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font-size:10.0pt; font-family:"Times New Roman",serif;} </style> <![endif]--><!--[if gte mso 9]><xml> <o:shapedefaults v:ext=3D"edit" spidmax=3D"1026"/> </xml><![endif]--><!--[if gte mso 9]><xml> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1"/> </o:shapelayout></xml><![endif]--> </head> <body bgcolor=3Dwhite lang=3DRU link=3Dnavy vlink=3D"#954F72" style=3D'tab-= interval:35.4pt'> <div class=3DWordSection1> <p class=3DMsoNormal align=3Dcenter style=3D'text-align:center;mso-hyphenat= e:none'><b style=3D'mso-bidi-font-weight:normal'>ІНСТРУКЦІЯ<o:p></o:p></b></p> <p class=3DMsoNormal align=3Dcenter style=3D'text-align:center;line-height:= 150%; mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'>для </b><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-ansi-lan= guage: UK'>медичного застосування лікарського засобу</span></b></p> <h2 style=3D'margin-left:0cm;text-indent:0cm;mso-list:l0 level2 lfo1;mso-hy= phenate: none;tab-stops:0cm'><span lang=3DUK>ГЛУТАРГІН</span><span lang=3DEN-US style=3D'mso-ansi-language:EN-US;mso-bidi-font-weight:bold'><o:p></o:p></sp= an></h2> <p class=3DMsoNormal align=3Dcenter style=3D'text-align:center;mso-hyphenat= e:none'><b><span lang=3DEN-US style=3D'mso-ansi-language:EN-US'>(GLUTARGIN)</span></b><b style=3D'mso-bidi-font-weight:normal'><i><span lang=3DUK style=3D'mso-ansi-= language: UK'><o:p></o:p></span></i></b></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><i><span lang=3DUK style=3D'mso-ansi-= language: UK'>Склад</span></i></b><b style=3D'mso-bidi-font-weight:normal'><i><span lang=3DEN-US style=3D'mso-ansi-language:EN-US'>:</span></i></b><i style=3D'= mso-bidi-font-style: normal'><span lang=3DUK style=3D'mso-ansi-language:UK'><o:p></o:p></span></= i></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-ansi-lang= uage:UK'>діюча речовина: </span></i><span lang=3DEN-US style=3D'mso-ansi-language:EN-US'>a= </span><span class=3DSpellE><span lang=3DUK style=3D'mso-ansi-language:UK'>rginine</span= ></span><span lang=3DUK style=3D'mso-ansi-language:UK'> <span class=3DSpellE>glutamate</s= pan></span><i style=3D'mso-bidi-font-style:normal'><span lang=3DEN-US style=3D'mso-ansi-l= anguage: EN-US'>;</span></i><span lang=3DUK style=3D'mso-ansi-language:UK'><o:p></o:= p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-ansi-language:UK'>1 мл </span>препарату<span lang=3DUK style=3D'mso-ansi-language:UK'> містить аргініну <span class=3DSpellE>глута= мату</span> 400 мг;<i style=3D'mso-bidi-font-style:normal'><o:p></o:p></i></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span class=3DSpellE><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-ansi-language:UK'>допоміжн</span></i></span><i style=3D'mso-bi= di-font-style: normal'>а</i><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-ansi-language:UK'> речовин</span>а</i><i style=3D'mso-bidi-fon= t-style: normal'><span lang=3DUK style=3D'mso-ansi-language:UK'>: </span></i><span l= ang=3DUK style=3D'mso-ansi-language:UK'>вода для ін</span><span lang=3DUK style=3D'm= so-bidi-font-size: 10.0pt;mso-ansi-language:UK'>’</span><span lang=3DUK style=3D'mso-ansi-lang= uage: UK'>єкцій.<b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-fon= t-style: normal'><o:p></o:p></i></b></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma= l'><span lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></span></i></b></= p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-ansi-lan= guage: UK'>Лікарська форма.</span></b><span lang=3DUK style=3D'mso-ansi-language:U= K'> Концентрат для розчину для інфузій.<i style=3D'mso-bidi-font-style:normal'>= <o:p></o:p></i></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-pagination:none;mso-hy= phenate: none'><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-= ansi-language: UK'>Основні фізико-хімічні властивості:<b style=3D'mso-bidi-font-weight:nor= mal'> </b></span></i><span lang=3DUK style=3D'mso-ansi-language:UK'>прозорий розчин жовтуватого кольор= у.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-ansi-lan= guage: UK'>Фармакотерапевтична група. </span></b><span lang=3DUK style=3D'mso-ansi= -language: UK'>Препарати, що застосовуються при захворюваннях печінки, <span class=3DS= pellE>ліпотропні</span> речовини. Аргініну глутамат.</span><span lang=3DUK style=3D'font-size:13.0p= t; mso-bidi-font-size:12.0pt;mso-ansi-language:UK'> </span><span lang=3DUK style=3D'mso-ansi-language:UK'>Код АТХ </span><span lang=3DUK style=3D'font= -size: 13.0pt;mso-bidi-font-size:12.0pt;mso-ansi-language:UK'>А</span><span lang= =3DUK style=3D'mso-ansi-language:UK'>05В А01.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><i><span lang=3DUK style=3D'mso-ansi-= language: UK'>Фармакологічні властивості.</span></i></b><i style=3D'mso-bidi-font-sty= le: normal'><span lang=3DUK style=3D'mso-ansi-language:UK'><o:p></o:p></span></= i></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-pagination:none;mso-hy= phenate: none'><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-= ansi-language: UK'>Фармакодинаміка.<span style=3D'mso-spacerun:yes'>  </span></span></i><s= pan lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>Глутаргі= н є сполученням аргініну і глутамінової кислоти, які відіграють важливу роль у забезпеченні біохімічних процесів нейтралізації і виведення з організму високотоксичного метаболіту обміну азотистих речовин – аміаку. <span class=3DSpellE>Гіпоамоніємічні</span> ефекти препарату реалізуються шляхом активації знешкодження аміаку в <span class=3DSpellE>орнітиновому</span> ци= клі синтезу сечовини, зв’язування аміаку у нетоксичний глутамін, а також підсил= ення виведення аміаку з центральної нервової системи і його екскреції з організм= у. Завдяки цим властивостям <span class=3DSpellE>Глутаргіну</span> знижуються = <span class=3DSpellE>загальнотоксичні</span>, у тому числі <span class=3DSpellE>н= ейротоксичні</span> ефекти аміаку.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>Глутаргін чинить т= акож <span class=3DSpellE>гепатопротекторну</span> дію завдяки своїм антиоксидантним, = <span class=3DSpellE>антигіпоксичним</span> і <span class=3DSpellE>мембраностабіл= ізуючим</span> властивостям, позитивно впливає на процеси енергозабезпечення у <span class=3DSpellE>гепатоцитах</span>.<o:p></o:p></span></p> <p class=3D31 style=3D'text-indent:0cm;mso-hyphenate:none;tab-stops:53.45pt= '><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>При алко= гольній інтоксикації Глутаргін стимулює утилізацію алкоголю у <span class=3DSpellE>= монооксигеназній</span> системі печінки, попереджає пригнічення ключового ферменту утилізації етано= лу – <span class=3DSpellE>алкогольдегідрогенази</span>; прискорює інактивацію і виведення токсичних продуктів метаболізму етанолу у результаті збільшення утворення та окиснення бурштинової кислоти; знижує <span class=3DSpellE>при= гнічувальний</span> вплив алкоголю на центральну нервову систему за рахунок <span class=3DSpell= E>нейромедіаторних</span> властивостей збуджувальної глутамінової кислоти. Завдяки цим властивостям Глутаргін виявляє антитоксичні і витверезні ефекти.</span><span lang=3DUK style=3D'mso-ansi-language:UK'><o:p></o:p></span></p> <p class=3D32 style=3D'text-indent:0cm;line-height:normal;mso-hyphenate:non= e; tab-stops:53.45pt'><span lang=3DUK style=3D'mso-ansi-language:UK'>При патол= огії вагітності завдяки <span class=3DSpellE>ендотелійпротективній</span> дії Глутаргін зменшує порушену проникність і <span class=3DSpellE>тромборезисте= нтність</span> судин, попереджує <span class=3DSpellE>гіперкоагуляцію</span>, знижує чутли= вість судин до судинозвужувальних агентів (<span class=3DSpellE>ендотелін</span>, ангіотензин, <span class=3DSpellE>тромбоксан</span>), що викликають генералізований <span class=3DSpellE>вазоспазм</span>. Аргінін після попере= дньої біотрансформації в оксид азоту виявляє судинорозширювальну дію, позитивно впливає на згортання крові і функціональні властивості циркулюючих елементів крові. У результаті судинорозширювальних і <span class=3DSpellE>антигіпокси= чних</span> ефектів <span class=3DSpellE>Глутаргіну</span> поліпшується <span class=3DS= pellE>материнсько</span>-плодова гемодинаміка, знижується внутрішньоутробна гіпоксія плода. При патології вагітності препарат виявляє також антитоксичну і <span class=3DSpellE>гепат= озахисну</span> активність, виступає як неспецифічний метаболічний регулятор обмінних проце= сів. Завдяки цим властивостям <span class=3DSpellE>Глутаргіну</span> у період вагітності знижується рівень циркулюючих у крові імунних комплексів, зменшується виразність синдрому «метаболічної» інтоксикації та <span class=3DSpellE>імунотоксикозу</span>, підвищуються <span class=3DSpellE>ком= пенсаторно</span>-пристосувальні реакції організму. <o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-ansi-language:UK'>Глутаргін не виявляє <span class=3DSpellE>ем= бріотоксичних</span>, <span class=3DSpellE>гонадотоксичних</span>, мутагенних і тератогенних ефек= тів, не викликає алергічних та <span class=3DSpellE>імунотоксичних</span> реакці= й.<i><o:p></o:p></i></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><i><sp= an lang=3DUK style=3D'mso-ansi-language:UK'>Фармакокінетика.</span></i><span l= ang=3DUK style=3D'mso-ansi-language:UK'> Не досліджувалась.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-ansi-lan= guage: UK'>Клінічні характеристики.<i style=3D'mso-bidi-font-style:normal'><o:p></= o:p></i></span></b></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma= l'><span lang=3DUK style=3D'mso-ansi-language:UK'>Показання. </span></i></b><span la= ng=3DUK style=3D'mso-ansi-language:UK'>У комплексній терапії</span><b style=3D'mso-= bidi-font-weight: normal'><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'ms= o-bidi-font-size: 10.0pt;mso-ansi-language:UK'> </span></i></b><span lang=3DUK style=3D'mso-b= idi-font-size: 10.0pt;mso-ansi-language:UK'>гострих і хронічних гепатитів різної етіології= , у тому числі при отруєнні <span class=3DSpellE>гепатотропними</span> отрутами (блідою поганкою, хімічними та лікарськими речовинами), цирозі печінки, лептоспірозі.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>Печінкова енцефало= патія, <span class=3DSpellE>прекома</span> і кома, що супроводжуються <span class=3DSpellE>гіперамоніємією</span>.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>Стан гострого алкогольного отруєння середнього і тяжкого ступеня, у тому числі алкогольна енцефалопатія і кома.</span><span lang=3DUK style=3D'mso-ansi-language:UK'>= <o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-ansi-language:UK'>Ускладнення у III триместрі вагітності: пізн= ій гестоз, включаючи тяжкі його форми – <span class=3DSpellE>прееклампсію</spa= n> і еклампсію, <span class=3DSpellE>фетоплацентарна</span> недостатність, хроні= чні патології гепатобіліарної системи у вагітних.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma= l'><span lang=3DUK style=3D'mso-ansi-language:UK'>Протипоказання</span></i></b><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-ansi-lan= guage: UK'>.</span></b><span lang=3DUK style=3D'mso-ansi-language:UK'> Підвищена чутливість до компонентів препарату, пропасниця, підвищена збудливість, тяж= ке порушення фільтраційної (<span class=3DSpellE>азотовидільної</span>) функції нирок.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-ansi-lang= uage:UK'>Взаємодія з іншими лікарськими засобами та інші види взаємодій. </span></i></b><span lang=3DUK style=3D'mso-ansi-language:UK'>Ефект <span class=3DSpellE>Глутарг= іну</span> на секрецію інсуліну підвищується при одночасному призначенні амінофіліну. Глутаргін може підсилювати ефект <span class=3DSpellE>антиагрегаційних</spa= n> засобів (дипіридамолу). Попереджає і послаблює <span class=3DSpellE>нейрото= ксичні</span> явища, які можуть виникнути при застосуванні <span class=3DSpellE>ізоніазид= у</span>. Послаблює ефект <span class=3DSpellE>вінбластину</span>.<o:p></o:p></span><= /p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma= l'><span lang=3DUK style=3D'mso-ansi-language:UK'>Особливості застосування.</span></= i></b><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-ansi-lan= guage: UK'> </span></b><span lang=3DUK style=3D'mso-ansi-language:UK'>При призначе= нні пацієнтам з порушеннями функцій ендокринних залоз слід враховувати, що преп= арат стимулює секрецію інсуліну і <span class=3DSpellE>гормона</span> росту. Глу= таргін активує зв</span><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ans= i-language: UK'>’</span><span lang=3DUK style=3D'mso-ansi-language:UK'>язування аміаку у сечовину, що закономірно може супроводжуватися короткочасним підвищенням її рівня у крові.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></span></p> <p class=3DLO-Normal style=3D'text-align:justify'><b style=3D'mso-bidi-font= -weight: normal'><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'fo= nt-size: 12.0pt;mso-ansi-language:UK'>Застосування у період вагітності або годування груддю. </span></i></b><span lang=3DUK style=3D'font-size:12.0pt;mso-ansi-l= anguage: UK'>Безпека клінічного застосування препарату у період вагітності у I і II триместрах вагітності і при годуванні груддю не досліджена</span><span lang= =3DUK style=3D'font-size:12.0pt;mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>.= <o:p></o:p></span></p> <p class=3DLO-Normal style=3D'text-align:justify'><span lang=3DUK style=3D'= font-size: 12.0pt;mso-bidi-font-size:10.0pt;mso-ansi-language:UK'><o:p> </o:p></s= pan></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma= l'><span lang=3DUK style=3D'mso-ansi-language:UK'>Здатність впливати на швидкість ре= акції при керуванні автотранспортом або іншими механізмами. </span></i></b><span lang=3DUK style=3D'mso-ansi-language:UK'>Оскільки під час лікування препара= том можуть виникати побічні реакції з боку ЦНС (головний біль, запаморочення, тремор), слід дотримуватися обережності при керуванні автотранспортом або іншими механізмами.<b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso= -bidi-font-style: normal'><o:p></o:p></i></b></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-pagination:none;mso-hy= phenate: none'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-st= yle: normal'><span lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></s= pan></i></b></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-pagination:none;mso-hy= phenate: none'><b style=3D'mso-bidi-font-weight:normal'><i><span lang=3DUK style=3D'= mso-ansi-language: UK'>Спосіб застосування та дози.</span></i></b><b style=3D'mso-bidi-font-we= ight: normal'><span lang=3DUK style=3D'font-size:13.0pt;mso-bidi-font-size:12.0pt; mso-ansi-language:UK'> </span></b><span lang=3DUK style=3D'mso-bidi-font-si= ze:10.0pt; mso-ansi-language:UK'>Препарат призначати дорослим внутрішньовенно.<i><o:p>= </o:p></i></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><i><sp= an lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>Гепатити= , <span class=3DSpellE>гіперамоніємія</span>. </span></i><span lang=3DUK style=3D'm= so-bidi-font-size: 10.0pt;mso-ansi-language:UK'>Вводити внутрішньовенно краплинно 2 рази на до= бу по 5 мл (2 г) на<span style=3D'mso-spacerun:yes'>      </span>150</span><sp= an style=3D'mso-bidi-font-size:10.0pt'>–</span><span lang=3DUK style=3D'mso-bi= di-font-size: 10.0pt;mso-ansi-language:UK'>250 мл 0,9 % розчину натрію хлориду або 5 % розчину глюкози зі швидкістю 60</span><span style=3D'mso-bidi-font-size:10.= 0pt'>–</span><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>70 крапе= ль за хвилину. У тяжких випадках добову дозу препарату підвищувати до 15</span><s= pan style=3D'mso-bidi-font-size:10.0pt'>–</span><span lang=3DUK style=3D'mso-bi= di-font-size: 10.0pt;mso-ansi-language:UK'>20 мл (</span><span style=3D'mso-bidi-font-siz= e: 10.0pt'>6–8</span><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-an= si-language: UK'> г), </span><span class=3DSpellE><span style=3D'mso-bidi-font-size:10.0= pt'>розпод</span><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>ілених</= span></span><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'> на 2 вв= едення.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>Максимальна добова= доза – 20 мл (8 г). Курс лікування – 5</span><span style=3D'mso-bidi-font-size:1= 0.0pt'>–</span><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>10 діб.<= i><o:p></o:p></i></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><i><sp= an lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>Алкоголь= не отруєння.</span></i><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-= ansi-language: UK'> Вводити внутрішньовенно краплинно 2 рази на добу по 2 мл (0,8 г) на<sp= an style=3D'mso-spacerun:yes'>            </span>150</span><span style=3D'mso-= bidi-font-size: 10.0pt'>–</span><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi= -language: UK'>250 мл 0,9 % розчину натрію хлориду або 5 % розчину глюкози зі швидкіст= ю 60</span><span style=3D'mso-bidi-font-size:10.0pt'>–</span><span lang=3DUK style=3D'mso-bi= di-font-size: 10.0pt;mso-ansi-language:UK'>70 крапель за хвилину протягом </span><span style=3D'mso-bidi-font-size:10.0pt'>2–3</span><span lang=3DUK style=3D'mso-= bidi-font-size: 10.0pt;mso-ansi-language:UK'> днів, потім дозу зменшити до 1 мл (0,4 г) 2 р= ази на добу протягом 10 днів. У тяжких випадках (алкогольна кома) добову дозу підвищити до 5 мл (2 г) 2 рази на добу.</span><span lang=3DUK style=3D'mso-= ansi-language: UK'><o:p></o:p></span></p> <p class=3DBodyText style=3D'line-height:normal;mso-hyphenate:none'><span l= ang=3DUK style=3D'font-size:12.0pt;mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>П= ісля курсу лікування 40 % розчином <span class=3DSpellE>Глутаргіну</span>, у разі необхідності, слід перейти на прийом таблеток <span class=3DSpellE>Глутаргі= ну</span>.</span><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'font-size:12.= 0pt; mso-ansi-language:UK'><o:p></o:p></span></i></p> <p class=3DLO-Normal style=3D'text-align:justify'><i style=3D'mso-bidi-font= -style: normal'><span lang=3DUK style=3D'font-size:12.0pt;mso-ansi-language:UK'>П</= span></i><span class=3DSpellE><i style=3D'mso-bidi-font-style:normal'><span style=3D'font-= size:12.0pt'>атолог</span></i><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'font-size:12.= 0pt; mso-ansi-language:UK'>ії</span></i></span><i style=3D'mso-bidi-font-style:n= ormal'><span style=3D'font-size:12.0pt'> <span class=3DSpellE>вагітності</span><span style=3D'mso-bidi-font-style:italic'>.</span></span></i><span style=3D'font= -size: 12.0pt'> </span><span lang=3DUK style=3D'font-size:12.0pt;mso-bidi-font-siz= e:10.0pt; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK'>Вводити краплинно </span><span style=3D'font-size:12.0pt'>1–2</span><span lang=3DUK style=3D'font-size:12.0pt;mso-ansi-language:UK'> рази на добу по 5 мл (2 г)= </span><span lang=3DUK style=3D'font-size:12.0pt;mso-bidi-font-size:10.0pt;mso-fareast-f= ont-family: "Times New Roman";mso-ansi-language:UK'>на </span><span style=3D'font-size:= 12.0pt; mso-bidi-font-size:10.0pt;mso-fareast-font-family:"Times New Roman"'>150–25= 0</span><span lang=3DUK style=3D'font-size:12.0pt;mso-bidi-font-size:10.0pt;mso-fareast-f= ont-family: "Times New Roman";mso-ansi-language:UK'> мл 0,9 % розчину натрію хлориду аб= о 5 % розчину глюкози зі швидкістю 60</span><span style=3D'font-size:12.0pt; mso-bidi-font-size:10.0pt;mso-fareast-font-family:"Times New Roman"'>–</spa= n><span lang=3DUK style=3D'font-size:12.0pt;mso-bidi-font-size:10.0pt;mso-fareast-f= ont-family: "Times New Roman";mso-ansi-language:UK'>70 крапель за хвилину</span><span lang=3DUK style=3D'font-size:12.0pt;mso-ansi-language:UK'>.<o:p></o:p></spa= n></p> <p class=3DLO-Normal style=3D'text-align:justify'><span lang=3DUK style=3D'= font-size: 12.0pt;mso-ansi-language:UK'>Вища добова доза – 10 мл (4 г). Курс лікування= – </span><span style=3D'font-size:12.0pt'>5–7</span><span lang=3DUK style=3D'font-size:12.= 0pt; mso-ansi-language:UK'> діб.<o:p></o:p></span></p> <p class=3DLO-Normal style=3D'text-align:justify'><span lang=3DUK style=3D'= font-size: 12.0pt;mso-ansi-language:UK'><o:p> </o:p></span></p> <p class=3DLO-Normal style=3D'text-align:justify'><b style=3D'mso-bidi-font= -weight: normal'><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'fo= nt-size: 12.0pt;mso-ansi-language:UK'>Діти. </span></i></b><span lang=3DUK style=3D'font-size:12.0pt;mso-ansi-language:UK'>Ефективність і безпека застосування препарату дітям не досліджені.<o:p></o:p></span></p> <p class=3DLO-Normal style=3D'text-align:justify'><span lang=3DUK style=3D'= font-size: 12.0pt;mso-ansi-language:UK'><o:p> </o:p></span></p> <p class=3DLO-Normal style=3D'text-align:justify;mso-pagination:widow-orpha= n'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma= l'><span lang=3DUK style=3D'font-size:12.0pt;mso-ansi-language:UK'>Передозування</sp= an></i></b><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'font-size:12= .0pt; mso-ansi-language:UK'>. </span></b><i style=3D'mso-bidi-font-style:normal'>= <span lang=3DUK style=3D'font-size:12.0pt;mso-ansi-language:UK'>Симптоми:</span><= /i><span lang=3DUK style=3D'font-size:12.0pt;mso-ansi-language:UK'> посилення проявів побічних реакцій, біль у грудній клітці, атріовентрикулярна блокада.</span>= <i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-ansi-lang= uage:UK'><o:p></o:p></span></i></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><i style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-ansi-lang= uage:UK'>Лікування:</span></i><span lang=3DUK style=3D'mso-ansi-language:UK'> внутрішньовенне введення кортикостероїдів. Симптоматична терапія.<b style=3D'mso-bidi-font-weight:no= rmal'><i style=3D'mso-bidi-font-style:normal'><o:p></o:p></i></b></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma= l'><span lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></span></i></b></= p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma= l'><span lang=3DUK style=3D'mso-ansi-language:UK'>Побічні реакції</span></i></b><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-ansi-lan= guage: UK'>. </span></b><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ans= i-language: UK'>Рідко можливі:<i><o:p></o:p></i></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><i><sp= an lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>загальні порушення:</span></i><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso= -ansi-language: UK'> задишка, біль за грудниною, підвищення температури тіла, озноб, зміни у місці введення, флебіт;<i><o:p></o:p></i></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><i><sp= an lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>з боку серцево-судинної системи:</span></i><span lang=3DUK style=3D'mso-bidi-font-= size: 10.0pt;mso-ansi-language:UK'> миготлива аритмія, зниження артеріального тис= ку, тахікардія;<i><o:p></o:p></i></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><i><sp= an lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>з боку т= равної системи:</span></i><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-a= nsi-language: UK'> нудота, біль в епігастральній ділянці;<i><o:p></o:p></i></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><i><sp= an lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>з боку н= ервової системи:</span></i><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-a= nsi-language: UK'> головний біль, запаморочення, тремор, слабкість;<i><o:p></o:p></i></sp= an></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><i><sp= an lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>з боку і= мунної системи:</span></i><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-a= nsi-language: UK'> реакції гіперчутливості, включаючи шкірні висипання, свербіж, гіперемі= ю, кропив’янку,<span style=3D'mso-spacerun:yes'>  </span>ангіоневротичний набр= як.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'><o:p> </o:p><= /span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma= l'><span lang=3DUK style=3D'mso-ansi-language:UK'>Термін придатності. </span></i></b= ><span lang=3DUK style=3D'mso-ansi-language:UK'>4 роки.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></span></p> <p class=3D320 style=3D'margin-bottom:0cm;margin-bottom:.0001pt'><b><span l= ang=3DUK style=3D'font-size:12.0pt;mso-ansi-language:UK'>Умови зберігання. </span></= b><span lang=3DUK style=3D'font-size:12.0pt;mso-ansi-language:UK'>Зберігати в оригі= нальній упаковці при температурі не вище 25 °С.<o:p></o:p></span></p> <p class=3D320 style=3D'margin-top:0cm;margin-right:-.05pt;margin-bottom:0c= m; margin-left:0cm;margin-bottom:.0001pt;text-align:justify;mso-hyphenate:none; tab-stops:212.65pt 326.05pt'><span lang=3DUK style=3D'font-size:12.0pt;mso-= ansi-language: UK'>Зберігати у недоступному для дітей місці.</span><span lang=3DUK style=3D'font-size:12.0pt;mso-bidi-font-size:10.0pt;mso-ansi-language:UK; mso-bidi-font-style:italic'><o:p></o:p></span></p> <p class=3D320 style=3D'margin-top:0cm;margin-right:-.05pt;margin-bottom:0c= m; margin-left:0cm;margin-bottom:.0001pt;text-align:justify;mso-hyphenate:none; tab-stops:212.65pt 326.05pt'><span lang=3DUK style=3D'font-size:12.0pt;mso-= bidi-font-size: 10.0pt;mso-ansi-language:UK;mso-bidi-font-style:italic'><o:p> </o:p></= span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma= l'><span lang=3DUK style=3D'mso-ansi-language:UK'>Несумісність. </span></i></b><span lang=3DUK style=3D'mso-ansi-language:UK'>Препарат не слід змішувати з іншими лікарськими засобами. Використовувати тільки рекомендовані розчинники.<b style=3D'mso-bidi-font-weight:normal'><o:p></o:p></b></span></p> <p class=3DMsoNormal style=3D'mso-hyphenate:none'><b style=3D'mso-bidi-font= -weight: normal'><span lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></s= pan></b></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-ansi-lan= guage: UK'>Упаковка.</span></b><span lang=3DUK style=3D'mso-ansi-language:UK'> П</= span><span lang=3DUK style=3D'mso-bidi-font-size:10.0pt;mso-ansi-language:UK'>о 5 мл в= ампул</span><span lang=3DUK style=3D'font-family:"Times New Roman CYR",serif;mso-ansi-languag= e:UK'>ах № </span><span style=3D'font-family:"Times New Roman CYR",serif'>5×2<= /span><span lang=3DUK style=3D'font-family:"Times New Roman CYR",serif;mso-ansi-languag= e:UK'> у блістерах у коробці; № 10 у коробці.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'font-family:"Times New Roman CYR",serif;mso-ansi-language:UK'><o:p= > </o:p></span></p> <p class=3DMsoNormal style=3D'mso-hyphenate:none'><b style=3D'mso-bidi-font= -weight: normal'><span lang=3DUK style=3D'mso-ansi-language:UK'>Категорія відпуску. = </span></b><span lang=3DUK style=3D'mso-ansi-language:UK'>За рецептом.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'mso-hyphenate:none'><span lang=3DUK style=3D'= mso-ansi-language: UK'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'mso-hyphenate:none'><b style=3D'mso-bidi-font= -weight: normal'><span lang=3DUK style=3D'mso-ansi-language:UK'>Виробник.</span></b>= <span lang=3DUK style=3D'mso-ansi-language:UK'> ТОВАРИСТВО З ОБМЕЖЕНОЮ ВІДПОВІДАЛ= ЬНІСТЮ «КОРПОРАЦІЯ «ЗДОРОВ’Я».<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'mso-hyphenate:none'><span lang=3DUK style=3D'= mso-ansi-language: UK'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-ansi-lan= guage: UK'>Місцезнаходження виробника та його адреса місця провадження діяльності.= </span></b><span lang=3DUK style=3D'mso-ansi-language:UK'>Україна, 61013, Харківська обл., м= істо Харків, вулиця Шевченка, будинок 22.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'text-align:justify;mso-hyphenate:none'><span = lang=3DUK style=3D'mso-ansi-language:UK'><o:p> </o:p></span></p> </div> </body> </html> ------=_NextPart_01DC9140.45F80990 Content-Location: file:///C:/68115B16/UA40220301_A576.files/themedata.thmx Content-Transfer-Encoding: base64 Content-Type: application/vnd.ms-officetheme UEsDBBQABgAIAAAAIQDp3g+//wAAABwCAAATAAAAW0NvbnRlbnRfVHlwZXNdLnhtbKyRy07DMBBF 90j8g+UtSpyyQAgl6YLHjseifMDImSQWydiyp1X790zSVEKoIBZsLNkz954743K9Hwe1w5icp0qv 8kIrJOsbR12l3zdP2a1WiYEaGDxhpQ+Y9Lq+vCg3h4BJiZpSpXvmcGdMsj2OkHIfkKTS+jgCyzV2 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