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<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table Grid 7"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table Grid 8"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table List 1"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table List 2"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table List 3"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table List 4"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table List 5"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table List 6"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table List 7"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table List 8"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table 3D effects 1"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table 3D effects 2"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table 3D effects 3"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table Contemporary"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table Elegant"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table Professional"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table Subtle 1"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table Subtle 2"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table Web 1"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table Web 2"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table Web 3"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Balloon Text"/>
<w:LsdException Locked=3D"false" Priority=3D"39" Name=3D"Table Grid"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
Name=3D"Table Theme"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" Name=3D"Placeholder =
Text"/>
<w:LsdException Locked=3D"false" Priority=3D"1" QFormat=3D"true" Name=3D"=
No Spacing"/>
<w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading"/>
<w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List"/>
<w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid"/>
<w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
"/>
<w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
"/>
<w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1"/>
<w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2"/>
<w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1"/>
<w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2"/>
<w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3"/>
<w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List"/>
<w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
"/>
<w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List"/>
<w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid"/>
<w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading Ac=
cent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List Accen=
t 1"/>
<w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid Accen=
t 1"/>
<w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
Accent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
Accent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1 Ac=
cent 1"/>
<w:LsdException Locked=3D"false" SemiHidden=3D"true" Name=3D"Revision"/>
<w:LsdException Locked=3D"false" Priority=3D"34" QFormat=3D"true"
Name=3D"List Paragraph"/>
<w:LsdException Locked=3D"false" Priority=3D"29" QFormat=3D"true" Name=3D=
"Quote"/>
<w:LsdException Locked=3D"false" Priority=3D"30" QFormat=3D"true"
Name=3D"Intense Quote"/>
<w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2 Ac=
cent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1 Ac=
cent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2 Ac=
cent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3 Ac=
cent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List Accent=
1"/>
<w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
Accent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List Ac=
cent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid Ac=
cent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading Ac=
cent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List Accen=
t 2"/>
<w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid Accen=
t 2"/>
<w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
Accent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
Accent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1 Ac=
cent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2 Ac=
cent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1 Ac=
cent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2 Ac=
cent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3 Ac=
cent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List Accent=
2"/>
<w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
Accent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List Ac=
cent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid Ac=
cent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading Ac=
cent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List Accen=
t 3"/>
<w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid Accen=
t 3"/>
<w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
Accent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
Accent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1 Ac=
cent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2 Ac=
cent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1 Ac=
cent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2 Ac=
cent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3 Ac=
cent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List Accent=
3"/>
<w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
Accent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List Ac=
cent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid Ac=
cent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading Ac=
cent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List Accen=
t 4"/>
<w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid Accen=
t 4"/>
<w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
Accent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
Accent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1 Ac=
cent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2 Ac=
cent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1 Ac=
cent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2 Ac=
cent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3 Ac=
cent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List Accent=
4"/>
<w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
Accent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List Ac=
cent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid Ac=
cent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading Ac=
cent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List Accen=
t 5"/>
<w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid Accen=
t 5"/>
<w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
Accent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
Accent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1 Ac=
cent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2 Ac=
cent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1 Ac=
cent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2 Ac=
cent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3 Ac=
cent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List Accent=
5"/>
<w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
Accent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List Ac=
cent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid Ac=
cent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading Ac=
cent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List Accen=
t 6"/>
<w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid Accen=
t 6"/>
<w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
Accent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
Accent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1 Ac=
cent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2 Ac=
cent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1 Ac=
cent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2 Ac=
cent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3 Ac=
cent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List Accent=
6"/>
<w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
Accent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List Ac=
cent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid Ac=
cent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"19" QFormat=3D"true"
Name=3D"Subtle Emphasis"/>
<w:LsdException Locked=3D"false" Priority=3D"21" QFormat=3D"true"
Name=3D"Intense Emphasis"/>
<w:LsdException Locked=3D"false" Priority=3D"31" QFormat=3D"true"
Name=3D"Subtle Reference"/>
<w:LsdException Locked=3D"false" Priority=3D"32" QFormat=3D"true"
Name=3D"Intense Reference"/>
<w:LsdException Locked=3D"false" Priority=3D"33" QFormat=3D"true" Name=3D=
"Book Title"/>
<w:LsdException Locked=3D"false" Priority=3D"37" SemiHidden=3D"true"
UnhideWhenUsed=3D"true" Name=3D"Bibliography"/>
<w:LsdException Locked=3D"false" Priority=3D"39" SemiHidden=3D"true"
UnhideWhenUsed=3D"true" QFormat=3D"true" Name=3D"TOC Heading"/>
<w:LsdException Locked=3D"false" Priority=3D"41" Name=3D"Plain Table 1"/>
<w:LsdException Locked=3D"false" Priority=3D"42" Name=3D"Plain Table 2"/>
<w:LsdException Locked=3D"false" Priority=3D"43" Name=3D"Plain Table 3"/>
<w:LsdException Locked=3D"false" Priority=3D"44" Name=3D"Plain Table 4"/>
<w:LsdException Locked=3D"false" Priority=3D"45" Name=3D"Plain Table 5"/>
<w:LsdException Locked=3D"false" Priority=3D"40" Name=3D"Grid Table Light=
"/>
<w:LsdException Locked=3D"false" Priority=3D"46" Name=3D"Grid Table 1 Lig=
ht"/>
<w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2"/>
<w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3"/>
<w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4"/>
<w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k"/>
<w:LsdException Locked=3D"false" Priority=3D"51" Name=3D"Grid Table 6 Col=
orful"/>
<w:LsdException Locked=3D"false" Priority=3D"52" Name=3D"Grid Table 7 Col=
orful"/>
<w:LsdException Locked=3D"false" Priority=3D"46"
Name=3D"Grid Table 1 Light Accent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2 Acc=
ent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3 Acc=
ent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4 Acc=
ent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k Accent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"51"
Name=3D"Grid Table 6 Colorful Accent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"52"
Name=3D"Grid Table 7 Colorful Accent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"46"
Name=3D"Grid Table 1 Light Accent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2 Acc=
ent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3 Acc=
ent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4 Acc=
ent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k Accent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"51"
Name=3D"Grid Table 6 Colorful Accent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"52"
Name=3D"Grid Table 7 Colorful Accent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"46"
Name=3D"Grid Table 1 Light Accent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2 Acc=
ent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3 Acc=
ent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4 Acc=
ent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k Accent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"51"
Name=3D"Grid Table 6 Colorful Accent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"52"
Name=3D"Grid Table 7 Colorful Accent 3"/>
<w:LsdException Locked=3D"false" Priority=3D"46"
Name=3D"Grid Table 1 Light Accent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2 Acc=
ent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3 Acc=
ent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4 Acc=
ent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k Accent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"51"
Name=3D"Grid Table 6 Colorful Accent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"52"
Name=3D"Grid Table 7 Colorful Accent 4"/>
<w:LsdException Locked=3D"false" Priority=3D"46"
Name=3D"Grid Table 1 Light Accent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2 Acc=
ent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3 Acc=
ent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4 Acc=
ent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k Accent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"51"
Name=3D"Grid Table 6 Colorful Accent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"52"
Name=3D"Grid Table 7 Colorful Accent 5"/>
<w:LsdException Locked=3D"false" Priority=3D"46"
Name=3D"Grid Table 1 Light Accent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2 Acc=
ent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3 Acc=
ent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4 Acc=
ent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k Accent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"51"
Name=3D"Grid Table 6 Colorful Accent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"52"
Name=3D"Grid Table 7 Colorful Accent 6"/>
<w:LsdException Locked=3D"false" Priority=3D"46" Name=3D"List Table 1 Lig=
ht"/>
<w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"List Table 2"/>
<w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"List Table 3"/>
<w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"List Table 4"/>
<w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"List Table 5 Dar=
k"/>
<w:LsdException Locked=3D"false" Priority=3D"51" Name=3D"List Table 6 Col=
orful"/>
<w:LsdException Locked=3D"false" Priority=3D"52" Name=3D"List Table 7 Col=
orful"/>
<w:LsdException Locked=3D"false" Priority=3D"46"
Name=3D"List Table 1 Light Accent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"List Table 2 Acc=
ent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"List Table 3 Acc=
ent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"List Table 4 Acc=
ent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"List Table 5 Dar=
k Accent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"51"
Name=3D"List Table 6 Colorful Accent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"52"
Name=3D"List Table 7 Colorful Accent 1"/>
<w:LsdException Locked=3D"false" Priority=3D"46"
Name=3D"List Table 1 Light Accent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"List Table 2 Acc=
ent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"List Table 3 Acc=
ent 2"/>
<w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"List Table 4 Acc=
ent 2"/>
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k-word'>
<div class=3DWordSection1>
<h1 style=3D'mso-list:l1 level1 lfo2'><span style=3D'mso-bidi-font-size:12.=
0pt;
color:black;mso-color-alt:windowtext;background:white;mso-ansi-language:UK'=
>ІНСТРУКЦІЯ</sp=
an><span
style=3D'mso-bidi-font-size:12.0pt;color:windowtext;mso-color-alt:windowtex=
t;
background:white;mso-ansi-language:UK'><o:p></o:p></span></h1>
<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><b style=3D=
'mso-bidi-font-weight:
normal'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
background:white;mso-ansi-language:UK'>для
медичного
застосуванl=
5;я
<span style=3D'mso-bidi-font-weight:bold'>лікаl=
8;ського
засобу</span></span></b><b
style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:6.0pt;color:=
windowtext;
mso-color-alt:windowtext;background:white;mso-ansi-language:UK'><o:p></o:p>=
</span></b></p>
<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><b style=3D=
'mso-bidi-font-weight:
normal'><span style=3D'font-size:6.0pt;color:windowtext;mso-color-alt:windo=
wtext;
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'mso-bidi-font-weight:
normal'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
background:white;mso-ansi-language:UK'>ПІРАЦ&=
#1045;ТАМ</span></b><b
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:windowtext;
mso-color-alt:windowtext;background:white;mso-ansi-language:UK'><o:p></o:p>=
</span></b></p>
<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><b style=3D=
'mso-bidi-font-weight:
normal'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
background:white;mso-ansi-language:UK'>(<span style=3D'mso-bidi-font-weight=
:bold'>PIRACETAM</span>)</span></b><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;backgro=
und:
white;mso-ansi-language:UK'><o:p></o:p></span></p>
<p class=3DMsoNormal><span style=3D'font-size:12.0pt;color:windowtext;mso-c=
olor-alt:
windowtext;background:white;mso-ansi-language:UK'><o:p> </o:p></span><=
/p>
<p class=3DMsoNormal><b><i style=3D'mso-bidi-font-style:normal'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;background:w=
hite;
mso-ansi-language:UK'>Склад:</span></i></b><i
style=3D'mso-bidi-font-style:normal'><span style=3D'font-size:12.0pt;color:=
windowtext;
mso-color-alt:windowtext;background:white;mso-ansi-language:UK'><o:p></o:p>=
</span></i></p>
<p class=3DMsoNormal><i style=3D'mso-bidi-font-style:normal'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;background:w=
hite;
mso-ansi-language:UK'>діюча
речовина: </span></i><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;background:w=
hite;
mso-ansi-language:UK'>пірацет
=
72;м;</span><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;backgro=
und:
white;mso-ansi-language:UK'><o:p></o:p></span></p>
<p class=3DMsoNormal><span style=3D'font-size:12.0pt;color:black;mso-color-=
alt:
windowtext;background:white;mso-ansi-language:UK'>1
таблетка
містить
пірацетам 200
мг або 400 мг;</span><i
style=3D'mso-bidi-font-style:normal'><span style=3D'font-size:12.0pt;color:=
windowtext;
mso-color-alt:windowtext;background:white;mso-ansi-language:UK'><o:p></o:p>=
</span></i></p>
<p class=3DMsoNormal style=3D'text-align:justify'><i style=3D'mso-bidi-font=
-style:
normal'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
background:white;mso-ansi-language:UK'>допом&=
#1110;жні
речовини: </span></i><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;background:w=
hite;
mso-ansi-language:UK'>лактози
моногідрат,
целюлоза
мікрокристk=
2;лічна,
крохмаль<span
style=3D'mso-spacerun:yes'>
</span>прежелатиl=
5;ізований,
магнію
стеарат,
кремнію
діоксид кол
=
86;їдний
безводний,
тальк.</span><b style=3D'mso-bidi-font-weight=
:normal'><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;backgro=
und:
white;mso-ansi-language:UK;mso-bidi-font-style:italic'><o:p></o:p></span></=
b></p>
<p class=3DMsoNormal><b style=3D'mso-bidi-font-weight:normal'><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;backgro=
und:
white;mso-ansi-language:UK;mso-bidi-font-style:italic'><o:p> </o:p></s=
pan></b></p>
<p class=3DMsoNormal><b style=3D'mso-bidi-font-weight:normal'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;background:w=
hite;
mso-ansi-language:UK;mso-bidi-font-style:italic'>Лікk=
2;рська
форма. </span></b><span style=3D'font-size:12=
.0pt;
color:black;mso-color-alt:windowtext;background:white;mso-ansi-language:UK;
mso-bidi-font-style:italic'>Таблетl=
2;и.</span><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;backgro=
und:
white;mso-ansi-language:UK'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'text-align:justify'><i><span style=3D'font-si=
ze:12.0pt;
color:black;mso-color-alt:windowtext;background:white;mso-ansi-language:UK'=
>Основні
фізико-хімі
=
95;ні
власт</span></i><i><span style=3D'font-size:1=
2.0pt;
color:windowtext;mso-ansi-language:UK'>ивост&=
#1110;:
</span></i><span style=3D'font-size:12.0pt;color:windowtext;mso-ansi-langua=
ge:
UK'>таблетки
білого з
кремуватим
відтінком к
=
86;льору,
плоскоциліl=
5;дричної
форми з фаск=
086;ю
та рискою; на
поверхні
таблеток
допускаєтьl=
9;я
мармуровісm=
0;ь.<span
style=3D'mso-bidi-font-style:italic'><o:p></o:p></span></span></p>
<p class=3DMsoNormal><span style=3D'font-size:12.0pt;color:windowtext;mso-a=
nsi-language:
UK;mso-bidi-font-style:italic'><o:p> </o:p></span></p>
<p class=3DMsoNormal><b style=3D'mso-bidi-font-weight:normal'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'>Ф=
072;рмакотерап&=
#1077;втична
група</span></b><b style=3D'mso-bidi-font-wei=
ght:
normal'><span style=3D'color:windowtext;mso-ansi-language:UK'>.</span></b><=
span
style=3D'color:windowtext;mso-ansi-language:UK'> </span><span style=3D'font=
-size:
12.0pt;color:windowtext;mso-ansi-language:UK'>Псих&=
#1086;стимулятор=
;и
та ноотропн =
10;
засоби.<o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK'>Код
АТХ N06B Х03.<o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK'><o:p> </o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><b><i><s=
pan
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Фармакl=
6;логічні
властивостo=
0;.</span></i></b><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><i><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Фармакl=
6;динаміка.</span></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Пірацеm=
0;ам
є ноотропни
=
84;
засобом, яки=
081;
діє на
головний
мозок,
покращуючи
когнітивні (=
087;ізнавальні)
процеси, так=
110;
як здатніст =
00;
до навчання,
пам’ять,
увага, а
також
розумову пр
=
72;цездатніст&#=
1100;.
Пірацетам
впливає на
центральну
нервову
систему
різними
шляхами: змі=
085;ює
швидкість
розповсюджk=
7;ння
збудження в
головному
мозку;
покращує
метаболічнo=
0; процеси
у нервових
клітинах;
покращує мі
=
82;роциркуляц&#=
1110;ю,
впливаючи н
=
72;
реологічні
характерисm=
0;ики
крові і не
спричиняючl=
0;
судинорозшl=
0;рювальної
дії. </span><span style=3D'font-size:12.0pt;color:windowt=
ext;
mso-color-alt:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'><o:p=
></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Покращm=
1;є
зв’язок між
півкулями
головного
мозку і
синаптичну
провідністn=
0;
у окортикал =
00;них
структурах.
Пірацетам
пригнічує а
=
75;регацію
тромбоцитіk=
4;
і відновлює
еластичнісm=
0;ь
мембрани
еритроцитіk=
4;,
зменшує адг
=
77;зію
еритроцитіk=
4;.
Пірацетам
чинить прот
=
77;кторну
і
відновлюваl=
3;ьну
дію при
порушенні
функції
головного
мозку
внаслідок
гіпоксії та
інтоксикацo=
0;ї.
Пірацетам
знижує вира
=
78;еність
і триваліст =
00;
вестибулярl=
5;ого
ністагму.</span><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><i><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Фармакl=
6;кінетика.</span></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Після
прийому
перорально
пірацетам
швидко і
практично
повністю
всмоктуєтьl=
9;я,
пікова
концентрацo=
0;я
досягаєтьсn=
3;
через 1 годин&#=
1091;
після
прийому.
Біодоступнo=
0;сть
становить =
майже
100 % після
прийому
одноразовоo=
1;
дози 2 г. Об’єм
розподілу
пірацетаму R=
12;
приблизно 0,6
л/кг. </span><span style=3D'font-size:12.0pt;color:window=
text;
mso-color-alt:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'><o:p=
></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Період
напіввиведk=
7;ння
лікарськогl=
6;
засобу з
плазми кров =
10;
становить 4–5
годин і 6–8 год=
ин
— зі
спинномозкl=
6;вої
рідини і
подовжуєтьl=
9;я
при ниркові
=
81;
недостатноl=
9;ті.
Пірацетам н
=
77;
зв’язуєтьсn=
3;
з білками
плазми кров =
10;,
не метаболі
=
79;ується
в організмі.
80–100 % пірацета
=
84;у
виводиться
нирками в
незміненомm=
1;
стані шляхо
=
84;
ниркової
фільтрації.
Нирковий кл =
10;ренс
пірацетаму
=
91;
здорових
добровольцo=
0;в
становить 86
мл/хв.
Фармакокінk=
7;тика
пірацетаму
не
змінюється
=
91;
пацієнтів з
печінковою
недостатніl=
9;тю.
Пірацетам
проникає кр =
10;зь
гематоенцеm=
2;алічний
і
плацентарнl=
0;й
бар’єри і
мембрани, як=
110;
використовm=
1;ються
при
гемодіалізo=
0;.
У
дослідженнn=
3;х
на тваринах<span
style=3D'background:yellow'> </span>пірац
=
77;там
вибірково
накопичуваk=
4;ся
у тканинах
кори
головного
мозку,
переважно в
лобних,
тім’яних і
потиличних
частках, у
мозочку і
базальних
гангліях.</span><span
style=3D'color:windowtext;mso-color-alt:windowtext;mso-ansi-language:UK;
mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><span
style=3D'color:black;mso-color-alt:windowtext;mso-ansi-language:UK;mso-fare=
ast-language:
CS'> </span><b style=3D'mso-bidi-font-weight:normal'><span style=3D'fo=
nt-size:
12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ansi-language:UK;
mso-bidi-font-style:italic'><o:p></o:p></span></b></p>
<p class=3DMsoNormal><b style=3D'mso-bidi-font-weight:normal'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-bidi-fo=
nt-style:
italic'>Клінічні
характерисm=
0;ики.</span></b><b><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'><o:p></o:p></span></i></b></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><b><i><s=
pan
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Показаl=
5;ня.</span></i></b><u><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></u></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><u><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Застосl=
6;вувати
дорослим:</span></u><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS;mso-bidi-font-style:italic'><o:p></o:p></span></=
p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS;mso-bidi-font=
-style:
italic'>–</span><span style=3D'font-size:12.0pt;color:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'> для
симптоматиm=
5;ного
лікування
патологічнl=
0;х
станів, що
супроводжуn=
2;ться
зниженням
пам’яті,
когнітивниl=
4;и
розладами, з=
072;
винятком
діагностовk=
2;ної
деменції
(слабоумств
=
72;);<span
style=3D'mso-bidi-font-style:italic'><o:p></o:p></span></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS;mso-bidi-font=
-style:
italic'>–</span><span style=3D'font-size:12.0pt;color:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'> для
лікування
кортикальнl=
6;ї
міоклонії: я=
082;
монопрепарk=
2;т
або у складі
комплексноo=
1;
терапії. </span><b style=3D'mso-b=
idi-font-weight:
normal'><i style=3D'mso-bidi-font-style:normal'><span style=3D'font-size:12=
.0pt;
font-family:"Calibri",sans-serif;color:windowtext;mso-ansi-language:UK;
mso-fareast-language:CS'><o:p></o:p></span></i></b></p>
<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><i style=3D'mso-bidi-font-style:normal'><span style=3D'font-size:12=
.0pt;
font-family:"Calibri",sans-serif;color:windowtext;mso-ansi-language:UK;
mso-fareast-language:CS'><o:p> </o:p></span></i></b></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><b><i=
><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>Протипоказ&=
#1072;ння.</span></i></b><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS;mso-bidi-font-style:italic'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS;mso-bidi-font-style:italic'>– </span><span style=3D'font-size:12.0=
pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>Іl=
5;дивідуальн=
072;
гіперчутлиk=
4;ість
до пірацета
=
84;у
або похідни
=
93;
піролідону, =
072;
також до інш=
080;х
компонентіk=
4;
лікарськогl=
6;
засобу.<span style=3D'mso-bidi-font-sty=
le:
italic'><o:p></o:p></span></span></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS;mso-bidi-font-style:italic'>– </span><span style=3D'font-size:12.0=
pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>Гl=
6;стре
порушення
мозкового
кровообігу (=
075;еморагічни&=
#1081;
інсульт).<span style=3D'mso-bidi-=
font-style:
italic'><o:p></o:p></span></span></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS;mso-bidi-font-style:italic'>– </span><span style=3D'font-size:12.0=
pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>Тk=
7;рмінальна
стадія
ниркової
недостатноl=
9;ті
(при кліренс=
110;
креатиніну
менше 20 мл/хв).<span
style=3D'mso-bidi-font-style:italic'><o:p></o:p></span></span></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS;mso-bidi-font-style:italic'>– </span><span style=3D'font-size:12.0=
pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>Хl=
6;рея
Хантінгтонk=
2;.</span><span
style=3D'font-size:12.0pt;font-family:"Calibri",sans-serif;color:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
font-family:"Calibri",sans-serif;color:windowtext;mso-ansi-language:UK;
mso-fareast-language:CS'><o:p> </o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><b><i><s=
pan
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Взаємоk=
6;ія
з іншими
лікарськимl=
0;
засобами та
інші види
взаємодій.</span></i>=
</b><i
style=3D'mso-bidi-font-style:normal'><u><span style=3D'font-size:12.0pt;col=
or:windowtext;
mso-color-alt:windowtext;mso-ansi-language:UK'><o:p></o:p></span></u></i></=
p>
<p class=3DMsoNormal style=3D'text-align:justify'><i style=3D'mso-bidi-font=
-style:
normal'><u><span style=3D'font-size:12.0pt;color:windowtext;mso-ansi-langua=
ge:
UK'>Фармакокін&=
#1077;тичні
взаємодії.</span></u>=
</i><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'><o:p></o:p=
></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK'>Можли&=
#1074;ість
зміни
фармакодинk=
2;міки
пірацетаму
під дією
інших
лікарських
засобів низ =
00;ка,
оскільки 90 %
пірацетаму
виводиться
=
91; незміненом&=
#1091;
стані з
сечею. <i style=3D'mso-bidi-font-style:normal=
'><o:p></o:p></i></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><i style=3D'mso-bidi-font=
-style:
normal'><span style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:=
UK'>In
vitro</span></i><span style=3D'font-size:12.0pt;color:windowtext;mso-ansi-l=
anguage:
UK'> пірацетам
не пригнічу =
08;
цитохром Р450
ізоформи CYP1A2, 2B6, 2C8, =
2C9,
2C19, 2D6, 2E1 i 4A9/11 у
концентрацo=
0;ї
142, 426, 1422 мкг/мл.<o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK'>При
концентрацo=
0;ї
1422 мкг/мл
спостерігаn=
8;ться
незначне
пригніченнn=
3;
CYP2А6 (21 %) і 3А4/5 (11 %).
Однак показ
=
85;ик
К<sub>і </sub>цих двох
CYP-ізомерів
достатній
при перевищ
=
77;нні
рівня 1422 мкг/мl=
3;.
Тому
метаболічнk=
2;
взаємодія з
препаратамl=
0;,
що
піддаються
біотрансфоl=
8;мації
цими
ферментами,
малоймовірl=
5;а.
<i style=3D'mso-bidi-font-style:normal'><u><o:p></o:p></u></i></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><i style=3D'mso-bidi-font=
-style:
normal'><u><span style=3D'font-size:12.0pt;color:windowtext;mso-ansi-langua=
ge:
UK'>Тиреоїдні
гормони.</span></u></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'><o:p></o:p=
></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK'>При
одночасномm=
1;
застосуванl=
5;і
з тиреоїдни
=
84;и
гормонами (Т<su=
b>3</sub>+Т<sub>4</sub>)
можлива
підвищена
дратівливіl=
9;ть,
дезорієнтаm=
4;ія
та порушенн =
03;
сну. <i style=3D'mso-bidi-font-style:normal'><u><o:p></o:=
p></u></i></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><i style=3D'mso-bidi-font=
-style:
normal'><u><span style=3D'font-size:12.0pt;color:windowtext;mso-ansi-langua=
ge:
UK'>Аценокумар&=
#1086;л.</span></u></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'><o:p></o:p=
></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK'>Під
час
клінічних
досліджень
=
91;
хворих із тя=
078;ким
перебігом
рецидивногl=
6;
тромбозу за
=
89;тосування
пірацетаму
=
91;
високих
дозах (9,6 г/добm=
1;)
не вимагало
зміни
дозування
аценокумарl=
6;лу
для
досягнення
значення
протромбінl=
6;вого
часу (МНВ —
міжнародноk=
5;о
нормалізовk=
2;ного
відношення) 2,5=
</span><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS;mso-bidi-font-style:italic'>–3,5, але
при його
одночасномm=
1;
застосуванl=
5;і
відзначалоl=
9;я</span><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'>
значне
зниження
рівня
агрегації
тромбоцитіk=
4;,
рівня
фібриногенm=
1;,
факторів
Віллібрандk=
2;
[коагуляцій
=
85;а
активність (VII=
I:
C); кофактор ри=
стоцетину
(VIII: vW: Rco) та
протеїну
плазми кров =
10;
(VIII: Ag)], в’язкості
крові та
плазми кров =
10;.
<i style=3D'mso-bidi-font-style:normal'><u><o:p></o:p></u></i></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><i style=3D'mso-bidi-font=
-style:
normal'><u><span style=3D'font-size:12.0pt;color:windowtext;mso-ansi-langua=
ge:
UK'>Протиепіле&=
#1087;тичні
лікарські
засоби.</span></u></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'><o:p></o:p=
></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK'>Засто&=
#1089;ування
пірацетаму
=
91;
дозі 20 мг на
добу щоденн
=
86;
протягом 4
тижнів не
змінювало
криву рівня
концентрацo=
0;ї
і
максимальнm=
1;
концентрацo=
0;ю
протиепілеl=
7;тичних
препаратів (=
082;арбамазепі&=
#1085;у,
фенітоїну,
фенобарбітk=
2;лу,
натрію
вальпроату) =
091;
хворих на
епілепсію. <i
style=3D'mso-bidi-font-style:normal'><u><o:p></o:p></u></i></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><i style=3D'mso-bidi-font=
-style:
normal'><u><span style=3D'font-size:12.0pt;color:windowtext;mso-ansi-langua=
ge:
UK'>Алкоголь.</span></u></i=
><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>Сm=
1;місний
прийом з
алкоголем н
=
77;
впливає на к=
086;нцентрацію
пірацетаму
=
91;
сироватці
крові, і
рівень
концентрацo=
0;ї
алкоголю в
сироватці
крові не
змінюється
при
одноразовоl=
4;у
прийомі 1,6 г
пірацетаму.<o:p=
></o:p></span></p>
<p class=3DMsoNormal><span style=3D'font-size:12.0pt;color:windowtext;mso-a=
nsi-language:
UK;mso-fareast-language:CS'>У</span><span style=3D'font-size:12.0pt;
mso-bidi-font-size:10.0pt;color:windowtext;mso-ansi-language:UK'>
людей
літнього
віку
пірацетам
посилює дію
антиангінаl=
3;ьних
засобів,
підвищує
ефективнісm=
0;ь
антидепресk=
2;нтів.</span><span
style=3D'color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'><o:=
p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><span
style=3D'color:windowtext;mso-color-alt:windowtext;mso-ansi-language:UK;
mso-fareast-language:CS'><o:p> </o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><b><i><s=
pan
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Особлиk=
4;ості
застосуванl=
5;я.</span></i></b><i><u><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></u></i></p>
<p class=3DMsoNormal style=3D'text-align:justify'><i><u><span style=3D'font=
-size:
12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>h=
2;плив
на агрегаці =
02;
тромбоцитіk=
4;</span></u></i><u><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>.</span></u><span style=3D'font-size:12.0pt;color:windowtext;mso-ansi-l=
anguage:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>У
зв’язку з
тим, що
пірацетам
знижує
агрегацію
тромбоцитіk=
4;,
необхідно з
обережністn=
2; призначати
лікарський
засіб хвори
=
84;
з порушення
=
84;
гемостазу,
станами, що
можуть супр
=
86;воджуватис&#=
1103;
крововиливk=
2;ми
(виразка шлу=
085;ково-кишков=
ого
тракту), під
час великих
хірургічниm=
3;
операцій
(включно зі
стоматологo=
0;чними
операціями),
хворим із
симптомами
=
90;яжкої
кровотечі;
хворим, які
мають в анам=
085;езі
геморагічнl=
0;й
інсульт;
пацієнтам,
які застосо
=
74;ують
антикоагулn=
3;нти,
тромбоцитаl=
8;ні
антиагрегаl=
5;ти,
включаючи
низькі дози =
072;цетилсаліц&=
#1080;лової
кислоти.<i><u><o:p></o:p></u></i>=
</span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><i><u><span style=3D'font=
-size:
12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>i=
5;орушення
функції
нирок.</span></u></i><span style=3D'font-size=
:12.0pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'><o:p></o:p><=
/span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>Лo=
0;карський
засіб
виводиться
нирками, том=
091;
необхідно
особливу
увагу
приділяти
хворим з
нирковою
недостатніl=
9;тю.<i><u><o:p></o:p></u></i></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><i><u><s=
pan
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Пацієнm=
0;и
літнього
віку.</span></u></i><span style=3D'font-size:12.0pt;
color:windowtext;mso-color-alt:windowtext;mso-ansi-language:UK;mso-fareast-=
language:
CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>При
тривалій
терапії для
хворих
літнього ві
=
82;у
рекомендуєm=
0;ься
регулярний
контроль
показників
функції
нирок, у разі
необхідносm=
0;і
слід
коригувати
дозу залежн
=
86;
від результ
=
72;тів
дослідженнn=
3;
кліренсу
креатиніну.</sp=
an><i><u><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></u></i></p>
<p class=3DMsoNormal style=3D'text-align:justify'><i><u><span style=3D'font=
-size:
12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>i=
5;ереривання
застосуванl=
5;я</span></u></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>.<o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>Пl=
8;и
лікуванні
хворих на
кортикальнm=
1;
міоклонію
слід уникат
=
80;
різкого
перериваннn=
3;
лікування у
зв’язку із
загрозою г=
енералізацo=
0;ї
міоклонії
або
виникнення
судом.<o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>Лo=
0;карський
засіб
проникає
через
фільтрувалn=
0;ні
мембрани
апаратів дл =
03;
гемодіалізm=
1;.<i><u><o:p></o:p></u></i></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><i><u><span style=3D'font=
-size:
12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>h=
2;ажлива
інформація
про
допоміжні
речовини.</span></u></i><sp=
an
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'><o:p></o:p=
></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK'>Препа&=
#1088;ат
містить
лактозу. Том=
091;
пацієнтам і
=
79;
рідкісними
спадковим
формами
непереносиl=
4;ості
галактози,
недостатніl=
9;тю
лактази або
синдромом
глюкозо-гал
=
72;ктозної
мальабсорбm=
4;ії
не слід
застосовувk=
2;ти
даний лікар
=
89;ький
засіб.</span><b><i><span style=3D'font-size:1=
2.0pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'><o:p></o:p><=
/span></i></b></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><b><i><s=
pan
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'> </span></i></b><i><span style=3D'font-siz=
e:
12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ansi-language:UK;
mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><i><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Застосm=
1;вання
у період
вагітності
або годуван
=
85;я
груддю.</span></i><span style=3D'font-s=
ize:
12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ansi-language:UK;
mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Не
застосовувk=
2;ти
лікарський
засіб у пері=
086;д
вагітності
та грудного
годування.</span><span
lang=3DRU style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p></=
span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><span la=
ng=3DRU
style=3D'color:windowtext;mso-color-alt:windowtext'><o:p> </o:p></span=
></p>
<p class=3DMsoNormal style=3D'background:white'><i><span style=3D'font-size=
:12.0pt;
color:black;mso-color-alt:windowtext;mso-ansi-language:UK;mso-fareast-langu=
age:
CS'>Здатність
впливати на
швидкість
реакції при
керуванні
автотранспl=
6;ртом
або іншими
механізмамl=
0;.</span></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK'>Слід
бути
обережними
під час
керування а
=
74;тотранспор&#=
1090;ом
або роботи з
іншими
механізмамl=
0;
через
можливість
розвитку
побічних
реакцій з
боку
центральноo=
1;
нервової си
=
89;теми.</span><b><i><span
style=3D'color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'><o:=
p></o:p></span></i></b></p>
<p class=3DMsoNormal style=3D'margin-right:1.4pt;text-align:justify;backgro=
und:
white'><b><i><span style=3D'color:black;mso-color-alt:windowtext;mso-ansi-l=
anguage:
UK;mso-fareast-language:CS'> </span></i></b><b><i><span style=3D'font-=
size:
12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ansi-language:UK;
mso-fareast-language:CS'><o:p></o:p></span></i></b></p>
<p class=3DMsoNormal style=3D'margin-right:1.4pt;text-align:justify;backgro=
und:
white'><b><i><span style=3D'font-size:12.0pt;color:black;mso-color-alt:wind=
owtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Спос&=
#1110;б
застосуванl=
5;я
та дози.</span></i></b><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.4pt;text-align:justify;backgro=
und:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Ліка&=
#1088;ський
засіб
застосовувk=
2;ти
всередину д
=
86;
або під час
їди. Таблетк=
080;
слід запива
=
90;и
рідиною
(водою або
соком).
Тривалість
лікування і
вибір
індивідуалn=
0;ної
дози залежи
=
90;ь
від тяжкост =
10;
стану
хворого і
швидкості з
=
74;оротної
динаміки
клінічної
картини зах
=
74;орювання.</span><u><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></u></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><u><s=
pan
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>Застосуван&=
#1085;я
дорослим.</span></u><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><i><s=
pan
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>Лікування
станів, що
супроводжуn=
2;ться погіl=
8;шенням
пам’яті,
когнітивниl=
4;и
розладами.</span></i>=
<span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>Початкова
добова доза
становить 4,8 г
протягом
першого
тижня
лікування.
Дозу слід
розподілятl=
0;
на 2–3 прийоми.
Підтримуваl=
3;ьна
доза станов
=
80;ть
2,4 г на добу
(розподілит
=
80;
на 2–3 прийоми).
Надалі
можливе
поступове
зниження до
=
79;и
на 1,2 г на добу.<i><=
u><o:p></o:p></u></i></span></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><i><u=
><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>Лікування
кортикальнl=
6;ї
міоклонії.</span></u>=
</i><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>Початкова
доза
становить 24
г/добу
протягом 3
днів. Якщо за
цей час не
досягнуто
бажаного
терапевтичl=
5;ого
ефекту,
потрібно
продовжуваm=
0;и
застосуванl=
5;я
лікарськогl=
6;
засобу у том=
091;
ж дозуванні (24
г/добу) до 7 діб=
;.</span><i><span
style=3D'font-family:"Calibri Light",sans-serif;color:windowtext;mso-ansi-l=
anguage:
UK;mso-fareast-language:CS'> </span></i><span style=3D'font-size:12.0pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>Яl=
2;що
на 7-му добу не
отримано
бажаного
терапевтичl=
5;ого
ефекту,
лікування
пірацетамоl=
4; слід
припинити.
Якщо
терапевтичl=
5;ого
ефекту було
досягнуто,
то, починаюч=
080;
з дня, коли на&=
#1089;тало
стійке
покращення,
потрібно
розпочати
зниження
дози
лікарськогl=
6;
засобу на 1,2 г
кожні 2 доби,
поки знову н=
077;
з’являться
прояви корт
=
80;кальної
міоклонії. Ц=
077;
дасть
можливість
встановити
середню
ефективну
дозу.<o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>Добову дозу
потрібно
розподілятl=
0;
на 2–3 прийоми.
Лікування
іншими
антиміоклоl=
5;ічними
засобами
підтримуваm=
0;и
у попереднь
=
86;
призначениm=
3;
дозах.
Терапію слі
=
76;
продовжуваm=
0;и
до зникненн =
03;
симптомів
захворюванl=
5;я.
Для
попередженl=
5;я
погіршення
стану хвори
=
93;
не можна
різко
припиняти
застосуванl=
5;я
лікарськогl=
6;
засобу.
Необхідно
поступово
знижувати
дозу на 1–2 г
кожні 2–3 дні.
Необхідно к
=
86;жні
6 місяців
призначати
повторні
курси лікув
=
72;ння,
коригуючи
при цьому
дозу залежн
=
86;
від стану
пацієнта, до
зникнення
або зменшен
=
85;я
проявів хво
=
88;оби.<u><o:p></o:p></u></span></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><u><s=
pan
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'><o:p><span style=3D'text-decoration:none'> </span></o:p></span></u=
></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><u><s=
pan
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>Застосуван&=
#1085;я
пацієнтам
літнього
віку</span></u><span style=3D'font-size:12.0pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>.<o:p></o:p>=
</span></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>Корекція
дози
рекомендуєm=
0;ься
пацієнтам л =
10;тнього
віку з
діагностовk=
2;ними
або підозрю
=
74;аними
розладами
функції
нирок. При до&#=
1074;готривалом=
у
лікуванні у
разі
необхідносm=
0;і
таким
пацієнтам
потрібно
контролюваm=
0;и
кліренс
креатиніну
=
79;
метою
адекватної
=
82;орекції
дози.<u><o:p></o:p></u></span></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><u><s=
pan
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>Дозування
для хворих і=
079;
порушенням
функції
нирок</span></u><span style=3D'font-size:12.0=
pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'>.<o:p></o:p>=
</span></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>Оскільки
лікарський
засіб
виводиться
=
79;
організму
нирками, слі=
076;
проявляти
обережністn=
0;
при
лікуванні
хворих з
нирковою
недостатніl=
9;тю.<o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:-.1pt;text-align:justify'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>Збільшення
періоду
напіввиведk=
7;ння
безпосередl=
5;ьо
пов’язано з
погіршенняl=
4;
функції
нирок і
кліренсу
креатиніну.
Це також сто=
089;ується
пацієнтів
літнього
віку, у яких в&=
#1080;ведення
креатиніну
залежить ві
=
76;
віку. Інтерв=
072;л
між
прийомами
потрібно
скоригуватl=
0;
відповідно
до
показників
функції нир
=
86;к.</span><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'><o:p></o:p=
></span></p>
<p class=3DMsoNormal><span style=3D'font-size:12.0pt;color:windowtext;mso-a=
nsi-language:
UK'>Дозу слід
розраховувk=
2;ти
на основі
оцінки клір
=
77;нсу
креатиніну
=
91;
пацієнта за
формулою:</span><span lang=
=3DRU
style=3D'color:windowtext'><o:p></o:p></span></p>
<p class=3DMsoNormal><!--[if gte vml 1]><v:shape id=3D"shape_0" o:spid=3D"_=
x0000_s1026"
style=3D'position:absolute;margin-left:153.6pt;margin-top:34.6pt;width:191=
.95pt;
height:.05pt;z-index:251657216;mso-wrap-style:none;v-text-anchor:middle'
coordsize=3D"21600,21600" o:spt=3D"100" o:allowincell=3D"f" adj=3D"0,,0" p=
ath=3D"m,l21600,21600nfe"
filled=3D"f" strokeweight=3D".26mm">
<v:stroke joinstyle=3D"miter" endcap=3D"square"/>
<v:formulas>
<v:f eqn=3D"val 1"/>
<v:f eqn=3D"val 2"/>
</v:formulas>
<v:path gradientshapeok=3D"t" o:connecttype=3D"rect" o:connectlocs=3D"0,0;=
21600,21600"
textboxrect=3D"0,0,21600,21600"/>
<v:handles>
<v:h position=3D"@3,#0" polar=3D"10800,10800"/>
<v:h position=3D"#2,#1" polar=3D"10800,10800" radiusrange=3D"0,10800"/>
</v:handles>
</v:shape><v:shapetype id=3D"_x0000_t202" coordsize=3D"21600,21600" o:spt=
=3D"202"
path=3D"m,l,21600r21600,l21600,xe">
<v:stroke joinstyle=3D"miter"/>
<v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/>
</v:shapetype><v:shape id=3D"_x0000_s1027" type=3D"#_x0000_t202" style=3D'p=
osition:absolute;
margin-left:3.2pt;margin-top:9.95pt;width:489pt;height:52.15pt;z-index:251=
658240;
mso-wrap-distance-left:9.05pt;mso-wrap-distance-right:9.05pt' o:allowincel=
l=3D"f"
strokeweight=3D".05pt">
<v:fill color2=3D"black"/>
<v:textbox inset=3D".05pt,.05pt,.05pt,.05pt">
<![if !mso]>
<table cellpadding=3D0 cellspacing=3D0 width=3D"100%">
<tr>
<td><![endif]>
<div>
<table class=3DMsoNormalTable border=3D0 cellspacing=3D0 cellpadding=3D0
style=3D'border-collapse:collapse;mso-padding-alt:0cm 0cm 0cm 0cm'>
<tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow:ye=
s;
height:21.3pt'>
<td width=3D509 style=3D'width:381.45pt;background:white;padding:0cm =
0cm 0cm 0cm;
height:21.3pt'>
<p class=3DMsoNormal style=3D'background:white'><span style=3D'mso-an=
si-language:
UK'><span
style=3D'mso-spacerun:yes'> =
&nb=
sp;
</span>[140 – вік (у ро
=
82;ах)]
× маса тіла</sp=
an><span
lang=3DRU> (</span><span style=3D'mso-ansi-language:UK'>у
кг)<o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'background:white'><span style=3D'mso-an=
si-language:
UK'>К<sub>кр</sub> =3D<span
style=3D'mso-spacerun:yes'>
</span>----------------------------------------------------------
(× 0,85 для жіноl=
2;) <o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'background:white'><span style=3D'mso-an=
si-language:
UK'><span
style=3D'mso-spacerun:yes'> =
&nb=
sp;
</span>72 × </span><span lang=3DRU style=3D'font-size:12.0pt'>&=
#1057;</span><span
lang=3DRU> <sub>креатин</su=
b></span><sub><span
style=3D'mso-ansi-language:UK'>і</span><span lang=3DRU>н<=
/span></sub><sub><span
style=3D'mso-ansi-language:UK'>у</span><span lang=3DRU> у=
</span></sub><sub><span
style=3D'mso-ansi-language:UK'>плаз<span
style=3D'background:white'>мі</span></span></sub><span la=
ng=3DRU
style=3D'background:white'> (мг/дл)</span></p>
</td>
</tr>
</table>
<p class=3DMsoNormal><span lang=3DRU><o:p> </o:p></span></p>
</div>
<![if !mso]></td>
</tr>
</table>
<![endif]></v:textbox>
</v:shape><![endif]--><![if !vml]><span style=3D'mso-ignore:vglayout;positi=
on:
relative;z-index:251657216'><span style=3D'position:absolute;left:-5px;
top:-642px;width:658px;height:75px'><img width=3D658 height=3D75
src=3D"UA57880102_CB60.files/image001.png" v:shapes=3D"shape_0 _x0000_s1027=
"></span></span><![endif]><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
RU'><o:p> </o:p></span></p>
<p class=3DMsoNormal><span style=3D'font-size:12.0pt;color:windowtext;mso-a=
nsi-language:
UK;mso-fareast-language:RU'><o:p> </o:p></span></p>
<p class=3DMsoNormal><span style=3D'font-size:12.0pt;color:windowtext;mso-a=
nsi-language:
UK;mso-fareast-language:RU'><o:p> </o:p></span></p>
<p class=3DMsoNormal><span style=3D'font-size:12.0pt;color:windowtext;mso-a=
nsi-language:
UK;mso-fareast-language:RU'><o:p> </o:p></span></p>
<p class=3DMsoNormal><span style=3D'font-size:12.0pt;color:windowtext;mso-a=
nsi-language:
UK;mso-fareast-language:RU'><o:p> </o:p></span></p>
<br style=3D'mso-ignore:vglayout' clear=3DALL>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify;mso-pa=
gination:
none'><span style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;
mso-fareast-language:RU'>Признач&=
#1072;ти
л</span><span style=3D'font-size:12.0pt;color:windowtext;mso-ansi-lan=
guage:
UK'>ікування
залежно </span><span lang=3DRU
style=3D'color:windowtext'>від
ступеня
тяжкості
ниркової
недостатноl=
9;ті,
дотримуючиl=
9;ь
таких
рекомендацo=
0;й:</span><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'><o:p></o:p=
></span></p>
<table class=3DMsoNormalTable border=3D0 cellspacing=3D0 cellpadding=3D0
style=3D'margin-left:1.95pt;border-collapse:collapse;mso-padding-alt:0cm 5=
.4pt 0cm 3.15pt'>
<tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:26.45pt'>
<td width=3D176 style=3D'width:132.3pt;border:solid navy 1.0pt;border-rig=
ht:none;
mso-border-top-alt:solid navy .5pt;mso-border-left-alt:solid navy .5pt;
mso-border-bottom-alt:solid navy .5pt;background:white;padding:0cm 5.4pt =
0cm 3.15pt;
height:26.45pt'>
<p class=3DMsoNormal align=3Dcenter style=3D'margin-right:2.85pt;text-ali=
gn:center;
mso-pagination:none'><span style=3D'font-size:12.0pt;color:black;mso-colo=
r-alt:
windowtext;mso-ansi-language:UK'>Ступіl=
5;ь
ниркової
недостатно=
089;ті</span><span
lang=3DRU style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p>=
</span></p>
</td>
<td width=3D207 style=3D'width:155.05pt;border:solid navy 1.0pt;border-ri=
ght:
none;mso-border-top-alt:solid navy .5pt;mso-border-left-alt:solid navy .5=
pt;
mso-border-bottom-alt:solid navy .5pt;background:white;padding:0cm 5.4pt =
0cm 3.15pt;
height:26.45pt'>
<p class=3DMsoNormal align=3Dcenter style=3D'margin-right:2.85pt;text-ali=
gn:center;
mso-pagination:none'><span style=3D'font-size:12.0pt;color:black;mso-colo=
r-alt:
windowtext;mso-ansi-language:UK'>Кліреl=
5;с
креатиніну
(мл/хв)</span><span lang=3DRU style=3D'color:wind=
owtext;
mso-color-alt:windowtext'><o:p></o:p></span></p>
</td>
<td width=3D274 style=3D'width:205.2pt;border:solid navy 1.0pt;mso-border=
-alt:
solid navy .5pt;background:white;padding:0cm 5.4pt 0cm 3.15pt;height:26.4=
5pt'>
<p class=3DMsoNormal align=3Dcenter style=3D'margin-right:2.85pt;text-ali=
gn:center;
mso-pagination:none'><span style=3D'font-size:12.0pt;color:black;mso-colo=
r-alt:
windowtext;mso-ansi-language:UK'>Дозувk=
2;ння</span><span
lang=3DRU style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p>=
</span></p>
</td>
</tr>
<tr style=3D'mso-yfti-irow:1;height:20.55pt'>
<td width=3D176 valign=3Dtop style=3D'width:132.3pt;border-top:none;borde=
r-left:
solid navy 1.0pt;border-bottom:solid navy 1.0pt;border-right:none;mso-bor=
der-top-alt:
solid navy .5pt;mso-border-top-alt:solid navy .5pt;mso-border-left-alt:so=
lid navy .5pt;
mso-border-bottom-alt:solid navy .5pt;background:white;padding:0cm 5.4pt =
0cm 3.15pt;
height:20.55pt'>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify;mso-=
pagination:
none'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
mso-ansi-language:UK'>Нормаль&#=
1085;а
функція
нирок</span><span lang=3DRU style=3D'color:=
windowtext;
mso-color-alt:windowtext'><o:p></o:p></span></p>
</td>
<td width=3D207 valign=3Dtop style=3D'width:155.05pt;border-top:none;bord=
er-left:
solid navy 1.0pt;border-bottom:solid navy 1.0pt;border-right:none;mso-bor=
der-top-alt:
solid navy .5pt;mso-border-top-alt:solid navy .5pt;mso-border-left-alt:so=
lid navy .5pt;
mso-border-bottom-alt:solid navy .5pt;background:white;padding:0cm 5.4pt =
0cm 3.15pt;
height:20.55pt'>
<p class=3DMsoNormal align=3Dcenter style=3D'margin-right:2.85pt;text-ali=
gn:center;
mso-pagination:none'><span style=3D'font-size:12.0pt;color:black;mso-colo=
r-alt:
windowtext;mso-ansi-language:UK'>> 80</span><span lang=3DRU
style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p></span></p>
</td>
<td width=3D274 valign=3Dtop style=3D'width:205.2pt;border:solid navy 1.0=
pt;
border-top:none;mso-border-top-alt:solid navy .5pt;mso-border-alt:solid n=
avy .5pt;
background:white;padding:0cm 5.4pt 0cm 3.15pt;height:20.55pt'>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify;mso-=
pagination:
none'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
mso-ansi-language:UK'>Звичайн&#=
1072;
доза,
розділена
на 2 або 4
прийоми</span><span lang=3DRU
style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p></span></p>
</td>
</tr>
<tr style=3D'mso-yfti-irow:2'>
<td width=3D176 valign=3Dtop style=3D'width:132.3pt;border-top:none;borde=
r-left:
solid navy 1.0pt;border-bottom:solid navy 1.0pt;border-right:none;mso-bor=
der-top-alt:
solid navy .5pt;mso-border-top-alt:solid navy .5pt;mso-border-left-alt:so=
lid navy .5pt;
mso-border-bottom-alt:solid navy .5pt;background:white;padding:0cm 5.4pt =
0cm 3.15pt'>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify;mso-=
pagination:
none'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
mso-ansi-language:UK'>Легкий</span><s=
pan
lang=3DRU style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p>=
</span></p>
</td>
<td width=3D207 valign=3Dtop style=3D'width:155.05pt;border-top:none;bord=
er-left:
solid navy 1.0pt;border-bottom:solid navy 1.0pt;border-right:none;mso-bor=
der-top-alt:
solid navy .5pt;mso-border-top-alt:solid navy .5pt;mso-border-left-alt:so=
lid navy .5pt;
mso-border-bottom-alt:solid navy .5pt;background:white;padding:0cm 5.4pt =
0cm 3.15pt'>
<p class=3DMsoNormal align=3Dcenter style=3D'margin-right:2.85pt;text-ali=
gn:center;
mso-pagination:none'><span style=3D'font-size:12.0pt;color:black;mso-colo=
r-alt:
windowtext;mso-ansi-language:UK'>50<span style=3D'mso-bidi-font-style:ita=
lic'>
– </span>79</span><span lang=3DRU style=3D'color:windowtext;mso-col=
or-alt:
windowtext'><o:p></o:p></span></p>
</td>
<td width=3D274 valign=3Dtop style=3D'width:205.2pt;border:solid navy 1.0=
pt;
border-top:none;mso-border-top-alt:solid navy .5pt;mso-border-alt:solid n=
avy .5pt;
background:white;padding:0cm 5.4pt 0cm 3.15pt'>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify;mso-=
pagination:
none'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
mso-ansi-language:UK'>2/3
звичайної
дози за 2<span style=3D'mso-bidi-font=
-style:
italic'> – </span>3 прийомl=
0;</span><span
lang=3DRU style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p>=
</span></p>
</td>
</tr>
<tr style=3D'mso-yfti-irow:3'>
<td width=3D176 valign=3Dtop style=3D'width:132.3pt;border-top:none;borde=
r-left:
solid navy 1.0pt;border-bottom:solid navy 1.0pt;border-right:none;mso-bor=
der-top-alt:
solid navy .5pt;mso-border-top-alt:solid navy .5pt;mso-border-left-alt:so=
lid navy .5pt;
mso-border-bottom-alt:solid navy .5pt;background:white;padding:0cm 5.4pt =
0cm 3.15pt'>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify;mso-=
pagination:
none'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
mso-ansi-language:UK'>Помірни&#=
1081;</span><span
lang=3DRU style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p>=
</span></p>
</td>
<td width=3D207 valign=3Dtop style=3D'width:155.05pt;border-top:none;bord=
er-left:
solid navy 1.0pt;border-bottom:solid navy 1.0pt;border-right:none;mso-bor=
der-top-alt:
solid navy .5pt;mso-border-top-alt:solid navy .5pt;mso-border-left-alt:so=
lid navy .5pt;
mso-border-bottom-alt:solid navy .5pt;background:white;padding:0cm 5.4pt =
0cm 3.15pt'>
<p class=3DMsoNormal align=3Dcenter style=3D'margin-right:2.85pt;text-ali=
gn:center;
mso-pagination:none'><span style=3D'font-size:12.0pt;color:black;mso-colo=
r-alt:
windowtext;mso-ansi-language:UK'>30<span style=3D'mso-bidi-font-style:ita=
lic'>
– </span>49</span><span lang=3DRU style=3D'color:windowtext;mso-col=
or-alt:
windowtext'><o:p></o:p></span></p>
</td>
<td width=3D274 valign=3Dtop style=3D'width:205.2pt;border:solid navy 1.0=
pt;
border-top:none;mso-border-top-alt:solid navy .5pt;mso-border-alt:solid n=
avy .5pt;
background:white;padding:0cm 5.4pt 0cm 3.15pt'>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify;mso-=
pagination:
none'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
mso-ansi-language:UK'>1/3
звичайної
дози за 2
прийоми</span><span lang=3DRU
style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p></span></p>
</td>
</tr>
<tr style=3D'mso-yfti-irow:4'>
<td width=3D176 valign=3Dtop style=3D'width:132.3pt;border-top:none;borde=
r-left:
solid navy 1.0pt;border-bottom:solid navy 1.0pt;border-right:none;mso-bor=
der-top-alt:
solid navy .5pt;mso-border-top-alt:solid navy .5pt;mso-border-left-alt:so=
lid navy .5pt;
mso-border-bottom-alt:solid navy .5pt;background:white;padding:0cm 5.4pt =
0cm 3.15pt'>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify;mso-=
pagination:
none'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
mso-ansi-language:UK'>Тяжкий</span><s=
pan
lang=3DRU style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p>=
</span></p>
</td>
<td width=3D207 valign=3Dtop style=3D'width:155.05pt;border-top:none;bord=
er-left:
solid navy 1.0pt;border-bottom:solid navy 1.0pt;border-right:none;mso-bor=
der-top-alt:
solid navy .5pt;mso-border-top-alt:solid navy .5pt;mso-border-left-alt:so=
lid navy .5pt;
mso-border-bottom-alt:solid navy .5pt;background:white;padding:0cm 5.4pt =
0cm 3.15pt'>
<p class=3DMsoNormal align=3Dcenter style=3D'margin-right:2.85pt;text-ali=
gn:center;
mso-pagination:none'><span style=3D'font-size:12.0pt;color:black;mso-colo=
r-alt:
windowtext;mso-ansi-language:UK'>< 30</span><span lang=3DRU
style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p></span></p>
</td>
<td width=3D274 valign=3Dtop style=3D'width:205.2pt;border:solid navy 1.0=
pt;
border-top:none;mso-border-top-alt:solid navy .5pt;mso-border-alt:solid n=
avy .5pt;
background:white;padding:0cm 5.4pt 0cm 3.15pt'>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify;mso-=
pagination:
none'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
mso-ansi-language:UK'>1/6
звичайної
дози
одноразово</s=
pan><span
lang=3DRU style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p>=
</span></p>
</td>
</tr>
<tr style=3D'mso-yfti-irow:5;mso-yfti-lastrow:yes;height:13.7pt'>
<td width=3D176 valign=3Dtop style=3D'width:132.3pt;border-top:none;borde=
r-left:
solid navy 1.0pt;border-bottom:solid navy 1.0pt;border-right:none;mso-bor=
der-top-alt:
solid navy .5pt;mso-border-top-alt:solid navy .5pt;mso-border-left-alt:so=
lid navy .5pt;
mso-border-bottom-alt:solid navy .5pt;background:white;padding:0cm 5.4pt =
0cm 3.15pt;
height:13.7pt'>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify;mso-=
pagination:
none'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
mso-ansi-language:UK'>Терміна&#=
1083;ьна
стадія</span><span lang=3DRU
style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p></span></p>
</td>
<td width=3D207 valign=3Dtop style=3D'width:155.05pt;border-top:none;bord=
er-left:
solid navy 1.0pt;border-bottom:solid navy 1.0pt;border-right:none;mso-bor=
der-top-alt:
solid navy .5pt;mso-border-top-alt:solid navy .5pt;mso-border-left-alt:so=
lid navy .5pt;
mso-border-bottom-alt:solid navy .5pt;background:white;padding:0cm 5.4pt =
0cm 3.15pt;
height:13.7pt'>
<p class=3DMsoNormal align=3Dcenter style=3D'margin-right:2.85pt;text-ali=
gn:center;
mso-pagination:none'><span style=3D'font-size:12.0pt;color:black;mso-colo=
r-alt:
windowtext;mso-ansi-language:UK'>–</span><span lang=3DRU
style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p></span></p>
</td>
<td width=3D274 valign=3Dtop style=3D'width:205.2pt;border:solid navy 1.0=
pt;
border-top:none;mso-border-top-alt:solid navy .5pt;mso-border-alt:solid n=
avy .5pt;
background:white;padding:0cm 5.4pt 0cm 3.15pt;height:13.7pt'>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify;mso-=
pagination:
none'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtex=
t;
mso-ansi-language:UK'>Протипо&#=
1082;азано</span><span
lang=3DRU style=3D'color:windowtext;mso-color-alt:windowtext'><o:p></o:p>=
</span></p>
</td>
</tr>
</table>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-ansi-language:UK'><o:p> </o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><u><s=
pan
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>Хворим з
порушенням
функції
печінки</span></u><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>
коригуваннn=
3;
дози не
потрібне.<o:p></o:p></span>=
</p>
<p class=3DMsoNormal style=3D'margin-right:2.85pt;text-align:justify'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK;mso-fareast=
-language:
CS'>У разі
діагностовk=
2;них
або
підозрюванl=
0;х
розладів
функції
печінки та
нирок
корекцію
дози
проводять
так, як
вказано у
розділі «До
=
79;ування
для хворих і=
079;
порушенням
функції
нирок».</span><b style=3D'mso-bidi-font=
-weight:
normal'><i style=3D'mso-bidi-font-style:normal'><span style=3D'font-size:8.=
0pt;
color:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'><o:p></o:p><=
/span></i></b></p>
<p class=3DMsoNormal><b style=3D'mso-bidi-font-weight:normal'><i style=3D'm=
so-bidi-font-style:
normal'><span style=3D'font-size:8.0pt;color:windowtext;mso-ansi-language:U=
K;
mso-fareast-language:CS'><o:p> </o:p></span></i></b></p>
<p class=3DMsoNormal style=3D'text-align:justify'><b><i><span style=3D'font=
-size:
12.0pt;color:windowtext;mso-ansi-language:UK'>Діти.=
</span></i></b><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'><o:p></o:p=
></span></p>
<p class=3DMsoNormal style=3D'mso-pagination:none;background:white'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK'>Не
застосовувk=
2;ти.</span><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
style=3D'font-size:8.0pt;color:windowtext;mso-color-alt:windowtext;mso-ansi=
-language:
UK'><o:p></o:p></span></i></b></p>
<p class=3DMsoNormal><b style=3D'mso-bidi-font-weight:normal'><i style=3D'm=
so-bidi-font-style:
normal'><span style=3D'font-size:8.0pt;color:windowtext;mso-ansi-language:U=
K'><o:p> </o:p></span></i></b></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><b><i><s=
pan
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Передоk=
9;ування.</span></i></b><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><i><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Симптоl=
4;и: </span></i><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>посилеl=
5;ня
проявів
побічної ді =
11;
лікарськогl=
6;
засобу.<b> </b>Сим=
087;томи
передозуваl=
5;ня
спостерігаl=
3;ися
при
пероральноl=
4;у
застосуванl=
5;і
лікарськогl=
6;
засобу у
дозі 75 г:
відзначені
диспепсичнo=
0;
явища, такі
як діарея з
домішками
крові і біль
у животі.</span><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><i><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Лікуваl=
5;ня</span></i><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'> симпто=
;матичне.
Одразу післ =
03;
значного пе
=
88;орального
передозуваl=
5;ня
слід промит
=
80;
шлунок або
викликати
блювання.
Специфічноk=
5;о
антидоту
немає, можна
застосовувk=
2;ти
гемодіаліз
(виведення 50–6=
0 %
пірацетаму).</s=
pan><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
style=3D'font-size:12.0pt;font-family:"Calibri",sans-serif;color:windowtext;
mso-color-alt:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'><o:p=
></o:p></span></i></b></p>
<p class=3DMsoNormal style=3D'text-align:justify;mso-pagination:none;backgr=
ound:
white'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-s=
tyle:
normal'><span style=3D'font-size:12.0pt;font-family:"Calibri",sans-serif;
color:windowtext;mso-color-alt:windowtext;mso-ansi-language:UK;mso-fareast-=
language:
CS'><o:p> </o:p></span></i></b></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><b><i><s=
pan
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Побічнo=
0;
реакції.</span></i></b><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Побічнo=
0;
реакції,
зокрема
відзначені
=
91;
ході
постмаркетl=
0;нгових
спостережеl=
5;ь,
перераховаl=
5;і
нижче за
системами
органів та
частотою
виникнення.</sp=
an><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;letter-=
spacing:
.2pt;mso-ansi-language:UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;letter-spaci=
ng:
.2pt;mso-ansi-language:UK;mso-fareast-language:CS'>Час=
090;ота
визначаєтьl=
9;я
таким чином:
дуже часто (≥
1/10), часто (≥ 1/100 до
<1/10), нечасто
(≥ 1/1000 до <1/100),
рідко (≥ 1/10 000 до
<1/1000), дуже рідкl=
6;
(<1/10000), поодинок=
;і
випадки (не</spa=
n><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>можливl=
6;
оцінити
частоту на
основі дост
=
91;пних
даних).</span><i><span style=3D'font-size:12.=
0pt;
color:windowtext;mso-color-alt:windowtext;mso-ansi-language:UK;mso-fareast-=
language:
CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><i><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>З боку
вестибулярl=
5;ого
апарату.</span></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'>Поодинl=
6;кі
випадки:
вертиго.</span><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p> </o:p></span></i></p>
<p class=3DMsoNormal style=3D'text-align:justify;background:white'><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p> </o:p></span></i></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><i><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowt=
ext;
mso-ansi-language:UK;mso-fareast-language:CS'>З
боку
шлунково-ки
=
96;кового
тракту.</span></i><span style=3D'font-s=
ize:
12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ansi-language:UK;
mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Поод&=
#1080;нокі
випадки:
анорексія,
абдомінальl=
5;ий
біль, біль у
верхній
частині
живота,</span><span style=3D'font-size:=
12.0pt;
color:black;mso-color-alt:windowtext;mso-ansi-language:UK'>
нудота,
діарея,
блювання,
запор. </span><i><span style=3D'font-size:12.=
0pt;
color:windowtext;mso-color-alt:windowtext;mso-ansi-language:UK'><o:p></o:p>=
</span></i></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><i><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowt=
ext;
mso-ansi-language:UK'>З боку
обміну
речовин,
метаболізмm=
1;.</span></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK'>Часто:
збільшення
маси тіла.</span><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><i><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowt=
ext;
mso-ansi-language:UK;mso-fareast-language:CS'>З
боку
нервової
системи.</span></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Част&=
#1086;: гіперакти=
;вність.</span><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Неча&=
#1089;то:
сонливість.&nbs=
p; </span><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Поод&=
#1080;нокі
випадки:
екстрапіраl=
4;ідні
порушення,<i> </i>=
072;таксія,
тремор,<i> </i>пор=
091;шення
рівноваги,
запаморочеl=
5;ня,
головний
біль,
збудження,
дратівливіl=
9;ть,
порушення
сну,
безсоння,
підвищення
частоти нап
=
72;дів
епілепсії,<span
style=3D'mso-spacerun:yes'>
</span>судоми.</span><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><i><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowt=
ext;
mso-ansi-language:UK;mso-fareast-language:CS'>З
боку психік
=
80;.</span></i><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;mso-ansi-lan=
guage:
UK;mso-fareast-language:CS'> <i> </i></span><span style=3D'font-s=
ize:
12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ansi-language:UK;
mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Част&=
#1086;:
нервозністn=
0;.</span><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Неча&=
#1089;то:
депресія.</span><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Поод&=
#1080;нокі
випадки:<i> </i> п=
;ідвищена
збудливістn=
0;,
збентеженнn=
3;,
тривожністn=
0;,
сплутаністn=
0;
свідомості,
галюцинаціo=
1;.</span><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><i><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowt=
ext;
mso-ansi-language:UK;mso-fareast-language:CS'>З
боку
серцево-суд
=
80;нної
системи.</span></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Поод&=
#1080;нокі
випадки:
погіршення
перебігу ст
=
77;нокардії,
артеріальнk=
2;
гіпертензіn=
3;</span><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'background:white'><i><span style=3D'font-size=
:12.0pt;
color:black;mso-color-alt:windowtext;mso-ansi-language:UK;mso-fareast-langu=
age:
CS'>З боку крові
та
лімфатичноo=
1;
системи.</span></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'background:white'><span style=3D'font-size:12=
.0pt;
color:black;mso-color-alt:windowtext;mso-ansi-language:UK;mso-fareast-langu=
age:
CS'>Поодинокі
випадки:<i> </i>тl=
8;омбофлебіт,<i>
</i>геморагічн&=
#1110;
розлади.</span><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><i><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowt=
ext;
mso-ansi-language:UK;mso-fareast-language:CS'>З
боку імунно =
11;
системи.</span></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Поод&=
#1080;нокі
випадки:
реакції
гіперчутлиk=
4;ості,
зокрема
анафілаксіn=
3;.</span><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><i><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowt=
ext;
mso-ansi-language:UK;mso-fareast-language:CS'>З
боку шкіри т=
072;
підшкірної
клітковини.</sp=
an></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Поод&=
#1080;нокі
випадки:
ангіоневроm=
0;ичний
набряк,
дерматити,
свербіж,
висипання,
кропив’янкk=
2;.</span><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><i><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowt=
ext;
mso-ansi-language:UK;mso-fareast-language:CS'>З
боку
репродуктиk=
4;ної
системи.</span></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Поод&=
#1080;нокі
випадки:
підвищення
сексуальноo=
1;
активності.</sp=
an><i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></i></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><i><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowt=
ext;
mso-ansi-language:UK;mso-fareast-language:CS'>Зага&=
#1083;ьні
розлади.</span></i><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;mso-ans=
i-language:
UK;mso-fareast-language:CS'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><span style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;
mso-ansi-language:UK;mso-fareast-language:CS'>Поод&=
#1080;нокі
випадки: гіl=
7;ертермія<i>,
</i>астенія.</span><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
style=3D'font-size:12.0pt;font-family:"Calibri",sans-serif;color:windowtext;
mso-color-alt:windowtext;mso-ansi-language:UK;mso-fareast-language:CS'><o:p=
></o:p></span></i></b></p>
<p class=3DMsoNormal style=3D'margin-right:1.45pt;text-align:justify;backgr=
ound:
white'><b style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-s=
tyle:
normal'><span style=3D'font-size:12.0pt;font-family:"Calibri",sans-serif;
color:windowtext;mso-color-alt:windowtext;mso-ansi-language:UK;mso-fareast-=
language:
CS'><o:p> </o:p></span></i></b></p>
<p class=3DMsoNormal><b style=3D'mso-bidi-font-weight:normal'><i style=3D'm=
so-bidi-font-style:
normal'><span style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:=
UK'>Термін
придатностo=
0;.</span></i></b><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'> 2
роки.<o:p></o:p></span></p>
<p class=3DMsoNormal><span style=3D'font-size:12.0pt;color:windowtext;mso-a=
nsi-language:
UK'>Не
застосовувk=
2;ти
після
закінчення
терміну
придатностo=
0;,
зазначеногl=
6;
на упаковці.<b
style=3D'mso-bidi-font-weight:normal'><o:p></o:p></b></span></p>
<p class=3DMsoNormal><b style=3D'mso-bidi-font-weight:normal'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'><o:p> =
;</o:p></span></b></p>
<p class=3DMsoNormal><b style=3D'mso-bidi-font-weight:normal'><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'>У=
084;ови
зберігання.</sp=
an></b><span
style=3D'font-size:12.0pt;color:windowtext;mso-ansi-language:UK'> </span><s=
pan
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;backgro=
und:
white;mso-ansi-language:UK'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:black;mso-color-alt:windowtext;background:white;mso-ansi-language:UK'=
>Зберігати
в
оригінальнo=
0;й
упаковці пр
=
80;
температурo=
0;
не вище 25 <sup>о</sup>С. <=
/span><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;backgro=
und:
white;mso-ansi-language:UK'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:black;mso-color-alt:windowtext;background:white;mso-ansi-language:UK'=
>Зберігати
у
недоступноl=
4;у
для дітей
місці.</span><span style=3D'font-size:12.0pt;
color:windowtext;mso-color-alt:windowtext;background:white;mso-ansi-languag=
e:
UK'><o:p></o:p></span></p>
<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
12.0pt;
color:windowtext;mso-color-alt:windowtext;background:white;mso-ansi-languag=
e:
UK'><o:p> </o:p></span></p>
<p class=3DMsoNormal><b style=3D'mso-bidi-font-weight:normal'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;background:w=
hite;
mso-ansi-language:UK'>Упаковк
=
72;.</span></b><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;background:w=
hite;
mso-ansi-language:UK'> </span><span style=3D'font-size:12.0pt;color:windowt=
ext;
mso-color-alt:windowtext;background:white;mso-ansi-language:UK'><o:p></o:p>=
</span></p>
<p class=3DMsoNormal><span style=3D'font-size:12.0pt;color:black;mso-color-=
alt:
windowtext;background:white;mso-ansi-language:UK'>По 10
таблеток у
блістері, по 6
блістерів у
пачці з
картону.</span><b style=3D'mso-bi=
di-font-weight:
normal'><span style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:wind=
owtext;
background:white;mso-ansi-language:UK'><o:p></o:p></span></b></p>
<p class=3DMsoNormal><b style=3D'mso-bidi-font-weight:normal'><span
style=3D'font-size:12.0pt;color:windowtext;mso-color-alt:windowtext;backgro=
und:
white;mso-ansi-language:UK'><o:p> </o:p></span></b></p>
<p class=3DMsoNormal><b style=3D'mso-bidi-font-weight:normal'><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;background:w=
hite;
mso-ansi-language:UK'>Категор =
10;я
відпуску.</span></b><span
style=3D'font-size:12.0pt;color:black;mso-color-alt:windowtext;background:w=
hite;
mso-ansi-language:UK'> </span><span style=3D'font-size:12.0pt;color:windowt=
ext;
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nsi-language:
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lang=3DRU style=3D'color:windowtext'><o:p> </o:p></span></h3>
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