MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01DD372A.7ECAFFD0" Цей документ ? веб-сторінка в одному файлі, яку також називають веб-архівом. Якщо ви бачите це повідомлення, ваш браузер або редактор не підтримує файли веб-архівів. Завантажте браузер, який підтримує такі файли. ------=_NextPart_01DD372A.7ECAFFD0 Content-Location: file:///C:/680BD482/UA202610101_63BB.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1251"

 

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=C2 =EE=E4=ED=EE=EC=F3 =EA=EE=E3=EE=F0=F2=ED=EE= =EC=F3 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=B3 =F3 =E7=E4=EE=F0=EE=E2=E8=F5 =E6= =B3=ED=EE=EA =F3 =EF=F0=E5=EC=E5=ED=EE=EF=E0=F3=E7=B3 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF = =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =EE=E4=E8=ED =F0=E0=E7 =ED=E0 = =E4=EE=E1=F3 =EF=F0=EE=F2=FF=E3=EE=EC 84 =E4=ED=B3=E2 =F1=F3=F2=F2=BA=E2=EE =EF=F0=E8=E3=ED=B3=F7=F3=E2=E0=EB=EE =F0=B3=F1=F2 =F4= =EE=EB=B3=EA=F3=EB=B3=E2 =EF=F0=EE=F2=FF=E3=EE=EC =F3=F1=FC=EE=E3=EE 84-=E4= =E5=ED=ED=EE=E3=EE =EF=E5=F0=B3=EE=E4=F3 =EB=B3=EA=F3=E2=E0=ED=ED=FF (=F1=E5=F0=E5=E4=ED=B3=E9 =F0=EE=E7=EC=B3=F0 = =E4=EE=EC=B3=ED=E0=ED=F2=ED=EE=E3=EE =F4=EE=EB=B3=EA=F3=EB=E0 =F1=F2=E0=ED= =EE=E2=E8=E2 =EF=F0=E8=E1=EB=E8=E7=ED=EE 6 =EC=EC), =E0 =EE=E2=F3=EB=FF=F6=B3=FF =B3=ED=E3=B3=E1=F3=E2=E0=EB=E0=F1=FC =F3 100 % =E6= =B3=ED=EE=EA =E7=E0 =EE=F6=B3=ED=EA=E0=EC=E8 =EF=EE =F8=EA=E0=EB=B3 =D5=EE= =E3=EB=E0=ED=E4=E0 =96 =D1=EA=F3=E1=B3. =CF=B3=F1= =EB=FF =EF=F0=E8=EF=E8=ED=E5=ED=ED=FF =EB=B3=EA=F3=E2=E0=ED=ED=FF =F3 =E2=F1=B3=F5 =E4=EE=F1=EB=B3=E4=E6=F3=E2=E0=ED=E8=F5 =E6=B3=ED=EE=EA (66 = =B3=E7 67) =EE=E2=F3=EB=FF=F6=B3=FF =E2=B3=E4=ED=EE=E2=E8=EB=E0=F1=FC =EF= =F0=EE=F2=FF=E3=EE=EC 43 =E4=ED=B3=E2 (=F3 =F1=E5=F0=E5=E4=ED=FC=EE=EC=F3 =EF=F0=EE=F2=FF=E3=EE=EC 23,5 =E4=ED=FF).

=CC=B3=EE=EC=E0 =EC=E0=F2=EA=E8

=C5=F4=E5=EA=F2=E8=E2=ED=B3=F1=F2=FC =F2=E0 =E1=E5=E7=EF=E5=EA=E0 = =EF=F0=EE=F2=FF=E3=EE=EC 24 =F2=E8=E6=ED=B3=E2=

=C5=F4= =E5=EA=F2=E8=E2=ED=B3=F1=F2=FC =F2=E0 =E1=E5=E7=EF=E5=EA=F3 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =EF=F0=E5=EF=E0= =F0=E0=F2=F3 =D0=B3=BA=EA=EE =EE=E4=E8=ED =F0=E0=E7 =ED=E0 =E4=EE=E1=F3 =EF=E0=F6=B3=BA=ED=F2=EA=E0= =EC =E7 =EC=B3=EE=EC=EE=FE =EC=E0=F2=EA=E8 =EE=F6=B3=ED=FE=E2=E0=EB= =E8 =F3 =E4=E2=EE=F5 =EF=EE=E2=F2=EE=F0=FE=E2=E0=ED=E8=F5, 24-=F2=E8=E6=ED=E5= =E2=E8=F5, =E1=E0=E3=E0=F2=EE=ED=E0=F6=B3=EE=ED=E0=EB=FC=ED=E8=F5, =F0=E0= =ED=E4=EE=EC=B3=E7=EE=E2=E0=ED=E8=F5, =EF=EE=E4=E2=B3=E9=ED=EE =F1=EB=B3=EF=E8=F5, =EF=EB=E0=F6=E5=E1=EE-=EA=EE=ED=F2=F0=EE=EB=FC=EE=E2=E0= =ED=E8=F5 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF=F5, =EF=F0=EE=E2=E5=E4=E5=ED=E8= =F5 =E7=E0 =F3=F7=E0=F1=F2=FE =EF=E0=F6=B3=BA=ED=F2=EE=EA =E2=B3=EA=EE=EC =E2=B3=E4 18 =E4=EE 50 =F0=EE=EA=B3=E2 =B3=E7 =F1=E8=EB=FC= =ED=E8=EC=E8 =EC=E5=ED=F1=F2=F0=F3=E0=EB=FC=ED=E8=EC=E8 =EA=F0=EE=E2=EE=F2= =E5=F7=E0=EC=E8, =EF=EE=E2=92=FF=E7=E0=ED=E8=EC=E8 =E7 =EC=B3=EE=EC=EE=FE =EC=E0=F2=EA=E8 (=E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF L1 =F2=E0 L2). =D3 =EF=E0=F6= =B3=BA=ED=F2=EE=EA =E1=F3=EB=E0 =EF=B3=E4=F2=E2=E5=F0=E4=E6=E5=ED=E0 =EC=B3= =EE=EC=E0 =EC=E0=F2=EA=E8 =E7=E0 =E4=EE=EF=EE=EC=EE=E3=EE=FE =F3=EB=FC=F2=F0=E0=E7=E2=F3=EA=F3 =F2=E0= =EC=E5=ED=F1=F2=F0=F3=E0=EB=FC=ED=E0 =EA=F0=EE=E2=EE=E2=F2=F0=E0=F2=E0 (= =CC=CA) ≥ 80 =EC=EB =EC=E5=F2=EE=E4=EE=EC =EB=F3=E6=ED=EE=E3=EE =E3=E5=EC=E0=F2=E8=ED=F3.

=C2 =EE=E1=EE=F5 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF=F5 =E1=F3=EB=EE 3 =E3=F0=F3= =EF=E8 =EB=B3=EA=F3=E2=E0=ED=ED=FF: =E6=B3=ED=EE=EA =E1=F3=EB=EE =F0=E0=ED= =E4=EE=EC=B3=E7=EE=E2=E0=ED=EE =E4=EB=FF =EF=F0=E8=E9=EE=EC=F3 =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 40 =EC=E3 + =E5=F1=F2=F0=E0=E4=B3=EE=EB= =F3 1 =EC=E3 =F2=E0 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3 =E0=F6=E5=F2=E0= =F2=F3 0,5 =EC=E3 (=D0=B3=BA=EA=EE) =EF=F0=EE=F2=FF=E3=EE=EC 24 =F2=E8=E6=ED=B3=E2 =E0=E1=EE =EF=EB=E0=F6=E5=E1= =EE =EF=F0=EE=F2=FF=E3=EE=EC 24 =F2=E8=E6=ED=B3=E2, =E0=E1=EE =F0=E5=EB=F3= =E3=EE=EB=B3=EA=F1=F3 40 =EC=E3 =EF=F0=EE=F2=FF=E3=EE=EC 12 =F2=E8=E6=ED=B3=E2 =E7 =EF=EE=E4=E0=EB=FC=F8=E8= =EC =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF=EC =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1= =F3 40 =EC=E3 =EE=E4=ED=EE=F7=E0=F1=ED=EE =E7 =E5=F1=F2=F0=E0=E4=B3=EE=EB= =EE=EC =F2=E0 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3 =E0=F6=E5=F2=E0=F2=EE=EC =EF= =F0=EE=F2=FF=E3=EE=EC 12 =F2=E8=E6=ED=B3=E2. =D1=E5=F0=E5=E4=ED=B3=E9 =E2= =B3=EA =E6=B3=ED=EE=EA =F1=F2=E0=ED=EE=E2=E8=E2 42 =F0=EE=EA=E8, =E0 =F1=E5=F0=E5=E4=ED=B3=E9 =B3=ED=E4=E5=EA=F1 =EC=E0=F1=E8 = =F2=B3=EB=E0 =96 31,7 =EA=E3/=EC2. =CF=F0=E8=E1=EB=E8=E7=ED=EE 4= 9,4 % =E6=B3=ED=EE=EA =E1=F3=EB=E8 =EF=F0=E5=E4=F1=F2=E0=E2=ED=E8=EA=E0=EC=E8 =ED= =E5=E3=F0=EE=BF=E4=ED=EE=BF =F0=E0=F1=E8, 44,7 % =96 =BA=E2=F0=EE=EF=E5=EE= =BF=E4=ED=EE=BF =F0=E0=F1=E8 =F2=E0 5,9 % =96 =EF=F0=E5=E4=F1=F2=E0=E2=ED=E8=EA=E0=EC=E8 =B3=ED=F8=E8=F5 =F0=E0=F1.

=C7=EC=E5=ED=F8=E5=ED=ED=FF =F2=FF=E6=EA=E8=F5 =EC=E5=ED=F1=F2=F0= =F3=E0=EB=FC=ED=E8=F5 =EA=F0=EE=E2=EE=F2=E5=F7

=C2 =EE=E1=EE=F5 =E4=EE=F1=EB=B3=E4=E6=E5=ED= =ED=FF=F5 =F1=EF=EE=F1=F2=E5=F0=B3=E3=E0=E2=F1=FF =F1=F2=E0=F2=E8=F1=F2= =E8=F7=ED=EE =E7=ED=E0=F7=F3=F9=E5 =E2=E8=F9=E8=E9 =E2=B3=E4=F1=EE=F2=EE=EA= =F0=E5=F1=EF=EE=ED=E4=E5=ED=F2=B3=E2, =FF=EA=E8=E9 =E2=E8=E7=ED=E0=F7=E0=E2=F1=FF =E7=E0 =EF=EE=EA=E0=E7=ED=E8=EA= =E0=EC=E8 =EE=E1=92=BA=EC=F3 =CC=CA < 80 =EC=EB =B3 =E7=EC=E5=ED=F8=E5= =ED=ED=FF =EE=E1=92=BA=EC=F3 =CC=CA =EF=F0=E8=ED=E0=E9=EC=ED=B3 =ED=E0 50 % =E2=B3=E4 =E2=E8=F5=B3=E4=ED=EE=E3=EE =F0=B3=E2=ED=FF, =ED=E0 = =EA=EE=F0=E8=F1=F2=FC =E6=B3=ED=EE=EA, =FF=EA=B3 =EE=F2=F0=E8=EC=F3=E2=E0= =EB=E8 =EF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA=EA=EE, =EF=EE=F0=B3=E2=ED=FF=ED=EE =E7 =F2=E8=EC=E8, =F5=F2=EE =EE=F2=F0=E8=EC=F3= =E2=E0=E2 =EF=EB=E0=F6=E5=E1=EE (=E4=E8=E2. =F2=E0=E1=EB=E8=F6=FE 1). =C7= =ED=E8=E6=E5=ED=ED=FF =EE=E1=92=BA=EC=F3 =CC=CA =F1=EF=EE=F1=F2=E5=F0=B3=E3=E0=EB=EE=F1=FF =E2=E6=E5 =EF=B3=E4 =F7=E0=F1 = =EF=E5=F0=F8=EE=BF =EE=F6=B3=ED=EA=E8 (4 =F2=E8=E6=E4=E5=ED=FC). =D0=E5=E7= =F3=EB=FC=F2=E0=F2=E8 =E4=EB=FF =B3=ED=F8=E8=F5 =E2=F2=EE=F0=E8=ED=ED=E8=F5 =EA=B3=ED=F6=E5=E2=E8=F5 =F2=EE=F7=EE=EA, =EF= =EE=E2=92=FF=E7=E0=ED=E8=F5 =B3=E7 =EA=F0=EE=E2=EE=F2=E5=F7=E5=FE, =EF=EE= =EA=E0=E7=E0=ED=EE =E2 =F2=E0=E1=EB=E8=F6=B3 1. =D3=F1=B3 =EA=EB=FE=F7=EE=E2=B3 =E2=F2=EE=F0=E8=ED=ED=B3 =EA=B3=ED=F6=E5=E2=B3 =F2=EE= =F7=EA=E8 =E1=F3=EB=E8 =E0=EB=FC=F4=E0-=EA=EE=ED=F2=F0=EE=EB=FC=EE=E2=E0=ED= =E8=EC=E8.

=A0= =A0=A0=A0 =D2=E0=E1=EB=E8=F6=FF 1

=D0=E5=E7=F3=EB=FC=F2=E0=F2=E8 =EF=E5=F0=E2=E8=ED=ED=E8=F5 =F2=E0 = =E2=E8=E1=F0=E0=ED=E8=F5 =E2=F2=EE=F0=E8=ED=ED=E8=F5 =EE=F6=B3=ED=EE=EA =E5= =F4=E5=EA=F2=E8=E2=ED=EE=F1=F2=B3 =E2 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=B3 L1 =F2=E0 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED= =B3 L2 (= =EC=B3=EE=EC=E0 =EC=E0=F2=EA=E8)

 

=CF=EE=EA=E0=E7=ED=E8=EA<= /p>

=C4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF L1

=C4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF L2

=D0=B3=BA=EA=EE

(N =3D 128)

=CF=EB=E0=F6=E5=E1=EE

(N =3D 127)

=D0=B3=BA=EA=EE

(N =3D 125)

=CF=EB=E0=F6=E5=E1=EE

(N =3D 129)

=CA=B3=EB=FC=EA=B3=F1=F2= =FC (%) =F0=E5=F1=EF=EE=ED=E4=E5=ED=F2=B3=E2=E0, b

94 (73,4 %)

24 (18,9 %)

89 (71,2 %)

19 (14,7 %)

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97 (75,8 %)

34 (26,8 %)

97 (73,6 %)

25 (19,4 %)

=CA=B3=EB=FC=EA=B3=F1=F2= =FC (%) =EF=E0=F6=B3=BA=ED=F2=EE=EA =E7=B3 =E7=EC=E5=ED=F8=E5=ED=ED=FF=EC =EE=E1=92=BA= =EC=F3 =CC=CA =ED=E0 ≥ 50 %

101 (78,9 %)<= /span>

28 (22,1 %)

96 (76,8 %)

28 (21,7 %)

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67 (52,3 %)

7 (5,5 %)

63 (50,4 %)

4 (3,1 %)

=CA=B3=EB=FC=EA=B3=F1=F2= =FC (%) =EF=E0=F6=B3=BA=ED=F2=EE=EA =E7=B3 =E7=E1=B3=EB=FC=F8=E5=ED=ED=FF=EC =F0=B3=E2=ED=FF =E3=E5=EC=EE=E3=EB=EE=E1=B3=ED=F3 > 2 =E3/=E4=EBd=

15 (50,0 %)

5 (21,7 %)

19 (61,3 %)

2 (5,4 %)

=CA=B3=EB=FC=EA=B3=F1=F2= =FC (%) =EF=E0=F6=B3=BA=ED=F2=EE=EA, =FF=EA=B3 =E4=EE=F1=FF=E3=EB=E8 =D7=D8=CE ≤ 1b, =E5

25 (43,1 %)

7 (10,1 %)

32 (47,1 %)

14 (17,1 %)

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-12,4 (5,62)<= /span>

-0,3 (5,40)

-17,4 (5,93)<= /span>

-7,4 (5,92)

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-12,9 (3,08)<= /span>

2,2 (3,01)

-13,8 (3,39)<= /span>

-1,5 (3,37)

=E0 =D0=E5=F1= =EF=EE=ED=E4=E5=ED=F2 =96 =F6=E5 =E6=B3=ED=EA=E0, =E2 =FF=EA=EE=BF =EF=EE=EA=E0=E7=ED=E8=EA=E8 =CC=CA < 8= 0 =EC=EB =F2=E0 =E7=ED=E8=E6=E5=ED=ED=FF =EE=E1=92=BA=EC=F3 =CC=CA =EF=F0=E8=ED=E0=E9=EC=ED=B3 =ED=E0 50 = ;% =EF=EE=F0=B3=E2=ED=FF=ED=EE =E7 =E2=E8=F5=B3=E4=ED=E8=EC =F0=B3=E2=ED=E5= =EC =E7=E0 =EE=F1=F2=E0=ED=ED=B3 35 =E4=ED=B3=E2 =EB=B3=EA=F3=E2=E0=ED=ED=FF.

b p-=E7=ED=E0=F7=E5=ED=ED=FF < 0,0001 =96 =F6=E5 =EF=EE=F0=B3=E2= =ED=FF=ED=ED=FF =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =F2=E0 =EF=EB= =E0=F6=E5=E1=EE, =F9=EE =F1=F2=F0=E0=F2=E8=F4=B3=EA=EE=E2=E0=ED=EE =E7=E0 =E2=E8=F5=B3=E4=ED=E8=EC =EE=E1=92=BA=EC=EE=EC =CC=CA (< 225 =EC=EB, ≥= 225 =EC=EB) =F2=E0 =E3=E5=EE=E3=F0=E0=F4=B3=F7=ED=E8=EC =F0=E5=E3=B3=EE=ED=EE=EC (=CF=B3=E2=ED= =B3=F7=ED=E0 =C0=EC=E5=F0=E8=EA=E0, =F0=E5=F8=F2=E0 =F1=E2=B3=F2=F3). =

c =C0=EC=E5=ED=EE=F0=E5=FF =E2=E8=E7=ED=E0=F7=E0=BA=F2=FC=F1=FF =FF=EA = =E7=E0=F0=E5=BA=F1=F2=F0=EE=E2=E0=ED=E0 =E0=EC=E5=ED=EE=F0=E5=FF, =EA=F0=EE= =E2=EE=EC=E0=E7=E0=ED=ED=FF =E0=E1=EE =ED=E5=E7=ED=E0=F7=ED=E0 =EA=F0=EE=E2=EE=F2=E5=F7=E0 (=CC=CA < 5 =EC=EB) =E7 =EF=B3=E4=F2=F0=E8= =EC=EA=EE=FE =EA=EE=EC=EF=EB=E0=BA=ED=F2=ED=EE=F1=F2=B3 =E2 =E5=EB=E5=EA=F2= =F0=EE=ED=ED=EE=EC=F3 =F9=EE=E4=E5=ED=ED=E8=EA=F3 =EF=B3=E4 =F7=E0=F1 2 =E2=B3=E4=E2=B3=E4=F3=E2=E0=ED=FC =EF=EE=F1=EF=B3=EB= =FC.

d =D3 =EF=E0=F6=B3=BA=ED=F2=EE=EA =E7 =E2=E8=F5=B3=E4=ED=E8=EC =F0=B3=E2= =ED=E5=EC =E3=E5=EC=EE=E3=EB=EE=E1=B3=ED=F3 ≤ 10,5 =E3/=E4=EB.= =

e =D3 =EF=E0=F6=B3=BA=ED=F2=EE=EA =E7 =EF=EE=EC=B3=F0=ED=E8=EC =E0=E1=EE = =F1=E8=EB=FC=ED=E8=EC =E1=EE=EB=E5=EC =ED=E0 =E2=E8=F5=B3=E4=ED=EE=EC=F3 = =F0=B3=E2=ED=B3.=

=D1=EA=EE=F0=EE=F7=E5=ED=ED=FF: =CC=CA =96 = =EC=E5=ED=F1=F2=F0=F3=E0=EB=FC=ED=E0 =EA=F0=EE=E2=EE=E2=F2=F0=E0=F2=E0; =D7= =D8=CE =96 =F7=E8=F1=EB=EE=E2=E0 =F8=EA=E0=EB=E0 =EE=F6=B3=ED=EE=EA.

= =C5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7

= =C5=F4=E5=EA=F2=E8=E2=ED=B3=F1=F2=FC =F2=E0 =E1=E5=E7=EF=E5=EA=E0 =F2=E5=F0=E0=EF=B3=BF =EF=F0=EE=F2=FF=E3=EE=EC= 24 =F2=E8=E6=ED=B3=E2

= =C5=F4=E5=EA=F2=E8=E2=ED=B3=F1=F2=FC =F2=E0 =E1=E5=E7=EF=E5=EA=E0 =F2=E5=F0=E0=EF=B3=BF =EF=F0=E5=EF=E0=F0=E0=F2= =EE=EC =D0=B3=BA=EA=EE =EF=F0=E8 =E9=EE=E3=EE =E7=E0=F1=F2=EE=F1=F3=E2=E0= =ED=ED=B3 =EE=E4=E8=ED =F0=E0=E7 =ED=E0 =E4=EE=E1=F3 =F3 =EF=E0=F6=B3=BA=ED= =F2=EE=EA =E7 =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=EE=EC =E1=F3=EB=E8 =E2=E8=E2=F7=E5=ED= =B3 =E2 =F5=EE=E4=B3 =E4=E2=EE=F5 24-=F2=E8=E6=ED=E5=E2=E8=F5 =EC=B3=E6=ED= =E0=F0=EE=E4=ED=E8=F5 =F0=E0=ED=E4=EE=EC=B3=E7=EE=E2=E0=ED=E8=F5 =EF=EE=E4=E2=B3=E9=ED=EE =F1=EB=B3=EF=E8=F5 =EF=EB=E0=F6=E5=E1=EE-=EA=EE=ED= =F2=F0=EE=EB=FC=EE=E2=E0=ED=E8=F5 =E4=EE=F1=EB=B3=E4=E6=E5=ED=FC =E7 =EF=EE= =E2=F2=EE=F0=FE=E2=E0=ED=E8=EC =E4=E8=E7=E0=E9=ED=EE=EC =E7=E0 =F3=F7=E0=F1=F2=FE =E6=B3=ED=EE=EA =E2=B3=EA=EE=EC 18=9650 =F0=EE=EA=B3=E2 = =E7 =EF=EE=EC=B3=F0=ED=E8=EC =E0=E1=EE =F1=E8=EB=FC=ED=E8=EC =E1=EE=EB=E5= =EC, =EF=EE=E2=92=FF=E7=E0=ED=E8=EC =E7 =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=EE=EC (=E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF = S1 =F2=E0 S2), =FF=EA=E8=E9 =A0=E1=F3=EB=EE =EF=B3=E4=F2=E2=E5=F0=E4= =E6=E5=ED=EE =E1=E5=E7=EF=EE=F1=E5=F0=E5=E4=ED=FC=EE=FE =E2=B3=E7=F3=E0=EB= =B3=E7=E0=F6=B3=BA=FE =EF=B3=E4 =F7=E0=F1 =F5=B3=F0=F3=F0=E3=B3=F7=ED=EE=E3=EE =E2=F2=F0=F3=F7=E0= =ED=ED=FF =F2=E0/=E0=E1=EE =E3=B3=F1=F2=EE=EB=EE=E3=B3=F7=ED=E8=EC =E4=EE= =F1=EB=B3=E4=E6=E5=ED=ED=FF=EC. =C1=EE=EB=FC=EE=E2=E8=E9 =F1=E8=ED=E4=F0=EE=EC (=EF=EE=EC=B3=F0=ED=E8=E9 =E0=E1=EE =F1=E8=EB=FC=ED= =E8=E9) =EE=F6=B3=ED=FE=BA=F2=FC=F1=FF =E7=E0 11-=E1=E0=EB=FC=ED=EE=FE =F6= =E8=F4=F0=EE=E2=EE=FE =F0=E5=E9=F2=E8=ED=E3=EE=E2=EE=FE =F8=EA=E0=EB=EE=FE (NRS).

=C2 =EE=E1=EE=F5 =E4=EE=F1=EB=B3=E4=E6=E5=ED= =ED=FF=F5 =E1=F3=EB=EE =EF=E5=F0=E5=E4=E1=E0=F7=E5=ED=EE =F2=F0=E8 =E3=F0= =F3=EF=E8 =EB=B3=EA=F3=E2=E0=ED=ED=FF. =C6=B3=ED=EA=E8 =E1=F3=EB=E8 =F0=E0=ED=E4=EE= =EC=B3=E7=EE=E2=E0=ED=B3 =F3 =E3=F0=F3=EF=E8 =EB=B3=EA=F3=E2=E0=ED=ED=FF = =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=EE=EC =F3 =E4=EE=E7=B3 40 =EC=E3 =F3 =EA=EE=EC=E1=B3=ED=E0=F6=B3=BF =E7 =E5=F1=F2=F0=E0=E4=B3=EE=EB=EE=EC = =F3 =E4=EE=E7=B3 1 =EC=E3 =F2=E0 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3 = =E0=F6=E5=F2=E0=F2=EE=EC =F3 =E4=EE=E7=B3 0,5 =EC=E3 (E2/NETA) (=EF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA=EA=EE) =EF=F0=EE=F2=FF=E3=EE= =EC 24 =F2=E8=E6=ED=B3=E2 =E0=E1=EE =EF=EB=E0=F6=E5=E1=EE =EF=F0=EE=F2=FF= =E3=EE=EC 24 =F2=E8=E6=ED=B3=E2, =E0=E1=EE =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=EE=EC =F3 =E4=EE=E7=B3 40 =EC=E3 = =EF=F0=EE=F2=FF=E3=EE=EC 12 =F2=E8=E6=ED=B3=E2 =E7 =EF=EE=E4=E0=EB=FC=F8=E8= =EC =EF=E5=F0=E5=E2=E5=E4=E5=ED=ED=FF=EC =ED=E0 =EA=EE=EC=E1=B3=ED=EE=E2=E0=ED=F3 =F2=E5=F0=E0=EF=B3=FE =F0=E5=EB=F3=E3=EE= =EB=B3=EA=F1=EE=EC =F3 =E4=EE=E7=B3 40 =EC=E3 =F2=E0 E2/NETA =EF=F0=EE=F2= =FF=E3=EE=EC 12 =F2=E8=E6=ED=B3=E2. =CF=E0=F6=B3=BA=ED=F2=EE=EA =E2=EA=EB=FE=F7=E0=EB=E8 =E2 =E4=EE=F1=EB=B3=E4= =E6=E5=ED=ED=FF =E7=E0 =ED=E0=FF=E2=ED=EE=F1=F2=B3 =EF=EE=EC=B3=F0=ED=EE=E3= =EE =E0=E1=EE =F1=E8=EB=FC=ED=EE=E3=EE =E1=EE=EB=FE =E4=EE =EF=EE=F7=E0=F2=EA=F3 =F1=EA=F0=E8=ED=B3=ED=E3=F3, =E9 =E4=EE =E7=E0=EA=B3= =ED=F7=E5=ED=ED=FF =EF=E5=F0=B3=EE=E4=F3 =E2=E2=E5=E4=E5=ED=ED=FF (=F2=EE= =E1=F2=EE, =F9=EE=ED=E0=E9=EC=E5=ED=F8=E5 =E4=E2=E0 =F6=E8=EA=EB=E8). =D3 =F1=EA=EB=E0=E4=B3 =F3=F7=E0=F1=ED=E8=F6=FC =E4=EE=F1=EB=B3=E4=E6=E5=ED= =FC S1 =F2=E0 S2 =EF=E0=F6=B3=BA=ED=F2=EA=E8, =FF=EA=B3 =F0=E0=ED=B3=F8=E5 = =EF=E5=F0=E5=ED=E5=F1=EB=E8 =EE=EF=E5=F0=E0=F6=B3=FE/=B3=ED=E2=E0=E7=E8=E2=ED=E5 =EB=B3=EA=F3=E2=E0=ED= =ED=FF =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=F3, =F1=F2=E0=ED=EE=E2=E8=EB=E8 = =96 83,2 %, =EF=E0=F6=B3=BA=ED=F2=EA=E8, =FF=EA=B3 =ED=E5 =EF=EE=E2=B3=E4=EE=EC=EB=FF=EB=E8 =EF=F0=EE =EF=EE=EF=E5=F0=E5=E4=ED= =BA =F5=B3=F0=F3=F0=E3=B3=F7=ED=E5 =F7=E8 =EC=E5=E4=E8=EA=E0=EC=E5=ED=F2=EE= =E7=ED=E5 =EB=B3=EA=F3=E2=E0=ED=ED=FF =E4=EE =E2=EA=EB=FE=F7=E5=ED=ED=FF =E2 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF, =96 8 %.= =CD=E0 =EF=EE=F7=E0=F2=EA=F3 =E4=EE=F1=EB=B3=E4=E6=E5=ED=FC =E1=B3=EB=FC= =F8=B3=F1=F2=FC =EF=E0=F6=B3=BA=ED=F2=EE=EA (92,6 %) =EF=F0=E8=E9=EC=E0=EB=E8 =E0=ED=E0=EB=FC=E3=E5=F2=E8=EA=E8 =E4=EB=FF =F3= =F1=F3=ED=E5=ED=ED=FF =F2=E0=E7=EE=E2=EE=E3=EE =E1=EE=EB=FE,=A0 29,1 % =EF=E0=F6=B3=BA=ED=F2=EE=EA = =F3 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=B3 S1 =F2=E0 48,4 % =EF=E0=F6=B3=BA=ED=F2=EE=EA =F3 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=B3 S2 =EF=F0= =E8=E9=EC=E0=EB=E8 =EE=EF=B3=EE=BF=E4=ED=B3 =E0=ED=E0=EB=FC=E3=E5=F2=E8=EA= =E8. =B2=ED=F8=E8=EC=E8 =EF=F0=E5=EF=E0=F0=E0=F2=E0=EC=E8, =FF=EA=B3 =ED=E0=E9=F7=E0=F1=F2=B3=F8=E5 =E7=E0=F1=F2=EE=F1=EE=E2=F3=E2=E0=EB=E8=F1= =FC =E4=EB=FF =EB=B3=EA=F3=E2=E0=ED=ED=FF =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7= =F3, =E1=F3=EB=E8 =E4=B3=BA=ED=EE=E3=E5=F1=F2 (19,4 %), =EF=E5=F0=EE=F0=E0=EB=FC=ED=B3 =EA=EE=ED=F2=F0=E0=F6=E5=EF=F2=E8=E2=E8, =F9= =EE =EC=B3=F1=F2=FF=F2=FC =E5=F1=F2=F0=EE=E3=E5=ED =F2=E0 =EF=F0=EE=E3=E5= =F1=F2=E8=ED (15,2 %) =F2=E0 =E0=E3=EE=ED=B3=F1=F2=E8 =C3=ED=D0=C3 (7,6 %). =CC=E5=E4=B3=E0=ED=E0 =E2=B3=EA=F3 =EF=E0=F6=B3=BA=ED= =F2=EE=EA =F1=F2=E0=ED=EE=E2=E8=EB=E0 34 =F0=EE=EA=E8, =F1=E5=F0=E5=E4=ED= =B3=E9 =B3=ED=E4=E5=EA=F1 =EC=E0=F1=E8 =F2=B3=EB=E0 =96 26 =EA=E3/=EC2. =CF=F0=E8=E1=EB=E8=E7=ED=EE 91 = % =E6=B3=ED=EE=EA =E1=F3=EB=E8 =EF=F0=E5=E4=F1=F2=E0=E2=ED=E8=F6=FF=EC=E8 =BA=E2=F0=EE=EF=E5=EE=BF=E4=ED=EE=BF =F0=E0=F1=E8, 6 % =96 =ED=E5=E3=F0=EE= =BF=E4=ED=EE=BF, =E0 3 % =EC=E0=EB=E8 =B3=ED=F8=F3 =F0=E0=F1=EE=E2=F3 =EF= =F0=E8=ED=E0=EB=E5=E6=ED=B3=F1=F2=FC.

= =C7=EC=E5=ED=F8=E5=ED=ED=FF =E4=E8=F1=EC=E5=ED=EE=F0=E5=BF =F2=E0 =F2=E0=E7=EE=E2=EE=E3=EE =E1=EE=EB=FE= , =ED=E5 =EF=EE=E2=92=FF=E7=E0=ED=EE=E3=EE =E7 =EC=E5=ED=F1=F2=F0=F3=E0=F6= =B3=BA=FE

=D3 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF=F5 S1 = =B3 S2 =E1=F3=EB=E8 =EF=E5=F0=E5=E4=E1=E0=F7=E5=ED=B3 =E4=E2=B3 =EA=EE=EC=E1=B3=ED=EE=E2=E0=ED=B3 =EF=E5=F0=E2=E8=ED=ED=B3 =EA=B3=ED=F6=E5= =E2=B3 =F2=EE=F7=EA=E8, =FF=EA=B3 =F1=EA=EB=E0=E4=E0=FE=F2=FC=F1=FF =E7 =E4= =E2=EE=F5 =EF=EE=EA=E0=E7=ED=E8=EA=B3=E2. =C2 =EE=E1=EE=F5 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF=F5 =F1=EF=EE=F1=F2=E5=F0=B3=E3=E0=EB=EE= =F1=FF =F1=F2=E0=F2=E8=F1=F2=E8=F7=ED=EE =E7=ED=E0=F7=F3=F9=E5 =E7=E1=B3=EB= =FC=F8=E5=ED=ED=FF =F7=E0=F1=F2=EA=E8 =EF=E0=F6=B3=BA=ED=F2=EE=EA, =FF=EA=B3 =E2=B3=E4=EF=EE=E2=B3=EB=E8 =ED=E0 =EB=B3=EA=F3=E2=E0=ED=ED=FF. = =C2=B3=E4=EF=EE=E2=B3=E4=E4=FE =ED=E0 =EB=B3=EA=F3=E2=E0=ED=ED=FF =E2=E2=E0= =E6=E0=EB=EE=F1=FF =E7=ED=E8=E6=E5=ED=ED=FF =EE=F6=B3=ED=EA=E8 =E4=E8=F1=EC=E5=ED=EE=F0=E5=BF =FF=EA =EC=B3=ED=B3=EC=F3=EC =ED=E0 2,8 =E1= =E0=EB=E0 =F2=E0 =E7=ED=E8=E6=E5=ED=ED=FF =EE=F6=B3=ED=EA=E8 =F2=E0=E7=EE= =E2=EE=E3=EE =E1=EE=EB=FE, =ED=E5 =EF=EE=E2=92=FF=E7=E0=ED=EE=E3=EE =E7 =EC=E5=ED=F1=F2=F0=F3=E0=F6=B3=BA=FE, =FF=EA =EC=B3=ED=B3=EC=F3=EC =ED= =E0 2,1 =E1=E0=EB=E0 =E7=E0 =EE=F1=F2=E0=ED=ED=B3 35 =E4=ED=B3=E2 =EB=B3=EA= =F3=E2=E0=ED=ED=FF =E1=E5=E7 =E7=E1=B3=EB=FC=F8=E5=ED=ED=FF =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =E0=ED= =E0=EB=FC=E3=E5=F2=E8=EA=B3=E2 (=B3=E1=F3=EF=F0=EE=F4=E5=ED=F3 =E0=E1=EE = =EE=EF=B3=EE=BF=E4=B3=E2) (=F2=E0=E1=EB=E8=F6=FF 2).

=D2=E0=E1=EB=E8=F6=FF 2

= =D0=E5=E7=F3=EB=FC=F2=E0=F2=E8 =EE=F6=B3=ED=EA=E8 =E4=E2=EE=F5 =EA=EE=EC=E1=B3=ED=EE=E2=E0=ED=E8=F5 =EF=E5= =F0=E2=E8=ED=ED=E8=F5 =EA=B3=ED=F6=E5=E2=E8=F5 =F2=EE=F7=EE=EA =E5=F4=E5=EA= =F2=E8=E2=ED=EE=F1=F2=B3 =F3 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF=F5 S1 =F2=E0 S2 (=E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7)

=C2=E8=E7=ED=E0=F7=E5=ED=ED=FF =EA=B3=ED= =F6=E5=E2=EE=BF =F2=EE=F7=EA=E8

=C4=EE=F1=EB=B3=E4=E6=E5=ED= =ED=FF S1

=C4=EE=F1=EB=B3=E4=E6=E5=ED= =ED=FF S2

=D0=B3=BA=EA=EE<= /o:p>

(N =3D 212)

=CF=EB=E0=F6=E5=E1=EE=

(N =3D 212)

=D0=B3=BA=EA=EE<= /o:p>

(N =3D 206)

=CF=EB=E0=F6=E5=E1=EE=

(N =3D 204)

=CA=B3=EB=FC=EA=B3=F1=F2=FC (%) =EF=E0=F6=B3=BA=ED=F2=EE=EA, =FF=EA=B3 =E2=B3=E4=EF=EE=E2=B3=EB=E8 = =ED=E0 =EB=B3=EA=F3=E2=E0=ED=ED=FF, =E7=E0 =EE=F6=B3=ED=EA=EE=FE =E4=E8=F1= =EC=E5=ED=EE=F0=E5=BFa,c

158=

(74,5 %)<= /span>

57<= /span>

(26,9 %)<= /span>

155=

(75,2 %)<= /span>

62<= /span>

(30,4 %)<= /span>

=CA=B3=EB=FC=EA=B3=F1=F2=FC (%) =EF=E0=F6=B3=BA=ED=F2=EE=EA, =FF=EA=B3 =E2=B3=E4=EF=EE=E2=B3=EB=E8 = =ED=E0 =EB=B3=EA=F3=E2=E0=ED=ED=FF, =E7=E0 =EE=F6=B3=ED=EA=EE=FE =F2=E0=E7= =EE=E2=EE=E3=EE =E1=EE=EB=FE, =ED=E5 =EF=EE=E2=92=FF=E7=E0=ED=EE=E3=EE =E7 =EC=E5=ED=F1=F2=F0=F3=E0=F6=B3=BA=FE (=CD=CC=D2=C1)b,c

124=

(58,5 %)<= /span>

84<= /span>

(39,6 %)<= /span>

136=

(66,0 %)<= /span>

87<= /span>

(42,6 %)<= /span>

=E0 =CF=E0=F6=B3=BA=ED=F2=EA=E8 =E2=E2= =E0=E6=E0=EB=E8=F1=FF =F2=E0=EA=E8=EC=E8, =F9=EE =E2=B3=E4=EF=EE=E2=B3=EB=E8 =ED=E0 =EB=B3=EA=F3=E2=E0=ED=ED=FF, =EF=F0=E8 =E7=ED=E8=E6=E5=ED=ED=B3 =EE= =F6=B3=ED=EA=E8 =E4=E8=F1=EC=E5=ED=EE=F0=E5=BF =E7=E0 =F8=EA=E0=EB=EE=FE NR= S =ED=E5 =EC=E5=ED=F8=E5 =ED=B3=E6 =ED=E0 2,8 =E1=E0=EB=E0 =E1=E5=E7 =E7=E1=B3=EB=FC=F8=E5=ED=ED=FF =EF=EE=F2=F0=E5=E1=E8= =E2 =E0=ED=E0=EB=FC=E3=E5=F2=E8=EA=E0=F5, =E4=EE=E7=E2=EE=EB=E5=ED=E8=F5 = =E4=EE =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =E2 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=B3, =E4=EB=FF =F3=F1=F3=ED=E5=ED=ED=FF =F2= =E0=E7=EE=E2=EE=E3=EE =E1=EE=EB=FE =E4=EE =F2=E8=E6=ED=FF 24/=E7=E0=E2=E5= =F0=F8=E5=ED=ED=FF =EB=B3=EA=F3=E2=E0=ED=ED=FF.

b =CF=E0=F6=B3=BA=ED=F2=EA=E8 = =E2=E2=E0=E6=E0=EB=E8=F1=FF =F2=E0=EA=E8=EC=E8, =F9=EE =E2=B3=E4=EF=EE=E2=B3=EB=E8 =ED=E0 =EB=B3=EA=F3=E2=E0=ED=ED=FF, =EF=F0=E8 = =E7=ED=E8=E6=E5=ED=ED=B3 =EE=F6=B3=ED=EA=E8 =CD=CC=D2=C1 =E7=E0 =F8=EA=E0= =EB=EE=FE NRS =ED=E5 =EC=E5=ED=F8=E5 =ED=B3=E6 =ED=E0 2,1 =E1=E0=EB=E0 =E1=E5=E7 =E7=E1=B3=EB=FC=F8=E5=ED=ED=FF =EF=EE=F2=F0=E5= =E1=E8 =E2 =E0=ED=E0=EB=FC=E3=E5=F2=E8=EA=E0=F5, =E4=EE=E7=E2=EE=EB=E5=ED= =E8=F5 =E4=EE =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =E2 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=B3, =E4=EB=FF =F3=F1=F3=ED=E5=ED=ED=FF =F2= =E0=E7=EE=E2=EE=E3=EE =E1=EE=EB=FE =E4=EE =F2=E8=E6=ED=FF 24/=E7=E0=E2=E5= =F0=F8=E5=ED=ED=FF =EB=B3=EA=F3=E2=E0=ED=ED=FF.

c =D0-=E7=ED=E0=F7=E5=ED=ED=FF < 0,0001 =E4=EB=FF =EF=EE=F0=B3=E2=ED=FF= =ED=ED=FF =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =E7 =EF=EB=E0=F6=E5= =E1=EE =E7 =EF=EE=EF=F0=E0=E2=EA=EE=FE =ED=E0 =E2=E8=F5=B3=E4=ED=F3 =E1=E0=EB=FC=ED=F3 =EE=F6=B3=ED=EA=F3 =E1=EE= =EB=FE, =F7=E0=F1, =F9=EE =EC=E8=ED=F3=E2 =E7 =EF=E5=F0=E2=E8=ED=ED=EE=BF = =EF=EE=F1=F2=E0=ED=EE=E2=EA=E8 =F5=B3=F0=F3=F0=E3=B3=F7=ED=EE=E3=EE =E4=B3=E0=E3=ED=EE=E7=F3 =E5=ED=E4=EE= =EC=E5=F2=F0=B3=EE=E7=F3, =F2=E0 =E3=E5=EE=E3=F0=E0=F4=B3=F7=ED=E8=E9 =F0= =E5=E3=B3=EE=ED.

=D1=EA=EE= =F0=EE=F7=E5=ED=ED=FF: N =96 =EA=B3=EB=FC=EA=B3=F1=F2=FC =EF=E0=F6=B3=BA=ED=F2=EE=EA; =CD=CC=D2=C1 =96 = =F2=E0=E7=EE=E2=E8=E9 =E1=B3=EB=FC, =ED=E5 =EF=EE=E2=92=FF=E7=E0=ED=E8=E9 = =E7 =EC=E5=ED=F1=F2=F0=F3=E0=F6=B3=BA=FE; NRS =96 =F6=E8=F4=F0=EE=E2=E0 =F0=E5=E9=F2=E8=ED=E3=EE=E2=E0 =F8=EA=E0=EB=E0 (0 =E1= =E0=EB=B3=E2 =96 =E1=B3=EB=FC =E2=B3=E4=F1=F3=F2=ED=B3=E9; 10 =E1=E0=EB=B3= =E2 =96 =E1=B3=EB=FC =ED=E0=F1=F2=B3=EB=FC=EA=E8 =F1=E8=EB=FC=ED=E8=E9, =ED=E0=F1=EA=B3=EB=FC=EA=E8 =EC=EE=E6=ED=E0 =F3=FF= =E2=E8=F2=E8).

 

=D0=E5=E7=F3=EB=FC=F2=E0=F2=E8 =EE=F6=B3=ED=EA=E8 =EA= =EB=FE=F7=EE=E2=E8=F5 =E2=F2=EE=F0=E8=ED=ED=E8=F5 =EA=B3=ED=F6=E5=E2=E8=F5 = =F2=EE=F7=EE=EA =E5=F4=E5=EA=F2=E8=E2=ED=EE=F1=F2=B3 =EF=F0=E5=E4=F1=F2=E0=E2=EB=E5=ED=EE = =E2 =F2=E0=E1=EB=E8=F6=B3 3. =D3=F1=B3 =EA=EB=FE=F7=EE=E2=B3 =E2=F2=EE=F0= =E8=ED=ED=B3 =EA=B3=ED=F6=E5=E2=B3 =F2=EE=F7=EA=E8 =EA=EE=ED=F2=F0=EE=EB=FE=E2=E0=EB=E8=F1=FF =E7=E0 =F0=B3=E2=ED=E5=EC =E4=EE= =F1=F2=EE=E2=B3=F0=ED=EE=F1=F2=B3 =E0=EB=FC=F4=E0.

=D2=E0=E1=EB=E8=F6=FF 3

=D0=E5=E7=F3=EB=FC=F2=E0=F2=E8 =E0= =ED=E0=EB=B3=E7=F3 =EE=E1=F0=E0=ED=E8=F5 =E2=F2=EE=F0=E8=ED=ED=E8=F5 =EA=B3=ED=F6=E5=E2=E8=F5 =F2=EE=F7=EE=EA =E5=F4=E5=EA=F2=E8=E2=ED=EE=F1=F2= =B3 =F3 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF=F5 S1 =F2=E0 S2 (=E5=ED=E4=EE=EC= =E5=F2=F0=B3=EE=E7)=

=C2=E8=E7=ED=E0=F7=E5=ED=ED=FF =EA=B3=ED=F6=E5=E2=EE=BF =F2=EE=F7=EA= =E8

=C4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF S1

=C4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF S2

=D0=B3=BA=EA=EE

(N =3D 212)

=CF=EB=E0=F6=E5=E1=EE

(N =3D 212)

=D0=B3=BA=EA=EE

(N =3D 206)

=CF=EB=E0=F6=E5=E1=EE

(N =3D 204)

=C7=EC=B3=ED=E0 =EE=F6=B3=ED=EA=E8 =E7=E0 = =F8=EA=E0=EB=EE=FE =E1=EE=EB=FE =EE=EF=E8=F2=F3=E2=E0=EB=FC=ED=E8=EA=E0 EHP-30, =CC=CD=CA-=F1=E5=F0=E5=E4=ED=BA (SE)a,b

-33,8 (1,83)

-18,7 (1,83)

-32,2 (1,68)

-19,9 (1,69)

=C7=EC=B3=ED=E0 =F1=E5=F0=E5=E4=ED=FC=EE= =BF =EE=F6=B3=ED=EA=E8 =E4=E8=F1=EC=E5=ED=EE=F0=E5=BF =E7=E0 =F8=EA=E0=EB= =EE=FE NRS, =CC=CD=CA-=F1=E5=F0=E5=E4=ED=BA (SE)a,b

-5,1 (0,19)

-1,8 (0,19)

-5,1 (0,19)

-2,0 (0,19)

=C7=EC=B3=ED=E0 =F1=E5=F0=E5=E4=ED=FC=EE= =BF =EE=F6=B3=ED=EA=E8 =CD=CC=D2=C1 =E7=E0 =F8=EA=E0=EB=EE=FE NRS, =CC=CD=CA-=F1=E5=F0=E5=E4=ED=BA (SE)a,b

-2,9 (0,18)

-2,0 (0,18)

-2,7 (0,17)

-2,0 (0,17)

=C7=EC=B3=ED=E0 =F1=E5=F0=E5=E4=ED=FC=EE= =BF =EE=F6=B3=ED=EA=E8 =E4=E8=F1=EF=E0=F0=E5=F3=ED=B3=BF =E7=E0 =F8=EA=E0= =EB=EE=FE NRS, =CC=CD=CA-=F1=E5=F0=E5=E4=ED=BA (SE)a,b

-2,4 (0,21)

-1,7 (0,22)

-2,4 (0,19)

-1,9 (0.19)

=D7=E0=F1=F2=EA=E0 =EF=E0=F6=B3=BA=ED=F2= =EE=EA, =FF=EA=B3 =ED=E5 =E7=E0=F1=F2=EE=F1=EE=E2=F3=E2=E0=EB=E8 =E4=EE=E7= =E2=EE=EB=E5=ED=B3 =EF=F0=EE=F2=EE=EA=EE=EB=EE=EC =EE=EF=B3=EE=BF=E4=ED=B3 =E0=ED=E0=EB=FC= =E3=E5=F2=E8=EA=E8 =E4=EB=FF =F3=F1=F3=ED=E5=ED=ED=FF =E1=EE=EB=FE, =EF=EE= =E2=92=FF=E7=E0=ED=EE=E3=EE =E7 =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=EE=EC, n (%)c

182

(85,8 %)

162

(76,4 %)

169

(82,0 %)

135

(66,2 %)

a =CC=CD=CA-= =F1=E5=F0=E5=E4=ED=B3 =F0=EE=E7=F0=E0=F5=EE=E2=E0=ED=B3 =E7 =E2=E8=EA=EE=F0=E8=F1=F2=E0=ED=ED=FF= =EC =EC=EE=E4=E5=EB=B3 =E7=EC=B3=F8=E0=ED=E8=F5 =E5=F4=E5=EA=F2=B3=E2, =E2 = =FF=EA=B3=E9 =EB=B3=EA=F3=E2=E0=ED=ED=FF, =E2=E8=F5=B3=E4=ED=E5 =E7=ED=E0=F7=E5=ED=ED=FF, =E2=B3=E7=E8=F2, =E3=E5=EE=E3=F0=E0=F4=B3=F7=ED= =E8=E9 =F0=E5=E3=B3=EE=ED (=CF=B3=E2=ED=B3=F7=ED=E0 =C0=EC=E5=F0=E8=EA=E0, = =F0=E5=F8=F2=E0 =EA=F0=E0=BF=ED =F1=E2=B3=F2=F3), =F7=E0=F1, =F9=EE =EC=E8=ED=F3=E2 =EF=B3=F1=EB=FF =E2=F1=F2=E0=ED=EE=E2=EB= =E5=ED=ED=FF =F5=B3=F0=F3=F0=E3=B3=F7=ED=EE=E3=EE =E4=B3=E0=E3=ED=EE=E7=F3 = =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=F3 (< 5 =F0=EE=EA=B3=E2, ≥ 5 =F0=EE=EA=B3=E2), =F2=E0 =E2=E7=E0=BA=EC=EE=E4= =B3=FF =EB=B3=EA=F3=E2=E0=ED=ED=FF =E7 =E2=B3=E7=E8=F2=EE=EC =E1=F3=EB=E8 = =E2=EA=EB=FE=F7=E5=ED=B3 =FF=EA =F4=B3=EA=F1=EE=E2=E0=ED=B3 =E5=F4=E5=EA=F2=E8; =E2=B3=E7=E8=F2 =F2=E0=EA=EE=E6 =E2=EA=EB=FE=F7=E5=ED= =E8=E9 =E2 =EC=EE=E4=E5=EB=FC =FF=EA =E2=E8=EF=E0=E4=EA=EE=E2=E8=E9 =E5=F4= =E5=EA=F2 =E4=EB=FF =EA=EE=E6=ED=EE=BF =EF=E0=F6=B3=BA=ED=F2=EA=E8. =C1=F3=EB=EE =EF=F0=E8=E9=ED=FF=F2=EE =ED=E5= =F1=F2=F0=F3=EA=F2=F3=F0=EE=E2=E0=ED=F3 =EA=EE=E2=E0=F0=B3=E9=ED=F3 =EC=E0= =F2=F0=E8=F6=FE.

b =C7=EC=B3= =ED=E0 =E2=E8=F5=B3=E4=ED=EE=E3=EE =E7=ED=E0=F7=E5=ED=ED=FF =E4=EE =F2=E8=E6=ED=FF 24/=C7=CB.

c =CD=E0 =F2= =E8=E6=ED=B3 24/=C7=CB.

=D1=EA=EE= =F0=EE=F7=E5=ED=ED=FF: =C7=CB =96 =E7=E0=E2=E5=F0=F8=E5=ED=ED=FF =EB=B3=EA=F3=E2=E0=ED=ED=FF; =CC=CD=CA =96 = =EC=E5=F2=EE=E4 =ED=E0=E9=EC=E5=ED=F8=E8=F5 =EA=E2=E0=E4=F0=E0=F2=B3=E2; N = =96 =EA=B3=EB=FC=EA=B3=F1=F2=FC =EF=E0=F6=B3=BA=ED=F2=EE=EA; =CD=CC=D2=C1 =96 =F2=E0=E7=EE=E2=E8=E9 =E1=B3=EB=FC, =ED=E5 =EF=EE=E2=92=FF= =E7=E0=ED=E8=E9 =E7 =EC=E5=ED=F1=F2=F0=F3=E0=F6=B3=BA=FE; NRS =96 =F6=E8=F4= =F0=EE=E2=E0 =F0=E5=E9=F2=E8=ED=E3=EE=E2=E0 =F8=EA=E0=EB=E0; SE =96 =F1=F2=E0=ED=E4=E0=F0=F2=ED=E0 =EF=EE=EC=E8=EB=EA= =E0.

=C2=E8=EC=B3=F0=FE=E2=E0=ED=ED=FF =EC= =B3=ED=E5=F0=E0=EB=FC=ED=EE=BF =F9=B3=EB=FC=ED=EE=F1=F2=B3 =EA=B3=F1=F2=EA= =EE=E2=EE=BF =F2=EA=E0=ED=E8=ED=E8 (=CC=D9=CA=D2) =EF=F0=EE=F2=FF=E3=EE=EC 104 =F2=E8=E6= =ED=B3=E2

=C2=EF= =EB=E8=E2 =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =ED=E0 =CC=D9=CA=D2 =EE=F6=B3=ED=FE=E2=E0=EB=E8 =EC=E5=F2= =EE=E4=EE=EC =EF=EE=E4=E2=B3=E9=ED=EE=BF =F0=E5=ED=F2=E3=E5=ED=B3=E2=F1=FC= =EA=EE=BF =E0=E1=F1=EE=F0=E1=F6=B3=EE=EC=E5=F2=F0=B3=BF (=CF=D0=C0) =ED=E0 =F2=E8=E6=ED=B3 12, 24, 36, 52 =B3 104. =C7=E0=E3=E0=EB=EE=EC 477 =E6=B3=ED= =EE=EA =E7 =EC=B3=EE=EC=EE=FE =EC=E0=F2=EA=E8, =FF=EA=B3 =E7=E0=E2=E5=F0=F8= =E8=EB=E8 =EE=F1=ED=EE=E2=ED=E5 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF =F2=F0=E8=E2=E0=EB= =B3=F1=F2=FE 24 =F2=E8=E6=ED=B3 (=E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF L1 =B3 L= 2), =E1=F3=EB=E8 =E2=EA=EB=FE=F7=E5=ED=B3 =F3 28-=F2=E8=E6=ED=E5=E2=E5 =E2=B3=E4=EA=F0=E8=F2=E5 =E4=EE=F1=EB=B3=E4=E6=E5= =ED=ED=FF =E7 =EE=E4=ED=B3=BA=FE =E3=F0=F3=EF=EE=FE (=E4=EE=F1=EB=B3=E4=E6= =E5=ED=ED=FF L3), =E4=E5 =E2=F1=B3 =E6=B3=ED=EA=E8 =EE=F2=F0=E8=EC=F3=E2=E0=EB=E8 =EF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA=EA=EE. = =C7=E0=E3=E0=EB=EE=EC 228 =E6=B3=ED=EE=EA, =FF=EA=B3 =E7=E0=E2=E5=F0=F8=E8= =EB=E8 =F0=EE=E7=F8=E8=F0=E5=ED=E5 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF, =E1=F3=EB=E8 =E2=EA=EB=FE=F7=E5=ED=B3 =E2 =E4=EE=E4=E0=F2=EA=EE=E2=E5 52-= =F2=E8=E6=ED=E5=E2=E5 =E4=EE=F1=EB=B3=E4=E6=F3=E2=E0=ED=ED=FF (=F0=E0=ED=E4= =EE=EC=B3=E7=EE=E2=E0=ED=E5 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF =E2=B3=E4=EC= =B3=ED=E8), =E4=E5 =E2=EE=ED=E8 =E1=F3=EB=E8 =EF=EE=E2=F2=EE=F0=ED=EE =F0=E0=ED=E4=EE= =EC=B3=E7=EE=E2=E0=ED=B3 =E4=EB=FF =EE=F2=F0=E8=EC=E0=ED=ED=FF =EF=F0=E5=EF= =E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =E0=E1=EE =EF=EB=E0=F6=E5=E1=EE. =C7=E0=E3= =E0=EB=EE=EC 802 =E6=B3=ED=EA=E8 =E7 =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=EE=EC, =FF=EA=B3 = =E7=E0=E2=E5=F0=F8=E8=EB=E8 =F3=F7=E0=F1=F2=FC =F3 24-=F2=E8=E6=ED=E5=E2=E8= =F5 =EE=F1=ED=EE=E2=ED=E8=F5 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF=F5 (=E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF=F5 = S1 =F2=E0 S2), =E1=F3=EB=E8 =E2=EA=EB=FE=F7=E5=ED=B3 =E4=EE =E4=EE=F1=EB=B3= =E4=E6=E5=ED=ED=FF =EF=F0=EE=E4=EE=E2=E6=E5=ED=ED=FF =F2=E5=F0=E0=EF=B3=BF (=E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF S3), =E2 =F0=E0=EC= =EA=E0=F5 =FF=EA=EE=E3=EE =E2=F1=B3 =EF=E0=F6=B3=BA=ED=F2=EA=E8 =EE=F2=F0= =E8=EC=F3=E2=E0=EB=E8 =EF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA=EA=EE. =CE=F6=B3=ED=EA=E8 =CC=D9=CA=D2 =E7=E0 104 =F2=E8=E6=ED=B3 =F3 =E6=B3=ED=EE= =EA =E7 =EC=B3=EE=EC=EE=FE =EC=E0=F2=EA=E8 =F2=E0 =E5=ED=E4=EE=EC=E5=F2=F0= =B3=EE=E7=EE=EC =ED=E0=E2=E5=E4=E5=ED=EE =F3 =F2=E0=E1=EB=E8=F6=B3 4.

=D2=E0=E1= =EB=E8=F6=FF 4

=C2=E8=EC=B3=F0=FE=E2=E0=ED=ED=FF =EC= =B3=ED=E5=F0=E0=EB=FC=ED=EE=BF =F9=B3=EB=FC=ED=EE=F1=F2=B3 =EA=B3=F1=F2=EA= =EE=E2=EE=BF =F2=EA=E0=ED=E8=ED=E8 (=CC=D9=CA=D2) =EF=F0=EE=F2=FF=E3=EE=EC 104 =F2=E8=E6= =ED=B3=E2 =F3 =EF=E0=F6=B3=BA=ED=F2=EE=EA =E7 =EC=B3=EE=EC=EE=FE =EC=E0=F2= =EA=E8 =F2=E0 =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=EE=EC=

=CF=EE=EA=E0=E7=ED=E8=EA

=D0=B3=BA=EA=EE

(N =3D 672)

=CF=EB=E0=F6=E5=E1=EE

(N =3D 672)

=CF=EE=EF=E5=F0=E5=EA=EE=E2=E8=E9 =E2=B3=E4=E4=B3=EB =F5=F0=E5=E1=F2=E0 (L1=96L4)

 

 

=C4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF L1 =F2= =E0 L2, S1 =F2=E0 S2

 

 

=D2=E8=E6=E4=E5=ED=FC 12

N

553

545

=C7=EC=B3=ED=E0 =CC=CD=CA-=F1=E5=F0=E5=E4=ED=FC=EE=E3=EE (%)a

-0,56=

0,15<= /p>

(95 % =C4=B2)

(-0,77; -0,3= 6)

(-0,05; 0,36= )

 

 

 

=D2=E8=E6=E4=E5=ED=FC 24

N

528

516

=C7=EC=B3=ED=E0 =CC=CD=CA-=F1=E5=F0=E5=E4=ED=FC=EE=E3=EE (%)a

-0,59=

0,13<= /p>

(95 % =C4=B2)

(-0,82; -0,3= 7)

(-0,09; 0,36= )

 

 

 

=C4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF L3 =F2= =E0 S3

=D0=B3=BA=EA=EE

=CF=EB=E0=F6=E5=E1=EE=A0=A0=A0=A0=A0=A0 =D0=B3=BA=EA=EE

=D2=E8=E6=E4=E5=ED=FC 36

N

387

379

=C7=EC=B3=ED=E0 =CC=CD=CA-=F1=E5=F0=E5=E4=ED=FC=EE=E3=EE (%)a

-0,66=

-0,00=

(95 % =C4=B2)

(-0,93; -0,4= 0)

(-0,27; 0,26= )

 

 

 

=D2=E8=E6=E4=E5=ED=FC 52

N

365

351

=C7=EC=B3=ED=E0 =CC=CD=CA-=F1=E5=F0=E5=E4=ED=FC=EE=E3=EE (%)a

-0,69=

-0,30=

(95 % =C4=B2)

(-1,00; -0,3= 8)

(-0,61; 0,01= )

 

 

 

=D0=E0=ED=E4=EE=EC=B3=E7=EE=E2=E0=ED=E5 = =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF =E7=B3 =F1=EA=E0=F1=F3=E2=E0=ED=ED=FF=EC =EF=F0=E5=EF=E0=F0=E0=F2=F3 =F2=E0 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF S3

=D0=B3=BA=EA=EE

 

=CF=EB=E0=F6=E5=E1=EEb<= /b>

=D2=E8=E6=E4=E5=ED=FC 104

N

221

229

=C7=EC=B3=ED=E0 =CC=CD=CA-=F1=E5=F0=E5=E4=ED=FC=EE=E3=EE (%)a

-0,40=

-0,18=

(95 % =C4=B2)

(-0,82; 0,02= )

(-0,60; 0,23= )

=D1=EA=EE= =F0=EE=F7=E5=ED=ED=FF: =CC=CD=CA =96 =EC=E5=F2=EE=E4 =ED=E0=E9=EC=E5=ED=F8=E8=F5 =EA=E2=E0=E4=F0=E0=F2=B3=E2= ; =C4=B2 =96 =E4=EE=E2=B3=F0=F7=E8=E9 =B3=ED=F2=E5=F0=E2=E0=EB; N =96 =EA= =B3=EB=FC=EA=B3=F1=F2=FC =EF=E0=F6=B3=BA=ED=F2=EE=EA.

a =C2=B3=E4= =F1=EE=F2=EA=EE=E2=E0 =E7=EC=B3=ED=E0 =E2=B3=E4 =E2=E8=F5=B3=E4=ED=EE=E3=EE =E7=ED=E0=F7=E5=ED=ED=FF.=

b =C1=B3=EB= =FC=F8=B3=F1=F2=FC =EF=E0=F6=B3=BA=ED=F2=EE=EA, =F0=E0=ED=E4=EE=EC=B3=E7=EE=E2=E0=ED=E8=F5 =E4= =EE =E3=F0=F3=EF=E8 =EF=EB=E0=F6=E5=E1=EE =F0=E0=ED=E4=EE=EC=B3=E7=EE=E2=E0= =ED=EE=E3=EE =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF =E7=B3 =F1=EA=E0=F1=F3=E2=E0=ED=ED=FF=EC =EF=F0=E5=EF=E0=F0=E0=F2=F3, =EF=F0=E8=E9= =EC=E0=EB=E8 =EF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA=EA=EE =EF=F0=E8=E1=EB=E8=E7= =ED=EE =EF=F0=EE=F2=FF=E3=EE=EC =E4=E2=EE=F5 =F6=E8=EA=EB=B3=E2 =EF=B3=F1=EB=FF =E2=B3=E4=ED=EE=E2=EB=E5=ED=ED=FF =F0=FF=F1=ED=E8=F5 =EC=E5= =ED=F1=F2=F0=F3=E0=EB=FC=ED=E8=F5 =EA=F0=EE=E2=EE=F2=E5=F7.

= =D3 =E3=F0=F3=EF=B3 =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =E2=B3=E4=F1=EE=F2=EA=EE=E2=E0 = =E7=EC=B3=ED=E0 =CC=CD=CA-=F1=E5=F0=E5=E4=ED=FC=EE=E3=EE =E4=EB=FF =CC=D9= =CA=D2 =F3 =EF=EE=EF=E5=F0=E5=EA=EE=E2=EE=EC=F3 =E2=B3=E4=E4=B3=EB=B3 =F5=F0=E5=E1=F2=E0 =E4=EE 52-=E3=EE =F2=E0 104-=E3=EE =F2=E8=E6=ED=B3=E2 = =F1=EA=EB=E0=EB=E0 =960,69 % =F2=E0 =960,40 % =E2=B3=E4=EF=EE=E2=B3=E4=ED= =EE.

=CF=F0=EE=F2=FF=E3=EE=EC 12 =EC=B3=F1=FF=F6= =B3=E2 =EF=B3=F1=EB=FF =EF=F0=E8=EF=E8=ED=E5=ED=ED=FF =EF=F0=E8=E9=EE=EC=F3 =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =F3 =E2=F1=B3=F5 =E6=B3=ED=EE= =EA =E7 =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=EE=EC, =FF=EA=B3 =EC=E0=EB=E8 =EA= =F0=E8=F2=E5=F0=B3=BF =E2=F2=F0=E0=F2=E8 =CC=D9=CA=D2, =F1=EF=EE=F1=F2=E5=F0=B3=E3=E0=EB=EE=F1=FF =E2=B3=E4=ED=EE=E2=EB=E5=ED=ED= =FF =E0=E1=EE =F2=E5=ED=E4=E5=ED=F6=B3=FF =E4=EE =E2=B3=E4=ED=EE=E2=EB=E5= =ED=ED=FF =CC=D9=CA=D2 =F3 =EF=EE=EF=E5=F0=E5=EA=EE=E2=EE=EC=F3 =E2=B3=E4=E4=B3=EB=B3 =F5=F0=E5=E1=F2=E0.

=C2=E8=EC=B3=F0=FE=E2=E0=ED=ED=FF =CC= =D9=CA=D2 =EF=F0=EE=F2=FF=E3=EE=EC 12 =F2=E8=E6=ED=B3=E2 =F3 =E6=B3=ED=EE= =EA, =FF=EA=B3 =EE=F2=F0=E8=EC=F3=E2=E0=EB=E8 =EC=EE=ED=EE=F2=E5=F0=E0=EF=B3=FE = =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=EE=EC =E4=EB=FF =EB=B3=EA=F3=E2=E0=ED=ED=FF =EC=B3= =EE=EC=E8 =EC=E0=F2=EA=E8 =E0=E1=EE =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=F3

=D3 =E6= =B3=ED=EE=EA, =FF=EA=B3 =EE=F2=F0=E8=EC=F3=E2=E0=EB=E8 =EC=EE=ED=EE=F2=E5=F0=E0=EF=B3=FE =F0=E5=EB= =F3=E3=EE=EB=B3=EA=F1=EE=EC =EF=F0=EE=F2=FF=E3=EE=EC 12 =F2=E8=E6=ED=B3=E2,= =F3 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF=F5 L1 =F2=E0 L2, S1 =F2=E0 S2 =CC=D9=CA=D2 =EF=EE=EF=E5=F0=E5=EA=EE=E2=EE=E3=EE =E2=B3=E4=E4= =B3=EB=F3 =F5=F0=E5=E1=F2=E0 =E7=EC=E5=ED=F8=E8=EB=E0=F1=FC =ED=E0 1,86 % = =E2=B3=E4 =E2=E8=F5=B3=E4=ED=EE=E3=EE =F0=B3=E2=ED=FF. =D0=B3=E7=ED=E8=F6=FF =EC=B3=E6 =E2=B3=E4=F1=EE=F2=EA=E0= =EC=E8 =E7=EC=B3=ED=E8 =CC=D9=CA=D2 =F3 =E6=B3=ED=EE=EA, =FF=EA=B3 =EE=F2= =F0=E8=EC=F3=E2=E0=EB=E8 =EF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA=EA=EE =F2=E0 =EC=EE=ED=EE=F2=E5=F0=E0=EF=B3=BA=FE =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1= =EE=EC, =ED=E0 12 =F2=E8=E6=ED=B3 =E1=F3=EB=E0 =F1=F2=E0=F2=E8=F1=F2=E8=F7= =ED=EE =E7=ED=E0=F7=F3=F9=EE=FE, =E4=E5=EC=EE=ED=F1=F2=F0=F3=FE=F7=E8 =E5=F4=E5=EA=F2=E8=E2=ED=B3=F1=F2=FC = =E2=E8=EA=EE=F0=E8=F1=F2=E0=ED=ED=FF =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =E2 = =EA=EE=EC=E1=B3=ED=E0=F6=B3=BF =E7 =E5=F1=F2=F0=E0=E4=B3=EE=EB=EE=EC/=ED=EE= =F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3 =E0=F6=E5=F2=E0=F2=EE=EC (=D0=B3=BA=EA=EE) =E4=EB=FF =E7=EC=E5=ED=F8=E5=ED= =ED=FF =E2=F2=F0=E0=F2=E8 =EA=B3=F1=F2=EA=EE=E2=EE=BF =EC=E0=F1=E8.

=C4=EB= =FF =E0=ED=E0=EB=B3=E7=F3 =E2=EF=EB=E8=E2=F3 =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =ED=E0 =E2=B3=E4=F1=EE=F2=EE=EA= =E7=EC=B3=ED=E8 =CC=D9=CA=D2 =EF=F0=EE=F2=FF=E3=EE=EC 52 =F2=E8=E6=ED=B3= =E2 =EB=B3=EA=F3=E2=E0=ED=ED=FF =E1=F3=EB=EE =EF=F0=EE=E2=E5=E4=E5=ED=EE =F1=EF=EE=F1=F2=E5=F0=E5=E6=ED=E5 =E4=EE=F1=EB= =B3=E4=E6=E5=ED=ED=FF =E7=E0 =F3=F7=E0=F1=F2=FE =ED=E5=EB=B3=EA=EE=E2=E0=ED= =E8=F5 =E6=B3=ED=EE=EA =E7 =EC=B3=EE=EC=EE=FE =EC=E0=F2=EA=E8 =F2=E0 =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=EE=EC, =E2=B3=E4=B3=E1=F0=E0=ED=E8=F5 =E7= =E0 =E2=B3=EA=EE=EC, =E4=EB=FF =EE=F6=B3=ED=EA=E8 =EF=EE=E7=E4=EE=E2=E6=ED= =FC=EE=BF =CC=D9=CA=D2 =E6=B3=ED=EE=EA =F3 =EF=F0=E5=EC=E5=ED=EE=EF=E0=F3=E7=B3 =F3 =E2=B3=F6=B3 =E2=B3=E4 18 =E4=EE 5= 0 =F0=EE=EA=B3=E2 (=B3=F1=F2=EE=F0=E8=F7=ED=E5 =E4=EE=F1=EB=B3=E4=E6=E5=ED= =ED=FF). =C7=E0 52 =F2=E8=E6=ED=B3 =F1=EF=EE=F1=F2=E5=F0=E5=E6=E5=ED=ED=FF =E2 =EA=EE=E3=EE=F0=F2=B3 =EF=F0=E5= =EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =E2=B3=E4=E7=ED=E0=F7=E0=EB=E8=F1=FF =EC= =B3=ED=B3=EC=E0=EB=FC=ED=B3 =E7=EC=B3=ED=E8 =CC=D9=CA=D2 =F3 =EF=EE=F0=B3=E2=ED=FF=ED=ED=B3 =E7 =EA=EE=ED=F2=F0=EE=EB=FC=ED=EE=FE =EA=EE= =E3=EE=F0=F2=EE=FE =EF=B3=E4=B3=E1=F0=E0=ED=E8=F5 =E7=E0 =E2=B3=EA=EE=EC = =E6=B3=ED=EE=EA, =FF=EA=B3 =ED=E5 =E4=EE=F1=FF=E3=EB=E8 =EC=E5=ED=EE=EF=E0=F3=E7=E8, =E7 =EC=B3=EE=EC=EE=FE =EC=E0=F2=EA=E8 =E0=E1= =EE =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=EE=EC.

=C2=EF=EB=E8=E2 =ED=E0 =E5=ED=E4=EE=EC= =E5=F2=F0=B3=E9

=CF=B3= =E4 =F7=E0=F1 =EA=EB=B3=ED=B3=F7=ED=E8=F5 =E4=EE=F1=EB=B3=E4=E6=E5=ED=FC =F3 =E6=B3=ED=EE= =EA, =FF=EA=B3 =EF=F0=E8=E9=EC=E0=EB=E8 =EF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA= =EA=EE =E4=EE 52 =F2=E8=E6=ED=B3=E2, =E7=E0 =F0=E5=E7=F3=EB=FC=F2=E0=F2=E0=EC=E8 =E1=B3=EE=EF=F1=B3=BF =ED=E5 =E2=E8=FF= =E2=E8=EB=E8 =E2=E8=EF=E0=E4=EA=B3=E2 =E3=B3=EF=E5=F0=EF=EB=E0=E7=B3=BF =E5= =ED=E4=EE=EC=E5=F2=F0=B3=FE =E0=E1=EE =F0=E0=EA=F3 =E5=ED=E4=EE=EC=E5=F2=F0=B3=FE.<= o:p>

=D4=E0=F0=EC=E0=EA=EE=EA=B3=ED=E5=F2=E8=EA=E0

=D4=E0=F0=EC=E0=EA=EE=EA=B3=ED=E5=F2=E8=F7=ED=B3 =EF=EE= =EA=E0=E7=ED=E8=EA=E8 =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3, =E5=F1=F2=F0=E0=E4= =B3=EE=EB=F3, =E7=E0=E3=E0=EB=FC=ED=EE=E3=EE =E5=F1=F2=F0=EE=ED=F3 =F2=E0 =ED=EE=F0=E5=F2= =E8=F1=F2=E5=F0=EE=ED=F3 =EF=B3=F1=EB=FF =EF=E5=F0=EE=F0=E0=EB=FC=ED=EE=E3= =EE =EF=F0=E8=E9=EE=EC=F3 =EE=E4=ED=B3=BA=BF =F2=E0=E1=EB=E5=F2=EA=E8 =EF= =F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =ED=E0=F2=F9=E5 =E7=E4=EE=F0=EE=E2=E8=EC=E8 =E6=B3=ED=EA=E0= =EC =F3 =EF=EE=F1=F2=EC=E5=ED=EE=EF=E0=F3=E7=B3 =ED=E0=E2=E5=E4=E5=ED=B3 = =E2 =F2=E0=E1=EB=E8=F6=B3 5.

=A0=A0=A0=A0=A0 =D2=E0=E1=EB=E8=F6=FF 5 <= o:p>

=D4=E0=F0=EC=E0=EA=EE=EA=B3=ED=E5=F2=E8=F7=ED=B3 =EF=EE=EA=E0=E7=ED= =E8=EA=E8 =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3, =E5=F1=F2=F0=E0=E4=B3=EE=EB=F3= , =E7=E0=E3=E0=EB=FC=ED=EE=E3=EE =E5=F1=F2=F0=EE=ED=F3 =F2=E0 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3 =EF=B3=F1=EB=FF =EE=E4=ED=EE= =F0=E0=E7=EE=E2=EE=E3=EE =EF=F0=E8=E9=EE=EC=F3 =F3 =E6=B3=ED=EE=EA =F3 =EF= =EE=F1=F2=EC=E5=ED=EE=EF=E0=F3=E7=B3

=CF=EE=EA=E0=E7=ED=E8=EA

=D0=E5=EB=F3=E3=EE=EB=B3=EA=F1=

=C5=F1=F2=F0=E0=E4=B3=EE=EB=

=CD=E5=EA=EE=ED=92=FE=E3= =EE=E2=E0=ED=E8=E9

=E5=F1=F2=F0=EE=ED

=CD=EE=F0=E5=F2=E8=F1=F2= =E5=F0=EE=ED

AUC 0-∞<= sub>

(=ED=E3*=E3=EE=E4/=EC=EB = =E0=E1=EE =EF=E3*=E3=EE=E4/=EC=EB)

198,1 (111,6)

818,7 (334,4)

4126 (1650)=

17,5 (8,46)=

Cmax (=ED=E3/= =EC=EB =E0=E1=EE =EF=E3/=EC=EB)

25,99 (18,21)

27,95 (19,15)

188,4 (59,09)

3,57 (1,43)=

=D2max (=E3=EE= =E4)

2,00<= span style=3D'mso-fareast-font-family:PMingLiU'>

(0,25; 5,00)<= /p>

7,00<= span style=3D'mso-fareast-font-family:PMingLiU'>

(0,25; 24,00)=

6,00<= span style=3D'mso-fareast-font-family:PMingLiU'>

(2,00; 12,00)=

1,01<= span style=3D'mso-fareast-font-family:PMingLiU'>

(0,50; 4,00)<= /p>

=CA=B3=ED=F6=E5=E2=E8=E9 = t1/2 (=E3=EE=E4)

61,5 (13,2)=

16,6 (7,67)=

15,9 (6,52)=

10,9 (3,05)=

=D1=EA=EE=F0=EE=F7=E5=ED=ED=FF: AUC0-&#= 8734; =96 =EF=EB=EE=F9=E0 =EF=B3=E4 =F4=E0=F0=EC=E0=EA=EE=EA=B3=ED=E5=F2=E8=F7=ED=EE=FE =EA=F0=E8=E2=EE=FE =EA= =EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FF=96=F7=E0=F1 =E2=B3=E4 =E5=EA=F1=F2=F0=E0= =EF=EE=EB=FC=EE=E2=E0=ED=EE=E3=EE =F7=E0=F1=F3 0 =E4=EE =ED=E5=F1=EA=B3=ED= =F7=E5=ED=ED=EE=F1=F2=B3; Cmax =96 =EC=E0=EA=F1=E8=EC=E0=EB=FC=ED=E0 =F1=EF=EE=F1=F2=E5=F0= =E5=E6=F3=E2=E0=ED=E0 =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FF; =D2max =96 =F7=E0=F1 =E4=EE =EC=E0=EA=F1=E8=EC=E0=EB=FC=ED=EE=BF =F1=EF=EE=F1=F2=E5=F0= =E5=E6=F3=E2=E0=ED=EE=BF =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=BF; t1/2=96 =EF=E5=F0=B3=EE=E4 =ED=E0=EF=B3=E2=E2=E8=E2=E5=E4=E5=ED=ED=FF.

=CF=F0=E8=EC=B3=F2=EA=E0: =D4=E0=F0=EC=E0=EA= =EE=EA=B3=ED=E5=F2=E8=F7=ED=B3 =EF=E0=F0=E0=EC=E5=F2=F0=E8 =E5=F1=F2=F0=E0= =E4=B3=EE=EB=F3 =F2=E0 =ED=E5=EA=EE=ED=92=FE=E3=EE=E2=E0=ED=EE=E3=EE =E5=F1=F2=F0=EE=ED=F3 =E7 =F3= =F0=E0=F5=F3=E2=E0=ED=ED=FF=EC =E1=E0=E7=EE=E2=EE=E3=EE =F0=B3=E2=ED=FF =EF= =F0=E5=E4=F1=F2=E0=E2=EB=E5=ED=EE =E2 =F6=B3=E9 =F2=E0=E1=EB=E8=F6=B3. =CD=E0=E2=E5=E4=E5=ED=EE =F1=E5=F0=E5=E4=ED=B3 =E0= =F0=E8=F4=EC=E5=F2=E8=F7=ED=B3 =F2=E0 =F1=F2=E0=ED=E4=E0=F0=F2=ED=B3 =E2=B3= =E4=F5=E8=EB=E5=ED=ED=FF, =E7=E0 =E2=E8=ED=FF=F2=EA=EE=EC =D2max, =E4=E5 =EF=EE=EA=E0=E7=E0=ED=EE =EC=E5=E4=B3=E0=ED=F3 =F2=E0 =E4=B3=E0=EF= =E0=E7=EE=ED (=EC=B3=ED=B3=EC=F3=EC, =EC=E0=EA=F1=E8=EC=F3=EC). AUC0-&= #8734; =EF=F0=E5=E4=F1=F2=E0=E2=EB=E5=ED=EE =F3 =ED=E3*=E3=EE=E4/=EC=EB =E4=EB=FF =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =F2= =E0 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3 =F2=E0 =F3 =EF=E3*=E3=EE=E4/=EC= =EB =E4=EB=FF =ED=E5=EA=EE=ED=92=FE=E3=EE=E2=E0=ED=EE=E3=EE =E5=F1=F2=F0=E0=E4=B3=EE=EB=F3 =F2=E0 =ED=E5=EA=EE=ED=92=FE=E3=EE=E2=E0=ED= =EE=E3=EE =E5=F1=F2=F0=EE=ED=F3. Cmax =EF=F0=E5=E4=F1=F2=E0=E2= =EB=E5=ED=EE =F3 =ED=E3/=EC=EB =E4=EB=FF =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =F2=E0 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE= =ED=F3 =F2=E0 =F3 =EF=E3/=EC=EB =E4=EB=FF =ED=E5=EA=EE=ED=92=FE=E3=EE=E2=E0= =ED=EE=E3=EE =E5=F1=F2=F0=E0=E4=B3=EE=EB=F3 =F2=E0 =ED=E5=EA=EE=ED=92=FE=E3=EE=E2=E0=ED=EE=E3=EE =E5=F1=F2=F0=EE=ED=F3.

=D4=E0=F0=EC=E0=EA=EE=EA=B3=ED=E5=F2=E8=F7=ED=B3 =EF=E0= =F0=E0=EC=E5=F2=F0=E8 =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3, =E5=F1=F2=F0=E0=E4= =B3=EE=EB=F3, =E7=E0=E3=E0=EB=FC=ED=EE=E3=EE =E5=F1=F2=F0=EE=ED=F3 =F2=E0 =ED=EE=F0=E5=F2= =E8=F1=F2=E5=F0=EE=ED=F3 =F3 =F0=B3=E2=ED=EE=E2=E0=E6=ED=EE=EC=F3 =F1=F2=E0= =ED=B3 =EF=B3=F1=EB=FF =EF=F0=E8=E9=EE=EC=F3 =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =EE=E4=E8=ED =F0=E0=E7 =ED=E0 = =E4=EE=E1=F3 =EF=F0=EE=F2=FF=E3=EE=EC 6 =F2=E8=E6=ED=B3=E2 =E7=E4=EE=F0=EE= =E2=E8=EC=E8 =E6=B3=ED=EA=E0=EC=E8 =E4=EE =EC=E5=ED=EE=EF=E0=F3=E7=E8 =EF=F0=E5=E4=F1=F2=E0=E2=EB=E5=ED=EE =E2 =F2=E0= =E1=EB=E8=F6=B3 6.

=A0=A0=A0=A0 =D2=E0=E1=EB=E8=F6= =FF 6

=D4=E0=F0=EC=E0= =EA=EE=EA=B3=ED=E5=F2=E8=F7=ED=B3 =EF=E0=F0=E0=EC=E5=F2=F0=E8 =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3, =E5=F1=F2=F0= =E0=E4=B3=EE=EB=F3, =E7=E0=E3=E0=EB=FC=ED=EE=E3=EE =E5=F1=F2=F0=EE=ED=F3 = =F2=E0 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3 =EF=B3=F1=EB=FF =E1=E0=E3=E0=F2=EE=F0=E0=E7=EE=E2=E8=F5 =E4=EE=E7 =F3 =E6=B3=ED=EE=EA =E4= =EE =EC=E5=ED=EE=EF=E0=F3=E7=E8

=CF=EE=EA=E0=E7=ED=E8=EA

=D0=E5= =EB=F3=E3=EE=EB=B3=EA=F1

=C5=F1= =F2=F0=E0=E4=B3=EE=EB

=CD=E5=EA=EE=ED=92=FE=E3=EE=E2=E0=ED=E8=E9

=E5=F1=F2=F0=EE=ED<= span style=3D'mso-fareast-font-family:PMingLiU'>

=CD=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED

AUC0-24 (=ED= =E3*=E3=EE=E4/=EC=EB =E0=E1=EE =EF=E3*=E3=EE=E4/=EC=EB)=

157 (= 94,7)

784 (= 262)

4450 (1980)=

25,5 = (11,4)

Cmax (=ED=E3/= =EC=EB =E0=E1=EE =EF=E3/=EC=EB)

26 (2= 1,4)

46,8 = (17,3)

303 (= 137)

5,21 = (1,53)

=D2max (=E3=EE= =E4)

3 (0,= 5; 6)

3 (0,= 50, 12,00)=

4 (1;= 8,08)

1 (1;= 2)

=C5=F4=E5=EA=F2=E8=E2=ED= =E8=E9 t1/2 (=E3=EE=E4)

~ 25<= span style=3D'mso-fareast-font-family:PMingLiU'>

17,1 = (4,03)

13,9 = (4,14)

8,28 = (1,87)

=D1=EA=EE=F0=EE=F7=E5=ED=ED=FF: AUC0-24= =96 =EF=EB=EE=F9=E0 =EF=B3=E4 =F4=E0=F0=EC=E0=EA=EE=EA=B3=ED=E5=F2=E8=F7=ED=EE=FE =EA=F0=E8=E2=EE=FE =EA= =EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FF=96=F7=E0=F1 =EF=F0=EE=F2=FF=E3=EE=EC =B3= =ED=F2=E5=F0=E2=E0=EB=F3 =E4=EE=E7=F3=E2=E0=ED=ED=FF (24); Cmax =96 =EC=E0=EA=F1=E8=EC=E0=EB=FC=ED=E0 =F1=EF=EE=F1=F2=E5=F0=E5=E6=F3= =E2=E0=ED=E0 =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FF; =D2max =96 = =F7=E0=F1 =E4=EE =EC=E0=EA=F1=E8=EC=E0=EB=FC=ED=EE=BF =F1=EF=EE=F1=F2=E5=F0=E5=E6=F3=E2=E0= =ED=EE=BF =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=BF.

=CF=F0=E8=EC=B3=F2=EA=E0: =ED=E0=E2=E5=E4=E5= =ED=EE =F1=E5=F0=E5=E4=ED=B3 =E0=F0=E8=F4=EC=E5=F2=E8=F7=ED=B3 =F2=E0 =F1=F2=E0=ED=E4=E0=F0=F2=ED=B3 =E2=B3=E4=F5=E8=EB=E5=ED=ED=FF, =E7=E0 =E2= =E8=ED=FF=F2=EA=EE=EC =D2max =E4=E5 =EF=EE=EA=E0=E7=E0=ED=EE =EC= =E5=E4=B3=E0=ED=F3 =F2=E0 =E4=B3=E0=EF=E0=E7=EE=ED (=EC=B3=ED=B3=EC=F3=EC, =EC=E0=EA=F1=E8=EC=F3=EC).= AUC0-24 =EF=F0=E5=E4=F1=F2=E0=E2=EB=E5=ED=EE =F3 =ED=E3*=E3=EE= =E4/=EC=EB =E4=EB=FF =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =F2=E0 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE= =ED=F3 =F2=E0 =F3 =EF=E3*=E3=EE=E4/=EC=EB =E4=EB=FF =ED=E5=EA=EE=ED=92=FE= =E3=EE=E2=E0=ED=EE=E3=EE =E5=F1=F2=F0=E0=E4=B3=EE=EB=F3 =F2=E0 =ED=E5=EA=EE=ED=92=FE=E3=EE=E2=E0=ED=EE=E3=EE =E5=F1=F2=F0=EE=ED=F3. C= max =EF=F0=E5=E4=F1=F2=E0=E2=EB=E5=ED=EE =F3 =ED=E3/=EC=EB =E4=EB=FF = =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =F2=E0 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3 =F2=E0 =F3 =EF=E3/=EC=EB =E4= =EB=FF =ED=E5=EA=EE=ED=92=FE=E3=EE=E2=E0=ED=EE=E3=EE =E5=F1=F2=F0=E0=E4=B3= =EE=EB=F3 =F2=E0 =ED=E5=EA=EE=ED=92=FE=E3=EE=E2=E0=ED=EE=E3=EE =E5=F1=F2=F0= =EE=ED=F3. =C5=F4=E5=EA=F2=E8=E2=ED=E8=E9 =EF=E5=F0=B3=EE=E4 =ED=E0=EF=B3=E2=E2=E8=E2= =E5=E4=E5=ED=ED=FF =E4=EB=FF =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =EE=F6=B3=ED= =FE=BA=F2=FC=F1=FF =E7=E0 =EA=EE=E5=F4=B3=F6=B3=BA=ED=F2=E0=EC=E8 =ED=E0=EA=EE=EF=E8=F7=E5=ED=ED=FF =ED=E0 =EE=F1=ED=EE=E2=B3 =E7=ED=E0=F7=E5= =ED=FC AUC =EF=B3=F1=EB=FF =E1=E0=E3=E0=F2=EE=F0=E0=E7=EE=E2=EE=E3=EE =E7= =E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =F3 =E4=EE=E7=B3 40 =EC=E3.

=C2=F1=EC=EE=EA=F2=F3=E2=E0=ED=ED=FF

=C0=E1=F1=EE=F0=E1=F6=B3=FF =F0=E5=EB=F3=E3=EE=EB=B3=EA= =F1=F3 =EF=B3=F1=EB=FF =EF=E5=F0=EE=F0=E0=EB=FC=ED=EE=E3=EE =EF=F0=E8=E9=EE= =EC=F3 =E2 =EE=F1=ED=EE=E2=ED=EE=EC=F3 =EE=EF=EE=F1=E5=F0=E5=E4=EA=EE=E2=F3=BA=F2=FC= =F1=FF =E2=E8=E4=B3=EB=E5=ED=ED=FF=EC =F2=F0=E0=ED=F1=EF=EE=F0=F2=E5=F0=E0 = P-gp, =E4=EB=FF =FF=EA=EE=E3=EE =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1 =BA =F1=F3=E1=F1=F2=F0=E0=F2=EE=EC. =CF=B3=F1=EB=FF =EF=E5=F0=EE=F0=E0=EB= =FC=ED=EE=E3=EE =EF=F0=E8=E9=EE=EC=F3 =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1 =F8=E2= =E8=E4=EA=EE =E2=F1=EC=EE=EA=F2=F3=BA=F2=FC=F1=FF, =E4=EE=F1=FF=E3=E0=FE=F7=E8 =EF=EE=F7=E0=F2=EA=EE=E2=EE=E3=EE =EF=B3=EA=E0 = =F7=E5=F0=E5=E7 0,25 =E3=EE=E4=E8=ED=E8 =EF=B3=F1=EB=FF =EF=F0=E8=E9=EE=EC= =F3 =E4=EE=E7=E8, =E0 =EF=EE=F2=B3=EC =EE=E4=ED=EE=E3=EE =E0=E1=EE =E4=E5=EA=B3=EB=FC=EA=EE=F5 =ED=E0=F1=F2=F3=EF=ED=E8=F5 =EF=B3=EA= =B3=E2 =E2=F1=EC=EE=EA=F2=F3=E2=E0=ED=ED=FF =F7=E5=F0=E5=E7 12 =E3=EE=E4=E8= =ED =EF=B3=F1=EB=FF =EF=F0=E8=E9=EE=EC=F3. =C0=E1=F1=EE=EB=FE=F2=ED=E0 =E1=B3=EE=E4=EE=F1=F2=F3=EF=ED=B3=F1=F2=FC =F0= =E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =F1=F2=E0=ED=EE=E2=E8=F2=FC 11,6 %. =CF=B3= =F1=EB=FF =EF=F0=E8=E9=EE=EC=F3 =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =E7 =E4=F3=E6=E5 =E6=E8=F0=ED=EE=FE =F2=E0 =EA=E0=EB=EE=F0= =B3=E9=ED=EE=FE =BF=E6=E5=FE AUC0-∞ =B3 =D1max = =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =E7=EC=E5=ED=F8=F3=E2=E0=EB=E8=F1=FC =ED=E0 38 % =F2=E0 55 % =E2=B3=E4=EF= =EE=E2=B3=E4=ED=EE =EF=EE=F0=B3=E2=ED=FF=ED=EE =B3=E7 =EF=F0=E8=E9=EE=EC=EE= =EC =ED=E0=F2=F9=E5.

=CF=B3=F1=EB=FF =EF=E5=F0=EE=F0=E0=EB=FC=ED=EE=E3=EE = =EF=F0=E8=E9=EE=EC=F3 =EE=E4=ED=EE=F0=E0=E7=EE=E2=EE=BF =E4=EE=E7=E8 =EF=F0= =E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =ED=E0=F2=F9=E5 =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FF =ED=E5=EA=EE=ED=92=FE= =E3=EE=E2=E0=ED=EE=E3=EE =E5=F1=F2=F0=E0=E4=B3=EE=EB=F3 =E7=F0=EE=F1=F2=E0= =EB=E0 =EF=EE=E2=B3=EB=FC=ED=EE, =F1=E5=F0=E5=E4=ED=B3 =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=BF =E4=EE=F1=FF=E3=E0=EB=E8 =EF=B3=EA=EE= =E2=E8=F5 =E7=ED=E0=F7=E5=ED=FC =F7=E5=F0=E5=E7 8 =E3=EE=E4=E8=ED =EF=B3=F1= =EB=FF =EF=F0=E8=E9=EE=EC=F3 =E4=EE=E7=E8. =D3 =F0=E0=E7=B3 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA= =EA=EE =EF=B3=F1=EB=FF =F1=EF=EE=E6=E8=E2=E0=ED=ED=FF =E4=F3=E6=E5 =E6=E8= =F0=ED=EE=BF =F2=E0 =EA=E0=EB=EE=F0=B3=E9=ED=EE=BF =BF=E6=B3 =ED=E5 =F1=EF=EE=F1=F2=E5=F0=B3=E3=E0=EB=EE=F1=FC =EA=EB=B3=ED=B3=F7=ED=EE =E7=ED= =E0=F7=F3=F9=EE=E3=EE =E2=EF=EB=E8=E2=F3 =ED=E0 =E5=F1=F2=F0=E0=E4=B3=EE=EB= =E0=E1=EE =E5=F1=F2=F0=EE=E3=E5=ED=ED=B3 =EC=E5=F2=E0=E1=EE=EB=B3=F2=E8.

=CF=B3=F1=EB=FF =EF=E5=F0=EE=F0=E0=EB=FC=ED=EE=E3=EE = =EF=F0=E8=E9=EE=EC=F3 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3 =E0=F6=E5=F2= =E0=F2 =F8=E2=E8=E4=EA=EE =EF=B3=E4=E4=E0=BA=F2=FC=F1=FF =E1=B3=EE=F2=F0=E0=ED=F1=F4=EE=F0=EC=E0=F6= =B3=BF =E2 =EA=E8=F8=E5=F7=ED=E8=EA=F3 =F2=E0 =EF=E5=F7=B3=ED=F6=B3 =E4=EE = =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3. =CF=B3=F1=EB=FF =EF=E5=F0=EE=F0=E0=EB=FC=ED=EE=E3=EE =EF=F0=E8=E9=EE=EC=F3 =EE=E4=ED=EE=F0= =E0=E7=EE=E2=EE=BF =E4=EE=E7=E8 =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE= =ED=E0=F2=F9=E5 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED =F1=EF=EE=F7=E0=F2=EA=F3 =E2=E8=E7=ED=E0=F7=E0=E2=F1=FF =EA=B3=EB=FC=EA=B3= =F1=ED=EE =F7=E5=F0=E5=E7 0,5 =E3=EE=E4=E8=ED=E8 =EF=B3=F1=EB=FF =EF=F0=E8= =E9=EE=EC=F3 =E4=EE=E7=E8, =EF=B3=F1=EB=FF =F7=EE=E3=EE =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FF =F8=E2=E8=E4=EA=EE =E7=F0=EE=F1=F2=E0= =EB=E0, =E4=EE=F1=FF=E3=E0=FE=F7=E8 =EF=B3=EA=EE=E2=E8=F5 =E7=ED=E0=F7=E5= =ED=FC =EF=F0=EE=F2=FF=E3=EE=EC 1 =E3=EE=E4=E8=ED=E8.

=C2=EF=EB=E8=E2 =EF=F0=E8=E9=EE=EC=F3 = =BF=E6=B3=

=CF=F0= =E8=E9=EE=EC =BF=E6=B3 =E7=ED=E8=E6=F3=BA AUC =B3 Cmax =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1= =F3 =ED=E0 38 % =F2=E0 55 % =E2=B3=E4=EF=EE=E2=B3=E4=ED=EE =EF=EE=F0=B3=E2= =ED=FF=ED=EE =E7 =EF=F0=E8=E9=EE=EC=EE=EC =ED=E0=F2=F9=E5; =EE=E4=ED=E0=EA =E7=EC=E5=ED=F8= =E5=ED=ED=FF =E5=EA=F1=EF=EE=E7=E8=F6=B3=BF =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1= =F3 =E2=E2=E0=E6=E0=BA=F2=FC=F1=FF =EA=EB=B3=ED=B3=F7=ED=EE =ED=E5 =E7=ED= =E0=F7=F3=F9=E8=EC. =CA=EB=B3=ED=B3=F7=ED=EE =E7=ED=E0=F7=F3=F9=EE=E3=EE =E2=EF=EB=E8=E2=F3 =BF= =E6=B3 =ED=E0 =E5=EA=F1=EF=EE=E7=E8=F6=B3=FE =E5=F1=F2=F0=E0=E4=B3=EE=EB=F3= , =E5=F1=F2=F0=EE=E3=E5=ED=ED=E8=F5 =EC=E5=F2=E0=E1=EE=EB=B3=F2=B3=E2 =E0=E1=EE =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3 =ED=E5 =F1=EF=EE=F1=F2=E5= =F0=B3=E3=E0=EB=EE=F1=FF.

=D0=EE=E7=EF=EE=E4=B3=EB

=D0=E5=EB=F3=E3=EE=EB=B3=EA=F1 =ED=E0 68=9671 % =E7=E2= =92=FF=E7=F3=BA=F2=FC=F1=FF =E7 =E1=B3=EB=EA=E0=EC=E8 =EF=EB=E0=E7=EC=E8 = =EA=F0=EE=E2=B3 =EB=FE=E4=E8=ED=E8 =EF=F0=E8 =F1=E5=F0=E5=E4=ED=FC=EE=EC=F3 =F1=EF=B3=E2=E2= =B3=E4=ED=EE=F8=E5=ED=ED=B3 =F6=B3=EB=FC=ED=EE=BF =EA=F0=EE=E2=B3 =E4=EE = =EF=EB=E0=E7=EC=E8 0,78. =C7=E2=92=FF=E7=F3=E2=E0=ED=ED=FF =E5=F1=F2=F0=E0=E4=B3=EE=EB=F3 =F2=E0 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED= =F3, =F9=EE =F6=E8=F0=EA=F3=EB=FE=FE=F2=FC =F3 =EA=F0=EE=E2=B3, =E7 =E3=EB= =EE=E1=F3=EB=B3=ED=EE=EC, =FF=EA=E8=E9 =E7=E2=92=FF=E7=F3=BA =F1=F2=E0=F2=E5=E2=B3 =E3=EE=F0=EC=EE=ED=E8 (=C3=C7=D1=C3; 36=9637 %),= =F2=E0 =E7 =E0=EB=FC=E1=F3=EC=B3=ED=EE=EC (61 %) =BA =EF=EE=E4=B3=E1=ED=E8= =EC, =EB=E8=F8=E5 =EF=F0=E8=E1=EB=E8=E7=ED=EE 1=962 % =E7=E0=EB=E8=F8=E0=FE=F2=FC=F1=FF =ED= =E5 =E7=E2=92=FF=E7=E0=ED=E8=EC=E8. =C7=ED=E0=F7=E5=ED=ED=FF =E2=B3=E4=ED= =EE=F1=ED=EE=E3=EE =EE=E1=92=BA=EC=F3 =F0=EE=E7=EF=EE=E4=B3=EB=F3 (Vz) 19 × 103 =EB, =EE=F2=F0=E8=EC=E0=ED=E5 =E7 =E4=EE=F1= =EB=B3=E4=E6=E5=ED=ED=FF =E0=E1=F1=EE=EB=FE=F2=ED=EE=BF =E1=B3=EE=E4=EE=F1=F2=F3=EF=ED=EE=F1=F2=B3 =EF=B3=F1=EB=FF =E2=ED=F3=F2=F0= =B3=F8=ED=FC=EE=E2=E5=ED=ED=EE=E3=EE =E2=E2=E5=E4=E5=ED=ED=FF, =E2=EA=E0=E7= =F3=BA =ED=E0 =F2=E5, =F9=EE =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1 =F8=E8=F0=EE=EA=EE =F0=EE=E7=EF=EE=E4=B3=EB=FF=BA=F2=FC=F1=FF =E2 =F2=EA=E0= =ED=E8=ED=E0=F5. =D0=EE=E7=EF=EE=E4=B3=EB =E5=EA=E7=EE=E3=E5=ED=ED=EE=E3=EE= =F2=E0 =E5=ED=E4=EE=E3=E5=ED=ED=EE=E3=EE =E5=F1=F2=F0=E0=E4=B3=EE=EB=F3 =EF=EE=E4=B3=E1=ED=E8=E9. =C5=F1=F2=F0=EE=E3= =E5=ED=E8 =F8=E8=F0=EE=EA=EE =F0=EE=E7=EF=EE=E4=B3=EB=FF=FE=F2=FC=F1=FF =E2= =EE=F0=E3=E0=ED=B3=E7=EC=B3 =B3, =FF=EA =EF=F0=E0=E2=E8=EB=EE, =EC=B3=F1=F2=FF=F2=FC=F1=FF =F3 =E1=B3=EB=FC=F8 =E2=E8=F1=EE=EA=E8=F5 =EA= =EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FF=F5 =E2 =EE=F0=E3=E0=ED=E0=F5-=EC=B3=F8=E5= =ED=FF=F5 =F1=F2=E0=F2=E5=E2=E8=F5 =E3=EE=F0=EC=EE=ED=B3=E2.

=C1=B3=EE=F2=F0=E0=ED=F1=F4= =EE=F0=EC=E0=F6=B3=FF=

=C4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF =B3n vitro =EF=EE=EA= =E0=E7=F3=FE=F2=FC, =F9=EE =EF=E5=F0=E2=E8=ED=ED=E8=EC=E8 =F4=E5=F0=EC=E5= =ED=F2=E0=EC=E8 CYP, =FF=EA=B3 =F1=EF=F0=E8=FF=FE=F2=FC =E7=E0=E3=E0=EB=FC=ED=EE=EC=F3 =EF= =E5=F7=B3=ED=EA=EE=E2=EE=EC=F3 =EE=EA=E8=F1=ED=EE=EC=F3 =EC=E5=F2=E0=E1=EE= =EB=B3=E7=EC=F3 =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3, =E1=F3=EB=E8 CYP3A4/5 (45 %) > CYP2C8 (37 %) > CYP2C19 (< 1 %) =E7 =EE=EA=E8=F1= =EB=FE=E2=E0=EB=FC=ED=E8=EC=E8 =EC=E5=F2=E0=E1=EE=EB=B3=F2=E0=EC=E8, =EC=E5=F2=E0=E1=EE=EB=B3=F2=EE=EC-=C0= =F2=E0 =EC=E5=F2=E0=E1=EE=EB=B3=F2=EE=EC-=C2, =F3=F2=E2=EE=F0=E5=ED=E8=EC= =E8 CYP3A4/5=A0 =F2=E0 CYP2C8 =E2=B3=E4=EF=EE=E2=B3= =E4=ED=EE.

=CC=E5=F2=E0=E1=EE=EB=B3=E7= =EC =E5=EA=E7=EE=E3=E5=ED=ED=EE=E3=EE =F2=E0 =E5=ED=E4=EE=E3=E5=ED=ED=EE=E3=EE =E5=F1=F2=F0=E0=E4=B3=EE=EB=F3 =EF=EE=E4= =B3=E1=ED=E8=E9. =CC=E5=F2=E0=E1=EE=EB=B3=E7=EC =E5=F1=F2=F0=E0=E4=B3=EE=EB= =F3 =E2=B3=E4=E1=F3=E2=E0=BA=F2=FC=F1=FF =E2 =EE=F1=ED=EE=E2=ED=EE=EC=F3 =E2 =EF=E5=F7=B3=ED=F6=B3 =F2=E0 =EA=E8=F8=E5=F7=ED=E8=EA=F3, =E0 =F2=E0=EA= =EE=E6 =E2 =EE=F0=E3=E0=ED=E0=F5-=EC=B3=F8=E5=ED=FF=F5 =B3 =E2=EA=EB=FE=F7= =E0=BA =F3=F2=E2=EE=F0=E5=ED=ED=FF =EC=E5=ED=F8 =E0=EA=F2=E8=E2=ED=E8=F5 =E0=E1=EE =ED=E5=E0=EA=F2=E8=E2=ED=E8=F5 =EC=E5=F2= =E0=E1=EE=EB=B3=F2=B3=E2, =E7=EE=EA=F0=E5=EC=E0 =E5=F1=F2=F0=EE=ED=F3, =EA= =E0=F2=E5=F5=EE=EB=E5=F1=F2=F0=EE=E3=E5=ED=B3=E2 =F2=E0 =E4=E5=EA=B3=EB=FC= =EA=EE=F5 =F1=F3=EB=FC=F4=E0=F2=B3=E2 =F2=E0 =E3=EB=FE=EA=F3=F0=EE=ED=B3=E4=B3=E2 =E5= =F1=F2=F0=EE=E3=E5=ED=F3. =C5=F1=F2=F0=EE=E3=E5=ED=E8 =E2=E8=E2=EE=E4=FF=F2= =FC=F1=FF =E7 =E6=EE=E2=F7=FE, =E3=B3=E4=F0=EE=EB=B3=E7=F3=FE=F2=FC=F1=FF =F2=E0 =F0=E5=E0=E1=F1=EE=F0=E1= =F3=FE=F2=FC=F1=FF (=E5=ED=F2=E5=F0=EE=E3=E5=EF=E0=F2=E8=F7=ED=E0 =F6=E8=F0= =EA=F3=EB=FF=F6=B3=FF) =B3 =EF=E5=F0=E5=E2=E0=E6=ED=EE =E2=E8=E2=EE=E4=FF=F2=FC=F1=FF =E7 =F1=E5=F7=E5=FE =E2 =E1=B3=EE=EB=EE=E3= =B3=F7=ED=EE =ED=E5=E0=EA=F2=E8=E2=ED=B3=E9 =F4=EE=F0=EC=B3. =CE=EA=E8=F1= =EB=E5=ED=ED=FF =E5=F1=F2=F0=EE=ED=F3 =F2=E0 =E5=F1=F2=F0=E0=E4=B3=EE=EB=F3 =E2=B3=E4=E1=F3=E2=E0=BA=F2=FC=F1=FF =E7=E0 = =E4=EE=EF=EE=EC=EE=E3=EE=FE =F4=E5=F0=EC=E5=ED=F2=B3=E2 =F6=E8=F2=EE=F5=F0= =EE=EC=F3 P450, =E3=EE=EB=EE=E2=ED=E8=EC =F7=E8=ED=EE=EC CYP1A2, CYP1A2 (=EF=EE=E7=E0 =EF=E5=F7=B3=ED=EA=EE=FE), CYP3A4, CYP3A5, =E0= =F2=E0=EA=EE=E6 CYP1B1 =F2=E0 CYP2C9.

=CD=E0=E9=E2=E0=E6=EB=E8=E2=B3=F8=E8=EC=E8 =EC=E5=F2= =E0=E1=EE=EB=B3=F2=E0=EC=E8 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3 =BA =B3= =E7=EE=EC=E5=F0=E8 5=E0=EB=FC=F4=E0-=E4=E8=E3=B3=E4=F0=EE=ED=EE=F0=E5=F2=E8= =F1=F2=E5=F0=EE=ED =F2=E0 =F2=E5=F2=F0=E0=E3=B3=E4=F0=EE=ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED, = =FF=EA=B3 =E2=E8=E2=EE=E4=FF=F2=FC=F1=FF =E3=EE=EB=EE=E2=ED=E8=EC =F7=E8=ED= =EE=EC =B3=E7 =F1=E5=F7=E5=FE =F3 =E2=E8=E3=EB=FF=E4=B3 =F1=F3=EB=FC=F4=E0=F2=ED=E8=F5 =E0=E1=EE =E3=EB=FE=EA=F3=F0=EE=ED=B3=E4=ED= =E8=F5 =EA=EE=ED=92=FE=E3=E0=F2=B3=E2.

=C2=E8=E2=E5=E4=E5=ED=ED=FF

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=D0=E5=EB=F3=E3=EE=EB=B3=EA=F1

=CF=E5=F0=EE=F0=E0=EB=FC=ED= =B3 =B3=ED=E3=B3=E1=B3=F2=EE=F0=E8 P-=E3=EB=B3=EA=EE=EF=F0=EE=F2=E5=BF=ED=F3 (P-gp)=

=CE=E4= =ED=EE=F7=E0=F1=ED=E5 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA= =EA=EE =E7 =EF=E5=F0=EE=F0=E0=EB=FC=ED=E8=EC=E8 =B3=ED=E3=B3=E1=B3=F2=EE=F0= =E0=EC=E8 P-gp =ED=E5 =F0=E5=EA=EE=EC=E5=ED=E4=EE=E2=E0=ED=E5. =D0=E5=EB=F3=E3=EE=EB=B3=EA=F1 =BA =F1=F3=E1=F1=F2=F0=E0=F2=EE=EC P-gp (=E4= =E8=E2. =F0=EE=E7=E4=B3=EB =AB=D4=E0=F0=EC=E0=EA=EE=EA=B3=ED=E5=F2=E8=EA=E0= =BB); =F3 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=B3 =E2=E7=E0=BA=EC=EE=E4=B3=BF =E7 =E5=F0=E8=F2=F0=EE=EC=B3=F6=E8=ED=EE=EC, P-= gp =F2=E0 =EF=EE=EC=B3=F0=ED=E8=EC =B3=ED=E3=B3=E1=B3=F2=EE=F0=EE=EC =F6=E8= =F2=EE=F5=F0=EE=EC=F3 P450 (CYP) 3A4 =EF=EB=EE=F9=E0 =EF=B3=E4 =F4=E0=F0=EC=E0=EA=EE=EA=B3=ED=E5=F2=E8=F7=ED= =EE=FE =EA=F0=E8=E2=EE=FE (AUC) =F2=E0 =EC=E0=EA=F1=E8=EC=E0=EB=FC=ED=E0 = =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FF (Cmax) =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =E7=E1=B3=EB=FC=F8=E8=EB=E8=F1=FC =F3 4,1= =F2=E0 3,8 =F0=E0=E7=E0 =E2=B3=E4=EF=EE=E2=B3=E4=ED=EE. =C5=EA=F1=EF=EE=E7= =E8=F6=B3=FF =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =EC=EE=E6=E5 =E7=E1=B3=EB=FC=F8=E8=F2=E8=F1=FF =F3 =F0=E0=E7=B3 =EE=E4=ED= =EE=F7=E0=F1=ED=EE=E3=EE =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =B3=ED=E3=B3= =E1=B3=F2=EE=F0=B3=E2 P-gp, =E2=EA=EB=FE=F7=ED=EE =E7 =EF=E5=E2=ED=E8=EC=E8 =EF=F0=EE=F2=E8=B3=ED=F4=E5=EA=F6=B3=E9=ED=E8=EC=E8 = =EB=B3=EA=E0=F0=F1=FC=EA=E8=EC=E8 =E7=E0=F1=EE=E1=E0=EC=E8 (=F2=E0=EA=E8=EC= =E8 =FF=EA =E5=F0=E8=F2=F0=EE=EC=B3=F6=E8=ED, =EA=EB=E0=F0=E8=F2=F0=EE=EC=B3=F6=E8=ED, =E3=E5=ED=F2=E0=EC=B3=F6=E8=ED, = =F2=E5=F2=F0=E0=F6=E8=EA=EB=B3=ED), =EF=F0=EE=F2=E8=E3=F0=E8=E1=EA=EE=E2=E8= =EC=E8 =EB=B3=EA=E0=F0=F1=FC=EA=E8=EC=E8 =E7=E0=F1=EE=E1=E0=EC=E8 (=EA=E5=F2=EE=EA=EE=ED=E0=E7=EE=EB, =B3=F2=F0=E0=EA=EE=ED=E0=E7=EE=EB), =E0= =ED=F2=E8=E3=B3=EF=E5=F0=F2=E5=ED=E7=E8=E2=ED=E8=EC=E8 =EB=B3=EA=E0=F0=F1= =FC=EA=E8=EC=E8 =E7=E0=F1=EE=E1=E0=EC=E8 (=ED=E0=EF=F0=E8=EA=EB=E0=E4, =EA=E0=F0=E2=E5=E4=E8=EB=EE=EB, =E2=E5=F0=E0= =EF=E0=EC=B3=EB), =E0=ED=F2=E8=E0=F0=E8=F2=EC=B3=F7=ED=E8=EC=E8 =EB=B3=EA= =E0=F0=F1=FC=EA=E8=EC=E8 =E7=E0=F1=EE=E1=E0=EC=E8 (=ED=E0=EF=F0=E8=EA=EB=E0=E4, =E0=EC=B3=EE=E4=E0=F0=EE=ED, =E4=F0=EE=ED=E5= =E4=E0=F0=EE=ED, =EF=F0=EE=EF=E0=F4=E5=ED=EE=ED, =F5=B3=ED=B3=E4=E8=ED), = =E0=ED=F2=E8=E0=ED=E3=B3=ED=E0=EB=FC=ED=E8=EC=E8 =EB=B3=EA=E0=F0=F1=FC=EA=E8=EC=E8 =E7=E0=F1=EE=E1=E0=EC=E8 (=ED=E0=EF=F0=E8= =EA=EB=E0=E4, =F0=E0=ED=EE=EB=E0=E7=E8=ED), =F6=E8=EA=EB=EE=F1=EF=EE=F0=E8= =ED=EE=EC, =B3=ED=E3=B3=E1=B3=F2=EE=F0=E0=EC=E8 =EF=F0=EE=F2=E5=E0=E7=E8 =E2=B3=F0=F3=F1=F3 =B3=EC=F3=ED=EE=E4=E5=F4=B3=F6= =E8=F2=F3 =EB=FE=E4=E8=ED=E8 (=C2=B2=CB) =E0=E1=EE =E3=E5=EF=E0=F2=E8=F2=F3= =D1 (=C2=C3=D1) (=ED=E0=EF=F0=E8=EA=EB=E0=E4, =F0=E8=F2=EE=ED=E0=E2=B3=F0, =F2=E5=EB=E0=EF=F0=E5=E2=B3=F0). =DF=EA=F9=EE = =EE=E4=ED=EE=F7=E0=F1=ED=E5 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =E7 =EF=E5= =F0=EE=F0=E0=EB=FC=ED=E8=EC=E8 =B3=ED=E3=B3=E1=B3=F2=EE=F0=E0=EC=E8 P-gp =EE=E4=E8=ED =E0=E1=EE =E4=E2=E0 =F0=E0=E7=E8 =ED=E0 =E4=EE=E1=F3 =ED= =E5=EE=E1=F5=B3=E4=ED=E5 (=ED=E0=EF=F0=E8=EA=EB=E0=E4 =E7 =E0=E7=E8=F2=F0= =EE=EC=B3=F6=E8=ED=EE=EC), =F1=EF=EE=F7=E0=F2=EA=F3 =F1=EB=B3=E4 =EF=F0=E8=E9=ED=FF=F2=E8 =EF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA=EA=EE =F2=E0 = =E2=B3=E4=F1=F2=F0=EE=F7=E8=F2=E8 =EF=F0=E8=E9=EE=EC =B3=ED=E3=B3=E1=B3=F2= =EE=F0=E0 P-gp =EF=F0=E8=ED=E0=E9=EC=ED=B3 =ED=E0 6 =E3=EE=E4=E8=ED, =EF=F0=E8 =F6=FC=EE=EC=F3 =EF=EE=F2=F0=B3=E1=ED=EE =F7=E0= =F1=F2=B3=F8=E5 =EF=E5=F0=E5=E2=B3=F0=FF=F2=E8 =F1=F2=E0=ED =EF=E0=F6=B3=BA= =ED=F2=E0 =ED=E0 =ED=E0=FF=E2=ED=B3=F1=F2=FC =EF=EE=E1=B3=F7=ED=E8=F5 =F0=E5=E0=EA=F6=B3=E9.

=D1=E8=EB=FC=ED=B3 =B3=ED=E4=F3=EA=F2= =EE=F0=E8 =F6=E8=F2=EE=F5=F0=EE=EC=F3 P450 3A4 (CYP3A4) =F2=E0/=E0=E1=EE P-gp

=CD=E5 = =F0=E5=EA=EE=EC=E5=ED=E4=EE=E2=E0=ED=E5 =EE=E4=ED=EE=F7=E0=F1=ED=E5 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =EF=F0=E5= =EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =B3=E7 =F1=E8=EB=FC=ED=E8=EC=E8 =B3=ED= =E4=F3=EA=F2=EE=F0=E0=EC=E8 CYP3A4 =F2=E0/=E0=E1=EE P-gp. =D3 =EA=EB=B3=ED=B3=F7=ED=EE=EC=F3 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=B3 = =E2=E7=E0=BA=EC=EE=E4=B3=BF =E7 =F0=E8=F4=E0=EC=EF=B3=F6=E8=ED=EE=EC, =F1= =E8=EB=FC=ED=E8=EC =B3=ED=E4=F3=EA=F2=EE=F0=EE=EC CYP3A4 =F2=E0 P-gp, Cmax =F2=E0 AUC =F2=E0 =F0=E5=EB=F3=E3=EE=EB= =B3=EA=F1=F3 =E7=EC=E5=ED=F8=E8=EB=E8=F1=FC =ED=E0 23 % =F2=E0 55 % =E2=B3=E4=EF=EE=E2=B3=E4=ED=EE. =CB=B3=EA=E0=F0=F1=FC=EA=B3 =E7=E0=F1=EE=E1= =E8, =F9=EE =F1=EF=F0=E8=F7=E8=ED=FF=FE=F2=FC =F1=E8=EB=FC=ED=F3 =B3=ED=E4= =F3=EA=F6=B3=FE CYP3A4 =F2=E0/=E0=E1=EE P-gp, =F2=E0=EA=B3 =FF=EA =EF=F0=EE=F2=E8=F1=F3=E4=EE=EC=ED=B3 =EB=B3=EA=E0= =F0=F1=FC=EA=B3 =E7=E0=F1=EE=E1=E8 (=ED=E0=EF=F0=E8=EA=EB=E0=E4 =EA=E0=F0= =E1=E0=EC=E0=E7=E5=EF=B3=ED, =F2=EE=EF=B3=F0=E0=EC=E0=F2, =F4=E5=ED=B3=F2=EE=BF=ED, =F4=E5=ED=EE=E1=E0=F0=E1=B3=F2=E0=EB, =EF=F0=E8= =EC=B3=E4=EE=ED, =EE=EA=F1=EA=E0=F0=E1=E0=E7=E5=EF=B3=ED, =F4=E5=EB=E1=E0= =EC=E0=F2), =EF=F0=EE=F2=E8=B3=ED=F4=E5=EA=F6=B3=E9=ED=B3 =EB=B3=EA=E0=F0=F1=FC=EA=B3 =E7=E0=F1=EE=E1=E8 (=ED=E0=EF=F0=E8=EA=EB=E0=E4= =F0=E8=F4=E0=EC=EF=B3=F6=E8=ED, =F0=E8=F4=E0=E1=F3=F2=E8=ED, =E3=F0=E8=E7= =E5=EE=F4=F3=EB=FC=E2=B3=ED), =E7=E2=B3=F0=EE=E1=B3=E9 =EF=F0=EE=E4=B3=F0=FF=E2=EB=E5=ED=E8=E9 (Hypericum perforatum) =E1=EE=E7=E5=ED=F2=E0=ED =F2=E0 =B3=ED=E3=B3=E1=B3=F2=EE=F0=E8 =EF=F0=EE=F2=E5=E0=E7=E8 =C2=B2=CB = =E0=E1=EE =C2=C3=D1 (=ED=E0=EF=F0=E8=EA=EB=E0=E4 =F0=E8=F2=EE=ED=E0=E2=B3= =F0, =E1=EE=F6=E5=EF=F0=E5=E2=B3=F0, =F2=E5=EB=E0=EF=F0=E5=E2=B3=F0), =E0 =F2=E0=EA=EE=E6 =ED=E5=ED=F3=EA=EB=E5=EE=E7=E8=E4=ED=B3 =B3=ED=E3=B3=E1= =B3=F2=EE=F0=E8 =E7=E2=EE=F0=EE=F2=ED=EE=BF =F2=F0=E0=ED=F1=EA=F0=E8=EF=F2= =E0=E7=E8 (=ED=E0=EF=F0=E8=EA=EB=E0=E4 =E5=F4=E0=E2=B3=F0=E5=ED=F6), =EC=EE=E6=F3=F2=FC =E7=ED=E8=E7=E8=F2=E8 =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3= =FE =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =E2 =EF=EB=E0=E7=EC=B3 =EA=F0=EE=E2= =B3 =F2=E0 =E7=EC=E5=ED=F8=E8=F2=E8 =F2=E5=F0=E0=EF=E5=E2=F2=E8=F7=ED=E8=E9 =E5=F4=E5=EA=F2.

=B2=ED=E3=B3=E1=B3=F2=EE=F0= =E8 CYP3A4

=CE=E4= =ED=EE=F7=E0=F1=ED=E5 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =E7 = =F1=E8=EB=FC=ED=E8=EC=E8 =B3=ED=E3=B3=E1=B3=F2=EE=F0=E0=EC=E8 CYP3A4, =F9= =EE =ED=E5 =B3=ED=E3=B3=E1=F3=FE=F2=FC P-gp (=E2=EE=F0=E8=EA=EE=ED=E0=E7=EE=EB), =ED=E5 =E7=E1=B3=EB=FC=F8=F3=E2=E0=EB= =EE =E5=EA=F1=EF=EE=E7=E8=F6=B3=FE =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3. =CA= =F0=B3=EC =F2=EE=E3=EE, =F3 =EA=EB=B3=ED=B3=F7=ED=EE=EC=F3 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=B3 =E2=E7=E0=BA=EC=EE=E4=B3=BF =EE=E4=ED=EE= =F7=E0=F1=ED=E8=E9 =EF=F0=E8=E9=EE=EC =E7 =E0=F2=EE=F0=E2=E0=F1=F2=E0=F2=E8= =ED=EE=EC, =F1=EB=E0=E1=EA=E8=EC =B3=ED=E3=B3=E1=B3=F2=EE=F0=EE=EC =F4=E5=F0=EC=E5=ED=F2=F3 CYP3A4, =EA=EB=B3=ED=B3=F7=ED=EE =E7=ED=E0=F7=F3= =F9=E5 =ED=E5 =E7=EC=B3=ED=E8=E2 =E5=EA=F1=EF=EE=E7=E8=F6=B3=FE =F0=E5=EB= =F3=E3=EE=EB=B3=EA=F1=F3.

=CE=F6=B3=ED=EA=F3 =E2=EF=EB=E8=E2=F3 =F1=F3=EF=F3=F2= =ED=B3=F5 =EB=B3=EA=E0=F0=F1=FC=EA=E8=F5 =E7=E0=F1=EE=E1=B3=E2 =ED=E0 =E5= =EA=F1=EF=EE=E7=E8=F6=B3=FE =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =E7=E0 =F0=E5=E7=F3=EB=FC=F2=E0=F2=E0=EC= =E8 =EA=EB=B3=ED=B3=F7=ED=E8=F5 =E4=EE=F1=EB=B3=E4=E6=E5=ED=FC =F2=E0 =F0= =E5=EA=EE=EC=E5=ED=E4=E0=F6=B3=BF =F9=EE=E4=EE =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =F3=E7=E0=E3=E0=EB=FC=ED=E5=ED=EE =F3 = =F2=E0=E1=EB=E8=F6=B3 7.

= =D2=E0=E1=EB=E8=F6=FF 7

=C2=EF=EB=E8=E2 =F1=F3=EF=F3= =F2=ED=FC=EE=BF =F2=E5=F0=E0=EF=B3=BF =ED=E0 =E5=EA=F1=EF=EE=E7=E8=F6=B3=FE =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 (AUC0= -∞, Cmax; =E2 =EF=EE=F0=FF=E4=EA=F3 = =E7=EC=E5=ED=F8=E5=ED=ED=FF =E2=E5=EB=E8=F7=E8=ED=E8 =E5=EA=F1=EF=EE=E7=E8=F6=B3=BF) =E7=E0 =E4=E0=ED=E8=EC=E8 =EA=EB=B3=ED=B3= =F7=ED=E8=F5 =E4=EE=F1=EB=B3=E4=E6=E5=ED=FC =F2=E0 =E2=B3=E4=EF=EE=E2=B3=E4= =ED=B3 =F0=E5=EA=EE=EC=E5=ED=E4=E0=F6=B3=BF

=D0=E5=E6=E8=EC =E4=EE=E7=F3=E2=E0=ED=ED= =FF =F1=F3=EF=F3=F2=ED=FC=EE=E3=EE =EF=F0=E5=EF=E0=F0=E0=F2=F3

=D0=E5=E6=E8=EC =E4=EE=E7=F3=E2=E0=ED=ED= =FF =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3

=C7=EC=B3=ED=E0

AUC0-∞ =F0=E5=EB=F3=E3=EE= =EB=B3=EA=F1=F3*

=C7=EC=B3=ED=E0 Cmax =F0=E5=EB= =F3=E3=EE=EB=B3=EA=F1=F3*

=D0=E5=EA=EE=EC=E5=ED=E4=E0=F6=B3=BF

=C5=F0=E8=F2=F0=EE=EC=B3=F6=E8=ED

500 =EC=E3 4 =F0/=E4=EE=E1=F3 =E1=E0=E3=E0= =F2=EE=F0=E0=E7=EE=E2=EE

40 =EC=E3 =EE=E4=ED=EE=F0=E0=E7=EE=E2=EE

=C7=E1=B3=EB=FC=F8=E5=ED=ED=FF =F3 4,1 =F0= =E0=E7=E0

=C7=E1=B3=EB=FC=F8=E5=ED=ED=FF =F3 3,8 =F0= =E0=E7=E0

=CE=E4=ED=EE=F7=E0=F1=ED=E5 =E7=E0=F1=F2= =EE=F1=F3=E2=E0=ED=ED=FF =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =E7 =E5=F0=E8=F2=F0=EE=EC=B3=F6=E8=ED=EE=EC =F2=E0 =B3=ED=F8=E8=EC=E8 =EF=E5= =F0=EE=F0=E0=EB=FC=ED=E8=EC=E8 =B3=ED=E3=B3=E1=B3=F2=EE=F0=E0=EC=E8 P-gp = =ED=E5 =F0=E5=EA=EE=EC=E5=ED=E4=F3=BA=F2=FC=F1=FF.

&nbs= p;

=DF=EA=F9=EE =EE=E4=ED=EE=F7=E0=F1=ED=EE= =E3=EE =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =E7 =EF=E5=F0=EE=F0=E0=EB=FC=ED= =E8=EC=E8 =B3=ED=E3=B3=E1=B3=F2=EE=F0=E0=EC=E8 P-gp (=ED=E0=EF=F0=E8=EA=EB=E0=E4 = =E7 =E0=E7=E8=F2=F0=EE=EC=B3=F6=E8=ED=EE=EC) =EE=E4=E8=ED =E0=E1=EE =E4=E2= =E0 =F0=E0=E7=E8 =ED=E0 =E4=EE=E1=F3 =F3=ED=E8=EA=ED=F3=F2=E8 =ED=E5 =EC=EE=E6=ED=E0, =F1=EB=B3=E4 =EF=F0=E8= =E9=ED=FF=F2=E8 =F1=EF=EE=F7=E0=F2=EA=F3 =EF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA= =EA=EE, =E0 =B3=ED=E3=B3=E1=B3=F2=EE=F0 P-gp =96 =ED=E5 =F0=E0=ED=B3=F8=E5 =ED=B3=E6 =F7=E5=F0=E5=E7 6 =E3=EE=E4=E8=ED. = =D2=E0=EA=EE=E6 =ED=E5=EE=E1=F5=B3=E4=ED=EE =E7=E4=B3=E9=F1=ED=FE=E2=E0=F2= =E8 =F0=E5=F2=E5=EB=FC=ED=B3=F8=E5 =F1=EF=EE=F1=F2=E5=F0=E5=E6=E5=ED=ED=FF =E7=E0 =F1=F2=E0=ED=EE=EC =EF=E0= =F6=B3=BA=ED=F2=EE=EA =F9=EE=E4=EE =F0=EE=E7=E2=E8=F2=EA=F3 =ED=E5=E1=E0=E6= =E0=ED=E8=F5 =F0=E5=E0=EA=F6=B3=E9.

=C0=E7=E8=F2=F0=EE=EC=B3=F6=E8=ED

500 =EC=E3 =EE=E4=ED=EE=F0=E0=E7=EE=E2=EE<= /span>

120 =EC=E3 =EE=E4=ED=EE=F0=E0=E7=EE=E2=EE*= *

=C7=E1=B3=EB=FC=F8=E5=ED=ED=FF =F3 1,5 =F0= =E0=E7=E0

=C7=E1=B3=EB=FC=F8=E5=ED=ED=FF =F3 1,6 =F0= =E0=E7=E0

=C0=E7=E8=F2=F0=EE=EC=B3=F6=E8=ED

500 =EC=E3 =EE=E4=ED=EE=F0=E0=E7=EE=E2=EE = =F7=E5=F0=E5=E7 6 =E3=EE=E4=E8=ED =EF=B3=F1=EB=FF =EF=F0=E8=E9=EE=EC=F3 =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3

=C7=E1=B3=EB=FC=F8=E5=ED=ED=FF =F3 1,4 =F0= =E0=E7=E0

=C7=E1=B3=EB=FC=F8=E5=ED=ED=FF =F3 1,3 =F0= =E0=E7=E0

=C2=EE=F0=E8=EA=EE=ED=E0=E7=EE=EB

200 =EC=E3 2 =F0/=E4=EE=E1=F3 =E1=E0=E3=E0= =F2=EE=F0=E0=E7=EE=E2=EE

40 =EC=E3 =EE=E4=ED=EE=F0=E0=E7=EE=E2=EE

=C7=E1=B3=EB=FC=F8=E5=ED=ED=FF =ED=E0 51 %=

&nbs= p;

=C7=E1=B3=EB=FC=F8=E5=ED=ED=FF =ED=E0 21 %=

=CF=F0=E8 =EE=E4=ED=EE=F7=E0=F1=ED=EE=EC= =F3 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=B3 =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 = =E7 =B3=ED=E3=B3=E1=B3=F2=EE=F0=E0=EC=E8 =B3=E7=EE=F4=E5=F0=EC=E5=ED=F2=F3 CY= P3A4, =FF=EA=B3 =ED=E5 =EC=E0=FE=F2=FC =B3=ED=E3=B3=E1=F3=FE=F7=EE=BF =E4= =B3=BF =ED=E0 P-gp, =EA=EE=F0=E5=EA=F6=B3=FF =E4=EE=E7=E8 =ED=E5 =F0=E5=EA=EE=EC=E5=ED=E4=F3= =BA=F2=FC=F1=FF.

=D4=EB=F3=EA=EE=ED=E0=E7=EE=EB

200 =EC=E3 1 =F0/=E4=EE=E1=F3 =E1=E0=E3=E0= =F2=EE=F0=E0=E7=EE=E2=EE

40 =EC=E3 =EE=E4=ED=EE=F0=E0=E7=EE=E2=EE

=C7=E1=B3=EB=FC=F8=E5=ED=ED=FF =ED=E0 19 %=

=C7=E1=B3=EB=FC=F8=E5=ED=ED=FF =ED=E0 44 %=

=C0=F2=EE=F0=E2=E0=F1=F2=E0=F2=E8=ED

80 =EC=E3 1 =F0/=E4=EE=E1=F3 =E1=E0=E3=E0= =F2=EE=F0=E0=E7=EE=E2=EE

40 =EC=E3 =EE=E4=ED=EE=F0=E0=E7=EE=E2=EE

=C7=ED=E8=E6=E5=ED=ED=FF =ED=E0 5 %=

=C7=ED=E8=E6=E5=ED=ED=FF =ED=E0 22 %

=D0=E8=F4=E0=EC=EF=B3=F6=E8=ED

600 =EC=E3 1 =F0/=E4=EE=E1=F3 =E1=E0=E3=E0= =F2=EE=F0=E0=E7=EE=E2=EE

40 =EC=E3 =EE=E4=ED=EE=F0=E0=E7=EE=E2=EE

=C7=ED=E8=E6=E5=ED=ED=FF =ED=E0 55 %

=C7=ED=E8=E6=E5=ED=ED=FF =ED=E0 23 %

=CE=E4=ED=EE=F7=E0=F1=ED=E5 =E7=E0=F1=F2= =EE=F1=F3=E2=E0=ED=ED=FF =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =E7 =F0=E8=F4=E0=EC=EF=B3=F6=E8=ED=EE=EC =F2=E0 =B3=ED=F8=E8=EC=E8 =EA=EE=EC= =E1=B3=ED=EE=E2=E0=ED=E8=EC=E8 =B3=ED=E4=F3=EA=F2=EE=F0=E0=EC=E8 P-gp =F2= =E0 =EF=EE=F2=F3=E6=ED=E8=EC=E8 =B3=ED=E4=F3=EA=F2=EE=F0=E0=EC=E8 =B3=E7=EE=F4=E5=F0=EC=E5=ED=F2=F3 CYP3A= 4 =ED=E5 =F0=E5=EA=EE=EC=E5=ED=E4=F3=BA=F2=FC=F1=FF, =EE=F1=EA=B3=EB=FC=EA= =E8 =E5=F4=E5=EA=F2=E8=E2=ED=B3=F1=F2=FC =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3, =F9=EE =E2=F5=EE=E4=E8=F2=FC =E4=EE = =F1=EA=EB=E0=E4=F3 =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE, =EC=EE=E6= =E5 =E1=F3=F2=E8 =E7=ED=E8=E6=E5=ED=E0.

*=C4=E0=ED= =B3, =EF=EE=E4=E0=ED=B3 =F3 =E2=E8=E3=EB=FF=E4=B3 =EA=F0=E0=F2=ED=EE=BF =E7=EC=B3=ED=E8, =BA =E2=B3=E4= =ED=EE=F8=E5=ED=ED=FF=EC =EF=EE=EA=E0=E7=ED=E8=EA=E0 =ED=E0 =F2=EB=B3 =F1= =F3=EF=F3=F2=ED=FC=EE=BF =F2=E5=F0=E0=EF=B3=BF =E4=EE =EF=EE=EA=E0=E7=ED=E8=EA=E0 =EF=F0=E8 =EC=EE=ED=EE=F2=E5=F0=E0=EF=B3=BF =F0= =E5=EB=F3=E3=EE=EB=B3=EA=F1=EE=EC. =C4=E0=ED=B3, =EF=F0=E5=E4=F1=F2=E0=E2= =EB=E5=ED=B3 =F3 =E2=E8=E3=EB=FF=E4=B3 =E2=B3=E4=F1=EE=F2=EA=EE=E2=EE=BF =E7=EC=B3=ED=E8, =BA =F0=B3=E7=ED=E8=F6=E5=FE =F3 =E2=B3=E4=F1=EE=F2=EA=E0= =F5 =EC=B3=E6 =EF=EE=EA=E0=E7=ED=E8=EA=EE=EC =ED=E0 =F2=EB=B3 =F1=F3=EF=F3= =F2=ED=FC=EE=BF =F2=E5=F0=E0=EF=B3=BF =F2=E0 =EF=EE=EA=E0=E7=ED=E8=EA=EE=EC =EF=F0=E8 =EC=EE=ED=EE=F2=E5=F0=E0=EF=B3=BF = =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=EE=EC.

** = =C1=B3=EB=FC=F8 =E4=E5=F2=E0=EB=FC=ED=E0 =B3=ED=F4=EE=F0=EC=E0=F6=B3=FF =EF=F0=E5=E4=F1=F2= =E0=E2=EB=E5=ED=E0 =E2 =B3=ED=F1=F2=F0=F3=EA=F6=B3=BF =E4=EB=FF =EC=E5=E4= =E8=F7=ED=EE=E3=EE =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =EF=F0=E5=EF=E0=F0=E0=F2=F3 =CE=F0=E3=EE=E2=B3=EA=F1 (Orgovyx). =C2=E7=E0= =BA=EC=EE=E4=B3=FF =E7 =E4=EE=E7=EE=FE 40 =EC=E3 =ED=E5 =E2=E8=E2=F7=E0=EB= =E0=F1=FF, =E0=EB=E5 =EF=E5=F0=E5=E4=E1=E0=F7=E0=BA=F2=FC=F1=FF, =F9=EE =E2=EF=EB=E8=E2 =E1=F3= =E4=E5 =E2=E8=F0=E0=E6=E5=ED=E8=E9 =F1=E8=EB=FC=ED=B3=F8=E5.

=A0AUC =96 =EF= =EB=EE=F9=E0 =EF=B3=E4 =F4=E0=F0=EC=E0=EA=EE=EA=B3=ED=E5=F2=E8=F7=ED=EE=FE =EA=F0=E8=E2=EE=FE; Cmax =96 =EC=E0=EA=F1=E8=EC=E0=EB=FC=ED=E0 =EA=EE=ED=F6=E5=ED=F2=F0= =E0=F6=B3=FF; 1 =F0/=E4=EE=E1=F3 =96 =A0=EE=E4=E8=ED =F0=E0=E7 =ED=E0 = =E4=EE=E1=F3; 2 =F0/=E4=EE=E1=F3 =96 =A0=E4=E2=B3=F7=B3 =ED=E0 =E4=EE=E1=F3; 4= =F0/=E4=EE=E1=F3 =96 =F7=EE=F2=E8=F0=E8 =F0=E0=E7=E8 =ED=E0 =E4=EE=E1=F3.<= /span>

= =C5=F1=F2=F0=E0=E4=B3=EE=EB =F2=E0 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3 =E0=F6=E5=F2=E0=F2

=B2= =ED=E3=B3=E1=B3=F2=EE=F0=E8 CYP3A4

=CB=B3= =EA=E0=F0=F1=FC=EA=B3 =E7=E0=F1=EE=E1=E8, =FF=EA=B3 =EF=F0=E8=E3=ED=B3=F7=F3=FE=F2=FC =E0=EA=F2= =E8=E2=ED=B3=F1=F2=FC =F4=E5=F0=EC=E5=ED=F2=B3=E2 =EF=E5=F7=B3=ED=EA=E8, = =F9=EE =EC=E5=F2=E0=E1=EE=EB=B3=E7=F3=FE=F2=FC =EB=B3=EA=E0=F0=F1=FC=EA=B3 =E7=E0=F1=EE=E1=E8, =ED=E0=EF=F0=E8=EA=EB=E0=E4= =EA=E5=F2=EE=EA=EE=ED=E0=E7=EE=EB, =EC=EE=E6=F3=F2=FC =EF=B3=E4=E2=E8=F9= =E8=F2=E8 =EA=EE=ED=F6=E5=ED=F2=F0=E0=F6=B3=FE =E5=F1=F2=F0=EE=E3=E5=ED=F3 =F2=E0 =ED=EE=F0=E5=F2=E8=F1=F2=E5=F0=EE=ED=F3.=

=B2= =ED=E4=F3=EA=F2=EE=F0=E8 =F4=E5=F0=EC=E5=ED=F2=F3 CYP

=CC=E5= =F2=E0=E1=EE=EB=B3=E7=EC =E5=F1=F2=F0=EE=E3=E5=ED=B3=E2 =B3 =EF=F0=EE=E3=E5=F1=F2=E0=E3=E5=ED=B3=E2 = =EC=EE=E6=E5 =EF=EE=F1=E8=EB=FE=E2=E0=F2=E8=F1=FF =EF=F0=E8 =EE=E4=ED=EE=F7= =E0=F1=ED=EE=EC=F3 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=B3 =F0=E5=F7=EE=E2=E8=ED, =FF=EA=B3, =FF=EA =E2=B3=E4=EE=EC=EE, =B3=ED=E4=F3= =EA=F3=FE=F2=FC =F4=E5=F0=EC=E5=ED=F2=E8, =F9=EE =EC=E5=F2=E0=E1=EE=EB=B3= =E7=F3=FE=F2=FC =EB=B3=EA=E0=F0=F1=FC=EA=B3 =E7=E0=F1=EE=E1=E8, =E7=EE=EA=F0=E5=EC=E0 =F4=E5=F0=EC=E5=ED=F2=E8 =F6=E8=F2=EE=F5=F0=EE=EC=F3 = =D0450, =F2=E0=EA=B3 =FF=EA =EF=F0=EE=F2=E8=F1=F3=E4=EE=EC=ED=B3 =EB=B3=EA= =E0=F0=F1=FC=EA=B3 =E7=E0=F1=EE=E1=E8 (=ED=E0=EF=F0=E8=EA=EB=E0=E4 =F4=E5=ED=EE=E1=E0=F0=E1=B3=F2=E0=EB, =F4=E5= =ED=B3=F2=EE=BF=ED, =EA=E0=F0=E1=E0=EC=E0=E7=E5=EF=B3=ED) =F2=E0 =EF=F0=EE= =F2=E8=B3=ED=F4=E5=EA=F6=B3=E9=ED=B3 =EB=B3=EA=E0=F0=F1=FC=EA=B3 =E7=E0=F1= =EE=E1=E8 (=ED=E0=EF=F0=E8=EA=EB=E0=E4 =F0=E8=F4=E0=EC=EF=B3=F6=E8=ED, =F0=E8=F4=E0= =E1=F3=F2=E8=ED, =ED=E5=E2=B3=F0=E0=EF=B3=ED, =E5=F4=E0=E2=B3=F0=E5=ED=F6).=

=D0=E8= =F2=EE=ED=E0=E2=B3=F0, =F2=E5=EB=E0=EF=F0=E5=E2=B3=F0 =F2=E0 =ED=E5=EB=F4=B3=ED=E0=E2=B3=F0, =F5= =EE=F7=E0 =E2=EE=ED=E8 =E2=B3=E4=EE=EC=B3 =FF=EA =F1=E8=EB=FC=ED=B3 =B3=ED= =E3=B3=E1=B3=F2=EE=F0=E8, =F2=E0=EA=EE=E6 =BA =B3=ED=E4=F3=EA=F2=EE=F0=E0=EC=E8 =F2=E0 =EC=EE=E6=F3=F2=FC =E7=EC=E5=ED=F8= =E8=F2=E8 =E5=EA=F1=EF=EE=E7=E8=F6=B3=FE =E5=F1=F2=F0=EE=E3=E5=ED=B3=E2 =F2= =E0 =EF=F0=EE=E3=E5=F1=F2=E0=E3=E5=ED=B3=E2.

=D0=EE= =F1=EB=E8=ED=ED=B3 =EF=F0=E5=EF=E0=F0=E0=F2=E8, =F9=EE =EC=B3=F1=F2=FF=F2=FC =E7=E2=B3=F0=EE= =E1=B3=E9 =EF=F0=EE=E4=B3=F0=FF=E2=EB=E5=ED=E8=E9 (Hypericum perforatum<= /i>), =EC=EE=E6=F3=F2=FC =B3=ED=E4=F3=EA=F3=E2=E0=F2=E8 =EC=E5=F2=E0=E1=EE=EB=B3=E7=EC =E5=F1=F2=F0= =EE=E3=E5=ED=B3=E2 =F2=E0 =EF=F0=EE=E3=E5=F1=F2=E0=E3=E5=ED=B3=E2. =CA=EB= =B3=ED=B3=F7=ED=EE =EF=B3=E4=E2=E8=F9=E5=ED=ED=FF =EC=E5=F2=E0=E1=EE=EB=B3=E7=EC=F3 =E5=F1=F2=F0=EE=E3=E5=ED=F3 =EC=EE=E6=E5 = =EF=F0=E8=E7=E2=E5=F1=F2=E8 =E4=EE =E7=ED=E8=E6=E5=ED=ED=FF =E5=F4=E5=EA=F2= =E8=E2=ED=EE=F1=F2=B3 =F9=EE=E4=EE =E7=E0=F5=E8=F1=F2=F3 =E2=B3=E4 =E2=F2=F0=E0=F2=E8 =EA=B3=F1=F2=EA=EE=E2=EE=BF =EC=E0=F1=E8. =D2=EE=EC=F3 = =ED=E5 =F0=E5=EA=EE=EC=E5=ED=E4=EE=E2=E0=ED=E5 =F2=F0=E8=E2=E0=EB=E5 =EE=E4= =ED=EE=F7=E0=F1=ED=E5 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =B3=ED=E4=F3=EA=F2=EE=F0=B3=E2 =F4=E5=F0=EC=E5=ED=F2=B3=E2 =EF=E5=F7=B3=ED= =EA=E8 =E7 =EF=F0=E5=EF=E0=F0=E0=F2=EE=EC =D0=B3=BA=EA=EE.

=CC= =EE=E6=EB=E8=E2=E8=E9 =E2=EF=EB=E8=E2 =EA=EE=EC=EF=EE=ED=E5=ED=F2=B3=E2 =EF=F0=E5=EF=E0=F0=E0=F2= =F3 =D0=B3=BA=EA=EE =ED=E0 =B3=ED=F8=B3 =EB=B3=EA=E0=F0=F1=FC=EA=B3 =E7=E0= =F1=EE=E1=E8

= =D0=E5=EB=F3=E3=EE=EB=B3=EA=F1

=D0=E5= =EB=F3=E3=EE=EB=B3=EA=F1 =BA =F1=EB=E0=E1=EA=E8=EC =B3=ED=E4=F3=EA=F2=EE=F0=EE=EC CYP3A4. =CF=B3=F1=EB= =FF =EE=E4=ED=EE=F7=E0=F1=ED=EE=E3=EE =EF=F0=E8=E9=EE=EC=F3 =E7 40 =EC=E3 = =ED=E0 =E4=EE=E1=F3 =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 AUC =F2=E0 Cmax =EC=B3=E4=E0=E7=EE=EB=E0=EC=F3, =F7=F3=F2=EB=E8= =E2=EE=E3=EE =F1=F3=E1=F1=F2=F0=E0=F2=F3 CYP3A4, =E7=EC=E5=ED=F8=E8=EB=E8= =F1=FC =ED=E0 18 % =F2=E0 26 % =E2=B3=E4=EF=EE=E2=B3=E4=ED=EE. =CE=E4=ED=E0=EA =ED=E0 =EE=F1= =ED=EE=E2=B3 =EA=EB=B3=ED=B3=F7=ED=EE=E3=EE =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED= =FF =E7 =EC=B3=E4=E0=E7=EE=EB=E0=EC=EE=EC =ED=E5 =EE=F7=B3=EA=F3=BA=F2=FC=F1=FF =EA=EB=B3=ED=B3=F7=ED=EE =E7=ED=E0=F7=F3=F9= =EE=E3=EE =E2=EF=EB=E8=E2=F3 =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =ED=E0 =B3= =ED=F8=B3 =F1=F3=E1=F1=F2=F0=E0=F2=E8 CYP3A4.

=C2=F1= =F2=E0=ED=EE=E2=EB=E5=ED=EE, =F9=EE =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1 =BA =B3=ED=E3=B3=E1=B3=F2=EE=F0=EE=EC =F1=F2= =B3=E9=EA=EE=E3=EE =E4=EE =F0=E0=EA=F3 =EC=EE=EB=EE=F7=ED=EE=BF =E7=E0=EB= =EE=E7=E8 =E1=B3=EB=EA=E0 (BCRP) in vitro, =F2=EE=EC=F3 =E1=F3=EB=EE =EF=F0=EE=E2=E5=E4=E5=ED=EE =E4=EE=F1= =EB=B3=E4=E6=E5=ED=ED=FF =E2=E7=E0=BA=EC=EE=E4=B3=BF =E7 =F0=EE=E7=F3=E2=E0= =F1=F2=E0=F2=E8=ED=EE=EC, BCRP =F2=E0 =EE=F0=E3=E0=ED=B3=F7=ED=E8=EC =E0=ED=B3=EE=ED=EE=EC, =F9=EE =F2=F0=E0=ED= =F1=EF=EE=F0=F2=F3=BA =EF=EE=EB=B3=EF=E5=EF=F2=E8=E4 1B1 (OATP1B1). =CF=B3= =F1=EB=FF =EE=E4=ED=EE=F7=E0=F1=ED=EE=E3=EE =EF=F0=E8=E9=EE=EC=F3 =E7 40 =EC=E3 =ED=E0 =E4=EE=E1=F3 =F0=E5=EB=F3=E3=EE= =EB=B3=EA=F1=F3 AUC =F2=E0 Cmax =F0=EE=E7=F3=E2=E0=F1=F2=E0=F2= =E8=ED=F3 =E7=EC=E5=ED=F8=E8=EB=E8=F1=FC =ED=E0 13 % =F2=E0 23 % =E2=B3=E4=EF=EE=E2= =B3=E4=ED=EE. =C5=F4=E5=EA=F2=E8 =ED=E5 =E2=E2=E0=E6=E0=FE=F2=FC=F1=FF =EA= =EB=B3=ED=B3=F7=ED=EE =E7=ED=E0=F7=F3=F9=E8=EC=E8, =B3 =F2=EE=EC=F3 =ED=E5 =F0=E5=EA=EE=EC=E5=ED=E4=EE=E2=E0=ED=EE =EA=EE=F0= =E8=E3=F3=E2=E0=F2=E8 =E4=EE=E7=F3 =F0=EE=E7=F3=E2=E0=F1=F2=E0=F2=E8=ED=F3 = =EF=F0=E8 =EE=E4=ED=EE=F7=E0=F1=ED=EE=EC=F3 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=B3 =E7 =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=EE= =EC. =CA=EB=B3=ED=B3=F7=ED=E8=E9 =E2=EF=EB=E8=E2 =EF=F0=E5=EF=E0=F0=E0=F2= =F3 =D0=B3=BA=EA=EE =ED=E0 =B3=ED=F8=B3 =F1=F3=E1=F1=F2=F0=E0=F2=E8 BCRP =ED=E5 =EE=F6=B3=ED=FE=E2=E0=E2=F1=FF, =E0 =E7=ED=E0=F7=F3=F9=B3=F1=F2= =FC =B3=ED=F8=E8=F5 =F1=F3=E1=F1=F2=F0=E0=F2=B3=E2 BCRP =ED=E5=E2=B3=E4=EE= =EC=E0.

=D0=E5=EB=F3=E3=EE=EB=B3=EA=F1 =EC=EE=E6=E5 = =F1=EF=F0=E8=F7=E8=ED=E8=F2=E8 =ED=E0=F1=E8=F7=E5=ED=ED=FF =EA=E8=F8=EA=EE= =E2=EE=E3=EE P-gp =EF=F0=E8 =E4=EE=E7=B3 40 =EC=E3, =EE=F1=EA=B3=EB=FC=EA=E8 =F0=E5=EB= =F3=E3=EE=EB=B3=EA=F1 =E4=E5=EC=EE=ED=F1=F2=F0=F3=BA =E1=B3=EB=FC=F8 =ED=B3= =E6 =E4=EE=E7=EE=EF=F0=EE=EF=EE=F0=F6=B3=E9=ED=F3 =F4=E0=F0=EC=E0=EA=EE=EA=B3=ED=E5=F2=E8=EA=F3, =E2 =E4=B3=E0=EF=E0=E7=EE=ED= =B3 =E4=EE=E7 10=96120 =EC=E3,=A0 =E0 =F6=E5 =EC=EE=E6=E5 = =EF=F0=E8=E7=E2=E5=F1=F2=E8 =E4=EE =E7=E1=B3=EB=FC=F8=E5=ED=ED=FF =E2=F1=EC=EE=EA=F2=F3=E2=E0=ED=ED=FF =EE=E4=ED=EE=F7=E0=F1=ED=EE =E2=E2=E5= =E4=E5=ED=E8=F5 =EB=B3=EA=E0=F0=F1=FC=EA=E8=F5 =E7=E0=F1=EE=E1=B3=E2, =FF= =EA=B3 =BA =F7=F3=F2=EB=E8=E2=E8=EC=E8 =F1=F3=E1=F1=F2=F0=E0=F2=E0=EC=E8 =D0-gp. =CF=F0=E8 =EE=E4=ED=EE=F7=E0=F1=ED=EE=EC=F3 =E7=E0=F1=F2=EE=F1=F3= =E2=E0=ED=ED=B3 =E7 =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=EE=EC =EA=EB=B3=ED=B3=F7= =ED=EE =E7=ED=E0=F7=F3=F9=E8=F5 =E2=B3=E4=EC=B3=ED=ED=EE=F1=F2=E5=E9 =F3 =F4=E0=F0=EC=E0=EA=EE=EA=B3=ED=E5=F2=E8=F6=B3 =E4=E0=E1=B3=E3=E0=F2=F0= =E0=ED=F3 =E5=F2=E5=EA=F1=E8=EB=E0=F2=F3 (=F1=F3=E1=F1=F2=F0=E0=F2=F3 P-gp)= =ED=E5 =F1=EF=EE=F1=F2=E5=F0=B3=E3=E0=EB=EE=F1=FF. =CA=EB=B3=ED=B3=F7=ED=EE =E7=ED=E0=F7=F3=F9=EE=E3=EE =E2=EF=EB=E8=E2=F3 =F0= =E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =ED=E0 =B3=ED=F8=B3 =F1=F3=E1=F1=F2=F0=E0=F2= =E8 P-gp =ED=E5 =EE=F7=B3=EA=F3=BA=F2=FC=F1=FF.

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=D3 =F0= =E0=E7=B3 =E2=E8=ED=E8=EA=ED=E5=ED=ED=FF =C0=D2=C5/=C2=D2=C5 =EB=B3=EA=F3=E2=E0=ED=ED=FF =F1=EB=B3=E4 =ED=E5=E3=E0= =E9=ED=EE =EF=F0=E8=EF=E8=ED=E8=F2=E8. =CF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA= =EA=EE =EF=F0=EE=F2=E8=EF=EE=EA=E0=E7=E0=ED=E8=E9 =E6=B3=ED=EA=E0=EC =E7 =E0=F0=F2=E5=F0=B3=E0=EB=FC=ED=E8=EC=E8 =E0=E1=EE =E2=E5=ED=EE=E7=ED=E8= =EC=E8 =F2=F0=EE=EC=E1=EE=E5=EC=E1=EE=EB=B3=F7=ED=E8=EC=E8 =F0=EE=E7=EB=E0= =E4=E0=EC=E8 =ED=E8=ED=B3 =E0=E1=EE =E2 =EC=E8=ED=F3=EB=EE=EC=F3 (=E4=E8=E2. =F0=EE=E7=E4=B3=EB =AB=CF=F0=EE=F2=E8=EF=EE=EA=E0=E7=E0=ED=ED= =FF=BB).

=D4=E0=EA=F2=EE=F0=E8 =F0=E8=E7=E8=EA= =F3 =E2=E5=ED=EE=E7=ED=EE=BF =F2=F0=EE=EC=E1=EE=E5=EC=E1=EE=EB=B3=BF (=C2= =D2=C5)

=D0=E8= =E7=E8=EA =F0=EE=E7=E2=E8=F2=EA=F3 =E2=E5=ED=EE=E7=ED=E8=F5 =F2=F0=EE=EC=E1=EE=E5=EC=E1=EE=EB=B3=F7=ED=E8=F5 = =F3=F1=EA=EB=E0=E4=ED=E5=ED=FC =F3 =E6=B3=ED=EE=EA, =FF=EA=B3 =E7=E0=F1=F2= =EE=F1=EE=E2=F3=FE=F2=FC =EB=B3=EA=E0=F0=F1=FC=EA=B3 =E7=E0=F1=EE=E1=E8, =F9=EE =EC=B3=F1=F2=FF=F2=FC =E5=F1=F2=F0=EE=E3=E5=ED = =F2=E0 =E3=E5=F1=F2=E0=E3=E5=ED, =EC=EE=E6=E5 =F1=F3=F2=F2=BA=E2=EE =E7=E1= =B3=EB=FC=F8=E8=F2=E8=F1=FF =F3 =E6=B3=ED=EE=EA =E7 =E4=EE=E4=E0=F2=EA=EE=E2=E8=EC=E8 =F4=E0=EA=F2=EE=F0=E0=EC=E8 =F0=E8=E7=E8= =EA=F3, =EE=F1=EE=E1=EB=E8=E2=EE =E7=E0 =ED=E0=FF=E2=ED=EE=F1=F2=B3 =E4=E5= =EA=B3=EB=FC=EA=EE=F5 =F4=E0=EA=F2=EE=F0=B3=E2 =F0=E8=E7=E8=EA=F3 (=E4=E8=E2. =F2=E0=E1=EB=E8=F6=FE 8 =ED=E8=E6=F7=E5).

=A0=A0=A0=A0 =D2=E0=E1=EB=E8=F6= =FF 8

<= b>=D4=E0=EA=F2=EE=F0=E8 =F0=E8=E7= =E8=EA=F3 =F0=EE=E7=E2=E8=F2=EA=F3 =C2=D2=C5

=D4=E0=EA=F2=EE=F0 =F0= =E8=E7=E8=EA=F3

=CF=F0=E8=EC=B3=F2=EA= =E0

=CE=E6= =E8=F0=B3=ED=ED=FF (=B3=ED=E4=E5=EA=F1 =EC=E0=F1=E8 =F2=B3=EB=E0 (=B2=CC=D2) =E1=B3=EB=FC=F8= =E5

30 =EA= =E3/=EC2).

=D0=E8= =E7=E8=EA =E7=ED=E0=F7=ED=EE =EF=B3=E4=E2=E8=F9=F3=BA=F2=FC=F1=FF =EF=F0=E8 =E7=E1=B3=EB=FC=F8=E5=ED= =ED=B3 =B2=CC=D2.

=D2=F0=E8=E2=E0=EB=E0 =B3=EC=EC= =EE=E1=B3=EB=B3=E7=E0=F6=B3=FF, =E2=E5=EB=E8=EA=E5 =EE=EF=E5=F0=E0=F2=E8=E2=ED=E5 =E2=F2=F0=F3=F7=E0=ED=ED=FF =E0=E1=EE =E2= =E5=EB=E8=EA=B3 =F2=F0=E0=E2=EC=E8.

 =

=D3 =F2=E0=EA=E8=F5 =E2= =E8=EF=E0=E4=EA=E0=F5 =F0=E5=EA=EE=EC=E5=ED=E4=F3=BA=F2=FC=F1=FF =EF=F0=E8=EF=E8=ED=E8=F2=E8 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =EB=B3= =EA=E0=F0=F1=FC=EA=EE=E3=EE =E7=E0=F1=EE=E1=F3 (=F3 =F0=E0=E7=B3 =EF=EB=E0= =ED=EE=E2=EE=E3=EE =EE=EF=E5=F0=E0=F2=E8=E2=ED=EE=E3=EE =E2=F2=F0=F3=F7=E0=ED=ED=FF =96 =ED=E5 =EC=E5=ED=F8=E5 =ED=B3=E6 =E7=E0 4= =F2=E8=E6=ED=B3) =B3 =ED=E5 =E2=B3=E4=ED=EE=E2=EB=FE=E2=E0=F2=E8 =E7=E0=F1= =F2=EE=F1=F3=E2=E0=ED=ED=FF =F0=E0=ED=B3=F8=E5 =ED=B3=E6 =F7=E5=F0=E5=E7 2 =F2=E8=E6=ED=B3 =EF=B3=F1=EB=FF =EF=EE=E2=ED= =EE=E3=EE =E2=B3=E4=ED=EE=E2=EB=E5=ED=ED=FF =F0=F3=F5=EE=E2=EE=BF =E0=EA=F2= =E8=E2=ED=EE=F1=F2=B3.

=CE=E1= =F2=FF=E6=E5=ED=E8=E9 =F1=B3=EC=E5=E9=ED=E8=E9 =E0=ED=E0=EC=ED=E5=E7 (=E2=E8=EF=E0=E4=EA=E8 =C2=D2=C5 =F3 =E1=F0=E0=F2= =B3=E2, =F1=E5=F1=F2=E5=F0 =E0=E1=EE =E1=E0=F2=FC=EA=B3=E2, =EE=F1=EE=E1=EB= =E8=E2=EE =F3 =E2=B3=E4=ED=EE=F1=ED=EE =EC=EE=EB=EE=E4=EE=EC=F3 =E2=B3=F6=B3 =97 =E4=EE 50 =F0=EE=EA=B3=E2).

=DF=EA=F9=EE =E2=E8=ED=E8= =EA=E0=BA =EF=B3=E4=EE=E7=F0=E0 =EF=F0=EE =F1=EF=E0=E4=EA=EE=E2=F3 =F1=F5=E8=EB=FC=ED=B3=F1=F2=FC, =E6=B3=ED=EA=E0 =EF=EE=E2=E8=ED=ED=E0 =E1= =F3=F2=E8 =ED=E0=EF=F0=E0=E2=EB=E5=ED=E0 =ED=E0 =EA=EE=ED=F1=F3=EB=FC=F2=E0= =F6=B3=FE =E4=EE =F4=E0=F5=B3=E2=F6=FF =E4=EE =EF=F0=E8=E9=ED=FF=F2=F2=FF =F0=B3=F8=E5=ED=ED=FF =EF=F0=EE =E7=E0=F1=F2= =EE=F1=F3=E2=E0=ED=ED=FF =EB=B3=EA=E0=F0=F1=FC=EA=EE=E3=EE =E7=E0=F1=EE=E1= =F3

=B2=ED= =F8=B3 =F1=F2=E0=ED=E8, =EF=EE=E2=92=FF=E7=E0=ED=B3 =E7 =C2=D2=C5.

=D0=E0=EA, =F1=E8=F1=F2= =E5=EC=ED=E8=E9 =F7=E5=F0=E2=EE=ED=E8=E9 =E2=EE=E2=F7=E0=EA, =E3=E5=EC=EE=EB=B3=F2=E8=EA=EE-=F3=F0=E5=EC=B3=F7=ED=E8=E9 =F1=E8=ED=E4= =F0=EE=EC, =F5=F0=EE=ED=B3=F7=ED=E5 =E7=E0=EF=E0=EB=FC=ED=E5 =E7=E0=F5=E2= =EE=F0=FE=E2=E0=ED=ED=FF =EA=E8=F8=E5=F7=ED=E8=EA=F3 (=F5=E2=EE=F0=EE=E1=E0 =CA=F0=EE=ED=E0 =E0=E1=EE =E2=E8=F0=E0=E7=EA=EE=E2= =E8=E9 =EA=EE=EB=B3=F2) =F2=E0 =F1=E5=F0=EF=EE=EF=EE=E4=B3=E1=ED=EE=EA=EB= =B3=F2=E8=ED=ED=E0 =E0=ED=E5=EC=B3=FF.

=C7=E1= =B3=EB=FC=F8=E5=ED=ED=FF =E2=B3=EA=F3.

=CE=F1= =EE=E1=EB=E8=E2=EE =EF=EE=ED=E0=E4 35 =F0=EE=EA=B3=E2.

=CD=E5= =EE=E1=F5=B3=E4=ED=EE =E2=F0=E0=F5=EE=E2=F3=E2=E0=F2=E8 =EF=B3=E4=E2=E8=F9=E5=ED=E8=E9 =F0=E8=E7= =E8=EA =F0=EE=E7=E2=E8=F2=EA=F3 =F2=F0=EE=EC=E1=EE=E5=EC=E1=EE=EB=B3=BF =EF= =B3=E4 =F7=E0=F1 =E2=E0=E3=B3=F2=ED=EE=F1=F2=B3,=A0 =EE=F1=EE=E1=EB=E8=E2=EE =EF=F0=EE=F2= =FF=E3=EE=EC 6-=F2=E8 =F2=E8=E6=ED=B3=E2 =EF=B3=F1=EB=FF =EF=EE=EB=EE=E3=B3= =E2 (=E4=E8=E2. =F0=EE=E7=E4=B3=EB =AB=C7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =F3 = =EF=E5=F0=B3=EE=E4 =E2=E0=E3=B3=F2=ED=EE=F1=F2=B3 =E0=E1=EE =E3=EE=E4=F3=E2= =E0=ED=ED=FF =E3=F0=F3=E4=E4=FE=BB).

=D1=E8=EC=EF=F2=EE=EC=E8 =C2=D2=C5 (= =F2=F0=EE=EC=E1=EE=E7 =E3=EB=E8=E1=EE=EA=E8=F5 =E2=E5=ED =B3 =F2=F0=EE=EC=E1=EE=E5=EC=E1=EE=EB=B3=FF =EB=E5=E3=E5=ED=E5=E2=EE=BF =E0=F0= =F2=E5=F0=B3=BF)

=D3 =F0= =E0=E7=B3 =EF=EE=FF=E2=E8 =F1=E8=EC=EF=F2=EE=EC=B3=E2 =E6=B3=ED=F6=B3 =ED=E5=EE=E1=F5=B3=E4=ED=EE =EF= =EE=F0=E0=E4=E8=F2=E8 =F2=E5=F0=EC=B3=ED=EE=E2=EE =E7=E2=E5=F0=ED=F3=F2=E8= =F1=FF =E4=EE =EB=B3=EA=E0=F0=FF =F2=E0 =EF=EE=E2=B3=E4=EE=EC=E8=F2=E8 =EF=F0=EE =F2=E5, =F9=EE =E2=EE=ED=E0 =EF=F0=E8=E9=EC=E0=BA =EF=F0=E5=EF=E0= =F0=E0=F2 =D0=B3=BA=EA=EE.

=D1=E8=EC=EF=F2=EE=EC=E0=EC=E8 =F2=F0=EE=EC=E1=EE= =E7=F3 =E3=EB=E8=E1=EE=EA=E8=F5 =E2=E5=ED (=D2=C3=C2) =EC=EE=E6=F3=F2=FC = =E1=F3=F2=E8:

-&nb= sp;         = =EE=E4=ED=EE=E1=B3=F7=ED=E8=E9 =ED=E0=E1=F0=FF=EA =ED=EE=E3=E8 =F2=E0/=E0=E1=EE =F1=F2=EE=EF=E8 =E0=E1=EE = =E4=B3=EB=FF=ED=EA=E8 =F3=E7=E4=EE=E2=E6 =E2=E5=ED=E8 =ED=E0 =ED=EE=E7=B3; =

-&nb= sp;         = =E1=B3=EB=FC =E0=E1=EE =EF=B3=E4=E2=E8=F9=E5=ED=E0 =F7=F3=F2=EB=E8=E2=B3=F1=F2=FC =F3 = =ED=EE=E7=B3, =F9=EE =EC=EE=E6=E5 =E2=B3=E4=F7=F3=E2=E0=F2=E8=F1=FF =F2=B3= =EB=FC=EA=E8 =EF=F0=E8 =F1=F2=EE=FF=ED=ED=B3 =E0=E1=EE =F5=EE=E4=FC=E1=B3;

-&nb= sp;         = =E2=B3=E4=F7=F3=F2=F2=FF =E6=E0=F0=F3 =E2 =F3=F0=E0=E6=E5=ED=B3=E9 =ED=EE=E7=B3; =EF=EE=F7=E5=F0=E2= =EE=ED=B3=ED=ED=FF =E0=E1=EE =E7=EC=B3=ED=E0 =EA=EE=EB=FC=EE=F0=F3 =F8=EA= =B3=F0=E8 =ED=E0 =ED=EE=E7=B3.

=D1=E8=EC=EF=F2=EE=EC=E0=EC=E8 =F2=F0=EE=EC=E1=EE= =E5=EC=E1=EE=EB=B3=BF =EB=E5=E3=E5=ED=E5=E2=EE=BF =E0=F0=F2=E5=F0=B3=BF (= =D2E=CB=C0) =EC=EE=E6=F3=F2=FC =E1=F3=F2=E8:

-&nb= sp;         = =F0=E0=EF=F2=EE=E2=E0 =E7=E0=E4=E8=F8=EA=E0 =E7 =ED=E5=E2=B3=E4=EE=EC=EE=BF =EF=F0=E8=F7=E8=ED=E8= =E0=E1=EE =EF=F0=E8=F1=EA=EE=F0=E5=ED=E5 =E4=E8=F5=E0=ED=ED=FF;

-&nb= sp;         = =F0=E0=EF=F2=EE=E2=E8=E9 =EA=E0=F8=E5=EB=FC, =EC=EE=E6=EB=E8=E2=EE =E7 =EA=F0=EE=E2=92=FE;

-&nb= sp;         = =E3=EE=F1=F2=F0=E8=E9 =E1=B3=EB=FC =F3 =E3=F0=F3=E4=ED=B3=E9 =EA=EB=B3=F2=F6=B3;

-&nb= sp;         = =EF=E5=F0=E5=E4=ED=E5=EF=F0=E8=F2=EE=EC=ED=E8=E9 =F1=F2=E0=ED =E0=E1=EE =E7=E0=EF=E0=EC=EE=F0=EE=F7=E5=ED=ED=FF; =

-&nb= sp;         =F7=E0=F1=F2=E5 =E0=E1=EE =ED=E5= =F0=E8=F2=EC=B3=F7=ED=E5 =F1=E5=F0=F6=E5=E1=E8=F2=F2=FF.

=C4=E5=FF=EA=B3 =E7 =F6=E8=F5 =F1=E8=EC= =EF=F2=EE=EC=B3=E2 (=ED=E0=EF=F0=E8=EA=EB=E0=E4 =E7=E0=E4=E8=F8=EA=E0, =EA=E0=F8=E5=EB=FC) =BA =ED=E5=F1=EF=E5=F6=E8=F4=B3=F7=ED=E8=EC=E8 =B3 =EC= =EE=E6=F3=F2=FC =E1=F3=F2=E8 =EF=EE=EC=E8=EB=EA=EE=E2=EE =EF=F0=E8=E9=ED=FF= =F2=B3 =E7=E0 =E1=B3=EB=FC=F8 =EF=EE=F8=E8=F0=E5=ED=B3 =E0=E1=EE =EC=E5=ED=F8 =F2=FF=E6=EA=B3 =E7=E0=F5=E2=EE=F0=FE=E2=E0=ED=ED=FF (=ED=E0= =EF=F0=E8=EA=EB=E0=E4 =B3=ED=F4=E5=EA=F6=B3=BF =E4=E8=F5=E0=EB=FC=ED=E8=F5 = =F8=EB=FF=F5=B3=E2).

=D4=E0=EA=F2=EE=F0=E8 =F0=E8=E7=E8=EA=F3 =F0=EE=E7=E2=E8=F2= =EA=F3 =E0=F0=F2=E5=F0=B3=E0=EB=FC=ED=EE=BF =F2=F0=EE=EC=E1=EE=E5=EC=E1=EE=EB= =B3=BF (=C0=D2=C5)

=C5=EF=B3=E4=E5=EC=B3=EE=EB=EE=E3=B3=F7=ED=B3 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF =E0=F1=EE=F6=B3=FE=FE=F2=FC =E7=E0=F1=F2= =EE=F1=F3=E2=E0=ED=ED=FF =E5=F1=F2=F0=EE=E3=E5=ED=F3/=EF=F0=EE=E3=E5=F1=F2= =E5=F0=EE=ED=F3 =E7 =EF=B3=E4=E2=E8=F9=E5=ED=E8=EC =F0=E8=E7=E8=EA=EE=EC =F0=EE=E7=E2=E8=F2=EA=F3 =E0=F0=F2=E5=F0=B3=E0=EB=FC=ED=EE=BF =F2=F0=EE=EC= =E1=EE=E5=EC=E1=EE=EB=B3=BF (=B3=ED=F4=E0=F0=EA=F2 =EC=B3=EE=EA=E0=F0=E4=E0= ) =E0=E1=EE =EF=EE=F0=F3=F8=E5=ED=ED=FF =EC=EE=E7=EA=EE=E2=EE=E3=EE =EA=F0=EE=E2=EE=EE=E1=B3=E3=F3 (=ED=E0=EF=F0=E8=EA=EB=E0=E4, =F2=F0=E0=ED= =E7=E8=F2=EE=F0=ED=E0 =B3=F8=E5=EC=B3=F7=ED=E0 =E0=F2=E0=EA=E0, =B3=ED=F1= =F3=EB=FC=F2). =C0=F0=F2=E5=F0=B3=E0=EB=FC=ED=E0 =F2=F0=EE=EC=E1=EE=E5=EC=E1=EE=EB=B3=FF =EC=EE=E6=E5 =EF=F0=E8=E7=E2=EE=E4= =E8=F2=E8 =E4=EE =EB=E5=F2=E0=EB=FC=ED=E8=F5 =ED=E0=F1=EB=B3=E4=EA=B3=E2.

=C9=EC=EE=E2=B3=F0=ED=B3=F1=F2=FC =F0=EE=E7=E2=E8=F2=EA=F3 =E0=F0=F2=E5=F0=B3=E0=EB=FC=ED=E8=F5 =F2=F0=EE=EC= =E1=EE=E5=EC=E1=EE=EB=B3=F7=ED=E8=F5 =F3=F1=EA=EB=E0=E4=ED=E5=ED=FC =E0=E1= =EE =EF=EE=F0=F3=F8=E5=ED=ED=FF =EC=EE=E7=EA=EE=E2=EE=E3=EE =EA=F0=EE=E2=EE=EE=E1=B3=E3=F3 =EF=F0=E8 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED= =B3 =EB=B3=EA=E0=F0=F1=FC=EA=E8=F5 =E7=E0=F1=EE=E1=B3=E2, =F9=EE =EC=B3=F1= =F2=FF=F2=FC =E5=F1=F2=F0=EE=E3=E5=ED =F2=E0 =EF=F0=EE=E3=E5=F1=F2=E5=F0=EE=ED, =EC=EE=E6=E5 =F1=F3=F2=F2=BA=E2= =EE =E7=E1=B3=EB=FC=F8=E8=F2=E8=F1=FF =F3 =E6=B3=ED=EE=EA =E7 =E4=EE=E4=E0= =F2=EA=EE=E2=E8=EC=E8 =F4=E0=EA=F2=EE=F0=E0=EC=E8 =F0=E8=E7=E8=EA=F3, =EE=F1=EE=E1=EB=E8=E2=EE =E7=E0 =ED=E0=FF=E2=ED=EE=F1= =F2=B3 =E4=E5=EA=B3=EB=FC=EA=EE=F5 =F4=E0=EA=F2=EE=F0=B3=E2 =F0=E8=E7=E8=EA= =F3 (=E4=E8=E2. =F2=E0=E1=EB=E8=F6=FE 9 =ED=E8=E6=F7=E5).

=A0=A0=A0=A0=A0 =D2=E0=E1=EB=E8= =F6=FF 9

<= b>=D4=E0=EA=F2=EE=F0=E8 =F0=E8=E7= =E8=EA=F3 =F0=EE=E7=E2=E8=F2=EA=F3 =C0=D2=C5

=D4=E0=EA=F2=EE=F0 =F0= =E8=E7=E8=EA=F3

=CF=F0=E8=EC=B3=F2=EA= =E0

=C7=E1= =B3=EB=FC=F8=E5=ED=ED=FF =E2=B3=EA=F3

=CE=F1=EE=E1=EB=E8=E2=EE = =EF=EE=ED=E0=E4 35 =F0=EE=EA=B3=E2.

=CF=E0= =EB=B3=ED=ED=FF

=C6=B3=ED=EA=E0=EC =F1=EB= =B3=E4 =F0=E5=EA=EE=EC=E5=ED=E4=F3=E2=E0=F2=E8 =E2=B3=E4=EC=EE=E2=E8=F2=E8=F1=FF =E2=B3=E4 =EF=E0=EB=B3=ED=ED=FF, =FF=EA= =F9=EE =E2=EE=ED=E8 =E1=E0=E6=E0=FE=F2=FC =E7=E0=F1=F2=EE=F1=EE=E2=F3=E2=E0= =F2=E8 =F6=E5=E9 =EB=B3=EA=E0=F0=F1=FC=EA=E8=E9 =E7=E0=F1=B3=E1

=C0=F0= =F2=E5=F0=B3=E0=EB=FC=ED=E0 =E3=B3=EF=E5=F0=F2=E5=ED=E7=B3=FF

 

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30 =EA= =E3/=EC2)

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=CE=E1= =F2=FF=E6=E5=ED=E8=E9 =F1=B3=EC=E5=E9=ED=E8=E9 =E0=ED=E0=EC=ED=E5=E7 (=E2=E8=EF=E0=E4=EA=E8 =C0= =D2=C5 =F3 =E1=F0=E0=F2=B3=E2, =F1=E5=F1=F2=E5=F0 =E0=E1=EE =E1=E0=F2=FC=EA= =B3=E2, =EE=F1=EE=E1=EB=E8=E2=EE =F3 =E2=B3=E4=ED=EE=F1=ED=EE =F0=E0=ED=ED=FC=EE=EC=F3 =E2=B3=F6=B3 =97 =E4=EE= 50 =F0=EE=EA=B3=E2)

=DF=EA= =F9=EE =E2=E8=ED=E8=EA=E0=BA =EF=B3=E4=EE=E7=F0=E0 =EF=F0=EE =F1=EF=E0=E4=EA=EE=E2=F3 =F1=F5=E8=EB=FC= =ED=B3=F1=F2=FC, =E6=B3=ED=EA=E0 =EF=EE=E2=E8=ED=ED=E0 =E1=F3=F2=E8 =ED=E0= =EF=F0=E0=E2=EB=E5=ED=E0 =ED=E0 =EA=EE=ED=F1=F3=EB=FC=F2=E0=F6=B3=FE =E4=EE =F4=E0=F5=B3=E2=F6=FF =E4=EE = =EF=F0=E8=E9=ED=FF=F2=F2=FF =F0=B3=F8=E5=ED=ED=FF =EF=F0=EE =E7=E0=F1=F2=EE= =F1=F3=E2=E0=ED=ED=FF =EB=B3=EA=E0=F0=F1=FC=EA=EE=E3=EE =E7=E0=F1=EE=E1=F3.

=CC=B3= =E3=F0=E5=ED=FC

=CF=B3= =E4=E2=E8=F9=E5=ED=ED=FF =F7=E0=F1=F2=EE=F2=E8 =E0=E1=EE =F2=FF=E6=EA=EE=F1=F2=B3 =EF=E5=F0=E5=E1= =B3=E3=F3 =EC=B3=E3=F0=E5=ED=B3 =EF=B3=E4 =F7=E0=F1 =E7=E0=F1=F2=EE=F1=F3= =E2=E0=ED=ED=FF =EB=B3=EA=E0=F0=F1=FC=EA=EE=E3=EE =E7=E0=F1=EE=E1=F3 (=F9=EE =EC=EE=E6=E5 =E1=F3=F2=E8 =EF=F0=EE=E2=B3=F1=ED=E8=EA=EE=EC =EF= =EE=F0=F3=F8=E5=ED=ED=FF =EC=EE=E7=EA=EE=E2=EE=E3=EE =EA=F0=EE=E2=EE=EE=E1= =B3=E3=F3) =EC=EE=E6=E5 =F1=F2=E0=F2=E8 =EE=E1=B4=F0=F3=ED=F2=F3=E2=E0=ED=ED=FF=EC =E4=EB=FF =ED=E5=E3=E0=E9=ED= =EE=E3=EE =EF=F0=E8=EF=E8=ED=E5=ED=ED=FF =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED= =FF =EF=F0=E5=EF=E0=F0=E0=F2=F3.

=B2=ED= =F8=B3 =F1=F2=E0=ED=E8, =E0=F1=EE=F6=B3=E9=EE=E2=E0=ED=B3 =E7 =ED=E5=E1=E0=E6=E0=ED=E8=EC=E8 =F0=E5=E0=EA=F6=B3=FF=EC=E8 =E7 =E1=EE=EA=F3 =F1=F3=E4=E8=ED

=D6=F3= =EA=F0=EE=E2=E8=E9 =E4=B3=E0=E1=E5=F2, =E3=B3=EF=E5=F0=E3=EE=EC=EE=F6=E8=F1=F2=E5=BF=ED=E5= =EC=B3=FF, =E2=E0=E4=E8 =EA=EB=E0=EF=E0=ED=B3=E2 =F1=E5=F0=F6=FF =B3 =F4=B3=E1=F0=E8=EB=FF=F6=B3=FF = =EF=E5=F0=E5=E4=F1=E5=F0=E4=FC, =E4=E8=F1=EB=B3=EF=EE=EF=F0=EE=F2=E5=BF=ED=E5=EC=B3=FF =F2=E0 =F1=E8=F1= =F2=E5=EC=ED=E8=E9 =F7=E5=F0=E2=EE=ED=E8=E9 =E2=EE=E2=F7=E0=EA.

=D1=E8=EC= =EF=F2=EE=EC=E8 ATE

=C6=B3= =ED=EA=E8 =EF=EE=E2=E8=ED=ED=B3 =E1=F3=F2=E8 =EF=EE=B3=ED=F4=EE=F0=EC=EE=E2=E0=ED=B3 =EF=F0=EE =F2=E5, =F9= =EE =E2 =F0=E0=E7=B3 =E2=E8=ED=E8=EA=ED=E5=ED=ED=FF =F1=E8=EC=EF=F2=EE=EC= =B3=E2 =BF=EC =F1=EB=B3=E4 =E7=E2=E5=F0=ED=F3=F2=E8=F1=FF =E7=E0 =ED=E5=E2=B3=E4=EA=EB=E0=E4=ED=EE=FE =EC=E5=E4=E8=F7=ED=EE=FE =E4=EE=EF=EE= =EC=EE=E3=EE=FE =B3 =EF=EE=E2=B3=E4=EE=EC=E8=F2=E8 =EC=E5=E4=E8=F7=ED=EE=EC= =F3 =EF=F0=E0=F6=B3=E2=ED=E8=EA=F3 =EF=F0=EE =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =EB=B3=EA=E0=F0=F1=FC=EA=EE=E3=EE =E7= =E0=F1=EE=E1=F3 =D0=B3=BA=EA=EE.

=D1=E8=EC= =EF=F2=EE=EC=E0=EC=E8 =EF=EE=F0=F3=F8=E5=ED=ED=FF =EC=EE=E7=EA=EE=E2=EE=E3=EE =EA=F0=EE=E2=EE=EE=E1=B3=E3=F3 =EC=EE=E6=F3=F2=FC =E1=F3=F2=E8:

-        = ;  =F0=E0=EF=F2=EE=E2=B3 =F1=EB=E0= =E1=EA=B3=F1=F2=FC =E0=E1=EE =EE=ED=B3=EC=B3=ED=ED=FF =EE=E1=EB=E8=F7=F7=FF, =ED=EE=E3=E8 =E0=E1=EE =F0=F3=EA=E8, =EE=F1=EE=E1=EB= =E8=E2=EE =EE=E4=ED=EE=E1=B3=F7=ED=B3;

-        = ;  =F0=E0=EF=F2=EE=E2=E5 =EF=EE=F0= =F3=F8=E5=ED=ED=FF =F5=EE=E4=E8, =E7=E0=EF=E0=EC=EE=F0=EE=F7=E5=ED=ED=FF, =E2=F2=F0=E0=F2=E0 =F0=B3=E2=ED=EE= =E2=E0=E3=E8 =E0=E1=EE =EA=EE=EE=F0=E4=E8=ED=E0=F6=B3=BF;

-        = ;  =F0=E0=EF=F2=EE=E2=E0 =F1=EF=EB= =F3=F2=E0=ED=B3=F1=F2=FC =F1=E2=B3=E4=EE=EC=EE=F1=F2=B3, =EF=EE=F0=F3=F8=E5=ED=ED=FF =EC=EE=E2=EB=E5=ED=ED=FF =E0=E1=EE =F0=EE=E7=F3= =EC=B3=ED=ED=FF;

-        = ;  =F0=E0=EF=F2=EE=E2=E5 =EF=EE=E3= =B3=F0=F8=E5=ED=ED=FF =E7=EE=F0=F3 =ED=E0 =EE=E4=ED=E5 =E0=E1=EE =EE=E1=E8=E4=E2=E0 =EE=EA=E0;

-        = ;  =F0=E0=EF=F2=EE=E2=E8=E9 =F1=E8= =EB=FC=ED=E8=E9 =E0=E1=EE =F2=F0=E8=E2=E0=EB=E8=E9 =E3=EE=EB=EE=E2=ED=E8=E9 =E1=B3=EB=FC =E1=E5=E7 =E2=E8=E7=ED=E0=F7=E5=ED=EE= =BF =EF=F0=E8=F7=E8=ED=E8;

-        = ;  =E2=F2=F0=E0=F2=E0 =F1=E2=B3=E4= =EE=EC=EE=F1=F2=B3 =E0=E1=EE =ED=E5=EF=F0=E8=F2=EE=EC=ED=B3=F1=F2=FC =B3=E7 =F1=F3=E4=EE=EC=E0=EC=E8 =E0=E1=EE =E1=E5=E7.

=D2=E8=EC= =F7=E0=F1=EE=E2=B3=F1=F2=FC =F1=E8=EC=EF=F2=EE=EC=B3=E2 =F1=E2=B3=E4=F7=E8=F2=FC =EF=F0=EE =F2=F0=E0=ED= =E7=E8=F2=EE=F0=ED=F3 =B3=F8=E5=EC=B3=F7=ED=F3 =E0=F2=E0=EA=F3. =

=D1=E8=EC= =EF=F2=EE=EC=E0=EC=E8 =B3=ED=F4=E0=F0=EA=F2=F3 =EC=B3=EE=EA=E0=F0=E4=E0 =EC=EE=E6=F3=F2=FC =E1=F3= =F2=E8:

-        = ;  =E1=B3=EB=FC, =E4=E8=F1=EA=EE=EC= =F4=EE=F0=F2, =F2=E8=F1=EA, =F2=FF=E6=EA=B3=F1=F2=FC, =E2=B3=E4=F7=F3=F2=F2=FF =F1=F2=E8=F1=EA=E0=ED=ED=FF =E0=E1=EE =F0=EE=E7=EF= =E8=F0=E0=ED=ED=FF =F3 =E3=F0=F3=E4=FF=F5, =F0=F3=F6=B3 =E0=E1=EE =E7=E0 = =E3=F0=F3=E4=ED=E8=ED=EE=FE;

-        = ;  =E4=E8=F1=EA=EE=EC=F4=EE=F0=F2 = =E7 =B3=F0=F0=E0=E4=B3=E0=F6=B3=BA=FE =F3 =F1=EF=E8=ED=F3, =ED=E8=E6=ED=FE =F9=E5=EB=E5=EF=F3, =E3=EE=F0=EB=EE, =F0=F3=EA=F3, =F8=EB= =F3=ED=EE=EA;

-        = ;  =E2=B3=E4=F7=F3=F2=F2=FF =EF=E5= =F0=E5=EF=EE=E2=ED=E5=ED=ED=FF =F8=EB=F3=ED=EA=E0, =EF=EE=F0=F3=F8=E5=ED=ED=FF =F2=F0=E0=E2=EB=E5=ED=ED=FF =E0=E1=EE =FF=E4=F3= =F5=E0;

-        = ;  =EF=EE=F1=E8=EB=E5=ED=E5 =EF=EE= =F2=EE=E2=E8=E4=B3=EB=E5=ED=ED=FF, =ED=F3=E4=EE=F2=E0, =E1=EB=FE=E2=E0=ED=ED=FF =E0=E1=EE =E7=E0=EF=E0=EC=EE=F0=EE=F7=E5=ED=ED=FF;=

-        = ;  =F1=E8=EB=FC=ED=E0 =F1=EB=E0=E1= =EA=B3=F1=F2=FC, =F2=F0=E8=E2=EE=E3=E0 =E0=E1=EE =E7=E0=E4=E8=F8=EA=E0;

-        = ;  =F8=E2=E8=E4=EA=E5 =E0=E1=EE =ED= =E5=F0=E8=F2=EC=B3=F7=ED=E5 =F1=E5=F0=F6=E5=E1=E8=F2=F2=FF.

=D0= =E8=E7=E8=EA =E2=F2=F0=E0=F2=E8 =EA=B3=F1=F2=EA=EE=E2=EE=BF =EC=E0=F1=E8

=CF= =B3=F1=EB=FF =EF=EE=F7=E0=F2=EA=EE=E2=EE=E3=EE =EA=EB=B3=ED=B3=F7=ED=EE =ED=E5=E7=ED=E0= =F7=ED=EE=E3=EE =E7=ED=E8=E6=E5=ED=ED=FF =EC=B3=ED=E5=F0=E0=EB=FC=ED=EE=BF = =F9=B3=EB=FC=ED=EE=F1=F2=B3 =EA=B3=F1=F2=EA=EE=E2=EE=BF =F2=EA=E0=ED=E8=ED=E8 (=CC=D9=CA=D2) =F7=E5=F0=E5=E7 12‒24 = =F2=E8=E6=ED=B3 =EF=F0=E8=E9=EE=EC=F3 =EF=F0=E5=EF=E0=F0=E0=F2=F3 =EF=EE=EA=E0=E7=ED=E8=EA = =CC=D9=CA=D2 =F1=F2=E0=E1=B3=EB=B3=E7=F3=BA=F2=FC=F1=FF =B3 =ED=E0=E4=E0=EB= =B3 =E7=E0=EB=E8=F8=E0=BA=F2=FC=F1=FF =F1=F2=E0=E1=B3=EB=FC=ED=E8=EC (=E7=E0 =F0=E5=E7=F3=EB=FC=F2=E0=F2=E0=EC=E8 =F1=EF=EE=F1=F2=E5=F0=E5=E6=E5= =ED=FC =E7=E0 2 =F0=EE=EA=E8). =D1=E5=F0=E5=E4=ED=BA =E7=ED=E8=E6=E5=ED=ED= =FF =CC=D9=CA=D2 =EF=F0=EE=F2=FF=E3=EE=EC =EF=E5=F0=F8=EE=E3=EE =F0=EE=EA=F3 =EF=F0=E8=E9=EE=EC=F3 =EF=F0=E5=EF=E0=F0= =E0=F2=F3 =D0=B3=BA=EA=EE =F1=F2=E0=ED=EE=E2=E8=F2=FC 0,69 %.

=CF= =F0=EE=F2=E5 =F3 21 % =EF=E0=F6=B3=BA=ED=F2=EE=EA =F1=EF=EE=F1=F2=E5=F0=B3=E3=E0=EB=EE=F1=FF =E7= =ED=E8=E6=E5=ED=ED=FF =CC=D9=CA=D2 =ED=E0 =EF=EE=ED=E0=E4 3 %. =D2=EE=EC=F3= =F0=E5=EA=EE=EC=E5=ED=E4=F3=BA=F2=FC=F1=FF =EF=F0=EE=E2=E5=F1=F2=E8 =EF=EE=E4=E2=B3=E9=ED=F3 =F0=E5=ED=F2=E3=E5=ED=B3=E2=F1=FC=EA=F3 =E0= =E1=F1=EE=F0=E1=F6=B3=EE=EC=E5=F2=F0=B3=FE (=CF=D0=C0) =EF=B3=F1=EB=FF =EF=E5=F0=F8=E8=F5= 52 =F2=E8=E6=ED=B3=E2 =EB=B3=EA=F3=E2=E0=ED=ED=FF =F2=E0 =EF=EE=E2=F2=EE=F0=FE=E2=E0=F2=E8 =BF=BF =F3 =F0=E0=E7=B3 =EF=EE=F2=F0=E5= =E1=E8. =C7=E0=EB=E5=E6=ED=EE =E2=B3=E4 =F1=F2=F3=EF=E5=ED=FF =E7=EC=B3=ED= =E8 =CC=D9=CA=D2 =EC=EE=E6=E5 =E1=F3=F2=E8 =ED=E5=EE=E1=F5=B3=E4=ED=E8=EC =EF=E5=F0=E5=E3=EB=FF=E4 =F1=EF=B3=E2=E2=B3= =E4=ED=EE=F8=E5=ED=ED=FF =EA=EE=F0=E8=F1=F2=FC/=F0=E8=E7=E8=EA =E7=E0=F1=F2= =EE=F1=F3=E2=E0=ED=ED=FF =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE. =

=CF= =E5=F0=E5=E4 =EF=EE=F7=E0=F2=EA=EE=EC =EB=B3=EA=F3=E2=E0=ED=ED=FF =F1=EB=B3=E4 =E2=F0=E0= =F5=EE=E2=F3=E2=E0=F2=E8 =EF=E5=F0=E5=E2=E0=E3=E8 =F2=E0 =F0=E8=E7=E8=EA=E8= =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA= =EA=EE =F3 =EF=E0=F6=B3=BA=ED=F2=EE=EA =E7 =EF=E5=F0=E5=EB=EE=EC=EE=EC =EF=F0=E8 = =ED=E5=E7=ED=E0=F7=ED=B3=E9 =F2=F0=E0=E2=EC=B3 =E2 =E0=ED=E0=EC=ED=E5=E7=B3= =E0=E1=EE =B3=ED=F8=E8=EC=E8 =F4=E0=EA=F2=EE=F0=E0=EC=E8 =F0=E8=E7=E8=EA=F3 =EE=F1=F2=E5=EE=EF=EE=F0=EE=E7=F3 =F7=E8 =E2=F2=F0=E0=F2= =E8 =EA=B3=F1=F2=EA=EE=E2=EE=BF =F2=EA=E0=ED=E8=ED=E8, =E2=EA=EB=FE=F7=E0= =FE=F7=E8 =F2=E8=F5, =F5=F2=EE =EF=F0=E8=E9=EC=E0=BA =EB=B3=EA=E0=F0=F1=FC= =EA=B3 =E7=E0=F1=EE=E1=E8, =F9=EE =EC=EE=E6=F3=F2=FC =E2=EF=EB=E8=E2=E0=F2=E8 =ED= =E0 =CC=D9=CA=D2. =CF=E5=F0=E5=E4 =EF=EE=F7=E0=F2=EA=EE=EC =EF=F0=E8=E9=EE= =EC=F3 =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =F3 =F6=E8=F5 =EF=E0=F6=B3=BA=ED=F2=EE=EA =F0=E5=EA=EE=EC=E5=ED=E4=F3=BA=F2=FC= =F1=FF =EF=F0=EE=E2=E5=F1=F2=E8 =CF=D0=C0. =CD=E5 =F1=EB=B3=E4 =E7=E0=F1=F2= =EE=F1=EE=E2=F3=E2=E0=F2=E8 =EF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA=EA=EE, =FF=EA=F9=EE =F0=E8=E7=E8=EA, =EF=EE=E2=92=FF=E7=E0=ED=E8=E9 =B3=E7 =E2=F2= =F0=E0=F2=EE=FE =CC=D9=CA=D2, =EF=E5=F0=E5=E2=E8=F9=F3=BA =EF=EE=F2=E5=ED= =F6=B3=E9=ED=F3 =EA=EE=F0=E8=F1=F2=FC =E2=B3=E4 =EB=B3=EA=F3=E2=E0=ED=ED=FF.

=CF=F3=F5=EB=E8=ED=E8 =EF=E5=F7=B3=ED=EA=E8 =E0=E1=EE =E7=E0=F5=E2=EE= =F0=FE=E2=E0=ED=ED=FF =EF=E5=F7=B3=ED=EA=E8

=CF=F0= =E5=EF=E0=F0=E0=F2 =EF=F0=EE=F2=E8=EF=EE=EA=E0=E7=E0=ED=E8=E9 =E6=B3=ED=EA=E0=EC =E7 =E4=EE=E1= =F0=EE=FF=EA=B3=F1=ED=E8=EC=E8 =E0=E1=EE =E7=EB=EE=FF=EA=B3=F1=ED=E8=EC=E8 = =EF=F3=F5=EB=E8=ED=E0=EC=E8 =EF=E5=F7=B3=ED=EA=E8 =F7=E8 =E7=E0=F5=E2=EE=F0=FE=E2=E0=ED=ED=FF=EC=E8 =EF=E5=F7=B3=ED=EA=E8, =EF=EE=EA= =E8 =EF=EE=EA=E0=E7=ED=E8=EA=E8 =F4=F3=ED=EA=F6=B3=BF =EF=E5=F7=B3=ED=EA=E8= =ED=E5 =ED=EE=F0=EC=E0=EB=B3=E7=F3=FE=F2=FC=F1=FF (=E4=E8=E2. =F0=EE=E7=E4=B3=EB =AB=CF=F0=EE=F2=E8=EF=EE=EA=E0=E7=E0=ED=ED=FF=BB). =DF= =EA=F9=EE =F0=EE=E7=E2=E8=E2=E0=BA=F2=FC=F1=FF =E6=EE=E2=F2=FF=ED=E8=F6=FF,= =EB=B3=EA=F3=E2=E0=ED=ED=FF =F1=EB=B3=E4 =EF=F0=E8=EF=E8=ED=E8=F2=E8.

=D3 =EA= =EB=B3=ED=B3=F7=ED=E8=F5 =E4=EE=F1=EB=B3=E4=E6=E5=ED=ED=FF=F5 =E1=E5=E7=F1=E8=EC=EF=F2=EE=EC=ED=E5 = =F2=E8=EC=F7=E0=F1=EE=E2=E5 =EF=B3=E4=E2=E8=F9=E5=ED=ED=FF =F0=B3=E2=ED=FF = =E0=EB=E0=ED=B3=ED=E0=EC=B3=ED=EE=F2=F0=E0=ED=F1=F4=E5=F0=E0=E7=E8 (=C0=CB=D2) =F3 =F1=E8=F0=EE=E2=E0=F2=F6=B3 =EA=F0=EE=E2=B3, =FF=EA=E5 =F9= =EE=ED=E0=E9=EC=E5=ED=F8=E5 =E2 3 =F0=E0=E7=E8 =EF=E5=F0=E5=E2=E8=F9=F3=BA = =E2=E5=F0=F5=ED=FE =EC=E5=E6=F3 =ED=EE=F0=EC=E8, =F1=EF=EE=F1=F2=E5=F0=B3=E3=E0=EB=EE=F1=FF =F3 < 1 % =F3=F7=E0=F1=ED=E8= =EA=B3=E2, =FF=EA=B3 =EE=F2=F0=E8=EC=F3=E2=E0=EB=E8 =EF=F0=E5=EF=E0=F0=E0= =F2 =D0=B3=BA=EA=EE. =D0=E0=EF=F2=EE=E2=B3 =E2=B3=E4=F5=E8=EB=E5=ED=ED=FF =EF=EE=EA=E0=E7=ED=E8=EA=B3=E2 =F4=F3=ED=EA= =F6=B3=BF =EF=E5=F7=B3=ED=EA=E8 =EC=EE=E6=F3=F2=FC =EF=F0=E8=E7=E2=E5=F1=F2= =E8 =E4=EE =ED=E5=EE=E1=F5=B3=E4=ED=EE=F1=F2=B3 =EF=F0=E8=EF=E8=ED=E5=ED=ED= =FF =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA= =EA=EE, =EF=EE=EA=E8 =EF=EE=EA=E0=E7=ED=E8=EA=E8 =F4=F3=ED=EA=F6=B3=BF =EF= =E5=F7=B3=ED=EA=E8 =ED=E5 =ED=EE=F0=EC=E0=EB=B3=E7=F3=FE=F2=FC=F1=FF.

=CF= =EE=F0=F3=F8=E5=ED=ED=FF =F4=F3=ED=EA=F6=B3=BF =ED=E8=F0=EE=EA

=C5=EA= =F1=EF=EE=E7=E8=F6=B3=FF =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3 =E7=E1=B3=EB=FC=F8=F3=BA=F2=FC=F1=FF =F3 = =EF=E0=F6=B3=BA=ED=F2=B3=E2 =E7 =EF=EE=F0=F3=F8=E5=ED=ED=FF=EC =F4=F3=ED=EA= =F6=B3=BF =ED=E8=F0=EE=EA =EF=EE=EC=B3=F0=ED=EE=E3=EE =E0=E1=EE =F2=FF=E6=EA=EE=E3=EE =F1=F2=F3=EF=E5=ED=FF (=E4=E8=E2. =F0=EE=E7=E4=B3=EB = =AB=D4=E0=F0=EC=E0=EA=EE=EA=B3=ED=E5=F2=E8=EA=E0=BB), =EF=F0=EE=F2=E5 =EA= =EE=F0=E8=E3=F3=E2=E0=ED=ED=FF =E4=EE=E7=E8 =ED=E5 =EF=EE=F2=F0=B3=E1=ED=E5 (=E4=E8=E2. =F0=EE=E7=E4=B3=EB =AB=D1=EF=EE=F1=B3= =E1 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =F2=E0 =E4=EE=E7=E8=BB). =CA=B3=EB= =FC=EA=B3=F1=F2=FC =F0=E5=EB=F3=E3=EE=EB=B3=EA=F1=F3, =F9=EE =EC=EE=E6=E5 =E1=F3=F2=E8 =E2=E8=E2=E5=E4=E5=ED=E0 =F8=EB=FF=F5=EE=EC =E3= =E5=EC=EE=E4=B3=E0=EB=B3=E7=F3, =ED=E5=E2=B3=E4=EE=EC=E0.

=C7= =EC=B3=ED=E0 =E3=F0=E0=F4=B3=EA=E0 =EC=E5=ED=F1=F2=F0=F3=E0=EB=FC=ED=E8=F5 =EA=F0=EE=E2=EE=F2=E5=F7

=CF=E0= =F6=B3=BA=ED=F2=E0=EC =F1=EB=B3=E4 =EF=EE=E2=B3=E4=EE=EC=E8=F2=E8, =F9=EE =EB=B3=EA=F3=E2=E0=ED=ED=FF =EF=F0= =E5=EF=E0=F0=E0=F2=EE=EC =D0=B3=BA=EA=EE =E7=E0=E7=E2=E8=F7=E0=E9 =EF=F0=E8= =E7=E2=EE=E4=E8=F2=FC =E4=EE =E7=EC=E5=ED=F8=E5=ED=ED=FF =EC=E5=ED=F1=F2=F0=F3=E0=EB=FC=ED=EE=BF =EA=F0=EE=E2=EE=E2=F2=F0=E0=F2=E8 = =E0=E1=EE =E4=EE =E0=EC=E5=ED=EE=F0=E5=BF =EF=F0=EE=F2=FF=E3=EE=EC =EF=E5= =F0=F8=E8=F5 2 =EC=B3=F1=FF=F6=B3=E2 =EB=B3=EA=F3=E2=E0=ED=ED=FF.

=D3 =E6= =B3=ED=EE=EA, =FF=EA=B3 =EE=F2=F0=E8=EC=F3=E2=E0=EB=E8 =EF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA=EA=EE =E4=EB=FF =EB=B3=EA=F3=E2=E0=ED=ED=FF =EC=B3=EE= =EC=E8 =EC=E0=F2=EA=E8, =ED=E0=E9=B3=EC=EE=E2=B3=F0=ED=B3=F8=E5 =E2= =E8=ED=E8=EA=E0=EB=E0 =E0=EC=E5=ED=EE=F0=E5=FF (51,6 %) =E0=E1=EE =EF=E5=F0=B3=EE=E4=E8=F7=ED=B3 = =EA=F0=EE=E2=EE=F2=E5=F7=B3 (15,4 %), =F2=E0=EA=EE=E6 =E1=F3=E2 =ED=E5=F0= =E5=E3=F3=EB=FF=F0=ED=E8=E9 =F5=E0=F0=E0=EA=F2=E5=F0 =EA=F0=EE=E2=EE=F2=E5=F7 (31,9 %) =EF=F0=E8 =EE=F6= =B3=ED=F6=B3 =EF=F0=EE=F2=FF=E3=EE=EC 24 =F2=E8=E6=ED=B3=E2. =CA=F0=B3=EC = =F2=EE=E3=EE, =EF=F0=E8 =EE=F6=B3=ED=F6=B3 =ED=E0 52 =F2=E0 104 =F2=E8=E6=ED=FF=F5 70,6 % =F2=E0 58,3 % =E6=B3=ED=EE= =EA =E2=B3=E4=EF=EE=E2=B3=E4=ED=EE, =FF=EA=B3 =EE=F2=F0=E8=EC=F3=E2=E0=EB= =E8 =EF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA=EA=EE, =E9=EC=EE=E2=B3=F0=ED=EE =EC=E0=EB=E8 =E0=EC=E5=ED=EE=F0= =E5=FE.

=D3 =E1= =B3=EB=FC=F8=EE=F1=F2=B3 =EF=E0=F6=B3=BA=ED=F2=EE=EA =E7 =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=EE=EC (65= ,2 %) =ED=E0 24-=EC=F3 =F2=E8=E6=ED=B3 =EB=B3=EA=F3=E2=E0=ED=ED=FF =F1=EF= =EE=F1=F2=E5=F0=B3=E3=E0=EB=E0=F1=FF =E0=EC=E5=ED=EE=F0=E5=FF. =CD=E0 52-=EC=F3 =F2=E0 104-=EC=F3 =F2=E8=E6=ED= =FF=F5 =BF=F5=ED=FF =F7=E0=F1=F2=EA=E0 =E7=E1=B3=EB=FC=F8=E8=EB=E0=F1=FF = =E4=EE 76,6 % =F2=E0 82,3 % =E2=B3=E4=EF=EE=E2=B3=E4=ED=EE.

=D3 =F0= =E0=E7=B3 =EF=EE=F1=F2=B3=E9=ED=EE=BF =ED=E0=E4=EC=B3=F0=ED=EE=BF =EA=F0=EE=E2=EE=F2=E5=F7=B3 =EF=E0=F6=B3=BA=ED= =F2=EA=E0 =EF=EE=E2=E8=ED=ED=E0 =E7=E2=E5=F0=ED=F3=F2=E8=F1=FC =E4=EE =EB= =B3=EA=E0=F0=FF.

=CA= =EE=ED=F2=F0=E0=F6=E5=EF=F2=E8=E2=ED=B3 =E2=EB=E0=F1=F2=E8=E2=EE=F1=F2=B3 =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA= =EE

=CF=F0= =E5=EF=E0=F0=E0=F2 =D0=B3=BA=EA=EE =E7=E0=E1=E5=E7=EF=E5=F7=F3=BA =E0=E4=E5=EA=E2=E0=F2=ED=F3 =EA=EE=ED=F2=F0= =E0=F6=E5=EF=F6=B3=FE =EF=F0=E8 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=B3 =EF=F0= =E8=ED=E0=E9=EC=ED=B3 =EF=F0=EE=F2=FF=E3=EE=EC 1 =EC=B3=F1=FF=F6=FF (=E4=E8=E2. =F0=EE=E7=E4=B3=EB =AB=D1=EF=EE=F1=B3=E1 =E7=E0=F1=F2=EE=F1=F3= =E2=E0=ED=ED=FF =F2=E0 =E4=EE=E7=E8=BB). =CE=E4=ED=E0=EA =E6=B3=ED=EA=E0=EC= =F0=E5=EF=F0=EE=E4=F3=EA=F2=E8=E2=ED=EE=E3=EE =E2=B3=EA=F3 =F1=EB=B3=E4 =EF=EE=E2=B3=E4=EE=EC=E8=F2=E8, =F9=EE =EE=E2=F3=EB=FF=F6=B3= =FF =F8=E2=E8=E4=EA=EE =E2=B3=E4=ED=EE=E2=E8=F2=FC=F1=FF =EF=B3=F1=EB=FF = =EF=F0=E8=EF=E8=ED=E5=ED=ED=FF =EB=B3=EA=F3=E2=E0=ED=ED=FF. =D2=EE=EC=F3 =F1=EB=B3=E4 =EF=EE=F7=E0=F2=E8 =E7=E0=F1=F2=EE=F1=EE=E2=F3=E2= =E0=F2=E8 =E0=EB=FC=F2=E5=F0=ED=E0=F2=E8=E2=ED=E8=E9 =EC=E5=F2=EE=E4 =EA=EE= =ED=F2=F0=E0=F6=E5=EF=F6=B3=BF =E2=B3=E4=F0=E0=E7=F3 =EF=B3=F1=EB=FF =EF=F0=E8=EF=E8=ED=E5=ED=ED=FF =EB=B3=EA=F3=E2=E0=ED=ED=FF.

=C7=ED=E8=E6=E5=ED=ED=FF =E7=E4=E0=F2=ED=EE=F1=F2=B3 =F0=EE=E7=EF= =B3=E7=ED=E0=E2=E0=F2=E8 =E2=E0=E3=B3=F2=ED=B3=F1=F2=FC

=D3 =E6= =B3=ED=EE=EA, =FF=EA=B3 =EF=F0=E8=E9=EC=E0=FE=F2=FC =EF=F0=E5=EF=E0=F0=E0=F2 =D0=B3=BA=EA=EE, =F7= =E0=F1=F2=EE =F1=EF=EE=F1=F2=E5=F0=B3=E3=E0=BA=F2=FC=F1=FF =E0=EC=E5=ED=EE= =F0=E5=FF =E0=E1=EE =E7=EC=E5=ED=F8=E5=ED=ED=FF =EA=B3=EB=FC=EA=EE=F1=F2=B3, =B3=ED=F2=E5=ED=F1=E8=E2=ED=EE=F1=F2=B3 =E0=E1= =EE =F2=F0=E8=E2=E0=EB=EE=F1=F2=B3 =EC=E5=ED=F1=F2=F0=F3=E0=EB=FC=ED=E8=F5 = =EA=F0=EE=E2=EE=F2=E5=F7.

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=C4= =EE=EF=EE=EC=B3=E6=ED=B3 =F0=E5=F7=EE=E2=E8=ED=E8

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=C6= =B3=ED=EA=E8 =F0=E5=EF=F0=EE=E4=F3=EA=F2=E8=E2=ED=EE=E3=EE =E2=B3=EA=F3

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=C2=E0=E3=B3=F2=ED=B3=F1=F2=FC

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=C2=B3= =E4=EE=EC=EE, =F9=EE =F3 =E4=B3=F2=E5=E9, =EC=E0=F2=E5=F0=B3 =FF=EA=E8=F5 =ED=E5=ED=E0=E2=EC=E8=F1= =ED=EE =E7=E0=F1=F2=EE=F1=EE=E2=F3=E2=E0=EB=E8 =E5=F1=F2=F0=EE=E3=E5=ED=E8 = =F2=E0 =EF=F0=EE=E3=E5=F1=F2=E0=E3=E5=ED=E8 =FF=EA =EF=E5=F0=EE=F0=E0=EB=FC=ED=F3 =EA=EE=ED=F2=F0=E0=F6=E5=EF=F6=B3=FE, =E2=B3= =E4=F1=F3=F2=ED=B3=E9 =E0=E1=EE =ED=E5=E7=ED=E0=F7=ED=EE =EF=B3=E4=E2=E8=F9= =E5=ED=E8=E9 =F0=E8=E7=E8=EA =F0=EE=E7=E2=E8=F2=EA=F3 =ED=E5=E3=E0=F2=E8=E2=ED=E8=F5 =E5=F4=E5=EA=F2=B3=E2. =CF=B3=E4 =F7=E0=F1 = =EF=EE=E2=F2=EE=F0=ED=EE=E3=EE =EF=EE=F7=E0=F2=EA=F3 =EF=F0=E8=E9=EE=EC=F3 = =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE =ED=E5=EE=E1=F5=B3=E4=ED=EE =E2=F0=E0=F5=EE=E2=F3=E2=E0=F2=E8 =EF=B3=E4=E2= =E8=F9=E5=ED=E8=E9 =F0=E8=E7=E8=EA =F0=EE=E7=E2=E8=F2=EA=F3 =C2=D2=C5 =F3 = =EF=B3=F1=EB=FF=EF=EE=EB=EE=E3=EE=E2=E8=E9 =EF=E5=F0=B3=EE=E4 (=E4=E8=E2. =F0=EE=E7=E4=B3=EB =AB=CE=F1=EE=E1=EB=E8=E2=EE=F1=F2=B3 =E7=E0= =F1=F2=EE=F1=F3=E2=E0=ED=ED=FF=BB).

=C3=EE=E4=F3=E2=E0=ED=ED=FF =E3=F0=F3=E4=E4=FE

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=C3=F0=F3=E4=ED=E5 =E2=E8=E3=EE=E4=EE= =E2=F3=E2=E0=ED=ED=FF =EF=F0=EE=F2=E8=EF=EE=EA=E0=E7=E0=ED=E5 =EF=B3=E4 =F7= =E0=F1 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=FF =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA= =EA=EE (=E4=E8=E2. =F0=EE=E7=E4=B3=EB =AB=CF=F0=EE=F2=E8=EF=EE=EA=E0=E7=E0= =ED=ED=FF=BB) =F2=E0 =EF=F0=EE=F2=FF=E3=EE=EC 2 =F2=E8=E6=ED=B3=E2 =EF=B3=F1=EB=FF =EF=F0=E8=EF=E8=ED=E5=ED=ED=FF =EF=F0=E8= =E9=EE=EC=F3 =EF=F0=E5=EF=E0=F0=E0=F2=F3 =D0=B3=BA=EA=EE.

=D4=E5=F0=F2=E8=EB=FC=ED=B3=F1=F2=FC

=CF=F0= =E5=EF=E0=F0=E0=F2 =D0=B3=BA=EA=EE =EF=F0=E8=E3=ED=B3=F7=F3=BA =EE=E2=F3=EB=FF=F6=B3=FE =B3 =F7=E0=F1=F2=EE = =E2=E8=EA=EB=E8=EA=E0=BA =E0=EC=E5=ED=EE=F0=E5=FE. =CE=E2=F3=EB=FF=F6=B3=FF= =F2=E0 =EC=E5=ED=F1=F2=F0=F3=E0=EB=FC=ED=B3 =EA=F0=EE=E2=EE=F2=E5=F7=B3 =F8=E2=E8=E4=EA=EE =E2=B3=E4=ED=EE=E2=EB=FF=F2= =FC=F1=FF =EF=B3=F1=EB=FF =EF=F0=E8=EF=E8=ED=E5=ED=ED=FF =EB=B3=EA=F3=E2=E0= =ED=ED=FF (=E4=E8=E2. =F0=EE=E7=E4=B3=EB =AB=D4=E0=F0=EC=E0=EA=EE=E4=E8=ED= =E0=EC=B3=EA=E0=BB).

 

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=CF=F0=E5=EF=E0=F0=E0=F2 =D0= =B3=BA=EA=EE =ED=E5 =E2=EF=EB=E8=E2=E0=BA =E0=E1=EE =EC=E0=BA =ED=E5=E7=ED=E0=F7=ED=E8=E9 =E2=EF=EB=E8=E2 =ED=E0 =E7=E4=E0=F2=ED=B3=F1=F2= =FC =EA=E5=F0=F3=E2=E0=F2=E8 =E0=E2=F2=EE=EC=EE=E1=B3=EB=E5=EC =E0=E1=EE = =EF=F0=E0=F6=FE=E2=E0=F2=E8 =E7 =B3=ED=F8=E8=EC=E8 =EC=E5=F5=E0=ED=B3=E7=EC= =E0=EC=E8.

&nb= sp;

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=C4= =EE=E7=F3=E2=E0=ED=ED=FF

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=D7=E5=F0=E5=E7 1 =F0=B3=EA =EF=B3=F1=EB=FF =EF= =EE=F7=E0=F2=EA=F3 =EB=B3=EA=F3=E2=E0=ED=ED=FF =F0=E5=EA=EE=EC=E5=ED=E4=F3= =BA=F2=FC=F1=FF =E2=E8=EA=EE=ED=E0=F2=E8 =EF=EE=E4=E2=B3=E9=ED=F3 =F0=E5=ED=F2=E3=E5= =ED=B3=E2=F1=FC=EA=F3 =E0=E1=F1=EE=F0=E1=F6=B3=EE=EC=E5=F2=F0=B3=FE (=CF=D0= =C0).= =CF=E0=F6=B3=BA=ED=F2=EA=E0=EC =E7 =F4=E0=EA=F2=EE=F0=E0=EC=E8 =F0=E8=E7=E8= =EA=F3 =F0=EE=E7=E2=E8=F2=EA=F3 =EE=F1=F2=E5=EE=EF=EE=F0=EE=E7=F3 =E0=E1=EE= =E2=F2=F0=E0=F2=E8 =EA=B3=F1=F2=EA=EE=E2=EE=BF =F2=EA=E0=ED=E8=ED=E8 =EF=E5=F0=E5=E4 =EF=EE=F7=E0=F2=EA=EE=EC =EB=B3=EA=F3=E2=E0=ED=ED=FF =EF=F0= =E5=EF=E0=F0=E0=F2=EE=EC =D0=B3=BA=EA=EE =F0=E5=EA=EE=EC=E5=ED=E4=EE=E2=E0= =ED=EE =EF=F0=EE=E2=E5=F1=F2=E8 =CF=D0=C0 (=E4=E8=E2. =F0=EE=E7=E4=B3=EB =AB=CE=F1=EE=E1=EB=E8=E2=EE=F1=F2=B3 =E7=E0=F1=F2=EE=F1= =F3=E2=E0=ED=ED=FF=BB).

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=D5=E0=F0=E0=EA=F2= =E5=F0=E8=F1=F2=E8=EA=E0 =EF=F0=EE=F4=B3=EB=FE =E1=E5=E7=EF=E5=EA=E8

=CD=E0= =E9=E1=B3=EB=FC=F8 =F7=E0=F1=F2=E8=EC=E8 =EF=EE=E1=B3=F7=ED=E8=EC=E8 =F0=E5=E0=EA=F6=B3=FF=EC=E8 =EF=F0=E8 =E7=E0=F1= =F2=EE=F1=F3=E2=E0=ED=ED=B3 =EF=F0=E5=EF=E0=F0=E0=F2=F3 =E4=EB=FF =EB=B3=EA=F3=E2=E0= =ED=ED=FF =EC=B3=EE=EC=E8 =EC=E0=F2=EA=E8 =E0=E1=EE =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=F3 =E1=F3=EB=E8 =E3=EE=EB=EE=E2=ED=E8=E9 = =E1=B3=EB=FC (13,2 %), =EF=F0=E8=EF=EB=E8= =E2=E8 (10,3 %) =F2=E0 =EC=E0=F2=EA=EE=E2=B3 =EA=F0=EE=E2=EE=F2=E5=F7=B3 (5,8 %).

=D2=E0=E1=EB=E8=F7= =ED=E8=E9 =EF=E5=F0=E5=EB=B3=EA =EF=EE=E1=B3=F7=ED=E8=F5 =F0=E5=E0=EA=F6=B3=E9 =ED=E0 =EB=B3=EA=E0=F0=F1=FC= =EA=E8=E9 =E7=E0=F1=B3=E1

=CF=EE= =E1=B3=F7=ED=B3 =F0=E5=E0=EA=F6=B3=BF =ED=E0 =EB=B3=EA=E0=F0=F1=FC=EA=E8=E9 =E7=E0=F1=B3=E1, =ED=E0=E2=E5=E4=E5= =ED=B3 =E2 =F2=E0=E1=EB=E8=F6=B3 10, =EA=EB=E0=F1=E8=F4=B3=EA=EE=E2=E0=ED= =EE =E2=B3=E4=EF=EE=E2=B3=E4=ED=EE =E4=EE =F7=E0=F1=F2=EE=F2=E8 =F2=E0 =EA=EB=E0=F1=F3 =F1=E8=F1=F2=E5=EC =EE=F0=E3=E0=ED=B3=E2. =D3 =EC=E5= =E6=E0=F5 =EA=EE=E6=ED=EE=BF =E3=F0=F3=EF=E8 =E7=E0 =F7=E0=F1=F2=EE=F2=EE= =FE =EF=EE=E1=B3=F7=ED=B3 =F0=E5=E0=EA=F6=B3=BF =EF=F0=E5=E4=F1=F2=E0=E2=EB=E5=ED=EE =E2 =EF=EE=F0=FF=E4=EA=F3 =E7=EC=E5=ED= =F8=E5=ED=ED=FF =F1=E5=F0=E9=EE=E7=ED=EE=F1=F2=B3. =D7=E0=F1=F2=EE=F2=E0 = =E2=E8=E7=ED=E0=F7=E0=BA=F2=FC=F1=FF =E7=E0 =F2=E0=EA=E8=EC=E8 =EA=E0=F2=E5=E3=EE=F0=B3=FF=EC=E8: =E4=F3=E6=E5 =F7=E0=F1=F2=B3 ( ≥ 1= /10), =F7=E0=F1=F2=B3 (=E2=B3=E4 ≥ 1/100 =E4=EE < 1/10), =ED=E5=F7=E0=F1=F2=B3 (=E2=B3=E4 ≥ 1/1000 =E4=EE < 1/100), = =EF=EE=EE=E4=E8=ED=EE=EA=B3 (=E2=B3=E4 ≥ 1/10000 =E4=EE < 1/1000), =F0=B3=E4=EA=B3=F1=ED=B3 (< 1/10000), =F7=E0=F1=F2= =EE=F2=E0 =ED=E5=E2=B3=E4=EE=EC=E0 (=ED=E5 =EC=EE=E6=ED=E0 =EE=F6=B3=ED=E8= =F2=E8 =ED=E0 =EE=F1=ED=EE=E2=B3 =ED=E0=FF=E2=ED=E8=F5 =E4=E0=ED=E8=F5).

=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0= =A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0= =A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0= =A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0= =A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0= =A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0 =A0=A0=A0=A0 =D2=E0=E1=EB=E8=F6=FF 10

=CF=EE=E1=B3=F7=ED=B3 =F0=E5=E0=EA=F6=B3=BF =ED=E0 =EB=B3=EA=E0=F0= =F1=FC=EA=E8=E9 =E7=E0=F1=B3=E1 =F3 =EF=E0=F6=B3=BA=ED=F2=EE= =EA =E7 =EC=B3=EE=EC=EE=FE =EC=E0=F2=EA=E8 =F2=E0 =E5=ED=E4=EE=EC=E5=F2=F0=B3=EE=E7=EE=EC

=CA=EB= =E0=F1 =F1=E8=F1=F2=E5=EC=E8 =EE=F0=E3=E0=ED=B3=E2

=C4=F3=E6=E5 =F7=E0=F1=F2=B3 (Ͱ= 5; 1/10)

=D7=E0=F1=F2=B3

(=E2= =B3=E4 ≥ 1/100 =E4=EE < 1/10)

=CD=E5=F7=E0=F1=F2=B3

(=E2=B3=E4 ≥ 1/1000 =E4= =EE < 1/100)

=CF=F1=E8=F5=B3=F7=ED=B3 =F0=EE=E7=EB=E0=E4=E8

 

=C4=F0=E0=F2=B3=E2=EB=E8=E2=B3=F1=F2=FC

=C7=ED=E8=E6=E5=ED=ED=FF =EB=B3=E1=B3=E4= =EE*

 

=C7 =E1=EE=EA=F3 =ED=E5=F0=E2=EE=E2=EE=BF =F1=E8=F1=F2=E5=EC=E8

=C3=EE=EB=EE=E2=ED=E8=E9 =E1=B3=EB=FC

=C7=E0=EF=E0=EC=EE=F0=EE=F7=E5=ED=ED=FF

 

=C7 =E1=EE=EA=F3 =F1=F3=E4=E8=ED

=CF=F0=E8=EF=EB=E8=E2=E8

 

 

=C7 =E1=EE=EA=F3 =F8=EB=F3=ED=EA=EE=E2= =EE-=EA=E8=F8=EA=EE=E2=EE=E3=EE =F2=F0=E0=EA=F2=F3

 

=CD=F3=E4=EE=F2=E0

=C4=E8=F1=EF=E5=EF=F1=B3=FF

=C7 =E1=EE=EA=F3 =F8=EA=B3=F0=E8 =E9 = =EF=B3=E4=F8=EA=B3=F0=ED=EE=BF =EA=EB=B3=F2=EA=EE=E2=E8=ED=E8

 

=C0=EB=EE=EF=E5=F6=B3=FF

=C3=B3=EF=E5=F0=E3=B3=E4=F0=EE=E7

=CD=B3=F7=ED=E5 =EF=EE=F2=EE=E2=E8=E4=B3=EB=E5=ED=ED=FF

=C0=ED=E3=B3=EE=ED= =E5=E2=F0=EE=F2=E8=F7=ED=E8=E9 =ED=E0=E1=F0=FF=EA

=CA=F0=EE=EF=E8=E2=92=FF=ED=EA=E0

=C7 =E1=EE=EA=F3 =EE=EF=EE=F0=ED=EE-=F0= =F3=F5=EE=E2=EE=E3=EE =E0=EF=E0=F0=E0=F2=F3 =F2=E0 =F1=EF=EE=EB=F3=F7=ED=EE= =BF =F2=EA=E0=ED=E8=ED=E8

 

=C0=F0=F2=F0=E0=EB=E3=B3=FF

 

=C7 =E1=EE=EA=F3 =F0=E5=EF=F0=EE=E4=F3= =EA=F2=E8=E2=ED=EE=BF =F1=E8=F1=F2=E5=EC=E8 =F2=E0 =EC=EE=EB=EE=F7=ED=E8=F5 =E7=E0=EB=EE=E7

 

=CC=E0=F2=EA=EE=E2=E0 =EA=F0=EE=E2=EE=F2=E5=F7= =E0**

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=CA=B3=F1=F2=E0 =EC=EE=EB=EE=F7=ED=EE=BF =E7=E0= =EB=EE=E7=E8

=C5=EA=F1=EF=F3=EB=FC=F1=B3=FF =EC=B3=EE=EC=E8 =EC=E0=F2=EA=E8

* =C2= =EA=EB=FE=F7=E0=BA =E7=ED=E8=E6=E5=ED=ED=FF =EB=B3=E1=B3=E4=EE, =E2=F2=F0=E0=F2=F3 =EB=B3=E1=B3=E4=EE =F2=E0 =EF=EE=F0= =F3=F8=E5=ED=ED=FF =EB=B3=E1=B3=E4=EE.

**  =C2=EA=EB=FE=F7=E0=BA =EC=E5=ED=EE=F0=E0=E3=B3=FE (=F0=FF=F1=ED=E0 =EC=E5=ED=F1=F2=F0=F3=E0=F6=B3= =FF), =EC=E5=F2=F0=EE=F0=E0=E3=B3=FE (=EC=B3=E6=EC=E5=ED=F1=F2=F0=F3=E0=EB= =FC=ED=E0 =EA=F0=EE=E2=EE=F2=E5=F7=E0), =E2=E0=E3=B3=ED=E0=EB=FC=ED=F3 =EA=F0=EE=E2=EE=F2=E5=F7=F3, =EC=E0=F2=EA=EE= =E2=F3 =EA=F0=EE=E2=EE=F2=E5=F7=F3, =EF=EE=EB=B3=EC=E5=ED=EE=F0=E5=FE =F2= =E0 =ED=E5=F0=E5=E3=F3=EB=FF=F0=ED=B3 =EC=E5=ED=F1=F2=F0=F3=E0=F6=B3=BF.

=CF= =EE=E2=B3=E4=EE=EC=EB=E5=ED=ED=FF =EF=F0=EE =EF=B3=E4=EE=E7=F0=FE=E2=E0=ED=B3 =EF=EE=E1=B3=F7=ED=B3 =F0=E5=E0= =EA=F6=B3=BF

=CF=EE= =E2=B3=E4=EE=EC=EB=E5=ED=ED=FF =EF=F0=EE =EF=EE=E1=B3=F7=ED=B3 =F0=E5=E0=EA=F6=B3=BF =EF=B3=F1=EB=FF =F0=E5=BA=F1=F2= =F0=E0=F6=B3=BF =EB=B3=EA=E0=F0=F1=FC=EA=EE=E3=EE =E7=E0=F1=EE=E1=F3 =EC=E0= =BA =E2=E0=E6=EB=E8=E2=E5 =E7=ED=E0=F7=E5=ED=ED=FF. =D6=E5 =E4=E0=BA =E7=EC=EE=E3=F3 =EF=F0=EE=E2=EE=E4=E8=F2=E8 =EC=EE=ED=B3=F2=EE=F0= =E8=ED=E3 =F1=EF=B3=E2=E2=B3=E4=ED=EE=F8=E5=ED=ED=FF =EA=EE=F0=E8=F1=F2=FC/= =F0=E8=E7=E8=EA =EF=F0=E8 =E7=E0=F1=F2=EE=F1=F3=E2=E0=ED=ED=B3 =F6=FC=EE=E3=EE =EB=B3=EA=E0=F0=F1=FC=EA=EE=E3=EE =E7=E0=F1=EE=E1=F3. =CC= =E5=E4=E8=F7=ED=E8=EC =F2=E0 =F4=E0=F0=EC=E0=F6=E5=E2=F2=E8=F7=ED=E8=EC =EF= =F0=E0=F6=B3=E2=ED=E8=EA=E0=EC, =E0 =F2=E0=EA=EE=E6 =EF=E0=F6=B3=BA=ED=F2=E0=EC =E0=E1=EE =BF=F5=ED=B3=EC =E7=E0=EA=EE=ED=ED=E8= =EC =EF=F0=E5=E4=F1=F2=E0=E2=ED=E8=EA=E0=EC =F1=EB=B3=E4 =EF=EE=E2=B3=E4=EE= =EC=EB=FF=F2=E8 =EF=F0=EE =F3=F1=B3 =E2=E8=EF=E0=E4=EA=E8 =EF=B3=E4=EE=E7=F0=FE=E2=E0=ED=E8=F5 =EF=EE=E1=B3=F7=ED=E8=F5 =F0=E5=E0=EA= =F6=B3=E9 =F2=E0 =E2=B3=E4=F1=F3=F2=ED=EE=F1=F2=B3 =E5=F4=E5=EA=F2=E8=E2=ED= =EE=F1=F2=B3 =EB=B3=EA=E0=F0=F1=FC=EA=EE=E3=EE =E7=E0=F1=EE=E1=F3 =F7=E5=F0=E5=E7 =E0=E2=F2=EE=EC=E0=F2=E8=E7=EE=E2=E0=ED=F3 =B3=ED=F4=EE=F0= =EC=E0=F6=B3=E9=ED=F3 =F1=E8=F1=F2=E5=EC=F3 =E7 =F4=E0= =F0=EC=E0=EA=EE=ED=E0=E3=EB=FF=E4=F3 =E7=E0 =EF=EE=F1=E8=EB=E0=ED=ED=FF=EC: https://aisf.dec.gov.ua/.

 

=D2=E5=F0=EC=B3=ED =EF=F0=E8=E4=E0=F2=ED=EE=F1=F2=B3. 3 =F0= =EE=EA=E8.

 

=D3=EC=EE=E2=E8 =E7=E1=E5=F0=B3=E3=E0=ED=ED=FF. =CB=B3=EA=E0=F0=F1=FC=EA=E8=E9 =E7=E0= =F1=B3=E1 =ED=E5 =EF=EE=F2=F0=E5=E1=F3=BA =F1=EF=E5=F6=B3=E0=EB=FC=ED=E8=F5= =F3=EC=EE=E2 =E7=E1=E5=F0=B3=E3=E0=ED=ED=FF.

=C7=E1=E5=F0= =B3=E3=E0=F2=E8 =E2 =ED=E5=E4=EE=F1=F2=F3=EF=ED=EE=EC=F3 =E4=EB=FF =E4=B3=F2=E5=E9 =EC=B3=F1=F6= =B3.

=  

=D3=EF=E0=EA=EE=E2=EA=E0. =CF=EE 28 =F2=E0=E1=EB=E5=F2=EE=EA, =E2=EA=F0=E8=F2=E8=F5 =EF=EB=B3=E2=EA=EE=E2=EE=FE =EE=E1=EE=EB=EE=ED=EA=EE=FE, =F3 =F4=EB=E0=EA= =EE=ED=B3 =E7 =EF=EE=EB=B3=E5=F2=E8=EB=E5=ED=F3 =E2=E8=F1=EE=EA=EE=BF =F9= =B3=EB=FC=ED=EE=F1=F2=B3 =E7 =E2=EE=EB=EE=E3=EE=EF=EE=E3=EB=E8=ED=E0=F7=E5=EC, =E7=E0=EA=F0=E8=F2=EE=EC= =F3 =B3=ED=E4=F3=EA=F6=B3=E9=ED=EE=FE =E3=E5=F0=EC=E5=F2=E8=F7=ED=EE=FE =EA= =F0=E8=F8=EA=EE=FE =E7 =EF=EE=EB=B3=EF=F0=EE=EF=B3=EB=E5=ED=F3 =B3=E7 =E7=E0=F5=E8=F1=F2=EE=EC =E2=B3=E4 =E2=B3=E4=EA=F0=E8=E2=E0=ED=ED=FF =E4=B3= =F2=FC=EC=E8. =CF=EE 1 =E0=E1=EE 3 =F4=EB=E0=EA=EE=ED=E8 =F3 =EA=E0=F0=F2= =EE=ED=ED=B3=E9 =EA=EE=F0=EE=E1=F6=B3 =E0=E1=EE

=EF=EE 14 =F2=E0=E1=EB=E5=F2=EE=EA, =E2=EA=F0=E8=F2=E8=F5 =EF=EB=B3=E2=EA=EE=E2=EE=FE= =EE=E1=EE=EB=EE=ED=EA=EE=FE, =F3 =E1=EB=B3=F1=F2=E5=F0=B3. =CF=EE 1 =E1=EB= =B3=F1=F2=E5=F0=F3 =F3 =EF=E0=EA=E5=F2=B3 =E7 =EB=E0=EC=B3=ED=EE=E2=E0=ED=EE=BF =E0=EB=FE=EC=B3=ED=B3=BA=E2=EE=BF =F4=EE= =EB=FC=E3=E8 =E7 =E2=EE=EB=EE=E3=EE=EF=EE=E3=EB=E8=ED=E0=F7=E5=EC. =CF=EE 2= =E0=E1=EE =EF=EE 6 =EF=E0=EA=E5=F2=B3=E2 =F3 = =EA=E0=F0=F2=EE=ED=ED=B3=E9 =EA=EE=F0=EE=E1=F6=B3.

 

=CA=E0=F2=E5=E3=EE=F0=B3=FF =E2=B3=E4=EF=F3=F1=EA=F3. =C7=E0 = =F0=E5=F6=E5=EF=F2=EE=EC.

 

=C2=E8=F0=EE=E1=ED=E8=EA. =C2=C0=D2 =AB=C3=E5=E4=E5=EE=ED =D0= =B3=F5=F2=E5=F0=BB.

 

=CC=B3=F1=F6=E5=E7=ED=E0=F5= =EE=E4=E6=E5=ED=ED=FF =E2=E8=F0=EE=E1=ED=E8=EA=E0 =F2=E0 =E0=E4=F0=E5=F1=E0 =EC=B3=F1=F6=FF =EF=F0=EE=E2=E0=E4=E6=E5=ED=ED=FF =E9=EE= =E3=EE =E4=B3=FF=EB=FC=ED=EE=F1=F2=B3.

=CD-1103, =C1=F3=E4=E0=EF=E5=F8=F2, =E2=F3=EB. =C4=E5=EC=F0=E5=BF, 19= -21, =D3=E3=EE=F0=F9=E8=ED=E0.

 

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