED.

=C0=ED=F2=E8=E1=B3=EE=F2=E8=EA= =E8 =E3=F0=F3=EF=E8 =EC=E0=EA=F0=EE=EB=B3=E4=B3=E2: =E5=F0=E8=F2=F0=EE=EC=B3=F6=E8=ED =EC=EE=E6=E5 =EF=B3=E4=E2=E8=F9=F3=E2=E0=F2=E8 =E5=EA=F1=EF=EE=E7=E8=F6=B3=FE =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3 =F3
4=967 =F0=E0=E7=B3=E2, =F9=EE =B3=ED=EA=EE=EB=E8 =BA =EF=F0=E8=F7=E8=ED=EE= =FE =ED=E5=F4=F0=EE=F2=EE=EA=F1=E8=F7=ED=EE=F1=F2=B3. =CF=EE=E2=B3=E4=EE=EC= =EB=FF=EB=EE=F1=FF, =F9=EE =EA=EB=E0=F0=E8=F2=F0=EE=EC=B3=F6=E8= =ED =F3=E4=E2=B3=F7=B3 =EF=B3=E4=E2=E8=F9=F3=BA =E5=EA=F1=EF=EE=E7=E8= =F6=B3=FE =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3. =C0=E7=E8=F2=F0=EE=EC=B3=F6=E8=ED =EF=B3=E4=E2=E8=F9=F3=BA =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FE =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3 = =EF=F0=E8=E1=EB=E8=E7=ED=EE =ED=E0 20 %.

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=CA=E0=ED=E0=E1=B3=E4=B3=EE=EB= (=B3=ED=E3=B3=E1=B3=F2=EE=F0 P-gp): =E1=F3=EB=E8 =EF=EE=E2=B3=E4=EE=EC=EB=E5=ED= =ED=FF =EF=F0=EE =EF=B3=E4=E2=E8=F9=E5=ED=ED=FF =F0=B3=E2=ED=FF =B3=ED=F8= =EE=E3=EE =B3=ED=E3=B3=E1=B3=F2=EE=F0=E0 =EA=E0=EB=FC=F6=E8=ED=E5=E2=F0=E8=ED=F3 =E2 = =EA=F0=EE=E2=B3 =EF=F0=E8 =EE=E4=ED=EE=F7=E0=F1=ED=EE=EC=F3 =E7=E0=F1=F2=EE= =F1=F3=E2=E0=ED=ED=B3 =E7 =EA=E0=ED=E0=E1=B3=E4=B3=EE=EB=EE=EC. =D6=FF =E2=E7=E0=BA=EC=EE=E4=B3=FF =EC=EE=E6=E5 =E2=E8=ED=E8=EA=E0=F2=E8 =E2=ED=E0= =F1=EB=B3=E4=EE=EA =EF=F0=E8=E3=ED=B3=F7=E5=ED=ED=FF =E2=E8=F2=EE=EA=F3 =EA= =E8=F8=EA=EE=E2=EE=E3=EE P-=E3=EB=B3=EA=EE=EF=F0=EE=F2=E5=BF=ED=F3, =F9=EE =EF=F0=E8=E7=E2=EE=E4=E8=F2=FC =E4=EE =EF=B3=E4=E2=E8=F9=E5=ED=ED=FF= =E1=B3=EE=E4=EE=F1=F2=F3=EF=ED=EE=F1=F2=B3 =B3=ED=E3=B3=E1=B3=F2=EE=F0=E0 = =EA=E0=EB=FC=F6=E8=ED=E5=E2=F0=E8=ED=F3. =D2=E0=EA=E8=EC =F7=E8=ED=EE=EC, =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED =B3 =EA=E0=ED=E0=E1=B3= =E4=B3=EE=EB =F1=EB=B3=E4 =EF=F0=E8=E7=ED=E0=F7=E0=F2=E8 =E7 =EE=E1=E5=F0= =E5=E6=ED=B3=F1=F2=FE, =F3=E2=E0=E6=ED=EE =E2=B3=E4=F1=F2=E5=E6=F3=FE=F7=E8 =ED=E0=FF=E2=ED=B3=F1=F2=FC =EF=EE=E1=B3= =F7=ED=E8=F5 =F0=E5=E0=EA=F6=B3=E9. =D3 =F0=E5=F6=E8=EF=B3=BA=ED=F2=B3=E2 = =F2=F0=E0=ED=F1=EF=EB=E0=ED=F2=E0=F2=E0 =F2=F0=E5=E1=E0 =EA=EE=ED=F2=F0=EE= =EB=FE=E2=E0=F2=E8 =EC=B3=ED=B3=EC=E0=EB=FC=ED=F3 =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FE =F6=E8= =EA=EB=EE=F1=EF=EE=F0=E8=ED=F3 =E2 =F6=B3=EB=FC=ED=B3=E9 =EA=F0=EE=E2=B3 = =F2=E0 =EA=EE=F0=E8=E3=F3=E2=E0=F2=E8 =E7=E0 =EF=EE=F2=F0=E5=E1=E8 =E4=EE=E7=F3 =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3. =D2=E0=EA=EE=E6 =F1=EB= =B3=E4 =F0=EE=E7=E3=EB=FF=ED=F3=F2=E8 =E4=EE=F6=B3=EB=FC=ED=B3=F1=F2=FC =EC= =EE=ED=B3=F2=EE=F0=E8=ED=E3=F3 =F0=B3=E2=ED=FF =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3 =E2 =EA=F0=EE=E2=B3 =E7 =E2=B3=E4=EF= =EE=E2=B3=E4=ED=E8=EC =EA=EE=F0=E8=E3=F3=E2=E0=ED=ED=FF=EC =E4=EE=E7=E8 =E4= =EB=FF =EF=E0=F6=B3=BA=ED=F2=B3=E2 =E1=E5=E7 =F2=F0=E0=ED=F1=EF=EB=E0=ED=F2=E0=F6=B3=BF (=E4=E8=E2. =F0=EE=E7=E4=B3=EB= =E8 =AB=CE=F1=EE=E1=EB=E8=E2=EE=F1=F2=B3 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED= =FF=BB =B3 =AB=D1=EF=EE=F1=B3=E1 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =F2=E0 =E4=EE=E7=E8=BB).

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=D2=E0=E1=EB=E8=F6=FF

=D3=E7=E0=E3=E0=EB=FC=ED=E5=ED=ED=FF =E7=EC=B3=ED =E7=ED=E0=F7=E5=ED=FC= =E5=EA=F1=EF=EE=E7=E8=F6=B3=BF =F8=E8=F0=EE=EA=EE =E7=E0=F1=F2=EE=F1=EE=E2= =F3=E2=E0=ED=E8=F5 =F1=F2=E0=F2=E8=ED=B3=E2 =EF=F0=E8 =EE=E4=ED=EE=F7=E0=F1=ED=EE=EC=F3 =EF=F0=E8=E7=ED=E0=F7=E5=ED=ED=B3 =E7 =F6= =E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=EE=EC

=D1=F2=E0=F2=E8= =ED

=CD=E0=FF=E2=ED= =B3 =E4=EE=E7=E8

=CA=F0=E0=F2=ED= =B3=F1=F2=FC =E7=EC=B3=ED =E7=ED=E0=F7=E5=ED=FC =E5=EA=F1=EF=EE=E7=E8=F6=B3=BF =E7 =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=EE= =EC

=C0=F2=EE=F0=E2=E0=F1=F2=E0=F2=E8=ED<= /o:p>

10=9680 =EC=E3

8=9610

=D1=E8=EC=E2=E0=F1=F2=E0=F2=E8=ED

10=9680 =EC=E3

6=968

=D4=EB=F3=E2=E0=F1=F2=E0=F2=E8=ED

20=9680 =EC=E3

2=964

=CB=EE=E2=E0=F1=F2=E0=F2=E8=ED<= /span>

20=9640 =EC=E3

5=968

=CF=F0=E0=E2=E0=F1=F2=E0=F2=E8=ED

20=9680 =EC=E3

5=9610

=D0=EE=E7=F3=E2=E0=F1=F2=E0=F2=E8=ED<= /o:p>

5=9640 =EC=E3

5=9610

=CF=B3=F2=E0=E2=E0=F1=F2=E0=F2=E8=ED<= /o:p>

1=964 =EC=E3

4=966

 

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=B2=ED=F4=E5=EA=F6= =B3=BF =F8=EA=B3=F0=E8, =F1=EF=F0=E8=F7=E8=ED=E5=ED=B3 Stap= hylococcus aureus, =ED=E5 =BA =E0=E1=F1=EE=EB=FE=F2=ED=E8=EC =EF=F0=EE=F2=E8=EF=EE=EA=E0=E7=E0=ED=ED=FF= =EC =E4=EE =F2=E5=F0=E0=EF=B3=BF =EF=F0=E5=EF=E0=F0=E0=F2=EE=EC =C5=EA=E2=EE=F0=E0=EB=AE, =E0=EB=E5 =E2=E8=EC=E0=E3=E0=FE=F2=FC =EB=B3=EA=F3= =E2=E0=ED=ED=FF =E2=B3=E4=EF=EE=E2=B3=E4=ED=E8=EC=E8 =E0=ED=F2=E8=E1=E0=EA= =F2=E5=F0=B3=E0=EB=FC=ED=E8=EC=E8 =E7=E0=F1=EE=E1=E0=EC=E8. =D1=EB=B3=E4 =F3=ED=E8=EA=E0=F2=E8 =EF=E5=F0=EE= =F0=E0=EB=FC=ED=EE=E3=EE =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =E5=F0=E8=F2= =F0=EE=EC=B3=F6=E8=ED=F3, =F9=EE, =FF=EA =E2=B3=E4=EE=EC=EE, =EC=E0=BA =E7=E4=E0=F2=ED=B3=F1=F2=FC =EF=B3=E4=E2=E8=F9=F3=E2=E0=F2=E8 =EA= =EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FE =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3 =F3 = =EA=F0=EE=E2=B3, =E0=E1=EE, =EF=F0=E8 =E2=B3=E4=F1=F3=F2=ED=EE=F1=F2=B3 =E0=EB=FC=F2=E5=F0=ED=E0=F2=E8=E2=E8, =F0= =E5=EA=EE=EC=E5=ED=E4=F3=BA=F2=FC=F1=FF =F0=E5=F2=E5=EB=FC=ED=E8=E9 =EC=EE= =ED=B3=F2=EE=F0=E8=ED=E3 =F0=B3=E2=ED=B3=E2 =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3 =F3 =EA=F0=EE=E2=B3, =F4=F3=ED=EA=F6= =B3=BF =ED=E8=F0=EE=EA =F2=E0 =EF=EE=E1=B3=F7=ED=E8=F5 =E5=F4=E5=EA=F2=B3= =E2 =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8=ED=F3.

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